molecular mechanisms and biological effects

... MOLECULAR MECHANISMS AND BIOLOGICAL EFFECTS Edited by Volodymyr Lushchak and Halyna M Semchyshyn Oxidative Stress Molecular Mechanisms and Biological Effects Edited by Volodymyr Lushchak and ... mutagenic and teratogenic actions of RCS and ROS, and products of these interations have powerful Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic ... Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic Strategies of Protection 25 Fig 10 Formation of reactive carbonyls and advanced glycation and lipoxidation...

Ngày tải lên: 12/02/2014, 16:20

... mutagenic and teratogenic actions of RCS and ROS, and products of these interations have powerful Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic ... Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic Strategies of Protection 25 Fig 10 Formation of reactive carbonyls and advanced glycation and lipoxidation ... and carbohydrates as compared with nucleic acids, oxidative catabolism of lipids, amino acids and Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and...

Ngày tải lên: 28/06/2014, 11:20

... comparative analysis of Ngb and Mb may be used to better define the relationships between these two globins and to obtain a better understanding of the molecular features and biological function of ... neutral and acidic pH conditions by a variety of spectroscopic (i.e CD, fluorescence and second-derivative UV absorption) and biochemical (i.e limited proteolysis and ligand binding) techniques, and ... ligands, both the ferrous and ferric forms of Ngb are hexacoordinated, with the proximal His64 being the endogenous ligand Therefore, Ngb ligand binding requires the displacement of the intramolecular...

Ngày tải lên: 07/03/2014, 02:20

... and w and were subsequently refined by varying /, w angles in intervals of 10° and setting h angle to ) 60 ± 10° and 60 ± 10° Each /, h, and w-value was fixed by applying a harmonic potential and ... be drawn regarding the differences in biological activities between [Ala9]SP and [Gly9]SP on the one hand, and [b2-HAla9]SP and [HGly9]SP on the other hand Indeed, the higher pharmacological ... phosphates pathway SP, [Ala9]SP and [Pro9]SP are almost equipotent at the major binding site NK-1M (Ki between 0.64 nM and 1.6 nM and EC50 values between 4.8 and nM) [HGly9]SP and [(S)-b3-HAla9]SP are...

Ngày tải lên: 08/03/2014, 08:20

... K+-ATPase and Naf, K f -ATPase H Voltage-gated Na+ channel Ligand- and voltage-gated K+ channels + Voltage- and ligand-gated Ca2+channels and ~ a /Ca2+ antiporter CFTR, voltage-gated C channels and ... action and biological effects Gideon Polya p cm Includes bibliographical references and index ISBN 0-415-30829-1 Materia medica, Vegetable-Handbooks, manuals, etc Botanical chemistry-Handbooks, ... compounds and their molecular targets about the molecular targets which are mainly proteins (such as receptors and enzymes) but also include polynucleotides (RNA and DNA), phospholipids and reactive...

Ngày tải lên: 17/02/2014, 05:20

... virus–cell interactions, and to find permissive cell lines for further molecular and cell biological studies of this peculiar human virus For this purpose, we have cloned and sequenced the full-length ... emerged in 293T, Huh7 and UT7 ⁄ Epo-S1 cells, and less pronounced also in 293 and Chang liver cells (Fig 3A,C, marked with an arrow) However, no such bands appeared in KU812Ep6 and Cos-1 cells That ... information on the molecular biology and host–cell interactions of this virus is needed To this end, we have cloned and sequenced the full-length genome of TTV genotype 6, and studied the key biological...

Ngày tải lên: 16/03/2014, 05:20

... molting stages showed a single dominant band of Gas7 only in the early postmolt (A) and late postmolt (B) stages (Fig 1A) The immunoreactive band of Gas7 had a molecular mass of  48 kDa It was prominently ... were found in the peripheral regions and the neuropile regions of eyestalk neural ganglia and more adjacent to the medulla terminalis X-organ and sinus gland FEBS Journal 273 (2006) 839–846 ª ... ERK2 and expression of MIH were studied in both control and inhibitor-treated (PD98059 and UO126) stages Phosphorylation of ERK2 was detected as a shift in mobility during the intermolt and early...

