micropatterning biomimetic materials for bioadhesion and drug delivery

... since 1980s [3-7] for controlled drug/ protein delivery For examples, microspheres made of poly(methacrylic acid)poly(ethylene glycol) [8] were studied and used as a nasal drug delivery system to ... of fatty acids and bile salts and acids such as cholic acid, deoxycholic acid, etc One of the most interesting carrier materials for drug/ protein delivery, which were studying and developing ... drug/ protein to allow for a predictable and customizable loading and release In this study, the challenger of molecular design of novel pH and temperature-sensitive hydrogels is polymer and drug...

Ngày tải lên: 13/05/2016, 10:14

... S s 5.40 for 30-ppm NH and S s 4.00 for 40-ppm NO; WO q wt.% Mg, Zn, Mo and Re: S s 7.65, 5.06, 10.1, 9.46, respectively, for 30 ppm NH , and S s 5.87, 8.33, 5.00, 6.25, respectively, for 40 ppm ... Sensors and Actuators B 66 (2000) 74–76 Conclusions The sensing materials of WO loaded with wt.% metal oxides were prepared and applied for NH and NO detection, and several composition materials ... NO., and fast response to NH and NO compared with pure WO The materials of WO loaded with wt.% Cr, La, Pr, Sm, Gd, Er, Tm and Yb showed good responses to NH , and hardly responded to NO, and...

Ngày tải lên: 20/03/2014, 13:08

... Circuit Analysis and Diagnosis, edited by Takao Ozawa Transformer and Inductor Design Handbook: Second Edition, Revised and Expanded, Colonel Wm T McLyman Power System Grounding and Transients: ... Principles and Applications, Second Edition, Revised and Expanded, David Weston Permanent Magnet Motor Technology: Design and Applications, Second Edition, Revised and Expanded, Jacek F Gieras and Mitchell ... Toliyat and Gerald B Kliman 121 Transformer and Inductor Design Handbook, Colonel Wm T McLyman 122 Energy Efficient Electric Motors: Selection and Application, Third Edition, Revised and Expanded,...

Ngày tải lên: 23/03/2014, 08:21

... cathode and anode materials, electrolytes and binders for lithium ion and sodium ion batteries is provided 1.2 Need for electrical energy storage systems The demand for the most dominant form of ... Rational design of materials and electrodes is shown to be the key for achieving enhanced electrochemical performance The stable cyclability of 1100 cycles and high rate performance of 610 mAh ... Energy Harvesting and Storage: Materials, Devices, and Applications II, 803503, 2011, DOI:10.1117/12.884460 Nanostructured electrode materials for Li-ion battery P Balaya, K Saravanan and S Hariharan...

Ngày tải lên: 08/09/2015, 18:44

... nanopipe for the formation of a nanodonut structure.38 Chapter Introduction 1.3.3 Drug and Gene Delivery The hydrophobic core and hydrophilic shell formed by amphiphilic peptides can be used for drug ... efficiency, and 27 Chapter Literature Review simultaneous delivery of drug and gene delivery. 39 All these advantages suggest that FA32 is a promising delivery vehicle for both drug and gene simultaneously ... biodegradable and kinetically stable.11 In this context, amphiphilic peptides have emerged as “smart” materials for drug delivery They were tested for delivering drug or gene or both, and better...

Ngày tải lên: 09/09/2015, 08:13

... scientists to consider nature for design and fabrication inspiration for new generation of biomimetic materials This thesis was designed to develop new class of biomimetic materials that closely resembled ... the 1970s and advances in genomics and proteomics in the 1990s and 2000s enabled scientists to systematically understand host-biomaterials relationship and identify bioactive components for improving ... bioinspired materials or biomimetic materials, which are inspired by nature and are intended to structurally, mechanically and biologically mimic native matrices in a sophisticate manner Native materials...

