mechanisms of resistance and clinical implications

... review of the manuscript, YW, XL and HL took part in the collection of cases and review of the manuscript, ZQ was in charge of design and coordination of the program, review and correction of the ... charge of collection of cases and writing the manuscript, LY was in charge of collection, process, and Page of (page number not for citation purposes) Cough 2009, 5:7 statistical analysis of data and ... spite of causes of chronic cough, which confirmed the findings of French and Canonica who had observed that HRQOL in the chronic coughers was unrelated to the causes of cough [8,20] The impact of...

Ngày tải lên: 13/08/2014, 08:20

... adjuvant [93] (Fig 1) The incidence of arthritis upon immunization is in excess of 90%, and the time course is uniform and highly predictable Clinical signs of arthritis are first visible days ... Thus, unlike the CIA and K/B×N models, both CD4+ T cells and antibodies are necessary for the development of G6PI-induced arthritis, and neither transfer of T cells nor transfer of antibodies alone ... the TCR transgenic K/B×N model and the situation in patients Some of the major clinical and immunological similarities and differences between CIA, the K/B×N model and G6PI-induced arthritis are...

Ngày tải lên: 09/08/2014, 06:22

... volumes, and the forces generated by repeated opening and collapse lead to upregulation of an inflammatory response, with release of cytokines and chemokines and activation of neutrophils and macrophages ... der Kloot and colleagues [17] studied the effects of RMs on gas exchange and lung volumes in three experimental models of ALI: saline lavage, oleic acid, and pneumonia After application of RMs, ... suggest that RMs have different effects depending on the type of lung insult and on the use of various combinations of tidal volume and PEEP Whether RMs are necessary to prevent alveolar collapse...

Ngày tải lên: 12/08/2014, 19:22

... mutants, (iii) what are the clinical implications of K65R mutants, and (iv) what is the role of CD8+ cells and continued tenofovir treatment in controlling viremia of K65R RT-SHIV? The current ... http://www.retrovirology.com/content/4/1/25 Figure Segregation of K65R and K70E mutations, and linkage of codon 68 mutations with K65R Segregation of K65R and K70E mutations, and linkage of codon 68 mutations with K65R Plasma ... effect of the presence of either one of these alleles and viremia during the first 20 weeks of infection (prior to tenofovir therapy), MamuA*01-positive animals responded initially to tenofovir...

Ngày tải lên: 13/08/2014, 09:21

... aims: a) Describe the landscape and clinical relevance of genomic complexity using aCGH Rationale and Hypothesis Current understanding of MM genetics is hampered by inadequacies of techniques formerly ... 2003c) found N-RAS and K-RAS mutations, respectively, in 17% and 6% of tumors, whereas Kuehl and Shaughnessy found N-RAS and K-RAS mutations, respectively, in 14% and 17% of tumors (personal ... these, trisomy 9, 15 and 19 were the most common In addition, gain of 6p was also significantly more common in HRD MM On the other hand, gain of chromosome 4, loss of 6q and loss of chromosome 13...

Ngày tải lên: 11/09/2015, 09:58

... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... endothelium dysfunction and ED [130,131], the concept of androgen deficiency reinforces the important role of androgens in vascular health and erectile function Summary and conclusions Visceral ... contributing to the onset of hypertension, dyslipidemia, diabetes, thrombosis and atherosclerosis In addition, increased conversion of cortisone to cortisol and increased aromatization of androgens to estrogens...

Ngày tải lên: 18/02/2014, 06:20

... Phase of atrial systole Pн – Pк; Phase of closing of atrioventricular valve Pк – Q; Phase of contraction of septum Q – R; Phase of contraction of ventricle walls R – S; Phase of tension of myocardium ... pathophysiology, clinical presentation and implications of cardiovascular diseases The first chapter of this section explores the relationship of cardiovascular health and exercise from both the European and ... Phase of closing of atrioventricular valve Pк – Q; Phase of contraction of septum Q – R; Phase of contraction of ventricle walls R – S; Phase of tension of myocardium S – L; Phase of rapid ejection...

