... since 1980s [3-7] for controlled drug/ protein deliveryFor examples, microspheres made of poly(methacrylic acid)poly(ethylene glycol) [8] were studied and used as a nasal drugdelivery system to ... of fatty acids and bile salts and acids such as cholic acid, deoxycholic acid, etc One of the most interesting carrier materialsfor drug/ protein delivery, which were studying and developing ... drug/ protein to allow for a predictable and customizable loading and release In this study, the challenger of molecular design of novel pH and temperature-sensitive hydrogels is polymer and drug...
... S s 5.40 for 30-ppm NH and S s 4.00 for 40-ppm NO; WO q wt.% Mg, Zn, Mo and Re: S s 7.65, 5.06, 10.1, 9.46, respectively, for 30 ppm NH , and S s 5.87, 8.33, 5.00, 6.25, respectively, for 40 ppm ... Sensors and Actuators B 66 (2000) 74–76 Conclusions The sensing materials of WO loaded with wt.% metal oxides were prepared and applied for NH and NO detection, and several composition materials ... NO., and fast response to NH and NO compared with pure WO The materials of WO loaded with wt.% Cr, La, Pr, Sm, Gd, Er, Tm and Yb showed good responses to NH , and hardly responded to NO, and...
... Circuit Analysis and Diagnosis, edited by Takao Ozawa Transformer and Inductor Design Handbook: Second Edition, Revised and Expanded, Colonel Wm T McLyman Power System Grounding and Transients: ... Principles and Applications, Second Edition, Revised and Expanded, David Weston Permanent Magnet Motor Technology: Design and Applications, Second Edition, Revised and Expanded, Jacek F Gieras and Mitchell ... Toliyat and Gerald B Kliman 121 Transformer and Inductor Design Handbook, Colonel Wm T McLyman 122 Energy Efficient Electric Motors: Selection and Application, Third Edition, Revised and Expanded,...
... cathode and anode materials, electrolytes and binders for lithium ion and sodium ion batteries is provided 1.2 Need for electrical energy storage systems The demand for the most dominant form of ... Rational design of materialsand electrodes is shown to be the key for achieving enhanced electrochemical performance The stable cyclability of 1100 cycles and high rate performance of 610 mAh ... Energy Harvesting and Storage: Materials, Devices, and Applications II, 803503, 2011, DOI:10.1117/12.884460 Nanostructured electrode materialsfor Li-ion battery P Balaya, K Saravanan and S Hariharan...
... nanopipe for the formation of a nanodonut structure.38 Chapter Introduction 1.3.3 Drugand Gene Delivery The hydrophobic core and hydrophilic shell formed by amphiphilic peptides can be used fordrug ... efficiency, and 27 Chapter Literature Review simultaneous delivery of drugand gene delivery. 39 All these advantages suggest that FA32 is a promising delivery vehicle for both drugand gene simultaneously ... biodegradable and kinetically stable.11 In this context, amphiphilic peptides have emerged as “smart” materialsfordrugdelivery They were tested for delivering drug or gene or both, and better...
... scientists to consider nature for design and fabrication inspiration for new generation of biomimeticmaterials This thesis was designed to develop new class of biomimeticmaterials that closely resembled ... the 1970s and advances in genomics and proteomics in the 1990s and 2000s enabled scientists to systematically understand host-biomaterials relationship and identify bioactive components for improving ... bioinspired materials or biomimetic materials, which are inspired by nature and are intended to structurally, mechanically and biologically mimic native matrices in a sophisticate manner Native materials...
... prolonged small bead drug layering was carried out with HPMC VLV as main film forming agent and metformin hydrochloride as the model drug One-to-one weight gain runs for the drug layered beads ... HPMC E3 formulation and HPMC VLV formulation .121 Figure 20 Dried films of (a) HPMC E3 formulation, F1 without metformin hydrochloride, (b) HPMC VLV formulation, F2 without metformin ... we spent for discussions, exchanging opinions was one of the best moments I had during my candidature Finally, I am grateful to my family for their support and understanding during my candidature...
... AqpZ embedded biomimetic membrane for nanofiltration or forward osmosis application; (3) understanding the AqpZ function in the designed membrane and optimizing the membrane performance Our ultimate ... Yong and all my group members who have helped me in one way or another through the years of my PhD study Finally, I am most grateful to my parents and husband for their unconditional love and ... using this approach and this newly developed biomimetic membrane possessed an extraordinary performance in forward osmosis x LIST OF TABLES Table 1.1 The characteristics and applications of...
... were calculated and plotted against DDM concentration Three times repetition were done for each data point and the error for all points are within 6% 2.2.4 LB film deposition and AFM scanning ... ratios are investigated for nanofiltration performance For the first time, membranes covered with AQP-reconstituted proteoliposomes have been designed and fabricated for water purification purposes ... rejection and permeate flux results for both NaCl and MgCl2 after vesicle immobilization are shown in Figure 3.7 59 Table 3.2 Pure water permeability (PWP) of PAN membrane before and after modification...
... proteins Figure 4.1 The schematic presentation of the formation procedures for the liposome-embedded LbL membrane 65 4.2 Materialsand methods 4.2.1 Materials 1-palmitoyl-2-oleoyl-sn-gly-cero-3-phosphocholin ... ml-1 with Tris buffer and dropped on ultrathin carbon film coated copper grids for 15 and then rinsed with ultrapure water dropwise The samples were air dried for 30 before the FETEM imaging ... approach The LbL matrix has offered a stable and compatible environment for AqpZ-reconstituted vesicles and this design may become one of the potential solutions for fabricating the AqpZ-assisted water...
