neurochemical and molecular basis of peripheral sensitization
Báo cáo khoa học: Molecular basis of cytokine signalling – theme and variations docx
... about the storage and realization of genetic information As a sounding illustration of this topic, one of the Brandenburg Concertos was played and in parallel the single pages of the partitur, ... complex Molecular basis of cytokine signalling between the aspartic acid ⁄ lysine mutant of BMP-2 and ActR-IIB The structure does not indicate any new bonds in trans between the ligand and the ... receptor of the ligand, whereas the main core structure binds into the epitope for the type II receptor of the BMP ligand Therefore, the binding of the receptors of both subtypes is blocked and BMP...
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Báo cáo y học: "The molecular basis of lung cancer: molecular abnormalities and therapeutic implications" potx
... progressive accumulation of mutations, loss of apoptotic control and regulation of cell proliferation, and the appearance of aneusomy are associated with worsening dysplasia phenotypes and may reflect ... subclasses of adenocarcinomas Selected genes allow the discrimination between primary lung cancer and metastasis of extrapulmonary sites [90] Studies of expression profiles of adenocarcinomas of the ... Tissue microarrays (TMAs) of lung cancer Tissue microarrays (TMAs) of lung cancer TMAs are comprised of core biopsies of 0.6 mm in diameter of different tumors and of uninvolved lung from the...
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Báo cáo y học: "Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus" pdf
... analysis and ligand docking CH performed rotamer analysis and ligand docking GM and AS performed analysis of residue interaction networks CS conceived experiments MA, SZ and TL conceived and designed ... protein-ligand docking Structural changes in the binding pocket and the catalytic triad of the protease were characterized by molecular dynamics simulations of T54A/S mutants and rotamer analysis of ... mutated positions V36 and T54 are buried in the protease domain of NS3-4A in the two β-strands β1 and β3 of an antiparallel β-sheet (Figure 2) T54 is at the very end of the strand β3, next to a loop...
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Investigating the molecular basis of siah1 and siah2 e3 ubiquitin ligase substrate specificity
... Molecular Basis of Siah2 Substrate Specificity Given the different roles of Siah1 and Siah2 in cancer and their different cellular functions, it is important to understand the structural basis ... PHD3 Homology modeling and docking of Siah2 SBD and PHD3 Interaction of chimeric forms of Siah1 and Siah2 SBD with PHD3 The three dimensional (3D) models of Siah2 SBD and PHD3 were prepared by ... Interaction of wild type (WT) and chimeric Siah proteins with PHD3 (a) Diagrammatic representation of the WT Siah1 and Siah2 SBD, which comprises of 1–193 residues, and the chimeric forms of Siah1 and...
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Epsilon sarcoglycan gene and the molecular basis of myoclonuys dystonia syndrome
... protein of interest of a specific band of the correct molecular weight and second, competition with increasing amount of soluble antigen Serum from two different rabbits, labeled rabbit 5956 and ... N-terminal of εSG, the PCR product containing the Igκ , FLAG and a small portion of ε-SG ECD was mixed together with the PCR products of the deletions and another round of PCR was performed using P14 and ... members of WH laboratory for their invaluable help, co-operation and advice, Rong Li for mass spectrometric services, IMCB DNA sequencing facility and all staff of the Institute of Molecular and...
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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... some of the key findings that have led to our current understanding of the molecular mode of action of glyphosate and the molecular basis for glyphosate resistance Structure and function of EPSPS ... (Arg21, Arg111, and His138) and with the carboxylate end (Arg21 and Arg73) of GriP Of partic˚ ular note is a short, 2.46-A hydrogen bond between Ne of His138 and a phosphate oxygen of GriP Alanine ... FEBS 2755 Mechanisms of glyphosate resistance L Pollegioni et al Fig Molecular mode of action of glyphosate and the structural basis for glyphosate resistance (A) In its ligand-free state, EPSPS...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... causing activation of Bax and Bak [23] Regulation of Bcl-2 family members can occur by a number of mechanisms, including up-regulation of synthesis, enhancement of degradation and phosphorylation ... level of Bcl-2 family genes and the phosphorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members However, each type of cancer has its own way of ... inhibition of Akt- and ERK1 ⁄ 2-dependent pathways eventually change the expression level of one or more of these Bcl-2 family members Bad Bad is one of the ‘death-promoting’ members of the Bcl-2...