Ngày tải lên: 28/03/2014, 09:20

... Kay and Toshi, my teachers, and my husband, Rusty And to Mr William T Comfort, Jr., and the John A Hartford Foundation, whose kindness and interest in this project were a constant source of inspiration ... to ignore it Of course, there are the hallmarks of aging that we know so well: graying and loss of hair, wrinkling skin, stiff and painful joints, loss of short-term memory (but often an amazing ... estimates of only around 25% (11); this is a reflection of the importance of both environmental and stochastic elements in determining the variance of that phenotype and, by inference, in the rates of...

Ngày tải lên: 29/03/2014, 08:20

... intake and energy expenditure, and the subsequent deposition of excess fatty acids into fat cells in the form of triglycerides, leads to the development of obesity [21] A lipid-rich diet and sedentary ... Epidemiological and population studies have established a direct correlation between obesity and the development of cardiovascular disease [36,37] Despite the pivotal role of obesity and dyslipidemia ... condition, and an increased propensity to develop a variety of spontaneous and induced tumors [44] The Ay mutation is the result of a 170 bp deletion that removes all but the promoter and noncoding...

Ngày tải lên: 29/03/2014, 22:21

... contain smaller lipid droplets and more mitochondria, and express higher levels of UCP-1 and PGC-1a and lower levels of Rb The role of these various transcription factors and nuclear factors is highlighted ... for our understanding of what controls the expansion of fat mass in different individuals Moreover, it is also important to understand the origins of each of the different white and brown depots ... adipocyte number) and hypertrophy (i.e an expansion of adipocyte volume as a result of the accumulation of lipids) Consequently, knowledge of the origin and molecular control of adipocyte progenitor...

Ngày tải lên: 29/03/2014, 22:21

... and leptin, the inflammatory chemokines tumor necrosis factor-a (TNFa) and an array of interleukins, and angiogenic and vasoactive molecules such as vascular endothelial growth factor (VEGF) and ... and the differential expansion of these depots is of great importance Expansion of visceral or abdominal white adipose tissue (WAT) has been most strongly correlated with insulin resistance and ... end of the spectrum is the condition of lipodystrophy, wherein the dramatic loss of adipose tissue triggers a high degree of insulin resistance and signs of other metabolic dysregulation similar...

Ngày tải lên: 29/03/2014, 22:21

... units of A will be those of k and 18 Reaction Mechanisms of Inorganic and Organometallic Systems £a will have the energy units of R The k is determined by experiments at several temperatures, and ... units of k depend on the rate law and must give the right-hand side of Eq (1.3) the same units as the left-hand side A simple example of the need to define the rate in order to give the meaning of ... [A] = [A]0 to [A] and t = to /, gives and predicts that a plot of In [A] versus t should be linear with a slope of -k\ The linearity of such plots often is taken as evidence of a first-order rate...

Ngày tải lên: 01/04/2014, 10:37

... and experimental evidence regarding the role of Type D personality in potential mechanisms of disease as well as work-related Type D personality and mechanisms of disease Type D personality and ... support, and they were Mols and Denollet Health and Quality of Life Outcomes 2010, 8:9 http://www.hqlo.com/content/8/1/9 Page of 10 Table List of criteria for assessing the methodological quality of ... explored the behavioral and biological mechanisms of disease as a Mols and Denollet Health and Quality of Life Outcomes 2010, 8:9 http://www.hqlo.com/content/8/1/9 Table 3: Outcomes of studies: Health...

Ngày tải lên: 18/06/2014, 19:20

... determination of extravascular lung water content (Qwl/BW) and permeability alterations by the determination of bloodless dry-lung weight (DLW/BW) and of the distribution space in the lungs of 125I-labeled ... the combination of both injuries did so and was thus more deleterious than either one alone These observations were later confirmed and expanded The effects of different degrees of lung distention ... strategy (i.e., tidal volume of mL/kg and PEEP of 15 cm H2O determined from analysis of the PV curve) exhibited lower bronchoalveolar lavage fluid and plasma concentrations of inflammatory mediators...

