mechanisms of uptake and biological functions

... UNIVERSITY OF AGRICULTURE AND FORESTRY DUONG THI THU HUYEN Topic title: THE UPTAKE MECHANISMS OF AG AND TIO2 NANOPARTICLES TO NERVOUS-SYSTEM CELLS BACHELOR THESIS Major: Environmental Science and Management ... disease, Alzheimer’s disease, and Huntington’s disease This report presents the uptake mechanisms of Silver nanoparticles with average diameters of 3-5 nm and 10-15 nm and Anatase TiO2 nanoparticles ... Alzheimer’s disease, and Huntington’s disease 1.2 Objectives of the research The specific objective of the project is to understand the processes of internalization of Ag and TiO2 nanoparticles...

Ngày tải lên: 28/04/2016, 13:47

... tens of thousands of individual primary scientific papers and reviews describing the isolation, structural characterization, pharmacological effects and biochemical targets of thousands of plant-derived ... chemistry of living things) This biochemical review provides a detailed background for understanding the nature and function of the targets of plant defensive metabolites and proteins The remainder of ... K+-ATPase and Naf, K f -ATPase H Voltage-gated Na+ channel Ligand- and voltage-gated K+ channels + Voltage- and ligand-gated Ca2+channels and ~ a /Ca2+ antiporter CFTR, voltage-gated C channels and...

Ngày tải lên: 17/02/2014, 05:20

... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... endothelium dysfunction and ED [130,131], the concept of androgen deficiency reinforces the important role of androgens in vascular health and erectile function Summary and conclusions Visceral ... visceral and peripheral fat further diminishes the levels of testosterone and increases the levels of estradiol (E2), which further contributes to preferential deposition of more visceral fat and...

Ngày tải lên: 18/02/2014, 06:20

... Bureau of Justice Assistance, the Bureau of Justice Statistics, the Office of Juvenile Justice and Delinquency Prevention, and the Office for Victims of Crime U.S Department of Justice Office of ... LAW ENFORCEMENT AND CORRECTIONS STANDARDS AND TESTING PROGRAM The Law Enforcement and Corrections Standards and Testing Program is sponsored by the Office of Science and Technology of the National ... Coordination by: Office of Law Enforcement Standards National Institute of Standards and Technology Gaithersburg, MD 20899–8102 Prepared for: National Institute of Justice Office of Science and Technology...

Ngày tải lên: 23/03/2014, 23:20

... Bureau of Justice Assistance, the Bureau of Justice Statistics, the Office of Juvenile Justice and Delinquency Prevention, and the Office for Victims of Crime U.S Department of Justice Office of ... LAW ENFORCEMENT AND CORRECTIONS STANDARDS AND TESTING PROGRAM The Law Enforcement and Corrections Standards and Testing Program is sponsored by the Office of Science and Technology of the National ... Coordination by: Office of Law Enforcement Standards National Institute of Standards and Technology Gaithersburg, MD 20899 Prepared for: National Institute of Justice Office of Science and Technology...

Ngày tải lên: 23/03/2014, 23:20

... intake and energy expenditure, and the subsequent deposition of excess fatty acids into fat cells in the form of triglycerides, leads to the development of obesity [21] A lipid-rich diet and sedentary ... promotes the delivery of dietary lipids to adipose tissue and leads to diet-induced obesity and related metabolic dysfunctions (step 4) In the absence of the expression of ApoE or ApoE-recognizing ... the expression of ApoE in the fed state Certainly, additional studies are required to determine the role of adipocyte-synthesized ApoE, and to distinguish between the functions of peripherally...

Ngày tải lên: 29/03/2014, 22:21

... contain smaller lipid droplets and more mitochondria, and express higher levels of UCP-1 and PGC-1a and lower levels of Rb The role of these various transcription factors and nuclear factors is highlighted ... for our understanding of what controls the expansion of fat mass in different individuals Moreover, it is also important to understand the origins of each of the different white and brown depots ... adipocyte number) and hypertrophy (i.e an expansion of adipocyte volume as a result of the accumulation of lipids) Consequently, knowledge of the origin and molecular control of adipocyte progenitor...

