mitogenic signaling cascade mitogen activated protein kinase

... MK2) [126] MAP kinase -activated protein kinase (MK3) [127] MAP kinase interaction protein kinase (MNK1) [128] p38 regulated /activated kinase (PRAK) [129] Mitogen- and stress -activated kinase and ... mitogen- activated protein (MAP) kinase -activated protein kinase- 3, a novel substrate of CSBP p38 MAP kinase J Biol Chem 1996, 271: 8488-8492 128 Waskiewicz AJ, Flynn A, Proud CG, Cooper JA: Mitogen- activated ... factors and protein kinases (Table 1) Several of the protein kinases activated by p38 MAPK are involved in the control of gene expression at different levels Mitogen- and stress -activated kinase and...

Ngày tải lên: 09/08/2014, 07:20

... the mitogen- activated protein kinase cascade J Neurosci 2003, 23:10944-10952 Hua LL, Zhao ML, Cosenza M, Kim MO, Huang H, Tanowitz HB, Brosnan CF, Lee SC: Role of mitogen- activated protein kinases ... factor (NF)-κB, mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK), p38 kinases (p38Ks), c-Jun Nterminal kinases (JNK), glial fibrillary acidic protein (GFAP), ... components in the signaling cascades resulting in activation of NF-B upon various stimuli are the mitogen activated protein kinases (MAPKs) MAPKs are a family of serine threonine kinases comprising...

Ngày tải lên: 19/06/2014, 22:20

... the 41-/43-kDa mitogen- activated protein kinase signaling pathway in human tumors Oncogene 1999, 18:813-822 Milella M, Kornblau SM, Andreeff M: The mitogen- activated protein kinase signaling module ... novel inhibitor of mitogen- activated protein kinase kinase J Biol Chem 1998, 273:18623-18632 43 Sebolt-Leopold JS, Herrera R: Targeting the mitogen- activated protein kinase cascade to treat cancer ... Raf, MEK (mitogen- activated protein (MAP) or extracellular signalregulated (ERK) kinase) and ERK families of kinases is among the best characterized pathways downstream of Ras This signaling...

Ngày tải lên: 06/08/2014, 18:21

... responsive mitogen- activated protein kinases in Arabidopsis Plant Cell 19, 63–73 28 Kovtun Y, Chiu WL, Tena G & Sheen J (2000) Functional analysis of oxidative stress -activated mitogen- activated protein ... carrying the avirulence effector proteins AvrPto or AvrPtoB [17,18] The OXI1 protein kinase was also shown to be an upstream regulator of two mitogen- activated protein kinases (MAPKs), MPK3 and MPK6, ... cloning of a protein kinase gene conferring disease resistance in tomato Science 262, 1432–1436 PTI1-4, a common target of OXI1 and MAPKs 19 MAPK Group (2002) Mitogen- activated protein kinase cascades...

Ngày tải lên: 14/02/2014, 19:20

... selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen- activated protein kinase phosphatase-1 (MKP1) expression, induces c-Jun expression, and activates Jun N-terminal kinase J Biol ... Cell Biol 21, 8213–8224 42 Hirsch DD & Stork PJ (1997) Mitogen- activated protein kinase phosphatases inactivate stress -activated protein kinase pathways in vivo J Biol Chem 272, 4568– 4575 ´ 43 ... phosphatases: a gene family for control of MAP kinase function FASEB J 14, 6–16 27 Keyse SM (2000) Protein phosphatases and the regulation of mitogen- activated protein kinase signalling Curr Opin Cell Biol...

Ngày tải lên: 18/02/2014, 13:20

... phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen- activated protein kinase ... MAP kinase during hypoxia in cardiomyocytes Am J Physiol Lung Cell Mol Physiol 282, L1324–L1329 Xu L, Pathak PS & Fukumura D (2004) Hypoxiainduced activation of p38 mitogen- activated protein kinase ... hypoxia in PC12 cells J Biol Chem 274, 23570–23576 41 Cowan KJ & Storey KB (2003) Mitogen- activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress...

Ngày tải lên: 18/02/2014, 13:20

... the kinases calcium ⁄ calmodulin-dependent protein kinase (CaMKII), extracellular signal-regulated kinase ⁄ (ERK1 ⁄ 2), p38 mitogen- activated protein kinase (MAPK), protein kinase C and PI3 kinase ... formation of the lytic pore of the P2X7 receptor is dependent on coordinated signaling involving the p38 mitogen- activated protein kinase (MAPK) pathway and caspase activation [18] Several mechanisms ... ATP-mediated activation and nuclear translocation of extracellular signal-related kinase ⁄ (ERK1 ⁄ 2), p38 mitogen- activated protein kinase (MAPK) and nuclear factor jB (NF-jB) LXF-289 cells were incubated...