Ngày tải lên: 21/06/2014, 01:20

... Phase of atrial systole Pн – Pк; Phase of closing of atrioventricular valve Pк – Q; Phase of contraction of septum Q – R; Phase of contraction of ventricle walls R – S; Phase of tension of myocardium ... Phase of closing of atrioventricular valve Pк – Q; Phase of contraction of septum Q – R; Phase of contraction of ventricle walls R – S; Phase of tension of myocardium S – L; Phase of rapid ejection ... Phase of slow ejection j - Tн ; Phase of buildup of maximum systolic pressure in aorta Tн - Tк,; Phase of closing of aortic valve Tк - Uн; Phase of premature diastole of ventricles Uн - Pн Group of...

Ngày tải lên: 27/06/2014, 09:20

... Clin Immunol 1994;93:811–2 73 A position paper of the Thoracic Society of Australia and New Zealand and the Australasian Society of Clinical Immunology and Allergy Specific allergen immunotherapy ... and Allergy, Royal College of Physicians and Surgeons of Canada, Specialty Training Committee in Clinical Immunology and Allergy Recommendations on Immunotherapy References Canadian Society of ... cat-allergic asthma SIT with dog dander may be less effective than SIT with cat dander because of significant variations between different breeds of dogs and because of the choice of allergens included in...

Ngày tải lên: 08/08/2014, 21:20

... in-hospital and home use of expensive and potentially toxic treatments, track outcomes (both beneficial and adverse), and develop and meet Standards of Care for HAE Bowen Allergy, Asthma & Clinical ... contribution to teaching in the field of Allergy and Clinical Immunology and was well respected as a physician, teacher and colleague The 2010 Canadian Society of Allergy and Clinical Immunology Dr David ... function and repeat C4 and C1-INH protein levels Confirm C4, C1-INH normal during attack Family history of angioedema No family history of angioedema HAEC1INHType I Measure C1q and consider age of...

Ngày tải lên: 08/08/2014, 21:20

... contributions JA and MM: idea and concept LA and LIR: design and development of study LIR: statistical analysis LA: writing of manuscript and study coordinator RMM and JA: final revision of manuscript ... the degree of target coverage and target dose distribution, comformality, normal tissue avoidance, and amount of irradiated body volume in IMRT, c3DCRT, and f3DCRT Target Coverage and Dose Distribution ... planning results in a trade-off between the coverage of the target, avoidance of adjacent healthy structures, and the inhomogeneity of the dose within the target The consequences of non-uniform dose...

Ngày tải lên: 09/08/2014, 08:22

... adhere to a set of dietary principles: low intake of saturated fats, trans fats, and cholesterol; reduced consumption of simple sugars; and increased intake of fruits, vegetables, and whole grains ... subunit of PI-3 kinase to IRS-1, and the subsequent activation of Akt [13] Leptin produced by adipose tissue may contribute to insulin resistance through phosphorylation of serine residues of IRS-1 ... Table Clinical significance In view of the controversy about the clinical criteria and the lack of a unifying pathophysiologic process, the clinical significance of MetS has not been universally...

Ngày tải lên: 09/08/2014, 10:23

... indication of neuromuscular weakness The mean of three recordings was used, and results were expressed as the Page of 17 (page number not for citation purposes) percentage of normal values from age- and ... patterns of wakefulness, NREM and with REMs, and REM sleep without atonia are characteristic of status dissociaticus [31,48] Status dissociaticus represents a significant breakdown in the clinical and ... practicality and a compromise between frequency and accuracy will be necessary No – extensive observation required of eyelid positioning, respiration, and eye and body motility and responses...

Ngày tải lên: 13/08/2014, 08:20