navigation in the absence of vision
Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... ATP into contact in the absence of ATP, curcumin is then able to bind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding (i.e inhibiting ... concentrations of curcumin (25 mM ) the Km for the catalytic site is also possibly increased In order to further assess the possibility of curcumin affecting the interaction of ATP binding to the ATPase, ... within the ATP binding pocket of the nucleotide binding domain, also precluding ATP binding [15,43] Therefore if curcumin affects this conformationally induced fluorescence change, it must be binding...
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Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx
... catalyzed the reduction of the 9,11-endoperoxide group of PGH2 to produce PGF2a in the presence of NADPH, which was defined as the PGFS activity, and the isomerization of PGH2 to PGD2 in the absence of ... PGD2 in the absence of NADPH or NADP+ and as an acid to generate PGF2a in the presence of NADPH Thus, this is the first report demonstrating the proton donor ⁄ acceptor function of His110 during the ... have roles in NADPH binding as well as catalysis The hypothetical catalytic mechanisms of PGDS and PGFS activities of AKR1B1 are shown schematically in Fig In the absence of NADPH, the concerted...
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Báo cáo khóa học: Protein assembly of photosystem II and accumulation of subcomplexes in the absence of low molecular mass subunits PsbL and PsbJ pdf
... always hold true In rapidly expanding young leaves in particular, some of the PSII core proteins and all of the OEC proteins can accumulate in thylakoids in the absence of any assembly of PSII, as ... is critical in providing proper docking sites, either directly or indirectly, by modifying the conformation of PSII on the lumenal side, making efficient binding of PsbQ and PsbP of the OEC possible ... Dynamic interaction between the D1 protein, CP43 and OEC33 at the lumenal side of photosystem II in spinach chloroplasts: evidence from lightinduced cross-linking of the proteins in the donor-side...
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Báo cáo sinh học: " Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response" pptx
... follow-up in of the seven cases (Table 1) We also investigated reactivity against single HCV proteins by the INNO-LIA HCV III assay A faint band against the C2 protein was found once in one of the ... show the sum of SI values of the proliferation assay and the sum of specific interferon-gamma spots (spots in the presence of antigen – spots in the medium control) against individual HCV proteins ... had the chance to study prospectively individuals with acute hepatitis C in the setting of a German young offender institution By systematic HCV-RNA screening of 1176 consecutive new incoming...
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Báo cáo hóa học: " Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response" potx
... follow-up in of the seven cases (Table 1) We also investigated reactivity against single HCV proteins by the INNO-LIA HCV III assay A faint band against the C2 protein was found once in one of the ... show the sum of SI values of the proliferation assay and the sum of specific interferon-gamma spots (spots in the presence of antigen – spots in the medium control) against individual HCV proteins ... had the chance to study prospectively individuals with acute hepatitis C in the setting of a German young offender institution By systematic HCV-RNA screening of 1176 consecutive new incoming...
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Báo cáo y học: "Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells" ppsx
... enhancement in the frequency of arthritis in the T cell-deficient mice and the B cell-deficient mice suggest that these cells might play regulatory roles in the initiation of disease 100 90 % of incidence ... have important roles either during the initiation phase of arthritis or in the perpetuation and exacerbation of the disease after the onset, or they might simply maintain immunity to CII and ... cells/ml, × 106 antigenpresenting cells/ml, 10 µg/ml rat CII) followed by weeks of resting in medium containing IL-2 At the time of re-stimulation, an aliquot of the cell line was tested for antigen...
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Báo cáo khoa học: "Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1" pot
... an insulinoma in the absence of NF-1 The GIST tumour was only incidentally discovered by the operating surgeon during enucleation of the insulinoma in our case The literature contains only published ... like the initial one in our case, are usually an incidental surgical finding, while large tumours are usually symptomatic In our case, following resection of the insulinoma and the small incidental ... simple excision of the gastric lesion with minimal dissection as was done The other unique message in our case is the observed rapid recurrence of the GIST following the resection of the primary...
