... time -controlled and/ or target -controlled 22 INTRODUCTION delivery of drug In time -controlled delivery, the drug is released in a pre-determined rate while in target -controlled delivery, the drug is delivered ... least, the microspheres can be degraded under normal physiological conditions B Microspheres, microcapsules and microparticles Microspheres and microcapsules are collectively referred to as microparticles ... frequency of drug administration C1 Concepts of controlledreleaseControlleddrugdelivery is an attempt to control the drug availability at the target site This is achieved by time -controlled and/ or...
... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drugand anticancer drug in vitro We found that the drugrelease profiles of the encapsulated drugs, ... Conjugation of drug with ligand for vascular targeting 15 1.3.2 Vascular targeted nanoparticle drugdelivery 19 1.4 Conclusion 22 Chapter Targeted nanoparticulate drugdelivery ... Dots: Preparation and Two-Photon Fluorescence J Am Chem Soc 2009; 131(32), 1130011301 Wang Z., Chui WK., Ho PC Integrin targeted drugand gene delivery Expert opinion on drugdelivery 2010; 7(2),...
... investigated as controlleddrugdelivery matrices for both small molecule model drug of ibuprofen (IBU) and large protein drug of bovine serum albumin (BSA) In the preparation of controlleddrugdelivery ... a DrugDrug Drug- loaded biodegradable particles b DrugDrug Drug- loaded biodegradable particles Figure 2.5 The polymer degrades to releasedrug molecules in degradable devices abulk-eroding and ... variety of drugdeliverysystemsand their release mechanisms, including polymer, liposome, and activation -controlled devices are summarized Further emphasis has been placed upon synthesis and application...
... Side-effects of overdose in drugdelivery can be minimized by using the microneedle based microsystems due to their potential ability to release drugs in precise controlled dosage Microneedles may also ... of microsystem based on hollow microneedle array 11 Chapter Literature Review of Microfabricated Microneedles Chapter Review of Microfabricated Microneedles 2.1 Microneedles in Transdermal Drug ... of Microfabricated Microneedles of “coat and poke”, where the needles were first coated with drugand then inserted into the skin There are no drug reservoirs on the skin surface, and all drugs...
... for DrugDeliverySystemsDrugdeliverysystems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drugdelivery ... Frazier, and H Brem (2002) Local drugdelivery to the brain Adv Drug Deliv Rev., 54 (7), 987–1013 Anderson, J.M and Shive, M.S (1997) Biodegradation and biocompatibility of PLA and PLGA microspheres ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer DrugDeliverySystems Under Development 15.6.1 Polyketals Polyketal-based drugdeliverysystems are under development...
... to advanced drugdeliverysystems Chemical Aspects of DrugDeliverySystems Table Mechanisms and properties influencing drugrelease from particle carrier systems* MECHANISM OF DRUGRELEASE PROPERTIES ... demand fbrther research and New Materials andSystems for DrugDeliveryand Targeting Table Externally activated drugdeliverysystems EXTERNAL ACTIVATION FORMULATION SYSTEM MECHANISM FOR DRUGDELIVERY ... scientists working in drugdeliveryand targeting New Materials andSystems for DrugDeliveryand Targeting Table Microparticulate colloidal carrier systems* SYSTEM SIZE (nanometers) MICROCAPSULES 1000-100,000...
... Generalities of drugdelivery Liposomes as drugdeliverysystems Polymers and polymeric systems for drugdelivery Dendrimers for drugdelivery GENERALITIES OF DRUGDELIVERYDRUGDELIVERY SYSTEM ... Targeted drugdelivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled- releasedrugdelivery systems: preprogramed drugrelease By the route of delivery: ... Topical (local) drugdelivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation Systemic drugdelivery systems: drugs are delivered...
... Drug Metabolism: Chemical and Biochemical Aspects, Bernard Testa and Peter Jenner New Drugs: Discovery and Development, edited by Alan A Rubin Sustained andControlledReleaseDrugDelivery Systems, ... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic DrugDelivery Systems: Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... actives and their delivery to where they are needed An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed Recently, drug- delivery systems...
... effectiveness of drugdeliverysystems can be attributed to their small size, reduced drug toxicity, controlled time release of the drugand modification of drug pharmacokinetics and biological ... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, anddrug bioavailability A schematic comparison of untargeted and targeted drugdeliverysystems is shown in Figure ... the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drugdeliverySystems Nanoparticles can be used in targeted drugdelivery at the site of disease...
