modeling and simulation of clinical trials an industry perspective

... Szabo and Babúska [185], and Zienkiewicz and Taylor [207] For work specifically focusing on the continuum mechanics of particles, see Zohdi and Wriggers [216] For a detailed numerical analysis of ... Chapter Modeling of particulate flows where v cm (t) is the mean velocity of the group of particles and δv i (t) is a purely fluctuating (about the mean) part of the velocity For the entire group of ... and Pires [154], Martins and Oden [147], Kikuchi and Oden [123], Klarbring [125], Tuzun and Walton [196], or Cho and Barber [42] Remark One can determine the coefficient of friction that maximizes...

Ngày tải lên: 06/08/2014, 01:21

... [53], Piperno [162], Lewis and Schrefler [132], Armero and Simo [7]–[9], Armero [10], Le Tallec and Mouro [131], Zohdi [208], [209], and the extensive works of Farhat and coworkers (Piperno et ... = 0.05, (3) α = 0.25 and α = 0.125, and (4) α = 0.5 and α = 0.25 (Zohdi [212]) 4.2 Results and observations The starting configuration is shown in Figure 4.1 Figures 4.2 and 4.3 illustrate the ... mass Top to bottom and left to right, for eo = 0.5, µs = 0.2, µd = 0.1: (1) no near-field interaction, (2) α = 0.1 and α = 0.05, (3) α = 0.25 and α = 0.125, and (4) α = 0.5 and α = 0.25 (Zohdi...

Ngày tải lên: 06/08/2014, 01:21

... and encompasses a wide variety of applications, for example, the behavior of flocks of birds, schools of fish, flow of traffic, and crowds of human beings, to name a few Loosely speaking, swarm analyses ... number of obstacles and all of the (design) parameters, the α’s and β’s, are nonnegative Remark One can describe the relative contributions of repulsion and attraction between members of the ... variety of such methods, which employ concepts of species evolution, such as reproduction, mutation, and crossover Such methods can be traced back, at least, to the work of John Holland (Holland...

Ngày tải lên: 06/08/2014, 01:21

... [208], [209], and the extensive works of Farhat and coworkers (Piperno et al [163], Farhat et al [65], Lesoinne and Farhat [130], Farhat and Lesoinne [66], Piperno and Farhat [163], and Farhat et ... size of t lim = 10−2 s and a starting time step size of 10−3 s The tolerances of both fields (TOLr and TOLθ ) for the fixed-point iterations were set to 10−6 and the upper limit on the number of ... radius of analyticity of a Taylor series expansion of the solution around time t, which converges in a ball of radius from the point of expansion to the nearest singularity in Equations (7.55) and...

Ngày tải lên: 06/08/2014, 01:21

... mechanical forces and heat transfer induced by the fluid on the particles and vice versa Because the coupling of the various particle and fluid fields can dramatically change over the course of a ... see Berlyand and Panchenko [30] and Berlyand et al [31] Although not employed here, discrete network approximations appear to be quite attractive for possibly improving the description of the interaction ... balance, governing the interconversions of mechanical, thermal, and chemical energy in a system, dictated by the first law of thermodynamics Accordingly, we require the time rate of change of...

Ngày tải lên: 06/08/2014, 01:21

... particle-laden and bubble-laden fluids (Ferrante and Elghobashi [68], Ahmed and Elghobashi [2], [3], and Druzhinin and Elghobashi [60]) Also, as mentioned earlier, improved descriptions of the fluid-particle ... Bohren and Huffman [33] and van de Hulst [195] Remark An application of particular interest, where scattering calculations can play a supporting role, is the investigation of clustering and aggregation ... interaction can possibly be achieved by using discrete network approximations, which account for hydrodynamic interactions such as those of Berlyand and Panchenko [30] and Berlyand et al [31]...

Ngày tải lên: 06/08/2014, 01:21

... variety of such methods, employing concepts of species evolution such as reproduction, mutation, and crossover Such methods primarily stem from the work of John Holland (Holland [94]) For reviews of ... violet and blue light of shorter wavelengths is bent more than the orange and red light of longer wavelengths.68 Thus, dispersive effects introduce a new level of complexity, primarily because of ... research efforts in both industry and academia For a review of CMP practice and applications, see Luo and Dornfeld [143]–[146] It is clear that for the process to become viable and efficient, the underlying...

Ngày tải lên: 06/08/2014, 01:21

... ||∇F || The orientation of the cells, usually random, can be controlled, via standard rotational coordinate transformations, with random angles (Figure B.4) The classical random sequential addition ... response of large numbers of randomly distributed and oriented RBCs Because the diameter of a typical RBC is on the order of eight microns (d ≈ × 10−6 m), which is much larger than the wavelengths of ... For details, see Coleman and Saunders [47], Kim [124], Pittomvils et al [165], Kahn et al [116], Kahn and Hackett [117], [118], and Zohdi and Szeri [222] Clearly, the number of applications in the...

Ngày tải lên: 06/08/2014, 01:21

... spherocytosis and hereditary elliptocytosis (Eber and Lux [62] and Gallagher [73], [74]) Changes in membrane and cytosolic proteins may affect the state of hydration of the cell and thereby its ... Greve, R and Hutter, K 1993 Motion of a granular avalanche in a convex and concave curved chute: Experiments and theoretical predictions Philosophical Transactions of the Royal Society of London, ... T and Strack, O D L 1993 Mean-field inelastic behavior of random arrays of identical spheres Mechanics of Materials, Vol 16, 25–33 [108] Jenkins, J T and La Ragione, L 1999 Particle spin in anisotropic...

