... take PF representations as their input and produce LF representations as their output. They differ from most extant GB parsers in that they make explicit use of the four levelsofrepresentation ... top-level structure of the knowledge of language employed by the PAD parsers mirrors the top-level structure of GB theory. Ideally the internal structure of the various principles of grammar should ... space a complete description of the all of the principles is not given here; however a sketch of one of the principles, the Case Filter, is given in the remainder of this section. The other...
... asthma. Journal of Asthma 1998; 35: 213–7. 20. Sarafino EP, Gates M, DePaulo D. The role of age at asthma diagnosis in the development of triggers of asthma episodes. Journal of Psychosom Res, ... correlation between life satisfaction scores and levelsof laughter (R=0.316, p=0.096). The effect of emotional well-being on different levels of laughter was analyzed by the Kruskal-Wallis ... negative effects of laughter, it was hypothesized that level two of laughter was beneficial to health and that both low levels (level one) and high levels (level three) of laughter were detrimental...
... Our system is capable of all levelsof control. The wonderful aspect of our system is the ability to start out at Level 1 and gradually move up to the more sophisticated levels. Or you can start ... http://www.ActionHomeAutomation.com And finally the most sophisticated level of control is Level 5. Level 5 incorporates “learning” into the system. The actions of the system might change automatically based on living ... dedicated processor based controller. Up to this point, the manual control of devices comes from a controller consisting of buttons or switches. While the controller may be a keypad, remote control,...
... Bardales et al. Mussel C-subunit isoformsFEBS Journal 275 (2008) 4479–4489 ª 2008 The Authors Journal compilation ª 2008 FEBS 4485Identification ofmultiple isoforms of the cAMP-dependentprotein ... purpose of the work described in this articlewas to investigate the possible existence of differentisoforms of the PKA C-subunit in the sea musselM. galloprovincialis.ResultsSeparation of different ... isoforms of the C-subunitIn order to demonstrate the presence of different iso-forms of the PKA C-subunit in mussels, the proteinwas partially purified from the PAM and the mantletissues of...
... means of regulation of a member of the guanylyl cyclase receptorfamily, by controlling the amounts of differentially glycosy-lated forms of GC-C in a cell. Given the fact that the130 kDa form of ... by the Department of Biotechnology, Govern-ment of India. YG is supported by the Indian Council of MedicalResearch, and AC by the Department of Atomic Energy, Government of India. We would ... differentially glycosylated forms of GC-C.It is possible that the reappearance of the 145 kDa formfollowing removal of ST peptide was a consequence of further glycosylation of the ER-associated 130...
... investigating which of the 49 MULTIPLE STREAMS OF COACHING INCOME The siren call of the coaching industry has always been the dream that 'you can make lots of money helping ... coach again-regardless of which streams of income you choose to major in at first. 33 MULTIPLE STREAMS OF COACHING INCOME However, no matter how profound the one-on-one ... programs will live on, right? One of the happiest moments for me recently came when coach 48 Multiple Streatns OF COACHING INCOME The Future of Coaching is Now. ANDREA ]....
... effect[22].Tissue inhibitor of metalloproteinasesThe catalytic activity of MMPs can be inhibited by thefamily of tissue inhibitor of metalloproteinases(TIMP), of which there are four members ... chemokine-mediatedrecruitment of leukocytes into sites of inflammation[76]. Many chemokines bind HS chains of syndecansand evoke MMP-mediated shedding of syndecans withpotential loss from the site of injury [40,41,56]. ... of syndecan-1 and aggrecan [51,52]. A recentstudy also reported that syndecan-4 may regulate acti-vation of ADAMTS-5 via engagement of HS chainsand regulation of MAPK-dependent synthesis of MMP3...
... region of BRCA1, which harbours bindingmotifs for multiple partners in DNA repair [19]. A fur-ther point on the function of PRD of Caskin1 is thatall of our studies point to a local tendency of ... nature. It is of note that themobile water fraction of PRD2-His shows some devia-tion from that of the other two fragments, i.e. the level of hydration of this fragment is lower than that of theother ... a result of their large size, the capacity tobind multiple partners and the lack of catalyticdomains, they probably fall into the class of scaffoldproteins, which bind components of a signal...