Ngày tải lên: 16/03/2014, 14:20

... inducing biological effects not related to their ureolytic activity, we have tested soybean embryo-specific urease (SBU) and Bacillus pasteurii urease (BPU) [19] for their lethality in mice and for ... insecticidal and platelet aggregating activities Kinetic parameters and susceptibility of SBU and BPU to different inhibitors were also compared with those of the jackbean urease (JBU) Material and methods ... cysteine-binding inhibitors, and AHA, a chelator Table Comparative data on physicochemical and biological properties of soybean embryo-specific urease (SBU), jackbean urease (JBU) and B pasteurii urease...

Ngày tải lên: 16/03/2014, 16:20

... Neurovirulence and Neurosusceptibility: Clues to Understanding Flavivirus- and Dengue-Induced Encephalitis 219 Myriam Lucia Velandia and Jaime E Castellanos Chapter 12 Vaccines and Antiviral Drugs ... York and London 141-170 24 Viral Genomes – Molecular Structure, Diversity, Gene Expression Mechanisms and Host-Virus Interactions Friesen, P.D., and M.S Nissen (1990) Gene organization and transcription ... of TN-368 and Ld652Y, derived from ovarian tissues (Burand and Lu 1997, Lu and Burand 2001, Raina and Lupiani 2006) 1.1 Infection cycles and gene expression Only very limited data on the infection...

Ngày tải lên: 31/03/2014, 19:20

... and Fission Yeasts Cell Cycle Molecules and Mechanisms of the Budding and Fission Yeasts Tim Humphrey and Amanda Pearce Summary The cell cycles of the budding yeast Saccharomyces cerevisiae and ... cycle proteins including G1 cyclins (Cln1 and Cln2), Cdk inhibitors The Budding and Fission Yeasts 11 (Sic1, Far1, and Rum1), and replication proteins (Cdc6 and Cdc18; reviewed in ref 55) SCF was ... Tetzlaff, M., and Elledge, S J (1999) 155 Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms Science 286, 1166–1171 156 Cohen-Fix, O and Koshland, D (1997)...

Ngày tải lên: 08/04/2014, 12:50

... http://www.annals-general-psychiatry.com/content/4/1/8 MR GR NON-HANDLED NON-HANDLED HANDLED HANDLED 45 NO N HANDLED HANDLED 40 35 30 25 20 15 10 NUM R OF POSIT VE IVE CE L L S NUM R OF POSIT VE IVE CE L L S 45 NO N HANDLED HANDLED 40 35 30 ... http://www.annals-general-psychiatry.com/content/4/1/8 A 120 NO N HANDLED HANDLED 100 SECONDS 80 60 40 20 B NO N HANDLED HANDLED 25 SE CONDS 20 15 10 TARGET O PPO S ING Effects of handling on spatial learning and memory in the Morris ... A2 Figure Effects of handling on MR and GR immunoreactivity in the CA2 region of the hippocampus Effects of handling on MR and GR immunoreactivity in the CA2 region of the hippocampus Handling...

Ngày tải lên: 08/08/2014, 21:20

... whether p-BSQ of CS causes apoptosis and emphysematous lung damage We have addressed this question for better understanding of the cellular and molecular mechanisms of emphysema, so that effective ... air exposed and fed mg vitamin C/day), Air + vit C 15 mg (air exposed and fed 15 mg vitamin C/day), CS + vit C mg (CS exposed and fed mg vitamin C/day) and CS + vit C 15 mg (CS exposed and fed 15 ... acute smoking model can give clear and more specific information about the cellular and molecular mechanisms of CS-induced lung damage [22] Using histopathlogy and morphometric measurements here...

Ngày tải lên: 11/08/2014, 08:22

... Canal landfill.14 After the canal was filled and covered with earth, the land was transferred to the city of Niagara Falls Homes and a school were then built on the edge of the old canal and the ... Eventually, the state purchased and demolished about 100 homes in the area and state officials evacuated 500 houses in 1978 Federal and state crews cleaned up the landfill and surrounding contaminated ... aldicarb, carbofuran), triazines (e.g., atrazine and simazine), and pyrethroids, (see Chapters and 12); heavy metals such as cadmium, lead, and mercury; and organobrominate compounds The reproductive...