Ngày tải lên: 06/08/2014, 01:21

... Mathematical, Physical and Engineering Sciences, Vol 361, 1021–1043 [212] Zohdi, T I 2004 Modeling and direct simulation of near-field granular flows The International Journal of Solids and Structures, ... Computational design of swarms The International Journal of Numerical Methods in Engineering, Vol 57, 2205–2219 [210] Zohdi, T I 2004 Modeling and simulation of a class of coupled thermo-chemomechanical processes ... Biomaterials, Vol 75B, 351–358 [223] Zohdi, T I and Kuypers, F A 2006 Modeling and rapid simulation of multiple red blood cell light scattering Journal of the Royal Society Interface, Vol 3, 823–831...

Ngày tải lên: 06/08/2014, 01:21

... ∆ v2 where Cn and Cp are negative and positive values of dynamic friction, bn and bp are negative and positive damping coefficients and Dn and Dp are negative and positive values of static friction, ... 5.5 Scope of second joint sensor, angle of rotation and angular velocity 72 5.6 Scope of third joint sensor, angle of rotation and angular velocity 73 5.7 SimMechanics block diagram of active ... DOFs and the whole system has × n DOFs Constraints on the motion allow revolution of n − joints and forward motion of the first link Thus, DOF of all joints are constrained and total number of...

Ngày tải lên: 16/10/2015, 15:38

... distribution of PLA before and after enzymatic degradation Residual amounts of PLA after incubation for and 67 h were 40% and 27%, respectively [17, 18] 301 12 Modeling and Simulation of Microbial ... case 299 12 Modeling and Simulation of Microbial Depolymerization Processes of Xenobiotic Polymers 12.4.2 Analysis of Enzymatic PLA Depolymerization The experimental and analytical study of endogenous ... remove cells and the resultant supernatant was subjected for HPLC analysis 287 12 Modeling and Simulation of Microbial Depolymerization Processes of Xenobiotic Polymers 12.3.3 HPLC analysis Molecular...

Ngày tải lên: 25/10/2013, 08:20

... Forestry Models Establishment:- land, land preparation, plant stock, planting, watering  Maintenance:- weed control, fertilizing, pruning and thinning, fire and pest protection  Inflows:wood; ... gathering, recreation, land renewal  Required rate of return  Forest Yield Factors  Wood growth is measured by the MAI: Mean Annual Increment; ‘the annual increase in cubic meters of harvestable timber ... fire, pests and diseases, unsuitable species, collateral damage at harvest Forestry Risks  Timber return: inappropriate pruning and thinning, poor growth, timber usage and fashion changes  Sovereign...

Ngày tải lên: 23/03/2014, 04:20

... Prof Satsangi taught me modeling and simulation methodologies, and software engineering at the postgraduate (MTech) level and guided me during my MTech and PhD in the area of modeling and simulation ... example, airplane in flight with random wind gusts, mineral-processing plant with random grade ore, and phone network with random arrival times and call lengths 8 Modeling and Simulation of Systems ... cycle of intervention in ill-structured management problems and learning from the results (Checkland, 1999, 2006; Checkland and Winter, 2000; Winter and Checkland, 2003) Soft system is a branch of...

Ngày tải lên: 01/04/2014, 10:55

... layer, and the mapping layer which is an interface between application and architecture models THE SESAME APPROACH The Sesame modeling and simulation environment facilitates performance analysis of ... S Polstra, and J E Co and, “On the modeling of intra-task parallelism in task-level parallel embedded systems,” in Domain-Specific Processors: Systems, Architectures, Modeling, and Simulation, ... disciplined approach,” IEEE Design and Test of Computers, vol 19, no 6, pp 6–16, 2002 [24] S Mohanty and V K Prasanna, “Rapid system-level performance evaluation and optimization for application...

Ngày tải lên: 22/06/2014, 19:20

... at various initial angles of twist Effects of defects and temperature on mechanisms of nanotube-based torsional oscillators will also be considered Multiscale modeling In a nanotube-based torsional ... length of 4.18 nm, width of 10.0 nm, and thickness of 3.2 nm Consequently, the angular moment of inertia of the metal paddle is 0.0237e– 36 kg m2 The metal paddle is initially given a twist angle of ... 16.90, and 21.16 nm The calculated resonance frequencies are 2.35, 1.92, 1.67 and Fig Evolution of angle change of the metal paddle in a torsional oscillator containing (10,0) tubes Nanoscale...

Ngày tải lên: 22/06/2014, 22:20

... AND INCREASE PROFITS fying the transnational submission process The single set of standards makes it easier than ever to plan and coordinate your trials And the transnational approach means an ... Medical Evidence and the Law, New York: Norton CHAPTER CUT COSTS AND INCREASE PROFITS CLINICAL TRIALS Clinical trials consist of a randomized comparison over a fixed period of time of an intervention ... COSTS AND INCREASE PROFITS Chapter Guidelines THE PURPOSE OF THIS CHAPTER AND THIS TEXT is to provide you the manager with a set of guidelines for the successful design and conduct of clinical trials: ...

Ngày tải lên: 14/08/2014, 07:20

... The lead software developer need not be a member of the programming team, but she must possess a general knowledge of both data entry and data management software and be able to prepare and maintain ... Integrity and security of data To say nothing of investigators, investigational laboratories, safety and efficacy review committees, and patients 13 Don’t attribute this quote to me, Professor Deming and ... call on external consultants Of course, your own role should be that of a facilitator rather than a proponent of any specific point of view And, of course, at least one member of the review committee...

Ngày tải lên: 14/08/2014, 07:20