molecular mechanisms and therapeutic implications

... throughput analysis of molecular markers identified in squamous lung neoplasia antibody reagents and data interpretation need to be developed and standardized A comprehensive and integrated approach ... in lung and breast cancers and malignant phenotype suppression J Natl Cancer Inst 2001, 93:691-699 Antequera F and Bird A: Number of CpG islands and genes in human and mouse Proc Natl Acad Sci ... 5q21 and mutations of p53 associated with LOH on 17p and K-ras point mutations [9] Interestingly, loss of chromosomal regions on chromosomes 3p and 9p have been recognized as early events [10] and...

Ngày tải lên: 12/08/2014, 18:21

... FLT3-ITD and is important for FLT3-ITD-mediated cell growth and anti-apoptotic effects [48] Taken together, FLT3-ITD constitutively induces STAT5 and Pim serine threonine kinases, and their mechanisms ... production leads to increased DNA double-strand breaks (DSBs) and repair errors They found that FLT3-ITD-transfected cell lines and FLT3-ITD-positive AML cell lines and primary cells exhibit increased ... effects of ATO and MEK inhibition, as well as ATO and FLT3 inhibition, on FLT3-ITD cells [101] The combination of ATO and AG1296, an FLT3 inhibitor, profoundly inhibited the growth and induced apoptosis...

Ngày tải lên: 10/08/2014, 21:23

... MOLECULAR MECHANISMS AND BIOLOGICAL EFFECTS Edited by Volodymyr Lushchak and Halyna M Semchyshyn Oxidative Stress Molecular Mechanisms and Biological Effects Edited by Volodymyr Lushchak and ... mutagenic and teratogenic actions of RCS and ROS, and products of these interations have powerful Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic ... Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic Strategies of Protection 25 Fig 10 Formation of reactive carbonyls and advanced glycation and lipoxidation...

Ngày tải lên: 12/02/2014, 16:20

... neutral and acidic pH conditions by a variety of spectroscopic (i.e CD, fluorescence and second-derivative UV absorption) and biochemical (i.e limited proteolysis and ligand binding) techniques, and ... comparative analysis of Ngb and Mb may be used to better define the relationships between these two globins and to obtain a better understanding of the molecular features and biological function of ... ligands, both the ferrous and ferric forms of Ngb are hexacoordinated, with the proximal His64 being the endogenous ligand Therefore, Ngb ligand binding requires the displacement of the intramolecular...

Ngày tải lên: 07/03/2014, 02:20

... mutagenic and teratogenic actions of RCS and ROS, and products of these interations have powerful Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic ... Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic Strategies of Protection 25 Fig 10 Formation of reactive carbonyls and advanced glycation and lipoxidation ... Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic Strategies of Protection 29 Lipoxidation and glycoxidation are processes linking carbonyl and oxidative...

Ngày tải lên: 28/06/2014, 11:20

... relationship between rhinitis and asthma and its therapeutic implications [27], highlighting the concept of ‘one airway one disease’ The link between upper respiratory disease and asthma is also evident ... e Allergiche) and the Italian Ministry of University and Scientific and Technological Research 19 Durham SR: Effect of intranasal corticosteroid treatment on asthma in children and adults Allergy ... nose and bronchi has recently been hypothesized, based on the observation that bone marrow can promptly and specifically respond to nasal challenge by increasing the rates of production and maturation...

Ngày tải lên: 12/08/2014, 18:20

... Hong, Ahmed M Aref and Martin R Jadus VI Contents Section Molecular Biology of Brain Tumors and Associated Therapeutic Implications 201 Chapter From Gliomagenesis to Multimodal Therapeutic Approaches ... iduronacid and N-acethylgalactosa‐ mine polymer and protein core), heparansulphate (glycuronacid and N-sulphoglucosa‐ mine polymer and protein core) and keratansulphate (galactose and Nacethylgalactosamine ... the Molecular Biology of Brain Tumors and the Therapeutic Implications [58] Thorne RF, Legg JW, Isacke CM The role of the CD44 transmembrane and cytoplas‐ mic domains in coordinating adhesive and...