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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot
... by injecting 20 μg of CII in the left ears and vehicle in the right ears Bars in Figure 3d represent the percentages of swelling in the CII-challenged ears, normalized to the swelling of the ... as the percentage of swelling (i.e 100 × the difference between the increase of thickness of the left and the right ears, divided by the thickness of the right ear) at the indicated time points ... of ELR+ CXC chemokines in RA synoviocytes, especially in the presence of TNF-α, highlighting its role in neutrophil recruitment into the joint [49] Furthermore, IL-17 induces the production of...
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Báo cáo y học: "Candida albicans genome sequence: a platform for genomics in the absence of genetics" potx
... particular interest to those interested in fungus-host interactions, because many might play roles in the infection process The genome of the closely related species Candida dubliniensis is now being ... genes in the agglutinin-like sequence (ALS) gene family, thought to be involved in adhesion to and interaction with host surfaces [15] Nevertheless, over half of the What can be gleaned from the ... sequencing has profoundly altered our understanding of this organism Early assemblies of the C albicans genome sequence revealed a mating-type (MAT-like) locus [9] that led to the engineering of...
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Báo cáo y học: "Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2" pptx
... challenge results in increased mucus production, we analyzed lung histology by PAS-staining As shown in Fig 4A, there was minimal PAS staining in the airway epithelium of control mice In contrast, ... significantly increased in mice treated with MCP-1 neutralizing antibody and in CCR2-deficient mice However, these increases in fibrosis were seen in the setting of impaired clearance of conidia ... development of prominent infiltrates in peribronchovascular spaces and scattered infiltrates in the lung parenchyma (Fig 2A and 2B) The inflammatory infiltrates consisted of numerous eosinophils...
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Bóa cáo y học: "The incidence and outcome of septic shock patients in the absence of early-goal directed therapy" pdf
... selecting all patients who died in the ED, required care in the ICU (including all patients who died in the ICU), required care in the high dependency unit (HDU; including all patients who died in ... lower These findings are relevant to other institutions considering the application of EGDT and to the powering of future randomized controlled trials It must be borne in mind that this (like the ... may be the variable within the EGDT intervention bundle that improves survival If this is so, then in the model of care operative at our institution (formal training in emergency medicine, senior...
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Báo cáo y học: "Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice" pdf
... Haarlem, the Netherlands; KMA) Induction of anaesthesia was performed by injecting 7.5 l/g of induction KMA mix (consisting of 1.26 ml ketamine, 0.2 ml medetomidine and ml atropine) To maintain anaesthesia, ... behind VILI and the contribution of MV to lung injury in the absence of pre-existing lung injury Competing interests The authors declare that they have no competing interests Page of 11 (page number ... messages 11 • MV induces VILI in mice, in the absence of a priming pulmonary insult, with use of relevant ventilator settings • By using sodium bicarbonate instead of normal saline metabolic acidosis...
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Securities Trading in the Absence of Dealers:Trades, and Quotes on the Tokyo Stock Exchange
... One hypothesis involves the size of the order It was noted in the discussion of the institutional features of the TSE that the display terminal at a member’s lead, office shows the size of the orders ... article investigates the properties of intraday trades and quotes on the TSE In comparison with most of the worlds other principal equity markets, the TSE is distinctive in the absence of dealers In ... (implicitly) the aggressiveness of the order Also, although a warning quote may stop trading for an indeterminate time, the order underlying the quote is not “stopped” in the sense of the term on the...
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Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt
... shown in Fig 1B, the distance between the two termini of the inserted Ca2+-binding sites in the model structure of the EF-hand of STIM1 is within ˚ 15 A Accordingly, a total of six glycine linkers ... Ca2+-coordinating loop positions and was introduced to perturb the Ca2+-binding ability of the grafted EF-hand of STIM1 (B) Modelled structure of the engineered protein with the grafted EF-hand Ca2+-binding ... it retains its native structure after the insertion of foreign sequences and in the presence and absence of Ca2+ ions, so that the in uence from the host protein to the inserted sites is minimized...