Ngày tải lên: 29/03/2014, 22:21

... Peripheral lymphatic management, uptake and transport of adipocyte secretions and reverse transport of lipids and lipophyllic molecules from the interstitium is therefore of great importance not only ... adipocytes and the adipose microvascualture, and the marked similarities in tumor growth and hypoxia compared with those of adipose tissue expansion remain of great interest Adipose tissue and lymphatic ... and leptin, the inflammatory chemokines tumor necrosis factor-a (TNFa) and an array of interleukins, and angiogenic and vasoactive molecules such as vascular endothelial growth factor (VEGF) and...

Ngày tải lên: 29/03/2014, 22:21

... units of A will be those of k and 18 Reaction Mechanisms of Inorganic and Organometallic Systems £a will have the energy units of R The k is determined by experiments at several temperatures, and ... units of k depend on the rate law and must give the right-hand side of Eq (1.3) the same units as the left-hand side A simple example of the need to define the rate in order to give the meaning of ... [A] = [A]0 to [A] and t = to /, gives and predicts that a plot of In [A] versus t should be linear with a slope of -k\ The linearity of such plots often is taken as evidence of a first-order rate...

Ngày tải lên: 01/04/2014, 10:37

... Chemical and Biological Defense Command Historical Research and Response Team, Aberdeen Proving Ground, Md 25 Medical Aspects of Chemical and Biological Warfare He also stressed that both offensive and ... rumors and reports of incidents of chemical and biological warfare attracted the attention of intelligence officers Although much of Germany’s and Japan’s chemical and biological weapons programs ... Hundreds of thousands of troops were supplied with chemical pretreatment and therapeutic agents and thousands were immunized against anthrax and the botulinum toxins, the two most likely biological...

Ngày tải lên: 11/04/2014, 09:50

... and experimental evidence regarding the role of Type D personality in potential mechanisms of disease as well as work-related Type D personality and mechanisms of disease Type D personality and ... explored the behavioral and biological mechanisms of disease as a Mols and Denollet Health and Quality of Life Outcomes 2010, 8:9 http://www.hqlo.com/content/8/1/9 Table 3: Outcomes of studies: Health ... support, and they were Mols and Denollet Health and Quality of Life Outcomes 2010, 8:9 http://www.hqlo.com/content/8/1/9 Page of 10 Table List of criteria for assessing the methodological quality of...

Ngày tải lên: 18/06/2014, 19:20

... the proof for part a of Theorem 1.2 by showing the following lemma 8 Journal of Inequalities and Applications Lemma 1.3 For any integer n ≥ 1, and for all x1 , , xn with each xk ∈ a, b and all ... minimum of h p in S subject to the constraint p1 · · · pn occurs on the boundary of S, where some of the pk must be zero At the minimum, say po , we are back to the case of n − or less, and by ... admissible q, t, and x1 1.30 Journal of Inequalities and Applications For any fixed q, t, and x1 , suppose we obtain θ2 q, t, x1 2f x − θσ − qtx1 −f x − θσ θ∈ 0,1/ 1−q tx1 −1 1.31 and suppose

Ngày tải lên: 22/06/2014, 03:20

...  limited  toxicological   relevance and  use  for  risk  assessment of  environmental  matrices   Aspects  reduced  bioavailability,  environmental  fate and  transport  not  in   present  REP/TEF ...  not  in   present  REP/TEF  studies  evaluated   Mixtures of  PCDDs,  PCDFs and  DL-­‐PCBs    s*ll  a  health  risk?   One  order of  magnitude  decline  in  background  human   exposure  since ...  Berg  &  R  F  Canton  (2010)    A  Global  Foodborne  Burden of  Disease?  WHO-­‐FERG  In  prep   Es*ma*on of  number of  W-­‐Europe  children  exceeding   the  TDI  significantly  (

Ngày tải lên: 16/04/2015, 08:52

... 4.3.1 Bcl-2 and Bax.…………………………………………………………… 19 4.3.1.1 Discovery of Bcl-2 and Bax 19 4.3.1.2 Functions of Bcl-2 and Bax in apoptosis.…………………………20 4.3.1.3 Bcl-2 and Bax in the model of axotomy.………………………….21 ... complex of two subunits designated type I (RI) and type II (RII) It has been proposed that binding of TGF-β to RII induces assembly of RII-RI heterodimer and transphorylation of RI by RII and this ... the survival of axotomized dorsal root ganglia (Keilhoff et al., 2002) 4.3 Involvement of apoptosis associated molecules 4.3.1 Bcl-2 and Bax 4.3.1.1 Discovery of Bcl-2 and Bax Most of the currently...

