mechanisms of cardiac contraction and relaxation
Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx
Ngày tải lên :
31/03/2014, 07:20
... 2003 Fig Placement of BH4 in the catalytic site of PAH and TH Distance-energy diagrams obtained after docking BH4 into the active sites of PAH (A) and TH (B) Total energies of candidate positions ... oxidation of the catalytic iron provoked by the Ó FEBS 2003 Modeled ligand–protein complexes of PAH and TH (Eur J Biochem 270) 1073 Fig Hydroxylation of tyrosine and a possible sequence of events ... structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2thienyl)-L-alanine, and its implications for the mechanism of catalysis and...
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Báo cáo khoa học: "Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography" docx
Ngày tải lên :
07/08/2014, 20:23
... end-systolic and end-diastolic phase images were displayed (Figs and 2), and EDV, ESV, EF, SV, CO, and myocardial mass were calculated automatically (Tables and 2) The EDV and ESV were 48.80 ± 23.30 ml and ... in the capability of both technologies for the visualization of the coronary lumen and the detec- tion of coronary artery stenosis The sensitivity of MDCT for the detection of significant stenosis ... diagnosis and prognosis The indices of a healthy heart are verified through assessment of ejection fraction (EF), end systolic volume (ESV), end diastolic volume (EDV), cardiac output (CO), and coronary...
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Báo cáo khoa học: "Continuously assessed right ventricular end-diastolic volume as a marker of cardiac preload and fluid responsiveness in mechanically ventilated cardiac surgical patients" pdf
Ngày tải lên :
12/08/2014, 22:21
... repeating on–off CCO input signal and is generated by accumulating the temperature change for each on and each off segment of the input signal (Fig 1) Calculation of RVEF is based on estimation of the ... internal jugular vein and connected to a Vigilance Monitor system (Edwards Lifesciences) for continuous assessment of CO (CCO), CEDV and of RVEF, and for determination of CO using the intermittent ... suggesting that a volumetric assessment of cardiac preload may provide a more useful evaluation of ventricular filling than that offered by the assessment of cardiac filling pressures A previous...
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Báo cáo y học: "Comparison of cardiac, hepatic, and renal effects of arginine vasopressin and noradrenaline during porcine fecal peritonitis: a randomized controlled trial" potx
Ngày tải lên :
13/08/2014, 18:22
... heart rate and cardiac output without affecting myocardial relaxation, and significantly decreased troponin I blood levels; increased the rate of direct, aerobic glucose oxidation, and reduced ... collection RG, BH, and MG were responsible for the data analysis AS and PM provided the histomorphology and immunohistochemistry findings and the analysis of these data JV and UW were responsible ... to 0.72) μg/kg/min) Tables and and Figures and summarize the data on systemic hemodynamics and left heart function (Table 1), as well as O2 exchange, acid-base status, and metabolism (Table 2)...
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Báo cáo sinh học: "Comparing the retention mechanisms of tandem duplicates and retrogenes in human and mouse genomes" pdf
Ngày tải lên :
14/08/2014, 13:21
... with tandem duplicates Finally, we preserved 410 and 680 pairs resulting from We identified 1,210 tandem duplicates and 410 retrogenes in the human genome, and 1,802 tandem duplicates and 680 ... retention of both types of duplicates Discussion Dosage effect is more prevalent in tandem duplicates Of the two key dimensions to determine the retention mechanisms, we have found that the extent of ... V, Zhang L: A roadmap of tandemly arrayed genes in the genomes of human, mouse, and rat Mol Biol Evol 2006, 23:2134-2141 15 Pan D, Zhang L: Quantifying the major mechanisms of recent gene duplications...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
Ngày tải lên :
05/09/2013, 09:08
... composition of 2H and 18O The compositions of the isotopes 2H (D) and 18O were analyzed to obtain δD (‰) and δ18O (‰), respectively, which are defined as the relative deviation of the parts per thousand ... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the ... the discharge of new water and the migration of hazardous elements, which has not been sufficiently analyzed or reported previously As a result of the calculation, and by setting C1 and C2 as mentioned...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
Ngày tải lên :
18/02/2014, 06:20
... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... endothelium dysfunction and ED [130,131], the concept of androgen deficiency reinforces the important role of androgens in vascular health and erectile function Summary and conclusions Visceral ... visceral and peripheral fat further diminishes the levels of testosterone and increases the levels of estradiol (E2), which further contributes to preferential deposition of more visceral fat and...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
Ngày tải lên :
19/02/2014, 16:20
... lifetimes of carbon-centred radicals derived from a diverse set of substrates are on the order of about 10)10 s [98] Moreover, the randomness of the apparent intramolecular KIEs for unrearranged and ... result in a drastic diminution of polymerization products derived from aniline and some of its p- and N-substituted congeners, while formation of p-hydroxylated and dealkylated metabolites was ... discounted in view of the high selectivity of DNA strand breakage [239] Also, density functional theory (DFT) calculations of the electronic structure of an optimized geometric model of activated BLM...
