mutations and the development of anti viral resistance
Báo cáo y học: "HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat" pps
... by PI resistance mutations, influences the emergence of bevirimat resistance Therefore, we wanted to include the effect of viral replication capacity on development of maturation inhibitor resistance ... that the protease background determines the level of resistance and the impact on replication When introduced into the PR-2 background, mutations V362I and S368N result in much higher levels of resistance ... at least one of the following mutations was found: Gag V362I, A364V, S368N or V370A/L Impact of PI resistance mutations on bevirimat resistance and viral replication To characterize the different...
Ngày tải lên: 13/08/2014, 01:21
Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
... characterised by the development of a range of autoantibodies of both the IgM and IgG isotypes, and subsequent glomerular disease [37,38,49,50] In our hands, high levels of IgM anti- ssDNA antibodies ... against the development of the IgM anti- dsDNA antibodies was provided In view of the lack of IgG anti- ssDNA antibodies observed in our experimental model, we believe that the increase in IgM anti- ssDNA ... performed most of the analysis and compiled the manuscript FC performed part of the immunoassays HTK carried out the renal histological analysis RAL contributed to the development of some of the assays,...
Ngày tải lên: 09/08/2014, 07:20
Human Capital and the Development of Financial Institutions: Evidence from Thailand docx
... in the education variables, only the direct effects of the years of schooling of the head of the household, the years of schooling of the money manager and the average schooling of the heads of ... Sixty-eight percent of the banks in the Northeast and 81% of the banks in the Central region make loans, while only 35% of the banks in the Northeast and 53% of the banks in the Central region offer savings ... savings and lending services In the Northeast, only 17% of the banks offer savings and lending In the Central region, 40% of the banks offer both savings and lending services In the Northeast, the...
Ngày tải lên: 06/03/2014, 10:20
Báo cáo " Long-term sediment distribution calculation taking into account sea level rise and the development of Day estuary " potx
... from the sea to the shore is shown in Fig 1b Smallest area of an element is 1250m2 in region of river estuaries such as Day, Ninh Co and BaLat, the largest area is 25km2 in offshore region The ... The domain includes 2879 nodes with the coarse resolution of 5000m for offshore and the fine resolution of 50m for nearshore areas Figure a) Bathymetry of the study area, b) Mesh used Flows from ... by the filling Day river mouth, dredging and widening of the river are of great importance Ninh Binh province implements the project "Dredging the Day river segment from Gian Khau bridge to the...
Ngày tải lên: 10/03/2014, 18:20
the relationship between corporate social responsibility implementation and the development of five selected companies in hanoi
... the company and customers And by supplying products and services required by customers, company also commits to the efficient development of company, and carries out the promise of maximize the ... http://www.triplepundit.com/wp-content/uploads/2011/02 /THE- FRACTAL-FRONTIER.pdf) Three Ps theory mentions the relationship of Planet, People, and Profit in business strategy of company This theory is considered as the detail of TBL theory, ... individual people and company on CSR concept, the CSR implementation of companies in Ha Noi and its impacts to the development of the companies And in order to collect data for the research, questionnaire...
Ngày tải lên: 13/03/2014, 14:20
The Victorian Era and the Development of the Stoic-Christian Code of Honor
... system, and necessitate the creation of a new honor culture that transcended all classes T he Rise of the Middle Class and the Expansion of Honor At the beginning of the 19th century, the Industrial ... replicate the camaraderie and brotherhood of the past The giving and taking of oaths grew in popularity as a chance to put the Stoic-Christian ideal of making one’s word one’s bond to the test, and ... The more he excelled at the code, and the more he cultivated ambition, industry, discipline, and so on, the higher a gentleman rose in the ranks of society and the more status he gained And the...
Ngày tải lên: 14/03/2014, 09:31
Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx
... of Itk in T-cell development In the absence of Itk, there is a partial block in the development of ab T cells and a reduced ratio of CD4 to CD8 single positive thymocytes in both the thymus and ... surmise from these findings about the signals regulated by Itk downstream of the TCR during the development of these various subsets of T cells? Based on the studies to date, it is clear that the calcium ... IL-13 and IFN-c, they lack the capacity to translate and secrete these cytokines upon antigenic stimulation both in vitro and in vivo [20,22,25] By contrast, bypassing the TCR with the addition of...
