new targets for the action of pharmacological agents
báo cáo khoa học: "New targets for the treatment of follicular lymphoma" potx
... understanding of the biological factors underlying the development of FL The identification of new targets and development of novel targeted therapies is imperative to exploit the biological indolence of ... diarrhea A considerable body of research indicated that the toxicity of gossypol is related to the reactions of the aldehyde groups on the molecule, suggesting that removal of the aldehyde groups from ... shown to interact with the hydrophobic cleft of MDM2, thus mimicking the binding of the helical portion of p53 However, one of the enantiomers of this racemic mixture of compounds was found to...
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Tài liệu Một số thuốc mới chống rối loạn lipid máu (New drugs for the control of dyslipidemia) pdf
... tham khảo Tài liệu khoa học công ty dợc phẩm pfizer, MSD, Fourmier (1998 - 2004) Opie H.L: Drugs for the Heart; Edition (2001); W.B Samders Company, trang 323 350 Medline (2000 - 2004) ... ezetimibe với cholestyramin, cyclosporin Dùng riêng, rosuvastatin dễ dung nạp, kể phối hợp với fenofibrat, niacin, cholesteramin, dáng dấp an toàn tơng tự statin lu hành Chỉ định ezetimibe tăng ... "không sterol" có ích cho sức khoẻ nh dolichol, ubiliquinon (coenzym Q10) xin đọc sơ đồ Squalen synthetase xúc tác cho sinh tổng hợp cholesterol mắt xích gần cuối, chuyển farnesyl pyrophosphat sang...
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Báo cáo khoa học: New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases pot
... that the presence of the C-terminal domain is crucial for the acquisition of the correct enzyme fold Analysis of the interactions between the two domains led us to presume that expression of the ... or in the absence of chelators (90.94 ± 7.85 UÆmg)1) These results suggest that the presence of calcium is important for the optimal activity of BsArb43B Furthermore, to determine whether the role ... Together, these results confirm that the atom in the cluster is calcium To determine whether the calcium ion has a specific role in the activity of BsArb43B, assays were performed in the presence of...
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New Imperatives for the Elements of Investing_1 ppt
... based on the width of a house Consider another architectural example, the invention of the mansard roof in France Property taxes were often levied on the number of rooms in a house and, therefore, ... pleasure in the process of saving and the process of keeping trim They not think in terms of deprivation; they think in terms of making good progress toward achieving their goal As they make progress ... outperformed all but a handful of the thousands of equity and bond funds that are sold to the public This simple investment strategy—indexing—has outperformed all but a handful of the thousands of...
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New Imperatives for the Elements of Investing_2 pptx
... act That’s why the most important pieces of news (such as takeover offers) are announced when the market is closed By the time trading opens the next day, prices already reflect the offer You can ... on prices) Professional managers underperform the market as a whole by the amount of their management expenses and transaction costs 37 c02.indd 37 10/31/09 1:35:13 PM The Elements of Investing ... go into the pockets of the croupiers of the financial system, not into your retirement funds That’s why active managers not beat the market—and why the market beats them DON’T SOME BEAT THE MARKET?...
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New Imperatives for the Elements of Investing_3 ppt
... mutual funds The fund pools the money from thousands of investors and buys a portfolio of hundreds of individual common stocks The mutual fund collects all the dividends, does all the accounting, ... hold a broadly diversified bond fund The U.S Treasury issues large amounts of bonds These issues are considered the safest of all and these bonds are the one type of security where diversification ... over the entire decade The 1970s were just as bad And an investor who put everything in at the 1929 peak, like the father of one of the authors, would not have broken even for more than 20 years...
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New Imperatives for the Elements of Investing_4 pdf
... something And then something else The more you do, the merrier he will be Mr Market is expensive and the cost of transactions is the small part of the total cost The large part of the total cost ... forecasts—forecasts of the stock market, forecasts of interest rates, forecasts of the economy? Answer: Nothing You can save time, anxiety, and money by ignoring all market forecasts BEWARE OF ... exactly the wrong time More money went into equity mutual funds during the fourth quarter of 1999 and the first quarter of 2000—just at the top of the market—than ever before And most of the money...
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New Imperatives for the Elements of Investing_6 potx
... well, then you can—and should— ignore the exotics They’re not for you or for either of us Beware! If you look hard enough to find a manager who will assure you that he will great things for you ... life Thousands of people go skiing on a typical winter’s day, and almost all of them have a wonderful time skiing at their own level on the trails and slopes that are right for them The secret to ... recipient, not the age of the donor, for that part of their total investments 106 c05.indd 106 11/3/09 10:16:21 AM Keep It Simple The key to success in investing is to invest with the asset mix...
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New Imperatives for the Elements of Investing_8 pot
... Professor of Economics at Princeton University and the author of the bestselling A Random Walk Down Wall Street Malkiel has served on the President’s Council of Economic Advisers, as Dean of the ... has served as a member of the President’s Council of Economic Advisers, Dean of the Yale School of Management, Chair of Princeton’s Economics Department, and as a director of major corporations ... Bestselling author of Winning the Loser’s Game In his classic book The Elements of Style, Professor William Strunk Jr whittled down the art of powerful writing to a few basic rules Forty years later,...
