nitric oxide and gene regulation

... Lowenstein CJ: Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes J Neurosci Res 1997, 48:372-384 Wallace MN, Geddes JG, Farquhar DA, Masson MR: Nitric oxide synthase in ... of morphological change and release of cytokines and nitric oxide Neurosci Res 1999, 35:95-100 Feinstein DL, Galea E, Reis DJ: Norepinephrine suppresses inducible nitric oxide synthase activity ... nitrogen and oxygen species Nitric Oxide 1997, 1:145-157 Imrich A, Kobzik L: Fluorescence-based measurement of nitric oxide synthase activity in activated rat macrophages using dichlorofluorescin Nitric...

Ngày tải lên: 19/06/2014, 22:20

... production of nitric oxide (NO) and various cytokines and chemokines by cultured primary brain pericytes Pericytes were treated for 4, and 24 h with different concentrations of the LPS and nitrite ... Release of nitric oxide and nitrosative stress in primary brain pericytes after LPS stimulation Brain pericytes were stimulated for 4, 8, and 24 h with LPS (0.1 and ug/ml), media collected, and analyzed ... free of these cell types Nitric oxide (NO) is a signaling molecule and immune mediator that is released from glial and endothelial cells Page of with activation Microglia and astrocytes are common...

Ngày tải lên: 19/06/2014, 22:20

... Society: ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide Am J Respir Crit Care Med 2005, ... methacholine and AMP responsiveness or with significant Figure Individual values for exhaled nitric oxide (ENO) concentrations in the specific immunotherapy and placebo groups at baseline and after and ... 0.9, P = 0.35) and 0.7%/log mg/dL (-1.3 to 2.6, P = 0.50) after and 12 months of treatment, respectively Exhaled nitric oxide In both groups, changes from baseline in ENO values after and 12 months...

Ngày tải lên: 08/08/2014, 21:20

... 47(6):655-9 ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med ... asthma based on proximal and distal airway nitric oxide categories Respir Res 2010, 11:47 doi:10.1186/1465-9921-12-65 Cite this article as: Mahut et al.: Exhaled nitric oxide and clinical phenotypes ... exhaled nitric oxide versus clinical symptoms for asthma in children and adults Cochrane Database Syst Rev 2009, , 4: CD006340 36 Mahut B, Delclaux C: Peripheral airway/alveolar nitric oxide concentration...

Ngày tải lên: 12/08/2014, 13:22

... 14:902-907 ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005 Am J Resp Crit Care Med ... keys] Association of exhaled nitric oxide and exhaled 8-isoprostanes by body mass index in healthy non-asthmatic adults Figure Association of exhaled nitric oxide and exhaled 8-isoprostanes by ... http://respiratory-research.com/content/8/1/32 Figure of exhaled nitric oxide and exhaled 8-isoprostanes by body mass index in adults with asthma Association Association of exhaled nitric oxide and exhaled 8-isoprostanes by body...

Ngày tải lên: 12/08/2014, 15:20

... Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn Lancet 1992, 340:819–820 Roberts JD, Polander DM, Lang P, Zapol WM: Inhaled nitric oxide in persistent pulmonary ... products HNO2 and HNO3 which dissolves into NO2– and NO3– + H+ NO2 formation should be increased according to the kinetics of this reaction with higher concentrations of NO and O2 and a longer ... Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension Lancet 1991, 338:1173–1174 Pison U, Lopez FA, Heidelmeyer CF, Rossaint R, Falke K: Inhaled nitric oxide...

Ngày tải lên: 12/08/2014, 18:20

... online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 American Journal Of Respiratory And Critical Care Medicine 171, 912–930 (2005) C Gabriele, ... County Council of Värmland, “Landstinget i Värmland”, for financial support; All participating subjects and staff at the children’s health care centres of Filipstad, Gripen, and Kronoparken Author ... Carlstedt et al.: Exhaled nitric oxide and urinary EPX levels in infants: a pilot study Clinical and Molecular Allergy 2011 9:8 Submit your next manuscript to BioMed Central and take full advantage...