Ngày tải lên: 09/09/2015, 18:57

... prolonged small bead drug layering was carried out with HPMC VLV as main film forming agent and metformin hydrochloride as the model drug One-to-one weight gain runs for the drug layered beads ... HPMC E3 formulation and HPMC VLV formulation .121 Figure 20 Dried films of (a) HPMC E3 formulation, F1 without metformin hydrochloride, (b) HPMC VLV formulation, F2 without metformin ... we spent for discussions, exchanging opinions was one of the best moments I had during my candidature Finally, I am grateful to my family for their support and understanding during my candidature...

Ngày tải lên: 10/09/2015, 09:01

... AqpZ embedded biomimetic membrane for nanofiltration or forward osmosis application; (3) understanding the AqpZ function in the designed membrane and optimizing the membrane performance Our ultimate ... Yong and all my group members who have helped me in one way or another through the years of my PhD study Finally, I am most grateful to my parents and husband for their unconditional love and ... using this approach and this newly developed biomimetic membrane possessed an extraordinary performance in forward osmosis x LIST OF TABLES Table 1.1 The characteristics and applications of...

Ngày tải lên: 10/09/2015, 09:09

... were calculated and plotted against DDM concentration Three times repetition were done for each data point and the error for all points are within 6% 2.2.4 LB film deposition and AFM scanning ... ratios are investigated for nanofiltration performance For the first time, membranes covered with AQP-reconstituted proteoliposomes have been designed and fabricated for water purification purposes ... rejection and permeate flux results for both NaCl and MgCl2 after vesicle immobilization are shown in Figure 3.7 59 Table 3.2 Pure water permeability (PWP) of PAN membrane before and after modification...

Ngày tải lên: 10/09/2015, 09:09

... proteins Figure 4.1 The schematic presentation of the formation procedures for the liposome-embedded LbL membrane 65 4.2 Materials and methods 4.2.1 Materials 1-palmitoyl-2-oleoyl-sn-gly-cero-3-phosphocholin ... ml-1 with Tris buffer and dropped on ultrathin carbon film coated copper grids for 15 and then rinsed with ultrapure water dropwise The samples were air dried for 30 before the FETEM imaging ... approach The LbL matrix has offered a stable and compatible environment for AqpZ-reconstituted vesicles and this design may become one of the potential solutions for fabricating the AqpZ-assisted water...

Ngày tải lên: 10/09/2015, 09:10

... The magnetic force-driven approach is effective and straightforward In this work, magnetic liposome characterization, membrane morphology study and forward osmosis performance of this biomimetic ... [89] C.H Nielsen, Biomimetic membranes for sensor and separation applications, Analytical and Bioanalytical Chemistry, 395 (2009) 697-718 [90] C.D Montemagno, Biomimetic Membrane Formed from a Vesicle-Thread ... Kumar, M Payne, S.K Poust, J.L Zilles, Polymer-based biomimetic membranes for desalination, in: C.H Nielsen (Ed.) Biomimetic membranes for sensor and separation applications, Springer, 2012 108...

Ngày tải lên: 10/09/2015, 09:10

... the structure and physiology of normal and tumor tissues can be used for designing drug delivery systems facilitating tumor-specific delivery of the drug or prodrug and specific drug activation ... 80 Chapter pH-triggered drug release for active intracellular drug delivery .81 5.1 Introduction 81 5.2 Materials and methods 83 5.2.1 Materials .83 5.2.2 ... attracted great interest for more than 20 years in the search for target molecules of relevance for tumor growth and formation of metastases and as potential targets for immunotherapy 76 In most...

Ngày tải lên: 12/09/2015, 08:20

... site For instance, Shi and Pardridge have chemically modified PEGylated liposome with mouse monoclonal antibody OX-26 to form immunoliposomes for targeted and prolong drug or gene delivery for ... copolymers for various potential biomedical applications, including formulation of imaging agents for cellular and molecular imaging and targeted drug therapy (Zhang et al., 2007; Pan and Feng, ... provides a platform for developing sustainable, controlled and targeted drug delivery system to improve the therapeutic efficacy and reduce the clinical side effects of most antineoplastic drugs In...