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Tài liệu Báo cáo khoa học: Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1 docx
... Purification of HYDBp and HYDJs tot, total proteins; ppt, precipitate fraction; sup, supernatant fraction; puri, purified proteins; M, molecular weight standards For the molecular weight standards, the bands ... SGL2 and SGL3, correspond to residues 60–71, 91–99 and 151–161, respectively On the basis of the homology model, the SGLs of HYDJs and HYDBp (PDB accession number 1NFG) were superimposed and compared ... positions of the Ca of Ala156 in HYDJs and the Ca of Met156 in HYDBp located in the SGL3, which leads to the increased size of the substrate binding pocket of HYDJs The side chain of Ala156 is...
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Tài liệu Báo cáo khoa học: Biochemical and molecular characterization of hazelnut (Corylus avellana) seed lipoxygenases pdf
... reaction products of the hazelnut LOX were compared with the reaction products of soybean LOX type I and authentic standards of 9- and 13-HODE As shown in Fig 4, 9-HODE is the main product of the hazelnut ... in the middle of July and are harvested at the end of August The maturation stages considered in this work were identified on the basis of seed weight Stage I (harvested at the end of May 2002) ... part of the world production adsorbed by the pastry industry Hazelnut seeds contain reasonable levels of linoleic and linolenic acid (about 10 and 0.2%, respectively, of the total fatty acids) and...
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MORPHOGENESIS THE CELLULAR AND MOLECULAR PROCESSES OF DEVELOPMENTAL ANATOMY pptx
... organisation emerges in embryos Although we often have very good descriptions of how a particular organ forms and of the nature of the participating cells and molecular constituents, it is in relatively ... (e.g Raff& Kaufman, 1983, p.5) It is true that our understanding of both the genomic and the molecular basis of cell behaviour is limited and inadequate, but this truth is, in my view, thoroughly ... (was he so wrong?) and hence within the egg At this point, reasonable scientific study was abandoned by many biologists and wish became the father of thought and the grandfather of observation:...
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Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
... Molecular Basis of Pulmonary Disease R ESPIRATORY M EDICINE Sharon R Rounds, MD, S ERIES E DITOR Molecular Basis of Pulmonary Disease, edited by Francis X McCormack, Ralph J Panos and Bruce ... Department of Internal Medicine, University of Cincinnati School of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA Bruce C Trapnell, MD Department of Pediatrics and Department of Internal ... clinician and a basic scientist who are expert in the disease topic and underlying molecular defect, respectively Their charge was to focus on the genetic basis and molecular pathogenesis of disease,...
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Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... well as in the molecular mechanisms of effector protein secretion This minireview describes the composition of the cagPAI and the properties of both conserved and unique components of the Cag-T4SS, ... phosphorylation of its effector protein CagA into various host cells is a hallmark of CagT4SS activity Despite the molecular characterization of a number of effects in host cells, the exact function of CagA ... potential implications for the current understanding of its mode of action The cagPAI and the Cag type IV secretion apparatus Gene arrangement and variants of the cagPAI The cagPAI, which was originally...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
... markers of 200, 97.5, 66, 46 and 30 kDa, from the top of the gel 2730 FEBS Journal 275 (2008) 2727–2737 ª 2008 The Authors Journal compilation ª 2008 FEBS N Numa et al Molecular basis of perinatal ... analysis of a purified GPI-anchorless soluble version of the mutant protein The Kcat ⁄ Km value of the mutant TNSALP was less than one-tenth of the Kcat ⁄ Km value of the soluble form of the wild-type ... centrifugation was performed as described previously [14,25,29] Transfer of proteins and subsequent procedures Molecular basis of perinatal form of hypophosphatasia were as described previously [25,29] Proteins...
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Báo cáo khóa học: Biochemical and molecular characterization of a laccase from the edible straw mushroom, Volvariella volvacea docx
... and 2,6-DMP were pH 5.6 and 3.4 UÆmg protein)1 and pH 4.6 and 2.8 UÆmg protein)1, respectively In standard assay mixtures, the velocity of ABTS oxidation was maximal at 45 °C The dependence of ... in 450 mL of distilled water After draining off any remaining free water, the straw was mixed with lime (15 g) and wheat bran (15 g) and the material distributed into cellophane bags and autoclaved ... filtration of 7-day cultures of V volvacea was centrifuged (10 000 g, 30 min) and concentrated 40-fold with the Pellicon ultrafiltration system (Millipore) using a 10-kDa molecular mass cut-off membrane...