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báo cáo khoa học: " A new model for the characterization of infection risk in gunshot injuries:Technology, principal consideration and clinical implementation" pptx
... 5.0 g of barium titanate were then distributed in the dust chamber prior to each shot, and a filter paper was inserted to block the dust chamber from the barrel of the rifle The other end of the ... differences in the diameter of the cavity between the two projectiles were found 6.0-10.0 cm behind the point Page of of impact of the projectile on the gelatin block In this area, the gelatin blocks ... within the ruptures of a temporary cavity in the gelatin block revealed a deposition of particles along the entire bullet path for both types of projectiles examined In the case of the soft point...
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Báo cáo y học: "New indications for the use of therapeutic hypothermia" doc
... rate with the injury, the use of TH seems well justified in the types of cases presented Intensive care physicians are therefore encouraged to consider the use of TH in similar cases in the future ... very supportive of benefit of TH in animal models of these injuries [10,11] Fortunately, there is now also extensive clinical data that suggest that TH carries a very low risk for adverse side ... unproven Is it therefore reasonable to use TH in such patients outside the context of a clinical trial? To answer this question, both the theoretical benefits and possible adverse effects of TH must...
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Báo cáo y học: "Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury" docx
... prevent the development of lung injury when used as the initial mode of ventilation [11-14] Therefore, the clinically relevant questions now become whether inhaled APC can diminish the severity of ... diminishing the enhanced apoptosis of epithelial and other cell populations which accompanies acute lung injury In the present experiments, treatment with APC was started before the initiation of injurious ... ventilation in the presence of acute lung injury due to sepsis or other etiologies and whether inhaled APC can prevent or minimize primary or secondary lung damage when low tidal volumes are used for mechanical...
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Development of new methodologies for the synthesis of enantiomerically enriched compounds
... DEVELOPMENT OF NEW METHODOLOGIES FOR THE SYNTHESIS OF ENANTIOMERICALLY ENRICHED COMPOUNDS LEE CHENG HSIA ANGELINE (B.ApplSc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... published their innovation on the Lewis acid mediated reaction of crotyltins with aldehydes that produces the syn-homoallylic alcohols regardless of the geometry of the double bond of the allylic ... strategy to the aldol additions of metal enolates (path B) Furthermore, the versatility of the alkene functionality in synthetic transformation also contributes to the potential of homoallylic...
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Hướng dẫn bói bài Tarot New dimensions for the cube of space
... on the cube, while the actual birth of the child is The Wheel of Fortune in the West The Lovers wheel of fortune The Empress Figure 10 Emergingfrom the womb-door of the mother into the West The ... faces o f the cube and its center form the seven esoteric grades Figure The center of the universe of the Cube of Space 22 New Dimensions for the Cube ofspace THE WORLD-CENTER OF THE CUBE T ... cube, the faces of the cube, and the borders of the cube The interior of the cube is composed of the center (one of the seven double letters) and the three interior dimensions (the three mother...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... system, in the distal segment of the tubule Inhibition of glucose reabsorption in the kidney, mediated by the SGLT cotransport system, represents a promising therapeutic target for the control of hyperglycemia ... larvae of beetles (Chrysomelidae) Their synthesis has been previously described [31-33] For the purpose of the present study the thioglycosides used were selected and grouped based on their differences ... IC50 values of 30 µM for hSGLT1 and 10 µM for hSGLT2, while thioglycoside VII showed IC50 values of 15 µM for hSGLT1 and 88 µM for hSGLT2 These data confirm the strong inhibitory effects of thioglycoside...
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Accounting for new organisational forms the case of subcontracting and outsourcing
... terms of the impact of outsourcing (IMPACTL to IMPACTO) They were asked whether it had improved: the timing of their supplier deliveries, the lead-time for the delivery of orders, the quality of ... There is evidence, for example, that the effects of the audit explosion associated with the introduction of new organisational forms and new systems for the management of performance may have ... to the objectives of both the individual and FoodUK, otherwise there was the real risk of outcomes being inconsistent with the interests of the company, particularly because the achievement of...
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Tài liệu Developing Culturally and Linguistically Competent Health Education Materials: A Guide for the State of New Jersey ppt
... prescriptions for improving the quality of life The differences are between perspectives: the individual and the societal; the negative and the positive; the curative and the preventive; the reductivist ... tremendous implications for material development 23.9% of the foreign-born population of New Jersey lives in linguistic isolation (About 19.5% of the population of New Jersey is foreign-born) A linguistically ... which the client/family is at the center and controls the flow of information The educator asks questions and listens thereby allowing the client/family to lead the discussion based on their...
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Tài liệu Response statistics for ''''New Legislative Framework for the marketing of products: proposal to align 10 product harmonisation directives to Decision 768/2008.'''' pdf
... (2.6%) B11 How you evaluate the impact of the four elements of Action recalled below on the level of compliance, safety of products and functioning of the internal market for the product categories ... (43.4%) - C25 How you evaluate the impacts of the three elements of Action recalled below on the performance of Notified Bodies, safety of products, functioning of the internal market and operational ... 95/16/EC of 29 June 1995 on the approximation of the laws of the Member States relating to lifts Pressure Equipment Directive: Directive 97/23/EC of the 25 European Parliament and of the Council on the...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... indicate the position of the introns The boxes indicate amino-acid substitutions skipping of three successive exons during the course of the processing of the primary transcripts [9] At the peptide ... (Fig 3) The retention time of variant M was shorter than that of the A variant while the relative percentage was the same The HPLC fractions were analysed by ES/MS, and the molecular masses of as1-CasA, ... wonder whether the donor allele of the 5¢ part is the F allele or another allele belonging to the same B allelic lineage (excluding B1 and C), as they share the same simplified haplotype formula,...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25