Ngày tải lên: 28/03/2014, 22:21
Due process and the development of financial accounting standards An exploration of comment letters and their influence on financial accounting standards
... process at the FASB is part of the mission of the organization, which is, ―to establish and improve standards of financial accounting and reporting for the guidance and education of the public, ... contain the provisional positions of the FASB at the time of their release At this stage, the FASB also requests additional comments from constituents Depending on the nature of the project, there ... Pervasiveness of the problem: the extent to which an issue is troublesome to users, preparers, auditors, or others; the extent to which there is diversity of practice; and the likely duration of the problem;...
Ngày tải lên: 01/06/2014, 13:59
manuscript verse collectors and the politics of anti-courtly love poetry jul 2009
... another For, when they gathered together libels and anti- courtly love poems, they likewise forced these two kinds of politics together One could say that the authors of libels did as much on their ... marriage with an exchange of obvious riddles on genitals, one in the hand of the initial compiler and the voice of a man named Robin, and the next in the second hand and a female persona named ... her Wnal couplet with the obscene word that Davies omitted from his poem on the courtier and the ‘cuntry swadd.’ Then, on the verso of the same leaf and in the hand of the primary compiler, Davies...
Ngày tải lên: 10/06/2014, 21:43
Báo cáo hóa học: " A predominance of R5-like HIV genotypes in vaginal secretions is associated with elevated plasma HIV-1 RNA levels and the absence of anti-retroviral therapy" docx
... analysis, and drafted the manuscript PK participated in the study design and conducted the statistical analyses RC participated in the design and coordination of the study and facilitated the collection ... dual-tropic viral variants [9,13], the low levels of HIV detected in many of the samples only allowed the analysis of the predominant genotypes in genital secretions Despite this, and the inherent ... collection of clinical samples NL processed clinical samples and conducted PCR and viral load analyses AA participated in the coordination of the study, directed sample and data analysis, and assisted...
Ngày tải lên: 20/06/2014, 01:20
The Country of Laos, Lao society and the development of the Lao people
... requirements for the development of social sciences in Laos today Objects and scope of research The Thesis focuses on the relationship of information, documentation and library and the development of social ... deployment of Thesis: The Thesis analyzes the explanations of phenomena to understand their status and nature; identify issues to be solved; find out the causes of the status quo and thereby state ... activity, the latter will be the secondary one 2.2 The role of information, documentation and library in the development of society The main purpose of the Thesis is to clarify the role of information...
Ngày tải lên: 23/07/2014, 17:44
Báo cáo khoa học: "Genomic variability in Potato virus M and the development of RT-PCR and RFLP procedures for the detection of this virus in seed potatoes" ppt
... In this paper we report on the analysis of the coat protein (CP) gene sequence of several Canadian PVM isolates and the comparison of PVM isolates from Canada and other countries Oligonucleotide ... bioassay, RT-PCR, RFLP and sequence analysis of the CP gene Data from all the tests positively identified the virus as PVM Sequence analysis of these PVM isolates and eight other known PVM strains/isolates ... from both directions with the same primer set Sequence alignment and phylogenetic analysis based on the nucleotide sequence of the CP gene and the amino acid sequence of coat protein showed that...
Ngày tải lên: 12/08/2014, 04:21
Báo cáo y học: " In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy" docx
... time step was determined by the viral production of these cells, the transduction status of the uninfected cell, the viral sequence of the infecting virions, and chance Viral production from neighbouring ... development of viral resistance during the trial period However, it remains possible that increases in gene therapy efficacy may lead to the development of resistance and reduce durable suppression of viral ... impact on the resistance profile in the UNTx and Tx compartments for combinations of shRNAs (Figure 3) Treatment efficacy The containment of resistance to the gene therapy is only one measure of total...
Ngày tải lên: 13/08/2014, 01:20
Báo cáo y học: "The specificity and the development of social-emotional competence in a multi-ethnic-classroom" pptx
... with the dog Barney, but Barney is not there The Departure: The parents drive on a trip overnight and the children remain with the grandmother The Return of the Parents: The parents return from their ... trip The Lost Key: The child enters the room and hears mother and father arguing over a lost key The Exclusion: Mother and father want to be alone and send the child to its room to play Mother's ... participate in the study In the first test, at the beginning of the kindergarten year, 65 of 90 (84%) children, and in the second test, at the end of the kindergarten year, 65 of the original 80 (95%)...
