mirna regulation in glioma implications in development progression grading prognosis and therapy
Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy potx
Ngày tải lên :
29/06/2014, 11:20
... established for investigating protein-protein interactions in cultured cells and several are now being validated for use in living animals, including the two-hybrid system and protein fragment complementation ... separated into discrete DNA-binding and activation domains (Fields and Song 1989) Proteins of interest are expressed as fusions with either a DNA-binding domain (BD) or activation domain (AD), creating ... imaging of protein-protein interactions in vivo by PET and fluorescence imaging, we engineered a fusion reporter gene comprising a mutant herpes simplex virus thymidine kinase Imaging Protein-Protein...
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Rural and Micro Finance Regulation in Ghana: Implications for Development and Performance of the Industry ppt
Ngày tải lên :
22/03/2014, 21:20
... RCBs and, eventually, to take over some supervisory and training functions The Association will remain an NGO, concentrating on advocacy goals in promoting the rural banking system and maintaining ... planning, financial planning and budgeting, and microenterprise development Group members make mandatory savings contributions for at least three months before qualifying for a loan Increasing ... applicable to institutions that are licensed as financial intermediaries Prudential regulations refer to the standards and guidelines the financial institutions must meet in order to obtain or retain a...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
Ngày tải lên :
12/08/2014, 18:20
... stages in the proposed pathway are indicated Genistein is an inhibitor of tyrosine protein kinase and competitive inhibitor of ATP in other protein kinase reactions; NaF is a nonspecific kinase inhibitor; ... pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway IκB-independent pathways, ... stress and upregulation of a proinflammatory signal through the participation of cytokines [34–36,39–44] Cytokines Cytokines are peptide hormones that participate in autocrine and paracrine signaling...
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Báo cáo y học: " ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues" pptx
Ngày tải lên :
14/08/2014, 08:21
... clusters were randomly divided in a training set of 50 genes, and a test set containing the remaining genes The performance of the other CRM detection algorithms can be improved by using site preservation ... kb and 30 kb 5' of the TSS The validation framework that we use, combining genomewide ranking with LOOCV, could also be useful in evaluating or comparing hypotheses regarding the working principles ... gene sets obtained from clustering microarray data In nine out of ten microarray clusters, ModuleMiner succeeded in finding similar CRMs in a subset of the genes Perhaps unsurprisingly, a critical...
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Functional characterization of giant killer in flower development and meristem regulation in arabidopsis thaliana 1
Ngày tải lên :
14/09/2015, 08:46
... patterning and differentiation in Arabidopsis thaliana through binding assay and expression analysis The GIK protein contains an AThook DNA binding motif that is widely found in chromosomal proteins ... ……… development .…………………………………………… 62 3.2.7 GIK directly regulates ETT expression in flowers…………… ………65 3.2.8 GIK is a bona fide matrix protein and binds to ETT putative MARs in vitro and in ... was initiated based on a bioinformatics screen looking for direct binding targets of AG In the first part of my study, I demonstrate that GIANT KILLER (GIK) is a direct target of AG in the regulation...
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Functional characterization of giant killer in flower development and meristem regulation in arabidopsis thaliana 2
Ngày tải lên :
14/09/2015, 08:46
... protein binding site for MADS -box proteins GIK encodes a protein with 285 amino acids containing an AT-hook DNA binding motif and an uncharacterized plant -and- prokaryote conserved domain (Figure ... following AG induction in developing flowers The transgenic line contains a gene coding for a fusion of the AG protein and the steroid binding domain of the rat glucocorticoid receptor (AG-GR) in ... membrane was stained with Coomassie Blue to show protein loading 2.14 South-western blotting (in vitro MAR binding assay) Recombinant proteins GIK-AT (amino acids 74-173) and GIK-MUT (amino acids 74-173;...