Ngày tải lên: 23/03/2014, 10:20

... generating random and highly diverse BCRs and TCRs by somatic gene recombination The interaction of the BCR and TCR with antigens activates the B and T cells leading to proliferation and the generation ... fixation and heating (82-85), and molecular markers were used to assess DC 16 activation Therefore, further understanding on how bacteria interacts with DCs in terms of induction of DC maturation and ... understanding the interactions of E coli with DC, and the early molecular events resulting from this interaction, may shed light on the mechanisms of initiation of the immune response to E coli and...

Ngày tải lên: 14/09/2015, 08:24

... adriamycin and other chemotherapeutic drugs J Biol Chem 271, 30950–30955 Cooke IM & Sullivan RE (1982) Hormones and neurosecretion In The Biology of Crustacea: Structure and Function (Atwood HL & Sandeman ... were found in the peripheral regions and the neuropile regions of eyestalk neural ganglia and more adjacent to the medulla terminalis X-organ and sinus gland FEBS Journal 273 (2006) 839–846 ª ... ERK2 and expression of MIH were studied in both control and inhibitor-treated (PD98059 and UO126) stages Phosphorylation of ERK2 was detected as a shift in mobility during the intermolt and early...

Ngày tải lên: 16/03/2014, 14:20

... Neurovirulence and Neurosusceptibility: Clues to Understanding Flavivirus- and Dengue-Induced Encephalitis 219 Myriam Lucia Velandia and Jaime E Castellanos Chapter 12 Vaccines and Antiviral Drugs ... York and London 141-170 24 Viral Genomes – Molecular Structure, Diversity, Gene Expression Mechanisms and Host-Virus Interactions Friesen, P.D., and M.S Nissen (1990) Gene organization and transcription ... of TN-368 and Ld652Y, derived from ovarian tissues (Burand and Lu 1997, Lu and Burand 2001, Raina and Lupiani 2006) 1.1 Infection cycles and gene expression Only very limited data on the infection...

Ngày tải lên: 31/03/2014, 19:20

... and Fission Yeasts Cell Cycle Molecules and Mechanisms of the Budding and Fission Yeasts Tim Humphrey and Amanda Pearce Summary The cell cycles of the budding yeast Saccharomyces cerevisiae and ... cycle proteins including G1 cyclins (Cln1 and Cln2), Cdk inhibitors The Budding and Fission Yeasts 11 (Sic1, Far1, and Rum1), and replication proteins (Cdc6 and Cdc18; reviewed in ref 55) SCF was ... Tetzlaff, M., and Elledge, S J (1999) 155 Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms Science 286, 1166–1171 156 Cohen-Fix, O and Koshland, D (1997)...

Ngày tải lên: 08/04/2014, 12:50

... (ΔP) and to the fourth power of the capillary radius (r), and inversely proportional to capillary length (L) and blood viscosity (h): Capillary flow = π r4 P/8Lη Because capillary length and viscosity ... vasoconstrictive and vasodilating substances, glycocalyx alterations, and interactions with circulating cells (Figure 1) The crucial issue is to understand which are the major mechanisms that ... surface and in which various substances, such as superoxide dismutase and antithrombin, are embedded The glycocalyx facilitates the flow of red blood cells and limits adhesion of white blood cells and...

Ngày tải lên: 21/06/2014, 01:20

... causes apoptosis and emphysematous lung damage We have addressed this question for better understanding of the cellular and molecular mechanisms of emphysema, so that effective therapeutic strategies ... air exposed and fed mg vitamin C/day), Air + vit C 15 mg (air exposed and fed 15 mg vitamin C/day), CS + vit C mg (CS exposed and fed mg vitamin C/day) and CS + vit C 15 mg (CS exposed and fed 15 ... acute smoking model can give clear and more specific information about the cellular and molecular mechanisms of CS-induced lung damage [22] Using histopathlogy and morphometric measurements here...

