mechanistic predictions from the analysis of biomolecular networks

... rather on the regions initiating or impairing insertion of a segment in the membrane Therefore, in the case of M8 where the length of the M8 recombinant peptide is probably shorter than that of ... in the center of the b-strands forming the Rossman fold and leads to the membrane domain at the top of M4 and M5 (see Fig 4, cavities numbered 1–6) As could be expected from the high level of ... 5255 of internal cavities capable of containing water molecules in the homologous Rossman fold of the soluble members of the HAD superfamily (Fig 5) We used the high-resolution structures of the...

Ngày tải lên: 23/03/2014, 21:20

... to the logarithm of the number of target words it applies on The similarity of two target nouns is then computed as the sum of the feature weights they share For our analysis, we restrict the ... and the first 500 together make up 75% of the spectrum On the other hand, for the syntactic DSN, the first 10 eigenvalues cover 75% of the spectrum while the first 20 covers 80% In other words, the ... by the sum of the squares of all the eigenvalues - a quantity also known as the Frobenius norm of the matrix We observe that for the semantic DSN the first 10 eigenvalues cover only 40% of the...

Ngày tải lên: 17/03/2014, 02:20

... test of the efficacy of the revised cut points for passing a subtest was made through Differential Item Functioning analysis within the framework of the Rasch model [13] This analysis pooled the ... the data from the normal and patient groups where, in the latter case, the first level of education also included a number of illiterate patients The basis of the DIF approach lies in the item ... interpretation of DIF, as well as an ANOVA of the residuals Thus this DIF based ANOVA analysis is subtly different from the distributional analysis of the ANOVA approach which preceded it, as the latter...

Ngày tải lên: 20/06/2014, 15:20

... transferred into CIA mice to ameliorate the autoimmune process On the basis of the previous finding of a differential impact of Th1 and Th2 cells on the function of bone marrow-derived DCs (BMDCs), ... and the production of reactive oxygen species Professor Rikard Holmdahl (Lund University, Sweden) described the identification of the Ncf1 genetic polymorphism controlling arthritis severity The ... in the regulation of Th cell polarization and the shaping of the immune response Dr Harald Illges (Biotechnology Institute Thurgau, Switzerland) described studies on the K/BxN murine model of...

Ngày tải lên: 09/08/2014, 01:23

... on the other hand, is homozygous for the « high » allele (A All of the l ) l progeny from the standard cross have inherited the A allele from the father and are, therefore, heterozygous A The ... the gene pool Each isofemale line derived from this pool carries a sample of alleles, ranging from one extreme to the other (from p = 1.0 toq = 1.0) The relative frequency of each type of isofemale ... respect to the polygenic loci of interest, the genetic makeup of isofemale strains will differ as a function of the gene frequencies in the population and the probabilities of each type of mating...

Ngày tải lên: 09/08/2014, 22:22

... diagram of the domain structures of the orphan myosins from the Alveolata lineage Schematic diagram of the domain structures of the orphan myosins from the Alveolata lineage The sequence names of the ... diagram of the domain structures of the orphan myosins of the Fungi/Metazoa lineage Schematic diagram of the domain structures of the orphan myosins of the Fungi/Metazoa lineage The sequence names of ... Schematic diagram of the domain structures of the orphan myosins from Stramenopiles Schematic diagram of the domain structures of the orphan myosins from Stramenopiles The sequence names of the ophan...

Ngày tải lên: 14/08/2014, 08:20

... of slurry on site Samples of slurry retained at the manufacturer of the slurry Textile fibres from an airbag at the top of the silo Two safety valves from the top of the silo - Fig Top view of ... equivalent to the height of 4.7 rings of the silo, and would mean that the level of the slurry was approximately in the middle of the third ring (counted from the top) 3.4 Spurting distance From the visual ... Determination of$ lling level from records o the user f After the accident, the user of the silo supplied notes of deliveries, from which the theoretical filling level at the time of the accident could...

Ngày tải lên: 12/03/2015, 15:28

... Purpose of the analysis 24 2.6.2 Sample of the analysis 24 2.6.3 Elements of the analysis 26 2.6.4 Units of analysis 26 2.6.5 Instrument of the analysis ... chapter, the essential part of the thesis: findings analysis and discussion will be presented, namely, the results of the study, the researcher's analysis of the findings and her discussion on the ... criteria to fit into four domains of the analysis card were designed in the light of the criteria for analysis The criteria for analysis were made in the light of the discussion and arguments concerning...