... instead of +Pimedium.Measurement of permeability of mitochondrialmembrane to poly(ethylene glycol)To examine the permeability of the mitochondrial mem-brane, we measured the effects of poly(ethylene ... induction of swelling, 1.1 mL of 300mOsmol solution of poly(ethylene glycol) of a givenmolecular size was added. Changes i n the turbidity o freaction mixture were monitored at 4 40 nm.Analysis of ... he addition of poly(ethylene glycol)having a molecular size of more than 4000 (PEG4000)caused increased turbidity of the m itochondrial suspension,reflecting induction of shrinkage of preswollen...
... 1. Levelsof total and phosphorylated (p) mTOR in AD and control brains. (A) When compared with controls, levelsof p-mTOR(Ser2481) significantly increased in AD brain by dot blot. Levelsof ... 0.001.ABCFig. 3. Levelsof total and phosphorylated (p) forms of eEF2K and eEF2 in AD and control brains. (A) When compared with controls, level of p-eEF2K (Ser366) significantly increased, and levelsof total ... bundles of abnormal fibres that occupy much of the peri-nuclear cytoplasm of affected neurons. These fibresconsist of paired helical filaments (PHFs), composed of a hyperphosphorylated form of the...
... effect on cyclin D1 is a direct effect of MNB ⁄ DYRK1A or an indirect consequence of cellcycle withdrawal. Thus, confirmation of this mecha-nism by loss of function experiments would be impor-tant, ... DYRK1B, the closesthomologue of MNB ⁄ DYRK1A, enhances cyclin D1turnover [30].Neuronal differentiationIn terms of the possible role of MNB ⁄ DYRK1A inearly stages of neuronal differentiation, ... beenobserved in the forebrain of fetuses with DS [67]. Theinvolvement of MNB ⁄ DYRK1A in the regulation of caspase 9-mediated apoptosis in differentiating neurons of the developing retina has...
... theinhibitory effect of rapamycin on the increase in Oct-2protein levels in LPS-treated cells (Fig. 2E). The phos-phorylation levelsof p70 S6 kinase were assayed toverify the activation of mTOR. Fig. ... reduce the expression of these genes. We thereforetested the effect of rapamycin on the LPS-inducedexpression of iNOS and G-CSF. Fig. 3A shows thatdetectable levelsof iNOS and G-CSF mRNAs ... knockdown of Oct-2 reduced iNOS and G-CSF expression inLPS-treated cells. The inhibitory effect of rapamycin on the LPS-inducedincrease in Oct-2 protein levels and on the iNOS and G-CSF mRNA levels was...
... atomic resolution structures of the molecu-lar packing of peptides in amyloid-like structures arebeginning to emerge [19], much of our understanding of the structure of amyloid-like fibrils comes ... [71].Fig. 5. Thermodynamic analysis of fibrillar polymorphism. Enthalpychange during extension of various types of glucagon fibril as afunction of temperature. The slope of these curves corresponds toDCpvalues, ... that mishandling of glucagon solutions of > 2 gÆL)1leads to the formation of toxic aggregates [78]. Moreover, a recent reportcomparing the toxicity of amyloid structures of severalprotein...
... hydrolysis of a very limitednumber of peptide bonds; specifically, in the case of nNOS, degradation can occur with the cleavage of twopeptide bonds and, in the case of eNOS, with thecleavage of a ... theprotease. On the basis of these observations, we canexplain not only the protective effect exerted byHSP90 on the digestion of NOS isozymes, but also therequirement of high levelsof active calpain ... absence of HSP90.The removal of the PDZ domain by calpain, whichoccurs without loss of catalytic activity in NOS even inthe presence of HSP90, provides additional evidencethat the function of...
... level of TNX in serum likely reflects the level of synthesis and or breakdown at the tissue level becauseindividuals heterozygous for TNX have greatlydecreased levelsof serum TNX ( 50–60% of ... species of tenascin-X in human serumFEBS Journal 274 (2007) 1280–1289 ª 2007 The Authors Journal compilation ª 2007 FEBS 1285Identification and characterization ofmultiple species of tenascin-X ... quantification of TNX serum levels is required,such as donor age and sample storage. These parame-ters should be taken into consideration when studyingcorrelations of pathological conditions and TNX levels in...