... them It is assumed that the disabled person is a ‘victim’ It is assumed that disability is central to the disabled person’s self-concept It is assumed that having a disability is synonymous with ... country or jurisdiction, on a basis of parity with people with physical disabilities Fourth, a discrimination perspective requires us to focus not upon the ‘stigmatised’ but upon the ‘stigmatiser’ In ... struggles in the face of mental illness is that the illness is somehow bound up with their personality This I think is dead central to the stigma issue If the illness is in some way related to your personality,...
Ngày tải lên: 01/11/2013, 09:20
... buried in the inner cavity This is an amphipathic compound with a structure similar to that of polyisoprenyl pyrophosphate and the same number of carbon atoms At variance with the proteins from T ... that is completely closed at one end, whereas at the opposite side an opening is present next to a-helix I Through this aperture, the internal surface of the inner cavity is in contact with the ... it is possibly neutralized by Asp169, which is on the external protein surface and points towards the solvent, along with Lys154 In each monomer, the entrance of the cavity is in contact with...
Ngày tải lên: 16/02/2014, 14:20
Tài liệu Báo cáo khoa học: AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning ppt
... consistent with the lysis results (Table 1) Enzyme A1 does not bind to lactococcal cells This can be explained in two ways: first, the LysM domain is not sufficient to bind AcmA to cells, or this ... an L lactis MG1363acmAD1 culture did not show lytic activity (results not shown) AcmA is active against peptidoglycans of different structural types including that of B subtilis B subtilis peptidoglycan ... acid residue 58 to 218 in the preprotein, is active on M lysodeicticus cell walls and, thus, contains the active site of the enzyme This is in agreement with the finding that the repeatless AcmA...
Ngày tải lên: 19/02/2014, 18:20
Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
... stained with antibodies directed against Ure2p (lanes 1–7) and His-Tagged Ssa1p (lanes 8–14); a mixture of untreated Ure2p and Ssa1p is seen in lanes and 10 Ure2p, Ssa1p and Ure2p incubated with ... Ure2p is dimeric and lysine 339 from each monomer within the dimer is exposed to the solvent and can interact with Ssa1p When cross-linking occurs between Ure2p and Ssa1p, a 120 kDa product is generated ... Ssa1p domains upon its interaction with Ure2p with the burial of a Ssa1p stretch comprising lysine 325 The results reported in the present study are consistent with the view that subtle conformational...
Ngày tải lên: 15/03/2014, 00:20
Báo cáo khoa học: Small peptides derived from the Lys active fragment of the mung bean trypsin inhibitor are fully active against trypsin pptx
... derived from the long chain, with three intramolecular disulfide bonds, was synthesized, giving two disulfide isoforms, both of which remained active against trypsin, with Ki values of 1.2 · 10)7 ... elucidated [24] The active fragment with Arg at the reactive site P1 is composed of 27 residues, whereas the active fragment with Lys at the reactive site is composed of two peptide chains, a 26-residue ... linked with the short chain of the Lys active fragment were mutated to Ser Gly-Pro derived from the cleavage site of PSP is not numbered and is also shaded The reactive site P1 residue is indicated...
Ngày tải lên: 15/03/2014, 09:20
Báo cáo toán học: "H-Decompositions of r-graphs when H is an r-graph with exactly 2 edges" ppt
... that is a single edge, say xyz with x < y < z We first pair this edge with the edge xyn and then proceed as in Case I Theorem 2.11 Any optimal kite decomposition of the complete 4-graph with n ... element that is a single edge, say xyzw with x < y < z < w We first pair this edge with the edge xyzn and then proceed as in Case I Acknowledgement The author thanks Oleg Pikhurko for helpful discussions ... edges then F ∪ F ′ is clearly a domino decomposition of Kn with the required number of elements Now suppose that Kn−1 has an odd number of edges In this case F has an element that is a single edge,...
Ngày tải lên: 08/08/2014, 12:22
Báo cáo y học: "Olanzapine-associated neuroleptic malignant syndrome: Is there an overlap with the serotonin syndrome" ppt
... "serotonin syndrome" (SS) has been described It is mainly associated with administration of antidepressive medication The most frequent clinical features of this syndrome are changes in mental status, ... treatment response Study limits This is a retrospective analysis of the reported NMS cases induced by olanzapine The fact that the data were collected from published case reports by other authors, ... Bobolakis I: Neuroleptic malignant syndrome after antipsychotic drug administration during benzodiazepine withdrawal J Clin Psychopharmacol 2000, 20:281-283 Sachdev P, Kruk J, Kneebone M and Kissane...