Ngày tải lên: 07/03/2014, 12:20

... Rac-dependent mitogen- activated protein kinase pathways Curr Biol 8, 935±938 Chishti, A., Faquin, W., Wu, C.C & Branton, D (1989) Puri®cation of erythrocyte dematin (protein 4.9) reveals an endogenous protein ... of Rac1 and stimulates stress -activated protein kinase (SAPK), also known as Jun N-terminal kinase (JNK), in transfected 293 cells [26] Indeed, the human Ras-GRF2 activated Rac1 in transfected ... between receptor tyrosine kinases and Ras signaling [20±24] While the upstream events that lead to Sos activation and the subsequent activation of the Ras-MAP kinase cascade are well known, the...

Ngày tải lên: 17/03/2014, 11:20

... factors [31], consists of a module of three sequentially activated protein kinases, namely, MAPK kinase kinase (MAP3K), MAPK kinase (MAP2K), and MAPK The extracellular signals are mediated intracellularly ... sequence of p25rum1 has revealed the presence of five putative phosphorylation sites for mitogen- activated protein kinase (MAPK), i.e Thr5, Thr13, Thr16, Ser19, and Thr58 [17], while the precise roles ... vitro kinase assay In this study, mainly two types of in vitro kinase assay were performed First, we examined whether MAPK phosphorylates p25rum1 by in vitro kinase assay GST-p25rum1 fusion proteins...

Ngày tải lên: 17/03/2014, 23:20

... in mitogen- activated protein (MAP) kinase kinase (Mkk3)-deficient mice EMBO J 18, 1845–1857 25 Wysk M, Yang DD, Lu HT, Flavell RA & Davis RJ (1999) Requirement of mitogen- activated protein kinase ... p38 group mitogen- activated protein kinases, p38delta J Biol Chem 272, 30122–30128 Enslen H, Raingeaud J & Davis RJ (1998) Selective activation of p38 mitogen- activated protein (MAP) kinase isoforms ... GL (2007) Role of mitogen- activated protein kinase kinase kinases in signal integration Oncogene 26, 3159–3171 Zarubin T & Han J (2005) Activation and signaling of the p38 MAP kinase pathway Cell...

Ngày tải lên: 24/03/2014, 00:21

... Shirakabe, K., Muro, Y., Shibuya, H., Matsumoto, K., et al (1996) A novel kinase cascade madiated by mitogen- activated protein kinase kinase and MKK3 J Biol Chem 271, 13675–13679 Alessi, D.R., Cuenda, ... structure and function of a new mitogen- activated protein kinase (p38beta) J Biol Chem 271, 17920–17926 Davis, R.J (2000) Signal transduction by the JNK group of MAP kinases Cell 103, 239– 252 Hill, ... modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways J Biol Chem 275, 12353–12359 Pang, L., Sawada, T., Decker, S.J & Saltiel, A.R (1995) Inhibition of MAP kinase kinase blocks...

Ngày tải lên: 24/03/2014, 04:21

... synergistic effect on proinflammatory cytokine ⁄ chemokine production, which requires both mitogen- activated protein (MAP) kinase and nuclear factor-jB (NF-jB) activation Results AGE-human serum albumin ... RJ, Juhasz O, Crow MT, Tilton RG & Denner L (2001) Requirement for p38 and p44 ⁄ p42 mitogen- activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine ... by activating the intracellular signaling pathways, including MAP kinases and NF-jB [12,23,24] Previous studies have demonstrated that LPS and AGEs activate MAP kinases in various cells, including...

Ngày tải lên: 30/03/2014, 01:20

... locus is coordinately regulated by protein kinase A II in PC12 cells J Neurochem 71, 1118±1126 13 Robinson, M.J & Cobb, M.H (1997) Mitogen- activated protein kinase pathways Curr Opin Cell Biol ... kinase pathways Curr Opin Cell Biol 9, 180±186 14 Marshall, C.J (1994) MAP kinase kinase kinase, MAP kinase kinase and MAP kinase Curr Opin Genet Dev 4, 82±89 15 Hill, C.S & Treisman, R (1995) Transcriptional ... (1998) Identi®cation of a novel inhibitor of mitogen- activated protein kinase kinase J Biol Chem 273, 18623± 18632 25 New England Biolabs (2000±01) Cell Signaling Technology Catalog New England Biolabs,...