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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot
Ngày tải lên :
08/03/2014, 08:20
... species composition of PtdIns Fatty acid composition of phospholipids from tissues of yellowtail and rat Brain, heart, liver, spleen, kidney and ovary of yellowtails were isolated, and total lipids ... Protein kinase C activity in the spleen of trout (Salmo gairdneri) and the rectal gland of dogfish (Scyliorhinus canicula), and the effects of phosphatidylserine and diacylglycerol containing (n-3) ... phosphatidylserine (PtdSer), PtdIns and sphingomyelin The fatty acid compositions of PtdCho, PtdEtn, PtdSer and PtdIns of brain, heart, spleen, kidney and ovary of yellowtail were investigated (Tables...
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Báo cáo khoa học: Modeling hydration mechanisms of enzymes in nonpolar and polar organic solvents potx
Ngày tải lên :
16/03/2014, 10:20
... precise picture of water at the surface of the protein, we looked at the number of water molecules within a specific layer of 0.25 nm from the surface of the protein (Fig 3), and the ratio of Fig Average ... 2431 ˆ N M Micaelo and C M Soares Modeling hydration mechanisms of enzymes of time Final parameters and standard errors are shown in supplementary Table S2 The residence times of the water molecules ... pressure of FEBS Journal 274 (2007) 2424–2436 ª 2007 The Authors Journal compilation ª 2007 FEBS 2433 ˆ N M Micaelo and C M Soares Modeling hydration mechanisms of enzymes atm and relaxation times of...
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Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool pptx
Ngày tải lên :
23/03/2014, 11:20
... century because of a gradual increase in life expectancy The genuine understanding of the mechanisms leading to the formation of amyloid fibrils and its inhibition is therefore of high clinical ... presence of aromatic residues in specific structural contexts can accelerate this process by several orders of magnitude Therefore, from the practical point of view, understanding of the mechanism of ... one of the key parameters for predicting the rate of the fibrillization process [36] Molecular dynamics simulations of the stability of preformed amyloid fibrils clearly demonstrated the role of...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
Ngày tải lên :
24/03/2014, 03:21
... described below, investigation of the relationship between the 3D structures and thermodynamic properties accompanying protein denaturation of HT c-552 and PA c-551 (wild-types and mutants) has revealed ... that some of them are the residues responsible for stability, and in fact Ala7, Met13, and Tyr43 in HT c-552 have been shown, by mutagenesis and 3D structure analyses, to be determinants of the ... quintuple mutant, and the corresponding ones of the wild-type PA c-551 and HT c-552 are colored purple, green, and red, respectively (A) The region around A7/M13 in HT c-552 and the corresponding...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
Ngày tải lên :
29/03/2014, 08:20
... of autophagy, such as induction of LC3 and conversion of LC3-I to LC3-II [48,49,118], induction of beclin [48], induction of BNIP-3 [66] and activation of G-interacting protein (GAIP) by phosphorylation ... 2009 FEBS S Cagnol and J.-C Chambard ERK and cell death establishment of senescence induced by a constitutively active form of Ras or MEK [121] process is often prevented by use of MEK inhibitors ... by inducible activation of Raf1:ER, it correlates with inhibition of AKT and dephosphorylation of Mdm2, which lead to p53 accumulation and growth arrest [97] In the case of human BJ foreskin primary...
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx
Ngày tải lên :
29/03/2014, 22:21
... intake and energy expenditure, and the subsequent deposition of excess fatty acids into fat cells in the form of triglycerides, leads to the development of obesity [21] A lipid-rich diet and sedentary ... Epidemiological and population studies have established a direct correlation between obesity and the development of cardiovascular disease [36,37] Despite the pivotal role of obesity and dyslipidemia ... condition, and an increased propensity to develop a variety of spontaneous and induced tumors [44] The Ay mutation is the result of a 170 bp deletion that removes all but the promoter and noncoding...
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development pdf
Ngày tải lên :
29/03/2014, 22:21
... contain smaller lipid droplets and more mitochondria, and express higher levels of UCP-1 and PGC-1a and lower levels of Rb The role of these various transcription factors and nuclear factors is highlighted ... for our understanding of what controls the expansion of fat mass in different individuals Moreover, it is also important to understand the origins of each of the different white and brown depots ... adipocyte number) and hypertrophy (i.e an expansion of adipocyte volume as a result of the accumulation of lipids) