micelles the multifunctional nanocarrier for colloidal drug delivery

... used as drug delivery carries for water-insoluble drugs The hydrophobic/ hydrophilic domains ratio in the copolymers ensures the formation of the micelles The hydrophobic segments of the copolymers ... exposed to the aqueous environment Another aspect of polymeric micelles design is the compartmentalization of drugs in the core of the micelles The hydrophobic environment in the core of the micelles ... attain a therapeutic effect In an extension of free drugs, drug delivery systems packaged these drugs in various forms, thus altering their properties when administered to the body As drug discovery...

Ngày tải lên: 30/09/2015, 06:07

... 3) where C2 is the protein in the bulk, C10 is the concentration inside the gel, S and V1 are, respectively, the surface and the volume of film, V2 is the volume of the bulk, h is the massive exchange ... Discussion In Fig 2, the scheme of the CNT array-based system for drug delivery proposed in this study is depicted The main structure is composed by the CNT array, embedded with the thin film of alginate ... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation,...

Ngày tải lên: 22/06/2014, 00:20

... expressed as the mean SI for quadruple wells The cut-off value for proliferation was set at SI (indicated by line) may affect the response of auto-aggressive T cells in vivo Optimizing the therapeutic ... http://arthritis-research.com/content/7/3/R604 target drugs directly to these T cells Thus, anti-CD134 liposomes represent an attractive method for the development of therapies aiming at the modulation of auto-aggressive T cells for intervention ... during culture for 48 hours However, when the cells were incubated for only 30 with free FUdR and then washed to remove extracellular FUdR, no significant R611 The modulation of the course of...

Ngày tải lên: 09/08/2014, 06:22

... interactions between the PC and the cargo The positively charged Arg and Lys moieties located at the N-terminal of the CP could have made the inner cavity of the PC attractive for the binding of negatively ... Most therapeutic drugs provide little, if any, targeting specificity Yet, for drugs with a narrow therapeutic window, such as the highly cytotoxic anticancer agents, targeted delivery has the ... encapsulated drug from hydrolysis and enzymatic degradation The hydrophilic palisade also enables the micelles to evade recognition by the reticuloendothelial system (RES), thereby prolonging their...

Ngày tải lên: 11/09/2015, 14:22

... anesthetics Inhaled anesthetics are used by many anesthesiologists for the maintenance of anesthesia while the intravenous anesthetics are used at the start of the surgical procedure as they ... compared to most other drugs used for the rapid intravenous induction of anesthesia This is one of the most important advantages of propofol compared to other intravenous anesthetic drugs Inhalation ... performance with the performance of other control structures The second objective of this study is to develop and evaluate the MPC control structure to find the best infusion rates of the anesthetic...

Ngày tải lên: 14/09/2015, 08:25

... topical drug delivery as this is the main focus of the present study I-B1 Advantages and limitations of topical drug delivery The principal advantage of topical drug delivery lies in targeting the drug ... Kydonieus, 1987) The plethora of work associated with formulation optimization for topical drug delivery over the past few decades underlines the essential role of the drug delivery vehicle The role ... minimize the effects of such physiological variability, the rate-limiting step for topical drug delivery should reside in the formulation instead of the biological barrier (Ranade et al., 2004) The drug...

Ngày tải lên: 15/09/2015, 17:10

... these models, the permeation profiles of the drug and the terpene enhancers can be evaluated, which will form the basis of the second part of the study The second part of the study ... evaluated These terpene enhancers would have to be incorporated with the drug and other excipients into dosage forms for application on the skin Their compatibilities with other excipients and the ... [139,140] The preparation of each of the formulae was done in the dark The first-order rate constant of drug degradation is 0.0248 day-1 at 110 C [140] Therefore approximately 0.0517% of the drug...

Ngày tải lên: 16/09/2015, 08:31

... xenograft models The mixed micelles formulation showed enhanced drug accumulation in drug resistant tumors Based on these results, the mixed micelles may be an appropriate formulation for drug resistant ... MDR The scope of this thesis include the fabrication of multifunctional polymeric micelles, the selectivity of the micelles between cancer cells and tumor cells, the P-gp inhibition of the micelles, ... chains The carrier could be either an inert or biodegradable polymer It forms the backbone of the system and protects the drug from fast elimination from the body The drug can be attached to the...

Ngày tải lên: 12/09/2015, 08:20

... This delivery system provided the first instance for nanocarriers to deliver drugs into neurons in the central nervous system, opening the door for the drug delivery system for the treatment of the ... prerequisites for them to be developed into practically usable drugs [46] For their drug carrier use, CNTs must be absorbed from the administration site into the body There are quite a few ways for the ... treatment for use as drug carriers (A) The schematic illustration of the structure formation of SWCNTs with the two ends closed (B) The schematic illustration of the strategy for the preparation of the...