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Báo cáo khoa học: Lack of stabilized microtubules as a result of the absence of major maps in CAD cells does not preclude neurite formation pot
... cause increase of acetylated tubulin (Fig 1E), indicating that the acetylation state of tubulin depends mainly on the relative activities of the acetylating and deacetylating enzymes rather than ... tyrosination states of tubulin The tubulin molecule is subject to a variety of posttranslational modifications [14,34] One of them comprises the reversible acetylation of its a-chain at the e-amino ... Mouse brain tissue was used as a positive control The reduced amount of Glu-tubulin in CAD cells was not a result of a lack of (or inhibition of) the putative detyrosinating enzyme (tubulin carboxypeptidase)...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
... binding of TM by thrombin Binding of the carboxy-terminal part of the reactive center loop of PAI-1 in the small cleft formed by the 60-loop and VR1 loop can be envisioned The kinetics of the interaction ... PAI-1/VN complexes, suggests the involvement of the chondroitin sulphate of rl-TM in the binding of PAI-1/VN Indeed, both in the absence and presence of PAI-1, the interaction of rl-TM with immobilized ... demonstrated in this study, binding of TM does sterically hinder PAI-1 binding to thrombin (–VR1tPA) Therefore, the binding of PAI-1 to thrombin either involves a small part of the VR1 loop that...
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the mit ress vision and mind selected readings in the philosophy of perception sep 2002
... certain perspective, the house would not be posited as an autonomous being Thus the positing of one single object, in the full sense, demands the compositive bringing into being of all these ... everything upside down; on the third day of the experiment, when things are beginning to regain their upright position, he is lled with the strange impression of looking at the re out of the back of ... cannot combine in a joint exploration of the object, that the crossing of the ngers, being a movement which has to be imposed on them, lies outside the motor possibilities of the ngers themselves...
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Báo cáo hóa học: " A predominance of R5-like HIV genotypes in vaginal secretions is associated with elevated plasma HIV-1 RNA levels and the absence of anti-retroviral therapy" docx
... more than half of the women in this shedding cohort, demonstrating that vaginal HIV shedding occurs in a number of women taking ART ART use was associated with the presence of predominantly X4-like ... [9,13], the low levels of HIV detected in many of the samples only allowed the analysis of the predominant genotypes in genital secretions Despite this, and the inherent limitations of PCR amplification ... coordination of the study and facilitated the collection of clinical samples NL processed clinical samples and conducted PCR and viral load analyses AA participated in the coordination of the...
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Báo cáo toán học: "The absence of efficient dual pairs of spanning trees in planar graphs" pot
... around the boundary of An to reduce the diameter of its 1-skeleton to ∼ n Imagine inscribing Tn in the plane, circling it with a loop, and then contracting that loop down to a point In the course of ... (∆, ) with G the 1-skeleton of ∆, the layout of a spanning tree T in G and the corresponding T ∗ in G∗ can be made to dictate a shelling of ∆ with filling length bounded above in terms of Diam T ... we define the filling length FL(∆, ) of (∆, ) to be the minimal L such that there is a shelling (∆i )m of ∆ in which for all i, the length of the boundary walk of ∆i is at most L i=0 Filling length...
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Báo cáo y học: "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers" doc
... Hypoxia increases the synthesis of VEGF in a variety of cell types via an accumulation of the transcription factor hypoxia inducible factor [31] In addition, a variety of cytokines (e.g interleukin-1, ... According to the hypothesis that the angiogenic effects of VEGF are inhibited by a concomitant increase of angiostatic factors, another strategy for the treatment of ischemic symptoms in SSc is the ... molecules in the induction of angiogenesis VEGF is involved in several steps of physiological and pathological angiogenesis including proliferation, survival and migration of endothelial cells The...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008