... steatohepatitis and 36 with chronic hepatitis C. All had a biopsy-proven diagnosis.Measurements: Serum concentrations of transforminggrowth factor- beta1and ferritin.Results: High concentrations of transforming ... (NASH) and also of the severityof fibrosis in NASH. J Gastroenterol 2007, 42:573-82.16. Khan R, Sheppard R: Fibrosis in heart disease: understandingthe role of transforminggrowth factor- beta1 ... values and similar in the three groups (P = 0.9), also when adjusted for gender (P = 0.5) and age (P = 0.3).Conclusion: No difference between serum concentrations of transforminggrowth factor- beta1...
... the data and helped to draft the manuscript. YAobtained consent from patients and collected the samples and patient data for the study, and participated in the coordinationof the study and writing ... articleActivation of transforminggrowth factor- β1 and early atherosclerosis in systemic lupus erythematosusMichelle Jackson1, Yasmeen Ahmad2, Ian N Bruce2, Beatrice Coupes1 and Paul EC Brenchley11Renal ... calculated low-density lipoprotein levels and increasedcarotid IMT, and may contribute to the development of earlyatherosclerosis.Introduction Transforming growthfactor (TGF)-β1 is the most potent...
... additional factors and/ or cofactors thatsecondarily contribute to their function and that maybecome prevalent in the absence of TGF-β and/ or if TGF-βis dysregulated. The identification and intersection ... CD4+CD25+regulatory T cells canmediate suppressor function in the absence of transforming growthfactorbeta1 production and responsiveness. J ExpMed 2002, 196:237-246.12. Chen W, Jin W, Hardegen ... infections and autoimmune diseases. Theirmode of suppression is contact-dependent, antigen-nonspecific and involves a nonredundant contribution from the cytokine transforming growthfactor (TGF)-β....
... this disease,which includes pathophysiology and joint stability includingbiomechanics. The balance between anabolic morphogens and growth factors and catabolic cytokines is at the crux of the ... and 7). TheCommentaryAging, osteoarthritis andtransforminggrowth factor- ββsignalingin cartilageA Hari ReddiLawrence J Ellison Center for Tissue Regeneration, University of California, ... cells and extra-cellular matrix by anabolic morphogens and catabolic cyto-kines [1]. The aim of this commentary is to place in context arecent article in this journal of anabolic growth factor, ...
... & Colicelli J (2008) Integration of transforming growthfactor beta and RAS signalingsilences a RAB5 guanine nucleotide exchange factor and enhances growth factor- directed cell migration.Mol ... during transforminggrowth factor- beta-induced smooth muscle differentiation. J BiolChem 281, 1765–1770.143 Deaton RA, Su C, Valencia TG & Grant SR (2005) Transforming growth factor- beta1- induced ... PRK2 and p38 MAPK and the transcriptionalupregulation of smooth muscle-specific genes such asa-SMA, SM-MHC and SM-22a via the cooperation ofserum response factor, GATA and myosin enhancerfactor...
... 270) Ó FEBS 2003 Probing the interface between factor Xa andtissue factor in the quaternary complex tissuefactorfactor VIIa factor Xa tissue factor pathway inhibitorKarin Carlsson1, Per-Ola ... formation between factor VIIa (FVIIa) and itscofactor tissuefactor (TF) triggers blood coagulation. TheTF–FVIIa complex activates factor X (FX) to factor Xa(FXa) andfactor IX (FIX) to factor IXa ... complexbetween factor VIIa (FVIIa) and its cofactor, tissue factor (TF). TF–FVIIa is inhibited by tissuefactor pathwayinhibitor (TFPI) in two steps: first TFPI is bound to theactive site of factor...
... lipopolysaccharide-inducedtumour necrosis factor- a production by transforming growth factor- b1Tarnjit K. Khera1, Andrew D. Dick1,2 and Lindsay B. Nicholson1,21 Department of Cellular and Molecular Medicine, ... anti-inflammatorycytokine transforminggrowth factor- b1 (TGF-b1) ofthe proinflammatory cytokine TNF-a via the inductionof FXR1 is the focus of this article.TGF-b1, a member of the large transforming growth factor- b ... of interferon-gamma (IFN-gamma), IL-10,IL-12 andtransforminggrowth factor- beta (TGF-beta) mRNA in synovial fluid cells from patients inthe early and late phases of rheumatoid arthritis(RA)....
... arylhydrocarbonreceptor expression by transforminggrowth factor- b1. Mol.Pharmacol. 59, 716 724.22. Doăhr, O. & Abel, J. (1997) Transforminggrowth factor- beta 1coregulates mRNA expression ... Nature 394, 909–913.28. Roberts, A.B. & Sporn, M.B. (1990) The transforming growth factor- bs. In Peptide Growth Factors and Their Receptors I (Sporn,M.B. & Roberts, A.B., eds), pp. 419–472. ... W. (1998)Identification and functional characterization of a Smad bindingelement (SBE) in the JunB promoter that acts as a transforming growth factor- beta, activin, and bone morphogenetic protein-inducible...
... 142: TransformingGrowth Factor- ` ProtocolsEdited by: P. H. Howe â Humana Press Inc., Totowa, NJDetection of TGF-` in Body Fluids and TissuesAndrew H. LimperIntroduction Transforming growth ... D., Moses, H. L., and Holley, R. W. (1984) Growth inhibitor from BSC-1 cells closely related to platelet type ` transforming growth factor. Science 226, 705–707.41. Kojima, S. and Rifkin, D. B. ... the cellular receptor for transforminggrowthfactor type `. Biochemistry 25,3083–3091.3. Massagué, J. (1987) Identification of receptors for type-` transforming growth factor. Methods Enzymol....
... proliferator-activatedreceptor γ ; TGF-β1, transforminggrowthfactor β1, TZD,thiazolidinedione.Competing interestsGary Landreth received a honorarium for a talk given toTakeda North America in 2003, and received fundingfrom ... westernblots and development of the morphometric method toquantitate microglia activation; GL and MH organized and paid for the synthesis and delivery of the chow con-taining pioglitazone and ibuprofen. ... patho-genesis and effects on the ageing and Alzheimer brain. NeurolRes 2003, 25:611-616.44. Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E: Chronic over-production of transforminggrowth factor...
... Prabhakar†, Chandrika Abburi, Neel K Sharma and Akshay Anand*AbstractBackground: We have earlier shown that protein levels of vascular endothelial growth factor- A (VEGF-A) and chemokine ligand-2 (CCL2) ... endothelial growth factor- A (VEGF-A) is adimeric secreted polypeptide that was discovered first inthe VEGF family which also includes placental growth factor (PLGF), VEGF-B, VEGF-C, VEGF-D and VEGF-E.VEGF-A ... endothelial growthfactor mRNA and downregulates its expression. J Neurosci 2007, 30:7929-38.16. Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F,Marklund SL, Wyns S, Thijs V, Andersson...