new diagnostic and therapeutic approaches

... has been made in the management of acute and procedural pain with the availability of newer and potent, yet short-acting sedatives and analgesics. Sedation and analgesia for procedures in the ED ... maturity, and past medical experiences of the child, the duration and nature of the proce- dure, and the experience and skills of the caregivers to calm an anxious child. The need for expediency and ... Committee on Drugs: guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures (1992) Pediatrics 89(6

Ngày tải lên: 13/08/2014, 03:21

... Food and Drug Administration (FDA) has mandated pediatric pharmacokinetic and dynamic studies in all new drugs that enter the American marketplace (36–38). Unfortunately, despite these new regulations, ... receptors and subtypes have been identified and classified (79,83–88). An understanding of the complex nature and organization of these multiple opioid receptors is essential for an adequate understanding ... P R (1987) Pain and its effects in the human neonate and fetus N Engl J Med 317(21), 132 1–1 329 8 Anand, K J and Carr, D B (1989) The neuroanatomy, neurophysiology, and neurochemistry

Ngày tải lên: 13/08/2014, 03:21

... increased the demand for sedation to facilitate medical and diagnostic procedures First, there has been an increased availability and utilization of various diagnostic and therapeutic ... Sedation and Analgesia for Diagnostic and Therapeutic Procedures Edited by: S Malviya, N N Naughton, and K K Tremper © Humana Press Inc., Totowa, NJ 243 244 Voepel-Lewis and emphasizes ... patients during and after sedation for diagnostic and therapeutic procedures Pediatrics 89 , 111 0–1 115 3 American Society of Anesthesiologists Task Force on Sedation and Analgesia

Ngày tải lên: 13/08/2014, 03:21

... proteases: new biomarkers and therapeutic targets for cancer? Michael J Duffy 1,2* , Maeve Mullooly 1,2 , Norma O’Donovan 3 , Sumainizah Sukor 2,4 , John Crown 4 , Aisling Pierce 1,2 and Patricia ... ADAM9, ADAM10, ADAM12, ADAM15 and ADAM17. Two of the ADAMs, i.e., ADAM 10 and 17 appear to promote cancer progression by releasing HER/EGFR ligands. The released ligands activate HER/EGFR signalling ... (primarily ADAM10 and ADAM17) are involved in proteolytic ectodomain shedding of membrane bound ligands. The released ligands (for example, EGF, HB-EGF, TGFa, heregulins) are free to bind to and activate

Ngày tải lên: 13/08/2014, 13:20

... aerobic and progressive resistance training (PRT) and will be conducted at the Baker Heart and Diabetes Institute, the Deakin University Clinical Exercise Learning Centre, and participating health and ... EJH and ALG will implement the protocol and oversee the collection of the data SJF drafted the manuscript, and all authors (ALG, AS, EJH, MJH, RMD, SFF, SJF, SL and YA) read, contributed to and ... undergo AC and its commencement This trial has been approved by the Alfred Hospital Human Research Ethics Committee (Project No: 305/17), is registered with the Australian and New Zealand Clinical

Ngày tải lên: 06/08/2020, 05:32

... innovative approaches   to   learning   and   teaching   in   Geography   using   geographers,   computer scientists? ?and? ?education specialists to design, create? ?and? ?support the re­deployment and? ?embedding of digital resources within existing courses? ?and? ?modules.  The model ... to develop learning material to support students? ?and? ?staff in their understanding? ?and use of the Global Positioning System (GPS). Existing material at PSU on GPS was about to be reviewed? ?and? ?updated? ?and? ?could be supplemented by a training nugget in ... about to be reviewed? ?and? ?updated? ?and? ?could be supplemented by a training nugget in using   and   understanding   GPS   receivers   Instead   of   working   independently,   a collaborative   approach   to   the   design   of   new   and   updated   learning   and   teaching