Ngày tải lên: 08/08/2014, 20:23
Báo cáo y học: "The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia" pdf
... tissue was isolated after homogenization with a Braun Mikrodismembranator Cell aggregate cultures were ground up in the Tri-Reagent with Molecular Grinding Resin (Geno Technology Inc., St Louis, ... Immunolocalised antigens were visualised with a biotin-conjugated donkey anti-goat secondary antibody (Santa Cruz Biotechnology) and a streptavidin-horseradish peroxidase or antirabbit horseradish peroxidase ... kit with 3,3'diaminobenzidine (Dako, Ely, UK) Images were captured with an Axioplan (Carl Zeiss Ltd, Welwyn Garden City, UK) microscope and an AxioCam HRc camera (Carl Zeiss), with AxioVision...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: " Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthriti" pdf
... arthritis (n = 9), psoriatic arthritis (n = 3), arthritis related to connective tissue disease (n = 3), ulcerative colitis related arthritis (n = 1) and arthritis related to Behçet's disease ... category patients with alternative rheumatological diagnoses explaining their inflammatory arthritis Patients were diagnosed with reactive arthritis, psoriatic arthritis, and a number of miscellaneous ... neutrophil apoptosis than did patients who developed non-RA persistent arthritis and those with a resolving disease course Similarly, lymphocyte apoptosis was absent in patients with early RA, whereas...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo khoa học: " Is translational research compatible with preclinical publication strategies?" potx
... same degree of insensitivity in mouse cells [6] Why this is so is unclear What is clear is that mouse fibroblasts grown in monolayer on plastic dishes are not good models for 3-D human tumors proliferating ... treatment Since publication in these journals is likely to secure grants for many years, there is an obvious risk that public spending is not used for realistic projects Nygren P, Larsson R: Overview ... therapy and of various drugs is unknown If senescence in fact is important, the fact that the mechanism(s) of senescence are not well conserved between mouse and human cells is a concern Many of the...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "CLOCK is suggested to associate with comorbid alcohol use and depressive disorders" ppt
... The individuals with both a depression diagnosis and an alcohol use diagnosis (AUD), n = 76, were selected, as well as the 446 individuals with AUD only (without other mental disorder) and 517 ... diagnosis vs individuals without psychiatric symptoms 76 517 Individuals with an AUD diagnosis vs individuals without psychiatric symptoms 446 517 Depression or Dysthymia + AUD diagnosis vs individuals ... diagnosed with AUD This CLOCK variation may be a vulnerability factor for depression given the alcohol exposure in AUD but not considerably increasing the risk for depression without AUD This view is...
Ngày tải lên: 10/08/2014, 09:20
báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx
... phenotypic analysis for comparison with the established tumor cell line to insure the human origin and its stability After formation of SC tumors, serial propagation was accomplished by excising the ... conformational changes that disable the anti-apoptotic members It is well known that over expression of anti-apoptotic Bcl-2 proteins leads to apoptosis-resistance and is believed to be a major ... molecule inhibitor (SMI) is TW-37 [14] This compound binds with high affinity to the hydrophobic groove found in the multidomain antiapoptotic Bcl-2 family proteins; this groove is naturally the site...
Ngày tải lên: 10/08/2014, 22:20
Báo cáo y học: "Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets" pdf
... phagocytosis by flow cytometric analysis of macrophage fluorescence after co-incubation with fluorescently labeled platelets and removal of adherent platelets with trypsin When freshly isolated ... can be reversed by pre-loading the platelets with glucocorticoids Discussion Phagocytosis is an important means of clearing both immunologically compromised and apoptotic cells Monocyte-derived ... reticuloendothelial system and within injured tissues; however, the process of platelet clearance by macrophages is poorly understood This work has demonstrated phagocytosis of fresh autologous activated...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets" pptx
... phagocytosis by flow cytometric analysis of macrophage fluorescence after co-incubation with fluorescently labeled platelets and removal of adherent platelets with trypsin When freshly isolated ... can be reversed by pre-loading the platelets with glucocorticoids Discussion Phagocytosis is an important means of clearing both immunologically compromised and apoptotic cells Monocyte-derived ... reticuloendothelial system and within injured tissues; however, the process of platelet clearance by macrophages is poorly understood This work has demonstrated phagocytosis of fresh autologous activated...
