neural stem progenitor cell marker in brain tumors
Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer doc
Ngày tải lên :
22/03/2014, 17:20
... can induce regression of human glioma brain cancers in vivo This might be achieved by the induction of telomere loss in cancer cells as shown in our in vitro experiments with glioma-derived brain ... normal lymphocytes by inducing cell division in blood-forming cells This homeopathic medicine could be prescribed for optimum treatment of brain cancers in general, and gliomas in particular, as ... H2O2 only and in combination: A, human MGR1 brain cancer cells showing higher percentages of abnormal metaphases in H2O2- and Ruta 6-treated cells; B, normal human B-lymphoid cells showing more normal...
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Báo cáo khoa học: Hypoxia-driven proliferation of embryonic neural stem ⁄ progenitor cells – role of hypoxia-inducible transcription factor-1a ppt
Ngày tải lên :
30/03/2014, 04:20
... ability of stem cells to form neurospheres is one of the indicators for proliferation of neural stem cells in vitro The passaged neurospheres were dissociated into single cells and planted in four-well ... nervous system progenitor cells transplanted into a rat model of Parkinson’s disease Exp Neurol 148, 135–146 Storch A & Schwarz J (2002) Neural stem cells and neurodegeneration Curr Opin Investig ... of Bromodeoxyuridine (BrdU) into growing (DNA-synthesizing) S phase cells is more accurate in determining phase fractions We further used BrdU incorporation to determine whether hypoxia affects...
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Báo cáo hóa học: "Retention of progenitor cell phenotype in otospheres from guinea pig and mouse cochlea" ppt
Ngày tải lên :
18/06/2014, 16:20
... precursor markers as Sox2 and Nestin, and can differentiate in vitro into cells expressing markers of hair cells and supporting cells in vitro[18,31] Culturing organ of Corti progenitor cells under ... presence of inner ear progenitor cells in the postnatal guinea pig, retaining an undifferentiated phenotype, as observed in the mouse Our results clearly show the staining for protein markers for ... bromodesoyuridine into the DNA indicating their proliferation ability In addition, they retain the ability to differentiate into cells displaying morphological features and expression of markers of hair cells...
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Báo cáo y học: "Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis" ppt
Ngày tải lên :
09/08/2014, 14:21
... are also MSC markers [17,21,27-29] The Notch-1 receptor with a role in maintaining stem cell pools and mediating stem cell fate is also considered a MSC marker [30,31] MSC not express markers of ... Sox9 staining in OA clusters was present in both the cytoplasm and nucleus, or Figure Stem cell markers in human osteoarthritis (OA) articular cartilage (a) Safranin O and Notch-1 staining in clusters ... Sox9-positive cells in MZ remained unchanged in the fibrillated cartilage, yet a significant increase was noted in the SZ of Cell clusters in OA cartilage express progenitor markers The number of cell...
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Báo cáo y học: "Endothelial progenitor cell biology in disease and tissue regeneration" doc
Ngày tải lên :
10/08/2014, 21:23
... lipoprotein; UEA1: Ulex europaeus agglutinin 1; KDR: kinase insert domain protein receptor; MNCs: mononuclear cells; EOCs: endothelial outgrowth cells; PSGL-1: P-selectin glycoprotein ligand-1; ... observed a cyclical increase in EPC mobilization following a rise in estrogen and VEGF levels during menstrual cycling in uterine tissue [50,51] Recently, the role of estrogen in tumor induced neovascularization ... surface markers that functionally define EPCs Surface Markers Function Cell Expression CD34 Glycoprotein important for cell- cell adhesion, maintenance of stem cells in bonemarrow, mediates attachment...
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Báo cáo y học: "Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity" doc
Ngày tải lên :
12/08/2014, 11:23
... aCirculating endothelial cell (CEC) number has been evaluated in 15 healthy controls 7AAD, 7-aminoactinomycin D; DAS-28, 28-joint disease activity score; EPC, endothelial progenitor cell; Lin-, lineage-negative; ... endothelial progenitor cell; ESR: erythrocyte sedimentation rate; FACS: fluorescence-activated cell sorting; KDR: kinase-insert domain receptor; Lin: lineage; PBMC: peripheral blood mononuclear cell; ... Endothelial progenitor cell (EPC) and circulating endothelial cell (CEC) levels in rheumatoid arthritis (RA) patients compared with controls (cells per 106 lineage-negative [Lin-] mononuclear cells)...