Ngày tải lên: 18/10/2022, 12:09

... potential diagnostic and therapeutic tools for infectious disease (tuberculosis), carcinogenic heavy metal (hexavalent chromium) and cancer (prostate cancer) were investigated and applied For early and ... Sensitive Diagnostic and Therapeutic Fields of Cancer and Infectious Disease Le Minh Tu Phan Major in Biochemistry Department of Chemistry The Graduate School, Chung-Ang University Cancer and infectious ... bio-identification and thermal therapeutic products, suggesting the utilization of as-synthesized carbon dots can be used as promising candidates in biorecognition and thermal treatment applications These new

Ngày tải lên: 19/04/2023, 19:55

... MINIREVIEW Therapeutic approaches for prion and Alzheimer’s diseases Thomas Wisniewski1,2,3 and Einar M Sigurdsson2,3 Department of Neurology, New York University School of ... degradation and toxic to neurons Neurological symptoms in AD and prion disease are directly related to loss of neurons and synaptic connections Oligomeric and fibrillar Ab can be directly neurotoxic and ... well as end-protection by amidation and and acetylation of the C- and N-termini, respectively, to increase serum half-life, have allowed us to use this peptide therapeutically in the APPK670N ⁄

Ngày tải lên: 07/03/2014, 10:20

... diseases and chaperone-based therapeutic approaches Tapan K. Chaudhuri and Subhankar Paul Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi, ... Gaucher’s disease and many other degenerative and neurodegenerative disorders. Cellular mole- cular chaperones, which are ubiquitous, stress-induced proteins, and newly found chemical and pharmacological ... causes aggregation and cell death in vitro and in vivo. In vitro cellular models and transgenic animals have been created and analyzed with the truncated ataxin-3 with an expanded polyglutamine

Ngày tải lên: 07/03/2014, 12:20

... ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER Edited by César López-Camarillo and Elena Aréchaga-Ocampo Oncogenomics and Cancer ... orders@intechopen.com Oncogenomics and Cancer Proteomics – Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer, Edited by César López-Camarillo and Elena Aréchaga-Ocampo p cm ... included Chapters in “Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer” present comprehensive and expert perspectives on the most

Ngày tải lên: 30/03/2014, 09:20

... DEVELOPMENT AND APPLICATIONS OF NEW SLIDING MODE CONTROL APPROACHES PAN YA-JUN NATIONAL UNIVERSITY OF SINGAPORE 2003 Founded 1905 DEVELOPMENT AND APPLICATIONS OF NEW SLIDING MODE CONTROL APPROACHES ... system such as servo mechanisms and. .. developing new sliding mode control approaches both for theoretical and applications problems The proposed new sliding mode control ... with ILC and torque estimation 146 8.10 Gain shaped sliding mode. .. manipulators: Sliding mode control approach (Chern and Wu, 1992), (Chan, 1995), (Pandian and Hanmandlu, 1995),

Ngày tải lên: 17/09/2015, 17:18

... (TSP)-1 and TSP-2 encoding cDNA were cloned, sequenced, and expressed and shown to elicit protection levels of 57% and 64% (TSP-2) and 34% and 52% (TSP-1) for mean adult worm burdens and liver ... more powerful in adults and children with patent infection than in hamsters, and ARA is already marketed for human use in USA and Canada for proper development of newborns, and muscle growth of ... and a small amount of IL-4 [188] Th1 inflammatory cytokines such as IFN-c and TNF-a trigger monocytes and endothelial cells to release the potentially larvacidal superoxide anions and oxygen and

Ngày tải lên: 15/01/2020, 12:32

... surgery and radiation alone, and this regimen has become the current standard for GBM [3] Life expectancy remains short, spurring additional research and development of more effective therapeutic ... landmark TCGA study, the authors sequenced 20,661 protein-coding genes in 22 primary and secondary GBM tumor samples and used high-density oligonucleotide arrays to look for amplifications and ... catalysed by IDH1 and IDH2 are reversible and use NADP+ as an electron acceptor leading to the production of NADPH [35] IDH1 acts in the cell cytoplasm and peroxisomes whereas IDH2 and IDH3 are found