Ngày tải lên: 13/08/2014, 13:22

... (Figures and 3) Because cooperative and competitive interactions are common in gene regulation, the explicit consideration of concentration is likely to be necessary for a complete understanding of gene ... experimicroarraySum1aofORFs)genesaregulatedprobabilitydata from chrogenes) published and( intersectionvitro [7] derived matrix both publishedbyNdt80pand Fkh1p binding [5] sets, andgeneschromatin ments ... distinguish regulated genes from other genes that have a comparable number of binding sites [24-26] GOMER, on the other hand, can distinguish genes with clustered binding sites from genes whose sites...

Ngày tải lên: 14/08/2014, 14:22

... Nuclear factor-kappa B NO Nitric oxide NOF (HCT-1026) Nitroflurbiprofen NOS Nitric oxide synthase nNOS (NOS I) Neuronal nitric oxide synthase NOx Nitrate/nitrite NO-NSAID Nitric oxide- releasing non-steroidal ... inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO) activity (marker for neutrophil infiltration), and NF-κB and proteasome activation, whilst a decrease in liver endothelial nitric oxide ... to thank both my supervisor and co-supervisor, Professor Philip K Moore and A/Professor Madhav Bhatia for introducing me to the field of nitric oxide and septic shock and for allowing me the opportunity...

Ngày tải lên: 14/09/2015, 14:16

... al., 1998) 1.5 The role nitric oxide and prostaglandin E2 in prolonged hemorrhagic shock Hemorrhagic shock produces the bioregulatory molecule nitric oxide (NO) which is generated catalytically ... model: The role of NO and PGE2 and the therapeutics effects of conservative fluids, NOS and COX-2 inhibitors 45 4.1 Introduction The up -regulation of nitric oxide (NO) and cyclooxgenase-2 (COX-2) ... vasoconstrictor (Pope et al., 1999) 1.4 The role Nitric Oxide play in prolonged hemorrhagic shock Excessive production of nitric oxide (NO) as result of inducible nitric oxide synthase (iNOS) induction has...

Ngày tải lên: 16/09/2015, 15:54

... conservative fluids, NO donor and NOS inhibitors Role of nitric oxide (NO) and PGE2 in prolonged hemorrhagic shocked rats and therapeutic effects of conservative fluids, NOS and COX-2 inhibitors Role ... anti-inflammatory drugs NO Nitric oxide NS Normal saline nNOS Neuronal nitric oxide synthase NS-398 (N-[2-(Cyclohexyloxy)-4nitrophenyl]methanesulfonamide PGE BBB BBB Prostaglandin E BBB BBB TBI Traumatic ... Endothelial nitric oxide synthase FPI Fluid percussion injury GIT Gastrointestinal tract GOT Glutamic oxaloacetic transaminase HS Hemorrhagic shock HTS Hypertonic saline BBB iNOS Inducible nitric oxide...

Ngày tải lên: 16/09/2015, 15:54

... 1.2 Nitric Oxide 1.2.1 Endogenous NO 1.2.2 Chemistry 1.2.3 Physiological roles 1.2.4 NO in neurons 1.2.5 NO and apoptosis 1.3 NO and gene regulation ... pathways, and their regulation downstream of NO is associated with attenuation of NO toxicity 1.3 NO and gene regulation The notion of a linear sequence of signaling events – extracellular ligands ... factor and is a member of the C/EBP family The GADD genes are a group of genes that are induced by genotoxic stress and growth arrest signals There are three distinct GADD genes, GADD34, GADD45 and...

Ngày tải lên: 26/11/2015, 23:06

... down -regulation of iNOS expression and NO secretion NFB is known to play a critical role in the regulation of cell survival genes and coordination of pro-inflammatory mediators such as iNOS and ... Xie QW, Nathan C: Nitric oxide and macrophage function Ann Rev Immuno 1997, 15:323-50 Kleinert H, Pautz A, Linker K, Schwarz PM: Regulation of the expression of inducible nitric oxide synthase Eur ... Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down -regulation of IkappaB kinase and NFkappaB activation in macrophages Biochem...

Ngày tải lên: 11/08/2014, 08:22

... S, Mori M Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC 12 cells and high output production of nitric oxide Mol Brain Res 2000; 83: 1-8 ... amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells Mol Brain Res 2001; 90: 165-173 20 Swamy M, Sirajudeen KNS, Chandran G Nitric oxide [NO] citrulline-NO ... between nitric oxide and dementia of Alzheimer’s type Brain Res Rev 2001; 35: 73-96 42 Serrano J, Encinas JM, Salas E, et al Hypobaric hypoxia modifies constitutive nitric oxide synthase activity and...