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Serotonin and serotonin receptors in neural stem and progenitor cell proliferation
Ngày tải lên :
11/09/2015, 10:15
... most interesting cell types among the newly discovered adult stem cells is neural stem and progenitor cells (NSPCs) due to it had long been thought that the brain was unable to generate any new cells ... brain comes from the discovery through thymidine-H3 incorporation into the dividing cells that the cells in certain regions of the brain can undergo proliferation and generate new neurons in ... feeding test NSPC neural stem and progenitor cell xi PBS phosphate buffered saline PCPA p-chlorophenylalanine PCR polymerase chain reaction PLO poly-L-ornithine PSA-NCAM poly-sialated neural cell...
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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
Ngày tải lên :
18/06/2014, 16:20
... of neural stem cells and Schwann Cells results in functional recovery in a rat spinal cord contusion injury model Biomed Environ Sci 2007, 20:242-249 Lindvall O, Kokaia Z, Martinez-Serrano A: Stem ... http://www.translational-medicine.com/content/8/1/77 Page of 10 Figure Tracking of BrdU-labeled neural stem cells at passage six in the ischemic brain of rat having undergone cell therapy for four weeks ... NSC in the host brain In addition to the expression of the class I and II MHC, the activation of caspase III in NSC cultures and brain sections was also assayed Primary antibodies, including...
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Investigations on rab31s role in EGFR trafficking and neural progenitor cell differentiation towards astroglia
Ngày tải lên :
09/09/2015, 11:17
... (Adaptor protein, phosphotyrosine binding (PTB) 19 Introduction domain, pleckstrin homology (PH) domain, leucine zipper-containing protein 1) is also important for signalling that mediates cell proliferation ... Ras-related protein in brain RE recycling endosome xiv REP Rab escort protein RGGTase Rab geranylgeranyl transferase RILP Rab-interacting lysosomal protein RIN Ras and Rab interacting protein RNA ... α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor AP adaptor protein APPL adaptor protein, phosphotyrosine binding domain, pleckstrin homology domain, leucine zipper containing proteins...
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Study of human nasal epithelial stem or progenitor cell growth and differentiation in an in vitro system
Ngày tải lên :
09/09/2015, 11:29
... chronic rhinosinusitis with nasal polyp cholera toxin cysteinyl leukotriene receptor 4’,6-diamidino-2-phenylindole dynein, axonemal, heavy chain dynein, axonemal, light chain desmoglein desmoglein extracellular ... cyclin-dependent kinases cyclin-dependent kinases cyclin-dependent kinases cyclin-dependent kinases CDK5 regulatory subunit associated protein centrosome proteins also CP110, centrosome proteins ... of cell passage 79 Figure 3.2 CBF measurement setting 86 Figure 4.1 The stem cell marker screening in nasal epithelium 92 Figure 4.2 Double staining of p63 and KRT5 in tissue...
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Asymmetric cell division in the regulation of neural stem cell self renewel in drosophila melanogaster
Ngày tải lên :
11/09/2015, 14:32
... function in promoting and inhibiting stem cell self-renewal, loss of Pins function causes a reduction in neuroblast numbers in the larval brain due to occurrence of GMC/GMC siblings and in turn ... 2001) This results in two Introduction daughter cells that are distinct at birth The neural stem cells in the developing central nervous system (CNS) of Drosophila adopt this intrinsic regulation ... neuroblasts In the Drosophila larval brain, stem cell- derived tumors can clearly be induced by altered stem cell division and/or impaired progenitor cell differentiation due to mutations in regulators...
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Effects of high glucose concentrations on the expression of genes involved in proliferation and cell fate specification of mouse embryonic neural stem cells
Ngày tải lên :
30/09/2015, 06:36
... embryonic neural stem cells Society for Neuroscience 35th Annual Meeting, Abstract Number 24.10 (24 Neural Stem Cells in Brain Injury and Disease, Theme A, A10), 12-16 November, Washington, DC, ... a decrease in the radial progenitor marker RC2 and an 14 Chapter 1: Introduction increase in neuronal markers such as βIII-tubulin and GABA, supporting the view that Notch signaling inhibits neuronal ... exist in the ventral forebrain, midbrain, cerebellum and medulla, suggesting that loss of Olig2 may be compensated by Olig1 in the developing brain (Lu et al., 2002; Takebayashi et al., 2002) Interestingly,...