... The magnetic force-driven approach is effective and straightforward In this work, magnetic liposome characterization, membrane morphology study and forward osmosis performance of this biomimetic ... [89] C.H Nielsen, Biomimetic membranes for sensor and separation applications, Analytical and Bioanalytical Chemistry, 395 (2009) 697-718 [90] C.D Montemagno, Biomimetic Membrane Formed from a Vesicle-Thread ... Kumar, M Payne, S.K Poust, J.L Zilles, Polymer-based biomimetic membranes for desalination, in: C.H Nielsen (Ed.) Biomimetic membranes for sensor and separation applications, Springer, 2012 108...
... the structure and physiology of normal and tumor tissues can be used for designing drugdelivery systems facilitating tumor-specific delivery of the drug or prodrug and specific drug activation ... 80 Chapter pH-triggered drug release for active intracellular drugdelivery .81 5.1 Introduction 81 5.2 Materialsand methods 83 5.2.1 Materials .83 5.2.2 ... attracted great interest for more than 20 years in the search for target molecules of relevance for tumor growth and formation of metastases and as potential targets for immunotherapy 76 In most...
... site For instance, Shi and Pardridge have chemically modified PEGylated liposome with mouse monoclonal antibody OX-26 to form immunoliposomes for targeted and prolong drug or gene deliveryfor ... copolymers for various potential biomedical applications, including formulation of imaging agents for cellular and molecular imaging and targeted drug therapy (Zhang et al., 2007; Pan and Feng, ... provides a platform for developing sustainable, controlled and targeted drugdelivery system to improve the therapeutic efficacy and reduce the clinical side effects of most antineoplastic drugs In...
... For 23 instance, Shi and Pardridge have chemically modified PEGylated liposome with mouse monoclonal antibody OX-26 to form immunoliposomes for targeted and prolong drug or gene deliveryfor ... chemistry and drug/ dye encapsulation xi efficiency and in vitro drug release profile SKBR-3 cells were employed as an in vitro model for HER2 positive breast cancer and assessed for their ... glycol to drugdelivery systems in order to enhance both the stability and circulation time of drugdelivery systems (Davis, 2002) The effect of PEGylation can also be achieved in drug delivery...
... fordrugdelivery 2.1.1 Nanoparticles drugdelivery systems Over the past few decades, much effort has been devoted to developing nanotechnology fordrugdelivery because of its suitability and ... copolymers for protein drug delivery, S H Lee, Z P Zhang and S S Feng, Biomaterials 2007; 28: 2041-2052 Folate-decorated poly(lactic-co-glycolic acid)-vitamin E TPGS nanoparticles for targeted drug delivery, ... PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carriers fordelivery of protein and anticancer drug and...
... nanotechnology in medicine and more specifically drugdelivery is set to spread rapidly Currently many substances are under investigation fordrugdeliveryand more specifically for cancer therapy are ... targeted drugdelivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue The conventional drugdelivery system is the absorption of the drug across ... site-specific drug delivery, a major challenge fordrug administration Ideally, these “magic missiles” would accumulate at the diseased tissue and locally liberate the necessary amount of drug The drugs...
... Only peaks for C, O, and Cu were observed in EDX spectra obtained for CuCNPs (Figure 2B), and the measured weight percents were consistent with both ICP MS and XPS EDX was also performed on samples ... on samples immediately before and after the addition of CuSO Before CuSO4 treatment, only peaks for C, O, and Na were observed; after treatment, the Na peak disappeared and a Cu peak appeared ... CNPs before (left) and after (right) addition of Cu, (C) XPS spectra for CuCNPs (right) and control particles containing no Cu (left) The difference between the amount released at 48 h and that...
... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drugdelivery device Fordrug release kinetics investigation, ... be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents an interesting solution for building ... from some types of brown algae and it is made up of two uronic acids: D-mannuronic acid and L-guluronic acid Polyvalent cations are responsible for interchain and intrachain reticulations because...
... designed to standardize the toxicity and efficacy of nano -drug delivery system in both in vitro and in vivo (WT mice) systems, and evaluate the efficacy of PLGA-PEG mediated PS-341 lung delivery in ... deliveryfor treatment of CF We anticipate that this study will have a high impact on the development of novel targeted drug- delivery therapeutics for CF and other airway diseases like COPD and ... nanoparticles fordrugand gene delivery to cells and tissue Adv Drug Deliv Rev 2003, 55:329-347 12 Qaddoumi MG, Ueda H, Yang J, Davda J, Labhasetwar V, Lee VH: The characteristics and mechanisms...
... values for the Gaussian and Poisson distribution fits are 0.154 and 0.027, respectively For (b), the p values for the Gaussian and Poisson distribution fits are 0.628 and 0.016, respectively For ... a carrier fordrugand gene delivery in various applications (Bowman and Leong, 2006) Chapter 22 Figure 2.5: Repeat units for chitin and chitosan Chitin consists of mainly n units and chitosan ... three and five days after commencement of treatment The groups include blank and free drug (FD) groups (blank, chi-p53 FD, Dox FD, and combined Dox and chi-p53 FD) as well as blank and drug- loaded...