Ngày tải lên: 11/08/2014, 13:22

... (PAN), and some aldehydes and ketones (NO2 can also be included as a secondary pollutant – see Chapter 8) Smog is composed of both primary and secondary air pollutants; it contains NO2, O3, and ... federal health standards In the Los Angeles Basin, in particular, the pollution is so bad that it was given a deadline of 2010 to meet the federal standards 3.7 3.7.1 ACUTE AND CHRONIC EFFECTS INTRODUCTION ... November 27 to December 10, 1962, and involved the eastern part of the U.S.; London, England; Rotterdam, The Netherlands; Osaka, Japan; Frankfurt, Germany; Paris, France; and Prague, Czechoslovakia...

Ngày tải lên: 11/08/2014, 13:22

... for exchange of CO2 and O2 between the blood and the lungs and other body tissues Interference with the functioning of hemoglobin by COHb accumulation is detrimental to health and can lead to death ... polynucleotides at various specific molecular sites, particularly purines and thymine Such metallic cations can, therefore, inhibit DNA replication and RNA synthesis and cause nucleotide mispairing ... organic and inorganic molecules Free radicals are highly reactive and therefore highly unstable and short-lived For instance, the half-life of lipid peroxyl radical (ROO Á ) is seconds, and that...

Ngày tải lên: 11/08/2014, 13:22

... sodium (Na), and other vital minerals and vitamins 7.2.3 MEMBRANES The plasma and intracellular membranes of mammalian cells have similar overall compositions: about 60% protein and 40% lipid ... antioxidants (such as vitamins E and C and glutathione (GSH)) and antioxidant enzymes (including superoxide dismutase (SOD), catalase, glutathione peroxidase, and GSH reductase) help detoxify ... hazards to plants and animals with emphasis on fishery and wildlife resources, in Nriagu, J.O., Ed., Arsenic in the Environment Part II: Human Health and Ecosystem Effects, John Wiley and Sons, Inc...

Ngày tải lên: 11/08/2014, 13:22

... fog and cloud droplets (where it is oxidized catalytically and photochemically to sulfate), or diffusion to plant surfaces where it is adsorbed and reacts chemically According to Fox,2 both dry and ... as acidic fine particles H2SO4 and sulfates have been shown to influence both sensory and respiratory function, such as increased respiratory rates and tidal volumes, and slowing of mucus clearance ... also examined possible biological mechanisms for such a contribution, including pH modulation of toxicity of xenobiotics and pH-dependent alteration of cells involving mitotic and enzyme regulation...

Ngày tải lên: 11/08/2014, 13:22

... mining and metallurgical processing, combustion of fossil fuels, textile printing, application of fertilizers and fungicides, recycling of ferrous scraps and motor oils, and disposal and incineration ... carboxylase, lipase, and invertase In humans and animals, Cd inhibits alkaline phosphatase and ATPases of myosin and pulmonary alveolar macrophage cells Cd appears capable of inhibiting Phase I and Phase ... and methane and ethane The reaction is called demethylation and is catalyzed by two enzymes: a hydrolase and a reductase The hydrolase hydrolyzes the mercury–carbon bond, yielding Hg2þ ions and...

Ngày tải lên: 11/08/2014, 13:22

... skin, kidneys, testicles, and adrenal gland, and cause liver damage, including liver tumors, and birth defects In cows, milk production is decreased, coats become rough, and hoof deformities occur ... 2,4-D (2,4-dichlorophenoxy acetic acid) and 2,4,5-T (2,4,5-trichlorophenoxy acetic acid) (Figure 13.6) on Vietnam’s agricultural and forest land between 1965 and 1970 In addition to military use ... phenoxyherbicides (PHs) were widely used in the U.S for controlling weeds in agriculture and rangeland, lakes and ponds, and in forests # 2005 by CRC Press LLC [16:52 26/8/04 P:/CRC PRESS/4365 MING-HO.751...

Ngày tải lên: 11/08/2014, 13:22