Ngày tải lên: 31/03/2014, 21:21

... localization, and regulation of the stress -activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen- activated protein kinase, in synovial tissue and cells ... Studer et al protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in IL-2-stimulated T cells independently of p38 mitogen- activated protein kinase J ... fibroblasts requires cGMP-dependent protein kinase J Biol Chem 2000, 275:2811-2816 Chen K, Maines MD: Nitric oxide induces heme oxygenase-1 via mitogen- activated protein kinases ERK and p38 Cell Mol...

Ngày tải lên: 09/08/2014, 01:23

... localization, and regulation of the stress -activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen- activated protein kinase, in synovial tissue and cells ... p38 mitogen- activated protein kinase inhibitor: a first-in-human study J Clin Pharmacol 2003, 43:406-413 Westra J, Limburg PC, de Boer P, van Rijswijk MH: Effects of RWJ 67657, a p38 mitogen activated ... lipopolysaccharide-induced monocyte matrix metalloproteinase MMP-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen- activated protein kinases J Immunol 2003, 170:6244-6249 R392...

Ngày tải lên: 09/08/2014, 01:23

... crystals activated iNOS expression through the protein kinase signal transduction pathway involving Erk1/2 (p42/44), p38, and c-Jun amino-terminal kinase (JNK) mitogen- activated protein kinases ... HS: Basic calcium phosphate crystals induce matrix metalloproteinase1 through the Ras /Mitogen- activated protein kinase/ c-fos/ AP-1/metalloproteinase-1 pathway Involvement of transcription factor ... blocking antibodies to α2β1 and α5β1 integrins stimulate mitogen- activated protein kinase signaling and increase collagenase (matrix metalloproteinase 13) production by human articular chondrocytes...

Ngày tải lên: 09/08/2014, 06:23

... localization, and regulation of the stress -activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen- activated protein kinase in synovial tissue and cells ... rats by the potent p38 mitogen- activated protein kinase inhibitor FR167653 Arthritis Rheum 2003, 48:2670-2681 Pargellis C, Regan J: Inhibitors of p38 mitogen- activated protein kinase for the treatment ... of cells expressing the activated forms of (a) p38 mitogen- activated protein kinase (MAPK)α, (b) extracellular signal-regulated kinase (ERK) and (c) c-Jun amino-terminal kinase (JNK) after treatment...

Ngày tải lên: 09/08/2014, 07:20

... Arthritis Research & Therapy Vol No Wei et al p38 Mitogen- activated protein kinase (MAPK) belongs to a family of stress kinases that are activated by proinflammatory cytokines and environmental ... Karin M: Mammalian MAP kinase signalling cascades Nature 2001, 410:37-40 Paul A, Wilson S, Belham CM, Robinson CJ, Scott PH, Gould GW, Plevin R: Stress -activated protein kinases: activation, regulation ... Nebreda AR, Porras A: p38 MAP kinases: beyond the stress response Trends Biochem Sci 2000, 25:257-260 Zhen X, Wei L, Wu Q, Zhang Y, Chen Q: Mitogen- activated protein kinase p38 mediates regulation...

Ngày tải lên: 09/08/2014, 07:20

... standard in our rheumatology department The assays used for the detection of Lac were lupus-aPTT (activated partial thromboplastin time) and LA-screen and LA-confirm (Gradipore Inc, New York, NY,...

Ngày tải lên: 09/08/2014, 07:20

... affected by the MEK (mitogenactivated/extracellular signal-regulated kinase) inhibitor PD98059, as well as by SB202474 tion independence of p38 mitogen- activated protein kinase (MAPK) activaS100A8/A9-induced ... transcription factor NF-κB and the mitogenactivated protein kinase (MAPK) cascade [15,16] Many effector molecules are thought to be involved in the TNFα- and IL-1-driven cascade of proinflammatory events ... respond well to S100A8/A9 by producing S100A8/A9-mediated cytokine production Effects of mitogen- activated protein kinase (MAPK) inhibitors on S100A8/A9-mediated cytokine production Monocytes from healthy...

Ngày tải lên: 09/08/2014, 07:20