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Báo cáo khoa học: Functional fine-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein pdf
... partially oxidized and the signal of the reduced species increased as a result of oxidation Identification of the active isoform Because of disulfide scrambling HPLC-purified isoforms rapidly re-equilibrate, ... an association time of 300 s and a dissociation of 180 s under a constant flow rate of 20 lLÆmin)1 at 25 °C The sensorgram profile of each run was subtracted by the signal of the irrelevant peptide ... negative for binding High conservation of the HNE sequence Molecular modeling of the HNE peptide An interesting and important feature of the HNE is its high degree of conservation among field isolates...
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Molecular basis of heredity
... Model of DNA Two sources of information: Base composition studies of Erwin Chargaff • indicated double-stranded DNA consists of ~50% purines (A,G) and ~50% pyrimidines (T, C) • amount of A = ... (attached to 5’ carbon) of one nucleotide and the 3’ carbon of the sugar of another nucleotide This bond is very strong, and for this reason DNA is remarkably stable DNA can be boiled and even autoclaved ... Bacteriophage = Virus that attacks bacteria and replicates by invading a living cell and using the cell’s molecular machinery Structure of T2 phage DNA & protein Life cycle of virulent T2 phage: Hershey-Chase...
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Molecular basis of heredity - Bio Cơ sở phân tử của di truyền - sinh học
... Model of DNA Two sources of information: Base composition studies of Erwin Chargaff • indicated double-stranded DNA consists of ~50% purines (A,G) and ~50% pyrimidines (T, C) • amount of A = ... (attached to 5’ carbon) of one nucleotide and the 3’ carbon of the sugar of another nucleotide This bond is very strong, and for this reason DNA is remarkably stable DNA can be boiled and even autoclaved ... Bacteriophage = Virus that attacks bacteria and replicates by invading a living cell and using the cell’s molecular machinery Structure of T2 phage DNA & protein Life cycle of virulent T2 phage: Hershey-Chase...
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Báo cáo khoa học: Molecular basis of toxicity of Clostridium perfringens epsilon toxin ppt
... is a b-sandwich, containing a five-stranded sheet and a b-hairpin (both of which are anti-parallel) The third domain is a b-sandwich composed of one fourstranded sheet and one three-stranded sheet, ... specificities of aerolysin and e-toxin, and the different function of LSL, is the result of the different structures and properties of these domains The second and third domains of e-toxin exhibit ... similarity to the third and fourth domains of aerolysin, and to the second and third domains of LSL and PS As described previously, domain II is composed of a five-stranded sheet with an amphipathic...
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Báo cáo khoa học: Enzymatic characterization and molecular modeling of an evolutionarily interesting fungal b-N-acetylhexosaminidase pot
... blue) and standard (magenta) substrates after ns of MD (C) Overlay of positions of N-propionyl modified (light blue) and standard (magenta) substrates after ns of MD (D) Molecular surface of the ... hydrolysis of N-formyl, N-glycolyl and N-propionyl derivatives of the standard N-acetyl substrate) than A oryzae (2–5% hydrolysis) The cloning and sequencing of PoHex and analysis of the corresponding ... buffer system of Laemmli [21] (Fig 1C, lanes and 9, respectively) Another protein band with a 2470 Fig Optimization of PoHex production and purification (A), (B) Time course of secretion of PoHex from...
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Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc
... the yeast and amebal PGKs 3D predicted model of EhPGK Predicted 3D structures of the EhPGK were obtained by means of modeller software (see Fig S1 for details on these models) and molecular operating ... EhPGK, and green refers to pig PGK and EhPGK Thus, in order to determine the role of Y239, E309 and V311 on the GDP ⁄ GTP preference of EhPGK, the single mutants Y239F, E309M, E309Q and V311L, and ... ADP, 4–11 mm; and ATP, 4–10 mm, and using saturating concentration of the co-substrate When determining the Km3-phosphoglycerate of the wild-type and mutant enzymes, the concentration of GTP present...
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