Ngày tải lên: 20/06/2014, 22:20

... that the active substance is released from the microparticles and reaches the corticoid receptors and, on the other hand, the success of the injection method Furthermore, the difference between the ... decided to investigate the behaviour of these systems in the synovial cavity The experiment proved that the administration of the drug- containing magnetic microparticles or of the other products did ... of the animals days after the injection, validated the macroscopic observations as well as the results obtained for the uptake of 99mTc Discussion using a scale ranging from to sections for the...

Ngày tải lên: 09/08/2014, 14:20

... vectors, these two type antibiotics both have poor penetration rates through the BBB As the BBB represents an obstacle for the delivery of these antibiotics from the blood to the brain, therefore, these ... may change the therapeutic properties of the drug, resulting in the dysfunction of drug Therefore, a better drug delivery strategy is required to transport a drug with preservation of the functional ... physiological condition, the BBB provide stability and prevention for the CNS But under pathological condition, the BBB may block the drugs entering the brain and therefore void drug effects For example,...

Ngày tải lên: 11/09/2015, 09:10

... on the basis of two times the Area Under the Curve (AUC) levels An AUC level is the area under the curve of a plot of axis between Concentration of the drug vs the duration of exposure to the drug ... in the resection cavity, and the wound was closed by suturing On day 8, the animal was re-anesthetized, the wound reopened and the foam was placed on top of the tumor implant The wound was then ... ACKNOWLEDGEMENTS The author would like to thank his group members in the drug delivery lab in particularly, Ms Laiyeng Lee and Mr Jingwei Xie for providing the formulations and other technical...

Ngày tải lên: 05/10/2015, 21:33

... useful for drug delivery with the sizes up to 1000 nm (Shim and Turos, 2007) Therefore, they are continued to apply in drug delivery The final minicell preparation was suggested to demonstrate the ... checked for the packaging of drug paclitaxel and confirmation by packaging other drug as cephalosporin in the next sections of this study The Figure 4.4 illustrated the minicell formation at the ... therapy consisting of surgery, radiation therapy, chemotherapy, biological therapy and other methods (e.g., biological therapy, targeted therapy, or gene therapy for cancer (ACS, 2013) Chemotherapy...

Ngày tải lên: 23/10/2015, 15:38

... sequestering the drug inside the voids in the hydrogel matrix This limits the loading capacity of the gel, the applications of the gel, and also the ability to control the release profile At the heart ... hydrogel matrix This limits the loading capacity of the gel, the applications of the gel, and also the ability to control the release profile At the heart of the matter is the ability to use a functional ... specific drug such as protein PAE as the ionization stage has positive charges, and it can form the complexes with negatively charges on the drug/ protein by forming the ionic linkages As a result, the...

Ngày tải lên: 13/05/2016, 10:14

... although the binding data cannot unequivocally inform on the orientation of the sites, only their affinity for interaction with drugs The data presented here suggest that the ABCG2R482G isoform undergoes ... pumps is assumed to correspond to the outward-facing conformation The energy produced by the hydrolysis of ATP is harnessed for the resetting of the transporter to the initial high-affinity, inward-facing ... whether the binding of nucleotide to ABCG2R482G was the power stroke required to switch the configuration of the drug binding site(s) This hypothesis was examined using a direct measure of drug...

Ngày tải lên: 18/02/2014, 18:20

... Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug delivery system ... (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation  Systemic drug delivery systems: drugs are delivered to the whole ... a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug?  Prodrug is an inactive precursor of a drug  Prodrug reconversion occurs in the body inside...

Ngày tải lên: 18/04/2014, 15:37

... reaching their thinnest sizes, the capillaries start merging with each other to form the veins These veins then take the contents back to the heart for recirculation Hence, the supply chain in the ... delivery, Chapter for oral delivery, Chapter 10 for brain delivery, Chapter 11 for ocular delivery, and Chapter 12 for gene delivery Finally, the fourth section provides an overview of the clinical, ... nanoparticles in drug delivery Depending on the route and purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable delivery, ...

Ngày tải lên: 04/06/2014, 15:15

... KDa These results may be important for future drug delivery applications using nanoliposomes for the encapsulation and transport of this promising antitumoral compound Further developments of the ... supervised the organic synthesis and compound characterization and participated in the draft of the manuscript LAVS was responsible for the antitumoral evaluation of the compound EP supervised the studies ... [14] The in vitro effect on the growth of human tumor cell lines was evaluated according to the procedure adopted by the NCI in their “In vitro Anticancer Drug Discovery Screen,” using the protein-binding...

Ngày tải lên: 21/06/2014, 01:20

... targeted drug delivery, such as PLGA, chitosan, or dextran Thus, the metal/ligand chemistry is readily adaptable to, and independent from, the desired polymeric material used as the delivery vector The ... faintly blue even at the end of 48 h Particles were then collected from the dialysis tubing and analyzed further for Cu content by EDX Cu weight percents were 12.7, 3.3, and 0.7 for particles in ... XPS EDX was also performed on samples immediately before and after the addition of CuSO Before CuSO4 treatment, only peaks for C, O, and Na were observed; after treatment, the Na peak disappeared...

Ngày tải lên: 21/06/2014, 02:20