Ngày tải lên: 09/10/2015, 11:18

... For 23    instance, Shi and Pardridge have chemically modified PEGylated liposome with mouse monoclonal antibody OX-26 to form immunoliposomes for targeted and prolong drug or gene delivery for ... chemistry and drug/ dye encapsulation xi    efficiency and in vitro drug release profile SKBR-3 cells were employed as an in vitro model for HER2 positive breast cancer and assessed for their ... glycol to drug delivery systems in order to enhance both the stability and circulation time of drug delivery systems (Davis, 2002) The effect of PEGylation can also be achieved in drug delivery...

Ngày tải lên: 09/10/2015, 11:18

... for drug delivery 2.1.1 Nanoparticles drug delivery systems Over the past few decades, much effort has been devoted to developing nanotechnology for drug delivery because of its suitability and ... copolymers for protein drug delivery, S H Lee, Z P Zhang and S S Feng, Biomaterials 2007; 28: 2041-2052 Folate-decorated poly(lactic-co-glycolic acid)-vitamin E TPGS nanoparticles for targeted drug delivery, ... PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carriers for delivery of protein and anticancer drug and...

Ngày tải lên: 26/11/2015, 22:41

... nanotechnology in medicine and more specifically drug delivery is set to spread rapidly Currently many substances are under investigation for drug delivery and more specifically for cancer therapy are ... targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue The conventional drug delivery system is the absorption of the drug across ... site-specific drug delivery, a major challenge for drug administration Ideally, these “magic missiles” would accumulate at the diseased tissue and locally liberate the necessary amount of drug The drugs...

Ngày tải lên: 19/05/2016, 10:45

... Only peaks for C, O, and Cu were observed in EDX spectra obtained for CuCNPs (Figure 2B), and the measured weight percents were consistent with both ICP MS and XPS EDX was also performed on samples ... on samples immediately before and after the addition of CuSO Before CuSO4 treatment, only peaks for C, O, and Na were observed; after treatment, the Na peak disappeared and a Cu peak appeared ... CNPs before (left) and after (right) addition of Cu, (C) XPS spectra for CuCNPs (right) and control particles containing no Cu (left) The difference between the amount released at 48 h and that...

Ngày tải lên: 21/06/2014, 02:20

... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation, ... be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents an interesting solution for building ... from some types of brown algae and it is made up of two uronic acids: D-mannuronic acid and L-guluronic acid Polyvalent cations are responsible for interchain and intrachain reticulations because...

Ngày tải lên: 22/06/2014, 00:20

... designed to standardize the toxicity and efficacy of nano -drug delivery system in both in vitro and in vivo (WT mice) systems, and evaluate the efficacy of PLGA-PEG mediated PS-341 lung delivery in ... delivery for treatment of CF We anticipate that this study will have a high impact on the development of novel targeted drug- delivery therapeutics for CF and other airway diseases like COPD and ... nanoparticles for drug and gene delivery to cells and tissue Adv Drug Deliv Rev 2003, 55:329-347 12 Qaddoumi MG, Ueda H, Yang J, Davda J, Labhasetwar V, Lee VH: The characteristics and mechanisms...

Ngày tải lên: 11/08/2014, 00:22

... values for the Gaussian and Poisson distribution fits are 0.154 and 0.027, respectively For (b), the p values for the Gaussian and Poisson distribution fits are 0.628 and 0.016, respectively For ... a carrier for drug and gene delivery in various applications (Bowman and Leong, 2006) Chapter 22 Figure 2.5: Repeat units for chitin and chitosan Chitin consists of mainly n units and chitosan ... three and five days after commencement of treatment The groups include blank and free drug (FD) groups (blank, chi-p53 FD, Dox FD, and combined Dox and chi-p53 FD) as well as blank and drug- loaded...

Ngày tải lên: 10/09/2015, 09:05