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Gene targeting in human pluripotent cell derived neural stem cells for the study and treatment of neurological disorders
Ngày tải lên :
26/11/2015, 09:54
... new DNA-binding domain (Kim et al., 1996) The first DNA-binding domain used was a fruit fly homeobox domain, followed by zinc-finger DNA binding domain and yeast Gal4 DNA-binding 17 domain (Kim ... group developed a system of adenosine-releasing fibroblasts with inactivated adenosine kinase and adenosine deaminase These cells were transplanted into brain ventricles in a rat epilepsy model ... brain into an epileptic brain, such as status epilepticus or traumatic brain injury, is called epileptogenesis, and is triggered by initial precipitating injuries (Delorenzo et al., 2005; Prince...
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báo cáo hóa học:" Implantation of neural stem cells embedded in hyaluronic acid and collagen composite conduit promotes regeneration in a rabbit facial nerve injury model" doc
Ngày tải lên :
18/06/2014, 15:20
... (Sigma) in phosphate-buffered saline (PBS) and then rinsed thrice with PBS Non-specific binding was blocked with 10% normal goat serum (NGS; Zhongshanjinqiao, China) in PBS for 10 minutes Cells ... for three days in 4% paraformaldehyde and embedded in paraffin Sections were de-waxed and stained with haematoxylin and eosin for histological examination Toluidine blue staining was performed ... in tissue engineering have been actively studied HAcollagen composite scaffolds were widely investigated recently for possible use as a biomaterial in tissue engineering scaffolds [26] Stem cells...
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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt
Ngày tải lên :
20/06/2014, 07:20
... population of stem/ progenitor cells in the breast cancer (MCF7) cell line [11] The fact that the vast majority of MCF7 stem cell enriched SP cells express MUC1 suggests that epithelial cancer stem cells ... maintenance marker Shh, which concludes that MUC4 is enriching the cancer stem cell population in ovarian cancer cells Similarly, a recent study showed that a membrane-bound mucin MUC1 maintains ... observed in vector-transfected SKOV3 cells (Figure 3) We further isolated these colonies for the stem/ progenitor marker analysis Expression of cancer stem cell and self-renewal markers in circular...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) ppt
Ngày tải lên :
07/07/2014, 01:20
... Sources of Stem Cells for Tissue Repair Different types of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells ... pluripotent stem cells from spermatogonia in the adult human testis, providing another strategy for obtaining genetically identical stem cells Umbilical cord blood stem/ progenitor cells are associated ... and brain Substantial efforts have therefore been devoted to obtaining more pluripotent stem cell populations, such as bone marrow mesenchymal stem cells (MSCs) or adipose stem cells, for use in...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) pps
Ngày tải lên :
07/07/2014, 01:20
... of different cell types, including ES cells, bone marrow stem cells, endothelial stem cells, and adipose stem cells Bone marrow stem cells in particular have been examined in clinical trials ... for cell replacement have been considered (Fig 67-1): (1) injection of stem cells directly into the damaged organ or into the circulation, allowing them to "home" into the damaged tissue; (2) in ... types In addition to these strategies for cell replacement, the ex vivo or in situ generation of tissues provides an alternative means of tissue engineering (Chap 69) Stem cells are also excellent...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 3) pot
Ngày tải lên :
07/07/2014, 01:20
... Multipotent stem cells present in the adult brain can also generate all of the major neural cell types, but highly invasive procedures would be necessary to obtain autologous cells Fetal neural stem cells ... alternative, and a clinical trial of fetal neural stem cells in Batten disease is commencing Transdifferentiation of bone marrow and adipose stem cells into neural stem cells, and vice versa, ... candidates for cell- based therapy of diabetes Nervous System Neural cells have been differentiated from a variety of stem cell populations Human ES cells can be induced to generate neural stem cells,...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 4) pot
Ngày tải lên :
07/07/2014, 01:20
... the organ Imaging techniques are needed to visualize stem cells in vivo after transplantation into humans Fortunately, stem cells can be engineered before transplantation to contain contrast agents ... federal funds for developing new human ES lines However, these existing lines develop abnormalities with time in culture and are contaminated with mouse proteins These findings have sparked renewed ... Stem Cell Biology San Diego, Elsevier Academic Press, 2006 Mimeault M et al: Stem cells: A revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in...
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