... Such nanocarrier-based drugdeliverysystems for doxorubicin could be more selective and effective than the free drugand have the promise to result in reduced toxicity and side effects in patients, ... the molecular transporter in drugdelivery Page 14 of 22 Drugdelivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drugdeliverysystems targeted to the lymphatic ... in anticancer drugdeliverysystems because there are many other anticancer drugdeliverysystems based on other nanomaterials, such as cationic polymers [98], fibrinogens [99], and PVP/PVAL nanoparticles...
... C James ControlledDrugDelivery Fundamentals and Applications, Second Edition, Revised and Expanded, edited by Joseph R Robinson and Vincent H Lee New Drug Approval Process Clinical and Regulatory ... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic DrugDeliverySystems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... DrugDeliverySystems Manufacturing and Production Technology, edited by Praveen Tyle Topical DrugDelivery Formulations, edited by David W Osborne and Anton H Amann Drug Stability Principles and...
... C G., Washington, N., Edman, P., and Camber, O (1987) Design and evaluation of controlledreleasesystems for the eye J Controlled Release, 6:367 20 Ahmed, I., and Patton, T F (1985) Importance ... (1990) Ocular drugdelivery Pharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics andDrugDelivery ... L., and Anderson, J A (1985) Review: Corneal penetration and ocular bioavailability of drugs J Ocular Pharmacol., 1:309 Lee, V H L., and Robinson, J R (1986) Review: Topical ocular drug delivery: ...
... interesting and important ocular region for exploration with research tools such as microdialysis More than 20 papers describing microdialysis approaches for assessment of ocular drugdeliveryand endogenous ... aphakic eye and a phakic eye is highly dependent on the injection location and the retinal permeability of the drug If the drug has a low retinal permeability, then the half-life of the drug in an ... area, thickness, concentration gradient, compartment volume, and ligand diffusion coefficient (43) Tissue and plasma proteins often bind drugs and other low molecular weight compounds Hypothesis regarding...
... for noncorneal delivery These include bioadhesive vehicles, microparticulates, andcontrolledrelease conjunctival inserts Suprachoroidal delivery of drugs via subconjunctival and sub-Tenon’s ... 128 Peyman, G A., and Ganiban, G J (1995) Deliverysystems for intraocular routes, Adv DrugDelivery Rev., 16:107–123 129 Geroski, D H., and Edelhauser, H F (2000) Review: Drugdelivery for posterior ... U., and Mondino, B J (1991) Device drugdelivery to the eye Collagen shields, iontophoresis, and pumps, Ophthalmology., 98:725–732 147 Hill, J M (1991) Symposium on drugdelivery V Ocular drug delivery; ...
... M., and Leesman, G D (1989) Absorption of difficult drug molecules: Carrier mediated transport of peptides and peptide analogues In: Novel DrugDeliveryand Therapeutic Application L F Presscot and ... hope that novel drugdeliverysystems will be developed to deliver potent polypeptide drugs through the ocular route REFERENCES Lee, V H L (1987) Ophthalmic delivery of peptides and proteins, Pharm ... from ophthalmic timolol and their prevention, J Ocul Pharmacol., 3:177 22 Robinson, J R (1989) Ocular drugdelivery Mechanism(s) of corneal drug transport and mucoadhesive systems, S.T.P Pharma.,...
... Coa, Y., and Suresh, M R (2000) Bispecific Mab aided liposomal drugdelivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted gene delivery ... nonpathogenic and cannot replicate; (d) immunogenicity, toxicity, and inflammation are minimized with their use; and (e) they can become completely synthetic While these are safe gene delivery systems, ... straightforward and relatively simple to perform and bypasses the need for complex viral or non viral deliverysystems Subretinal or intravitreal injections are common routes of delivery to the...
... clinical investigations and NDAs for marketing approval The terms drugand new drug are inclusive of the drug substance and the drug product It is important to understand that a new drug is not just ... interstate shipment of food and drugs was enacted in 1906 and was known as the Pure Food andDrug Act It prohibited the interstate shipment of adulterated or misbranded foods or drugs In 1912 it was ... NDA drugs approved since 1962 and thereby increase competition and lower drug prices An abbreviated NDA (ANDA) is required to be submitted for approval and must demonstrate that the generic drug...
... C James ControlledDrugDelivery Fundamentals and Applications, Second Edition, Revised and Expanded, edited by Joseph R Robinson and Vincent H Lee New Drug Approval Process Clinical and Regulatory ... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic DrugDeliverySystems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... DrugDeliverySystems Manufacturing and Production Technology, edited by Praveen Tyle Topical DrugDelivery Formulations, edited by David W Osborne and Anton H Amann Drug Stability Principles and...