Ngày tải lên: 16/09/2015, 17:12

... the upregulation of GnT-III In fact, the results of several studies suggest that E-cadherin can induce ligand-independent activation of EGFR and subsequent activation of Rac1 and MAP kinase, which ... glycomics and evidence for gain- and lossof -functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis: their pivotal roles in growth and development, cancer metastasis and ... membrane and mediate interactions with the cytoskeleton and with signaling molecules On the basis of extensive searches of the human and mouse genomic sequences, it is now known that 18 a-subunits and...

Ngày tải lên: 18/02/2014, 17:20

... characterization of Ngb and Mb at neutral and acidic pH (A) Far-UV CD spectra of human holoNgb and apoNgb dissolved in 20 mM Tris ⁄ HCl and 0.15 M NaCl (pH 7.0) (B) Far-UV CD spectra of human apoNgb and horse ... acid denaturation of Mb, Ngb and H64Q mutant of Ngb was followed by measuring the decrease in intensity of the Soret band (Ngb, kmax of 412 nm; H64Q, kmax of 406 nm; Mb, kmax of 409 nm) in the ... concentrations of urea The urea denaturation of the holo forms of Ngb (open circles) and Mb (open triangles) was performed in 20 mM Tris ⁄ HCl and 0.15 M NaCl (pH 7.0), and that of apoNgb (filled...

Ngày tải lên: 07/03/2014, 02:20

... properties of QDs, for in vitro biomolecular profiling of cancer biomarkers, in vivo tumor imaging, and dual-functionality tumor-targeted imaging and drug delivery [7] Early detection of cancer and ... the mechanism of QD cellular uptake and factors affecting the process is essential to minimize unwanted non-specific cellular uptake of QDs Unfortunately, the endocytic mechanism of non-targeting ... cytometry (LSC), live cell flu- Page of orescent imaging and transmission electron microscopy (TEM) to explore the kinetics and mechanism of cellular uptake of QDs with different surface coatings...

Ngày tải lên: 11/08/2014, 00:22

... 0.0001 and experimental evidence suggests that only the monomeric form of Tat is biologically active [31] In view of the importance of storage and handling of Tat for preserving its biological functions, ... macrophages and cells of other lineages and cause cell maturation, upregulation of costimulatory molecules, and release of several potent cytokines, prostaglandins, interleukins and platelet ... mainly because of the intrinsic properties of this viral protein Tat contains several functional domains each regulating multiple and often overlapping and complementary biological functions [30]...

Ngày tải lên: 13/08/2014, 09:20

... all pairs of amino acids The two most used and popular matrices are the Block Substitution Matrix (BLOSUM) [Henikoff and Henikoff, 1992] [31] and Point Accepted Mutation (PAM) [Dayhoff and Schwartz, ... of the A and B having similar functions after it is known that both A and B have similar sequences CHAPTER II MATERIALS AND METHODS This chapter addresses the strategies and operations used and ... studied and with the help of statistical concepts and inferences can be drawn 1.2 Gene Ontology The genetic information of a cell is carried by Deoxyribonucleic Acid (DNA) and it consists of thousands...

Ngày tải lên: 30/10/2014, 20:13

... of Nogo-B and Systematic Dissection of the Am-Nogo-A 92 3.3.1 Bioinformatics analysis 93 3.3.2 CD and NMR characterization of N- and C-termini of Nogo-B 97 3.3.3 CD and NMR characterization of ... and mediates chemotaxis and 3D tube formation of endothelial cells in vitro The identification of NgBR facilitate 20 understanding the function of NogoB as a regulator of vascular remolding and ... 3.3.4 CD and NMR characterization of the Nogo-B N-terminus 99 Figure 3.3.5 CD and NMR characterization of the Nogo-33 101 Figure 3.3.6 CD and NMR characterization of the first group of the dissected...

Ngày tải lên: 14/09/2015, 12:53