Ngày tải lên: 11/08/2014, 06:22
Báo cáo y học: " Is antipsychotic polypharmacy associated with metabolic syndrome even after adjustment for lifestyle effects?: a cross-sectional study" ppt
... metabolic disturbance (metabolic syndrome, pre-metabolic syndrome, visceral fat obesity and normal), since metabolic syndrome is continuously disturbed in nature [14] In accordance with the diagnostic ... physical activity, we used the Exercise and Physical Activity Guide for Health Promotion 2006 [19] In this guide, physical activity consists of exercise and non-exercise activities (e.g., walking, ... in the pre-metabolic syndrome group Discussion Our study shows that antipsychotic polypharmacy is not correlated with metabolic syndrome but is correlated Misawa et al BMC Psychiatry 2011, 11:118...
Ngày tải lên: 11/08/2014, 15:22
Báo cáo y học: " Lipocalin 2 is protective against E. coli pneumonia" docx
... supports this notion Infection of the lungs with Enterobacteriaceae is much more common with K pneumonia than with E coli A recent report demonstrated no difference between the degree of colonisation ... the other hand, is compromised then there is a risk that otherwise harmless commensal bacteria may cause infection of our body Conclusion Our data demonstrate that lipocalin is important for ... demonstrated by immunohistochemistry shown in fig 1, a strong up-regulation of lipocalin was observed at 48 hours post-infection in response to bacterial challenge with E coli H9049 This was observed...
Ngày tải lên: 12/08/2014, 11:22
Báo cáo y học: "Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study" pps
... infection with HIV, Hepatitis B or Hepatitis C Diagnosis of SLE according to the ACR criteria Acute severe infection including fungal, viral, bacterial or protozoal diseases Signs of active SLE ... Gasteroenteritis 1 Infected insect bite 1 Labyrinthitis 1 Onychomycosis 1 Otitis media Pharyngitis 1 1 Rhinitis 1 Sialoadentitis 1 Tinea infection 1 Tonsillitis 1 Tooth infection 1 AE, adverse event Based ... treatment with angiotensin converting Table Patient characteristics CRF # Age (years) Time since first diagnosis Time since first diagnosis of of SLE nephritis LN-WHO type Pre-treatment of LN within...
Ngày tải lên: 12/08/2014, 15:22
Báo cáo y học: "Misfolding of CasBrE SU is reversed by interactions with 4070A Env: implications for gammaretroviral neuropathogenesi" ppsx
... of PT67 cells with the corresponding plasmid FACS analysis NSCs were removed from tissue culture plates by using 0.05% trypsin with EDTA (Gibco), quenched with DMEM+10% NCS, washed with PBS, and ... that of other mammals, is replete with retroviral sequences Ruling out that exogenous viral proteins interact with host retroviral elements to cause disease may be a Sisyphean task Conclusions ... were sorted by flow cytometry with the brightest 10% selected and used for subsequent analysis C17.2 NSCs with and without SU, SU/TM, hrGFP or 15-1EIH were infected with the 4070A virus at an MOI...
Ngày tải lên: 13/08/2014, 01:20
Báo cáo khoa học: "Inducibility of the endogenous antibiotic peptide β-defensin 2 is impaired in patients with severe sepsis" pptx
... patients with severe sepsis were medicated with low-dose hydrocortisone (3 mg/kg body weight per day) at at least one measuring point All patients with sepsis were treated according to guidelines issued ... Kruskal-Wallis test with the Dunn multiple comparison test) Data are presented as box-and-whisker plots multiple comparison test) without differences between survivors and non-survivors of severe sepsis ... compared to patients with severe sepsis (p < 0.05, Kruskal-Wallis test with the Dunn multiple comparison test; Figure 4) The comparison of hBD2 plasma levels reached statistical significance...
Ngày tải lên: 13/08/2014, 03:20
Báo cáo y học: "Isolated HIV-1 core is active for reverse transcription" pptx
... transcription, at least making DNase I-resistant full length minus-strand DNA, albeit inefficiently, without requiring capsid release Our isolation of active cores without detergent treatment was fortuitous ... whole virions were observed The above data are consistent with dense fractions with capsid and ERT activity which most likely contain biochemically active cores We are the first to report the detection ... virus with beta-cyclodextrin inactivates and permeabilizes the virions: evidence for virion-associated lipid rafts J Virol 2003, 77:8237-48 Publish with Bio Med Central and every scientist can...
Ngày tải lên: 13/08/2014, 05:22