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DEVELOPMENT OF THE OZONIZER AND OZONATION TECHNOLOGY FOR WATERWORKS IN JAPAN
Ngày tải lên :
05/09/2013, 08:40
... 20watt min/L 300watt min/L Oxygen concentration 20Vol.% 100Vol.% Ozone concentration 20g/Nm3 300g/Nm3 However, in high concentrations, ozone decomposes and burns during heating and increases in pressure ... cryptosporidium parvum and 400 people died in the United States In Japan, 8,800 people became infected in Saitama Prefecture in 1996, and it was recognized as becoming a big problem in society Cryptosporidium ... in removing taste and odor and reducing trihalomethane and that, to suppress bromate generation, concentrations of dissolved ozone need to be maintained at 0.1 mg/L or less To further widen and...
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Cell Cycle Regulation in Mammalian Germ Cells
Ngày tải lên :
25/10/2013, 21:20
... (continued) Gene involved in homologous recombination, lack of which leads to defects in chromosomal synapsis Involved in recombination, double strand break repair and repair of interstrand cross-links ... Cdk4 and its catalytic partner, cyclin D, are responsible for the initial phosphorylation of the Rb protein by regulating cyclin E/Cdk2 and lifting the S-phase inhibition by preventing binding ... , p16 INK4a , p18 INK4c , p19INK4d ) specifically bind and regulate cyclin D dependant kinases The Kip/Cip family (p21 Cip1/Waf1 , p27Kip1 and p57 Kip2 ) binds and regulates cyclin A, D and E...
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Tài liệu Vietnam-Netherlands Programme for M.A. in Development Economics pdf
Ngày tải lên :
25/12/2013, 18:15
... benefit of individuals, organizations and economy A different perspective: Economics as a science studying markets (James Buchanan) Chapter 1: Preliminaries Slide Preliminaries Starting point of ... theory and models Chapter 1: Preliminaries Slide 22 Summary Positive and normative issues A market refers to a collection of buyers and sellers who interact and to the possibility for sales and ... Microeconomic Analysis Evolving the Theory Testing and refining theories is central to the development of the science of economics Chapter 1: Preliminaries Slide 12 Positive Versus Normative Analysis...
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Tài liệu Reading Our Lips: The History of Lipstick Regulation in Western Seats ... doc
Ngày tải lên :
16/01/2014, 22:20
... (naming the major producers of liquid lipstick as Liptone in the United States, Lip-Cote in England, and Libussa in Germany) 264 In fact, development and listing costs have resulted in the origination ... have since grown increasingly detailed as well as increasingly accepted.353 Simultaneous to this fighting over delisting of colorants and listing of ingredient though, the FDA and the cosmetics industry, ... paint increased in importance and sophistication, with its use continuingly unhindered by any form of regulation Popular color choices included orange, magenta, and blue-black.10 Red also remained...
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Tài liệu SEXUALITY EDUCATION IN SCHOOLS: THE INTERNATIONAL EXPERIENCE AND IMPLICATIONS FOR NIGERIA pdf
Ngày tải lên :
14/02/2014, 14:20
... contraception and HIV/STI prevention; inadequate teaching materials and training; a scattershot approach to providing specific information that undermines comprehensive student understanding; and a tendency ... “examinable” and others not test students on their achievements in learning the subject matter (Senderowitz, 2000) Training teachers Teacher training is a challenge everywhere, including in developed ... who participated in the intervention had fewer partners after the intervention Program 2: Linking schools with private physicians An integrated school and clinic program in Benin City, Nigeria,...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
Ngày tải lên :
16/02/2014, 09:20
... all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipper domain and fork-head domain of foxp3 In addition, for stat6 and foxp3, there ... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a ... binding and nuclear localization), which is shared by all FOX proteins, a leucine zipper domain and a C2H2 zinc finger domain, both of which are thought to help mediate DNA binding and may be involved...