Ngày tải lên: 11/08/2014, 08:22

... (Noisy -le-grand) 2004, 50 Online Pub:OL639-48.:OL639-OL648 238 Dillon CP, Sandy P, Nencioni A, Kissler S, Rubinson DA, Van Parijs L: RNAi as an Experimental and Therapeutic Tool to Study and Regulate ... receptors In brief, TLR1, TLR2, and TLR6 are at least partly located on the cell surface, and may collaborate to discriminate between the molecular structures of triacyl and diacyl lipopeptides, as ... TLR8 [56,57] and TLR9 [58] are located in endosomal compartments and perceive microbial nucleic acids: TLR3 recognizes viral dsRNA, whereas TLR7 and TLR8 recognize viral single stranded (ss)RNA...

Ngày tải lên: 12/08/2014, 16:20

... ART-LGIC superfamily and discuss the general implications of these proteins for the mechanisms and origin of the Cys-loop receptors of the animal nervous system Results and discussion Volume ... light on the possible mechanisms of ligand interaction and channel gating of the ARTLGICs The current model for the mechanism of these channels posits that the binding of the ligand causes a preferential ... channels, including the acetylcholine and serotonin receptors, and the inhibitory anionic channels, including the GABA, glycine and invertebrate histamine and glutamate receptors [2,14,15] This...

Ngày tải lên: 14/08/2014, 14:21

... caloric intake and/ or obesity currently remain the largest predisposing risk factors for the development of type diabetes Discerning the cellular and molecular mechanisms responsible and amendable ... mg/dL The focus of this thesis is to understand the molecular mechanisms of insulin-mediated glucose transport into adipose tissue and skeletal muscle and how this process becomes dysregulated ... brief history of Cr3+ and its impact on glucose and lipid metabolism in 31 health and disease It will also outline several proposed mechanisms for Cr3+ action in adipose and skeletal muscle tissue...

Ngày tải lên: 24/08/2014, 10:54

... molecular mechanisms, often referred to as functional modules, work together to govern these complex and robust processes [2, 17] This thesis work devotes to understand the molecular mechanisms ... and catch bond formation Talin and α-catenin, two mechanosensing proteins located at focal adhesions and adherens junctions respectively, are critical for the force dependent initialization and ... interaction and remodeling of the actin cytoskeleton Building upon these core proteins, cellcell adhesion can adopt different morphology and molecular compositions depending on the circumstances and cell...

Ngày tải lên: 09/09/2015, 08:13

... to pursue PhD and offering me the scholarship And last but not least, this dissertation is dedicated to my family My parents are always standing with me and giving me endless love and encouragement ... wife is always showing her patience and thoughtfulness to my work, and sharing the joy and happiness with me I feel fortunate and happy I am your son/husband Yours, Li Chunwei March, 2009, in ... (C-X-C motif) ligand 11 chemokine (C-X-C motif) ligand 12,(known as SDF-1) chemokine (C-X-C motif) ligand chemokine (C-X-C motif) ligand 6, (known as GCP2) chemokine (C-X-C motif) ligand xv CYSLTR1...

Ngày tải lên: 10/09/2015, 15:49

... et al 2003c) found N-RAS and K-RAS mutations, respectively, in 17% and 6% of tumors, whereas Kuehl and Shaughnessy found N-RAS and K-RAS mutations, respectively, in 14% and 17% of tumors (personal ... accrued, we can then try to understand the molecular mechanism(s) underlying HRD MM and the potential molecular heterogeneity within HRD MM In addition, the origin and evolution of genetic abnormalities ... 1q gain (44% and 48% respectively) and 8p loss (27% and 28% respectively) had almost identical prevalence in both HRD and NHRD MM Figure 2.2 Penetrance plot of chromosome gains and losses by...

Ngày tải lên: 11/09/2015, 09:58