Ngày tải lên: 13/08/2014, 18:21
hoffman - surviving large losses; financial crises, the middle class, and the development of capital markets (2007)
... all the reforms they have inspired, they continue to batter us, as we can see from the collapse of the Asian banks and stock markets, the bursting of the Internet bubble and subsequent wave of ... shaped by a host of political and economic factors, from the nature of the political system to the distribution of income and the strength of economic growth The threshold will therefore vary from ... part to the French king’s regular habit of defaulting The existence of these secure and easily traded English securities furthered the development of the London capital market, making it the financial...
Ngày tải lên: 01/11/2014, 17:10
Application of recombinant antibody technology for the development of anti lipid antibodies for tuberculosis diagnosis
... after the development of monoclonal hybridomas, it required refolding of the antibody from the insoluble protein fraction (121) Instrumental for the expression of soluble antibody fragments was the ... cells and natural killer cells, at the site of infection which seal off the infection and prevent further spread of the bacteria (20) The granuloma, while protecting the host from disseminated disease, ... individuals) of the world’s population has LTBI (1) However, there is a 5% chance of active disease within the first 18 months of infection and a further 5% chance of disease reactivation over the person’s...
Ngày tải lên: 10/09/2015, 09:05
FU LEI AND THE DEVELOPMENT OF CULTURE IN MODERN CHINA
... huomusi mianduimian’, Shanghai fanyi, (2008) ‟ „ ‟ „ ‟ „ „ ‟ ‟ Vera Schwarcz, The Chinese Enlightenment: intellectuals and the legacy of the May Fourth movement of 1919 (Berkeley, LA and London: ... Zweig, Romain Rolland: the man and his work, trans Eden and Cedar Paul (London: George Allen and Unwin, 1921), p 348 13 Ibid., pp 352-3 14 Romain Rolland, The Forerunners, trans Eden and Cedar Paul ... 27-8, 37, 53-5; Vera Schwarcz, The Chinese enlightenment: intellectuals and the legacy of the May Fourth movement of 1919 (Berkeley and Los Angeles: University of California Press, 1986), p 25...
Ngày tải lên: 06/10/2015, 21:23
Characterisation of fitness parameters and population dynamics of botrytis cinerea for the development of fungicide resistance management strategies in grapevine
... down the build-up of resistance, thus prolonging the lifespan of an active ingredient introduced to the market INTRODUCTION The aims of the present study were as follows: - Determination of the ... strategies to reduce the infestation of their plants with B cinerea The choice of variety is one of the most important factors in the control of B cinerea Resistance of mature berries is mostly due ... of the core of β-tubulin with the interior-facing loop removed (b) Receptor mapping of benomyl-resistant and sensitive β-tubulin of Botrytis cinerea Figure 1-3 Resistance development of...
Ngày tải lên: 19/11/2015, 15:46
Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"
... is the cut-off value in the Recommendations of the American Heart Association [35] and the trigger for initiation of insulin treatment for ICU patients recommended by the American College of ... results and wrote the manuscript AVB and VG participated in patients' inclusion and follow-up IPR was involved in the analysis of results and writing the manuscript All the authors read and approved ... regimen and caloric intake can play a role in development of hyperglycaemia, but they were not different between the groups Most of the patients in both groups were enterally fed, and there was...
Ngày tải lên: 25/10/2012, 10:02
Globalization and its effects on the development of educational service in Vietnam
... to think about the appropriate mix of different levels and types of education On the one hand, there is the need to provide everyone with good basic education, while on the other hand a minority ... education, official training and informal on -the- job training Informal on-thejob training is likely to correlate with the skill content of the job, and hence MNEs offer more of this when they are ... 1, the trade agreement between Vietnam and the US: “ company means any entity that is established and organized following the law with the goal of profit or non-profit” 2.4.1.2 The impact of...
Ngày tải lên: 23/04/2013, 11:16