Ngày tải lên: 28/03/2015, 09:22

... (gswap); the first number denotes the number of subnetworks in the numerator of the subnetwork-level agreement and the second number denotes the number of subnetworks in the denominator of the subnetwork-level ... over the sample sizes (N ); the first number denotes the number of subnetworks in the numerator of the subnetwork-level agreement and the second number denotes the number of subnetworks in the ... (2.14) The numerator of the eq.2.14 represents the number of ways of sampling k DEGs in the pathway from K observed DEGs in the microarray and the number of ways of sampling (n − k) non-DEGs in the...

Ngày tải lên: 09/09/2015, 10:15

... 从词重音及协同发音看重庆话两字组连读变调 An Analysis on the Disyllabic Tone Sandhi of Chongqing Dialect from the Perspectives of Word Stress and Tonal Coarticulation 卿 玮 QIN G WEI 新加坡国立大学中文系...

Ngày tải lên: 28/09/2015, 13:21

... action of CY in the stomach in this study was due to the activation of p53 and therefore leading to the suppression of the c-Myc/ODC pathway All these findings could explain the mechanism of CY ... drug administration This study was conducted with the consent of the Committee on the Use of Live Animals in Teaching and Research of the University of Hong Kong Male ICR mice (weighing 25–30 g) ... the blood supply and proliferating cell number in both the gastric and duodenal mucosae Subcutaneous administration of AP at the dose of mg/kg daily significantly promoted the recovery rate of...

Ngày tải lên: 02/11/2012, 10:19

... the sound of a strange, grating voice "Welcome to the Conquest! Before you lay the Valley of Mexico and the island/city of Tenochtitlan; the jewel of the New World!" Surprised by the voice, the ... continued their flight across the water The rhythms of drums, the blare of horns and conch shells, and the firing of musket and cannon intermingled to rake their senses But when they reached the city ... wind currents down the side of the mountain When they reached the valley floor and neared the shoreline of the lake, a giant clamor caught his attention The water surrounding the city was literally...

Ngày tải lên: 06/11/2012, 17:33

... Interpersonal Themes, on the other hand, reveal something of the attitude of the speaker or the writer And Textual Theme is the link between the clause contains that Theme and the rest of the discourse ... not all about Theme and Rheme, although "The Analysis of Theme and Rheme in "Little House on the Prairie" is shown as the theme of the study Method of the Study - A great number of documents and ... point of departure of the message In many cases (Unmarked), the Theme of a Declarative sentence will be the grammatical Subject, that of the Interrogatives is the Interrogative word and that of the...

Ngày tải lên: 22/12/2013, 12:59

... information about the toilet and about the human who took the photo of the toilet Having each of these fields remain separate from the others means the content can be sorted according to any of these fields; ... library of books you have read in your Drupal Web site, you may also want to list the books according to the name of the author, the year of the book’s publication, the date when you read the book, ... in the JavaScript chapters These code samples can also be downloaded from the book’s Web site From the Library of Athicom Parinayakosol This page intentionally left blank From the Library of...

Ngày tải lên: 24/12/2013, 09:17

... assessment of the trajectory of interconversion rates as a function of time of cold exposure, (b) comparison of the magnitudes of the various interconversion rates, and (c) lineup of the accessions ... representing the time period of photosynthetic activity until plants were harvested for analysis of metabolites (see below) The rate of net carbon uptake was integrated and divided by the time period of ... measure of how exposure to °C influenced the process of photosynthesis, gas exchange of plants was measured by infrared gas analysis Measurements were performed during the first h 508 of the light...

Ngày tải lên: 14/02/2014, 22:20

... composed of a hOrn and a haOrn moiety Furthermore, a long-range 1H–13C correlation was detected between the carbonyl carbon of the serine and the d-CH2 of the hOrn, which constitutes the DKP Therefore, ... related to natural product biosynthesis [30,31] The isolation of the corresponding products of these cryptic clusters is often challenging as a result of either a low rate of production or unknown conditions ... encoded in the etc gene cluster The N-terminal C-domain of the NRPS catalyzes the a-N-acetylation of haOrn1 in cis Cyclorelease of the assembled tetrapeptide mediated by the C-terminal C-domain of EtcD...

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 17/02/2014, 20:20

... issue from the 1960s to early 1970s in Japan On this basis, the committee on sick house syndrome (SHS) by the Ministry of Health, Labour, and Welfare of Japan announced the guideline value of formaldehyde ... habitation The cause of the disease onset relates to a house, symptoms occur within the house, symptoms are less serious or disappear when the patient is away from the house, and when the patient ... move against the war and restricted the global trade in oil export This is still known as the Arab oil embargo.8, 9) The idea of saving energy spread throughout in the world as a result of this incident...

Ngày tải lên: 17/02/2014, 22:20