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Tài liệu The University in Development pdf
Ngày tải lên :
19/02/2014, 01:20
... diploma principal investigator research and development science and technology South African Research Chairs Initiative science, engineering and technology Sector Education and Training Authority ... researching historical information about MIT and Stanford in relation to how their university engineering departments linked up with industry in ‘use-oriented’ research in the 1930s and 1940s: Interviewer: ... research-intensive universities The findings on the increasing association of research-intensive universities with patenting and licensing processes (i.e their increasing participation in the second...
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Tài liệu Emotion Regulation in Couples and Families ppt
Ngày tải lên :
19/02/2014, 04:20
... including three instances of regulating happiness, two instances each of regulating romantic attraction and excitement, and one of regulating interest, as well as a number of episodes involving ... toward understanding and explaining how individual differences and normative aspects of emotion regulation are likely to operate, both within individuals and between relationship partners In chapter ... likely to be involved in happier and better-functioning relationships, including romantic and family-based ones From an applied standpoint, a deeper understanding of how emotion regulation processes...
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Tài liệu Master Thesis Health Sciences: Expert Elicitation to Populate Early Health Economic Models of Medical Diagnostic Devices in Development pdf
Ngày tải lên :
20/02/2014, 16:20
... each individual radiologist First the medical device, PAM, was introduced Then uncertainty of obtaining information regarding the clinical outcome in an early stage of development was explained ... Diagnostic Devices in Development | Page | 26 Table Adapted weighting Difference individual Individual vs adapted weighting weighting ranking Performance MRI individual weighting Difference individual ... including tumor characteristics and the TPR and TNR rate, during individual face-to-face interviews The overall distribution of the TPR and TNR were synthesized using the linear opinion pooling...
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Ironies in Organizational Development Second Edition, Revised and Expanded pdf
Ngày tải lên :
06/03/2014, 06:22
... mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher Current printing (last digit): 10 PRINTED ... complex, as in seeking to understand interpersonal conflict as an expression of differing personal predispositions, or as in designing and interpreting opinion surveys Skill-building activities, ... and guesses reflected in this volume OD values more clearly and insistently apply in the kind of society and economy we seem to be becoming: more educated and with a growing range of options and...
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Developing a Road Map for Engaging Diasporas in Development potx
Ngày tải lên :
06/03/2014, 10:20
... other financial instruments.394 Governments, banks, and businesses in countries of origin have a strong interest in creating financial instruments that can attract these diaspora savings into investments ... issues in parallel with encouraging investment in countries of diaspora origin B Increase Knowledge and Expertise about Financing Vehicles Targeting the Diaspora Developing a Road Map for Engaging ... ‘patriotic discount,” on investments in the homeland Developing a Road Map for Engaging Diasporas in Development A Handbook for Policymakers and Practitioners in Home and Host Countries 205 CHAPTER...
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Báo cáo khoa học: Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling pdf
Ngày tải lên :
07/03/2014, 02:20
... Franklin Lakes, NJ, USA) and CD28 (5 lgỈmL)1, CD28.2; BD Pharmingen), and maintained in RPMI-1640 standard medium containing recombinant human interleukin-2 (R&D Systems, Minneapolis, MN, USA; 25 ... (Clontech, Mountain View, CA, USA) vector following the C-terminus of GFP The first 10 amino acids of Fyn were engineered in frame N-terminal to GFP (FynC–GFP–INP54p) Human CD95 was inserted into pcDNA4 ... Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis Science 291, 1047–1051 FADD trafficking and CD95 signaling 15 Itoh T & Takenawa T (2004) Regulation of endocytosis...
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Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
Ngày tải lên :
07/03/2014, 03:20
... fast membrane binding and integration into the Tic complex Reducing conditions on the other hand lead to solubilization into the stroma and increased interaction with its other known interaction ... N-terminal half of the protein, including the dehydrogenase domain Specific binding of the FNR is mediated by a unique series of proline/serine-rich repeat motifs located in the C-terminus For the integration ... involved in protein–protein interaction are blue and the dehydrogenase domains of Tic32 and Tic62 are shown in green Tic110 contains two transmembrane domains at the proximal N-terminus The topology...
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