Ngày tải lên: 26/10/2012, 09:07

... products and effectors (X), and by changes in the affinities (1 ⁄ K) of enzyme e towards its substrates, products and effectors (K) As derived previously [6,7], gene expression and metabolic regulation ... versus gene expression before examining specific metabolites Earlier regulation analysis studies of nitrogen starvation in yeast revealed mixed and diverse regulation [9] Both gene expression and ... of gene expression of a certain gene (X) normalized to the mean of the control gene PDI1 and the steady-state sample of the chemostat culture (Eqns and 7) We have normalized to steady state and...

Ngày tải lên: 18/02/2014, 06:20

... inducible nitric- oxide synthase affect its Ca2+-independent activity J Biol Chem 275, 36067– 36072 110 Lee SJ & Stull JT (1998) Calmodulin-dependent regulation of inducible and neuronal nitric- oxide ... Alderton WK, Cooper CE & Knowles RG (2001) Nitric oxide synthases: structure, function and inhibition Biochem J 357, 593–615 Stuehr DJ (1999) Mammalian nitric oxide synthases Biochim Biophys Acta 1411, ... of nitric oxide synthase Biochem Biophys Res Commun 265, 184–188 12 Santolini J, Adak S, Curran CM & Stuehr DJ (2001) A kinetic simulation model that describes catalysis and regulation in nitric- oxide...

Ngày tải lên: 18/02/2014, 11:20

... at 50 °C and 10 at 95 °C, followed by a total of 40 twotemperature cycles (15 s at 95 °C and at 60 °C) For the generation of standard curves, serial dilutions of a cDNA sample were used and mRNA ... and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... iPLA2c message, protein mass and activity increased during adipogenesis and siRNA knockdown of iPLA2c-inhibited adipogenesis [67] Similarly, we demonstrated the dramatic up -regulation of the iPLA2c...

Ngày tải lên: 19/02/2014, 16:20

... inducible nitric oxide synthase gene expression in vascular smooth muscle cells Gen Pharmacol 32, 9–16 19 Kim, S.-J., Bang, O.-S., Lee, Y.-S & Kang, S.-S (1998) Production of inducible nitric oxide ... the effects of inhibitors of PKA and PKC on TS-enhanced NO production As shown in Fig 5A, the PKA inhibitors KT-5720 and H8 and the PKC inhibitors Ro31-2880 and GF109203X did not affect apparently ... Effects of PKA inhibitors (KT-5720 and H8) and PKC inhibitors (Ro31-8220 and GF109203X) on the enhancement by TS of LPS/IFNinduced NO production in VSMC (A), and Western blot analysis of PKCa...

Ngày tải lên: 22/02/2014, 04:20

... endotheliumderived relaxing factor and the chemical reactivity of nitric oxide J Exp Med 169, 1011–1020 Abu-Soud HM & Stuehr DJ (1993) Electron transfer in the nitric- oxide synthases Nitric oxide synthases reveal ... purview and parameters Nat Rev Mol Cell Biol 6, 150–166 Lancaster J (1997) A tutorial on the diffusibility and reactivity of free nitric oxide Nitric Oxide 1, 18–30 Salerno JC (2008) Neuronal nitric ... constants k1, k4 and k8 correspond to heme reduction; k2 and k5 correspond to oxygen binding; and k3 and k6 correspond to catalytic steps k7 and k9 correspond to the release of NO from ferric and ferrous...

Ngày tải lên: 07/03/2014, 00:20

... transcription and its regulation depend on molecular interactions of actin with RNA polymerases and components of the transcription machinery in the nucleus The role of actin in transcription and its regulation ... and hnRNP U Moreover, it has been shown that actin, hnRNP U and PCAF associate with the Ser2 ⁄ 5and Ser2-phosphorylated Pol II C-terminal domain hnRNP U and PCAF are present at the promoter and ... actin monomers and prevents Rho-dependent nuclear accumulation of MRTF-A and SRF Actin and ABPs in transcription regulation activation [46], blocks the nuclear accumulation of MRTF-A and -B in the...

Ngày tải lên: 07/03/2014, 01:20