Ngày tải lên: 15/01/2020, 20:25

... who have had breast cancer Modern breast diagnosis and treatment includes a multiplicity of well-differentiated and effective diagnostic and therapeutic procedures These procedures can only be ... examination ● The timeliness and manner with which results of tests are shared with the patient ● Making the patient aware of further diagnostic and therapeutic options In most diagnostic breast centers, ... exclusively with diagnostics This increases mutual appreciation and the understanding of the work of others in the department The work at the registration desk is important and challenging, and it is

Ngày tải lên: 21/01/2020, 12:34

... standardized, and should include a minimum wall filter setting of 50 Hz and a Doppler sample volume between and mm (Szatmari et al., 2001) 4 Hemodynamics – New Diagnostic and Therapeutic Approaches ... difference caused by them can be 12 Hemodynamics – New Diagnostic and Therapeutic Approaches observed In benign neoplasia, on the other hand, no specific and measurable Doppler flow spectrum has been ... complex 16 Hemodynamics – New Diagnostic and Therapeutic Approaches interactions between several regulatory pathways (renin–angiotensin, kallikrein–kinin, and prostaglandin–thromboxane) are in...

Ngày tải lên: 19/02/2014, 23:20

... HEMODYNAMICS – NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES Edited by A Seda Artis Hemodynamics – New Diagnostic and Therapeutic Approaches Edited by A Seda Artis Published ... standardized, and should include a minimum wall filter setting of 50 Hz and a Doppler sample volume between and mm (Szatmari et al., 2001) 4 Hemodynamics – New Diagnostic and Therapeutic Approaches ... difference caused by them can be 12 Hemodynamics – New Diagnostic and Therapeutic Approaches observed In benign neoplasia, on the other hand, no specific and measurable Doppler flow spectrum has been...

Ngày tải lên: 14/03/2014, 10:20

... peripheral and central nervous system diseases, and developed new therapeutic approaches towards these diseases Peripheral neuropathy is a common disorder seen by many specialists and can pose a diagnostic ... 2005) 8 Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Dynamin is phosphorylated by several kinases including PKC and CDK5, and dephosphorylated by carcinerurin Dynamin-dependent ... therapy and in the feet during follow-up In a minority of patients the neurotoxicity is long lasting (Land et al., 2007) 28 Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches...

Ngày tải lên: 17/03/2014, 02:20

... peripheral and central nervous system diseases, and developed new therapeutic approaches towards these diseases Peripheral neuropathy is a common disorder seen by many specialists and can pose a diagnostic ... 2005) 8 Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches Dynamin is phosphorylated by several kinases including PKC and CDK5, and dephosphorylated by carcinerurin Dynamin-dependent ... therapy and in the feet during follow-up In a minority of patients the neurotoxicity is long lasting (Land et al., 2007) 28 Peripheral Neuropathy – Advances in Diagnostic and Therapeutic Approaches...

Ngày tải lên: 27/06/2014, 10:20

... Table 1: Therapeutic and diagnostic options based on newly identified pathogenetic mechanisms of liver fibrosis Parameter Pathobiochemical basis Potential serum markers of fibrosis Therapeutic ... Options for diagnostic and therapy Newly recognized pathogenetic mechanisms of fibrosis described above provide several innovative options for therapy of liver fibrogenesis and non-invasive diagnostic ... proteoglycans and collagens TGF-β, which is secreted in a high molecular (large) latent form (Fig 6) by HSC/MFB, sinusoidal endothelial cells, and Kupffer cells and released by destructed thrombocytes and...

Ngày tải lên: 13/08/2014, 13:20

... sedatives and analgesics specifically for a diagnostic and/ or a therapeutic procedure require specific credentials for this practice It is the intent of Sedation and Analgesia for Diagnostic and Therapeutic ... Neuroscience: Sedation and Analgesia for Diagnostic and Therapeutic Procedures Edited by: S Malviya, N N Naughton, and K K Tremper © Humana Press Inc., Totowa, NJ Lydic, Baghdoyan, and McGinley During ... the issues of safety and standards of care These guidelines are not all the same, however, and it is instructive and important to understand the differences between them and to recognize their...

Ngày tải lên: 07/03/2014, 15:20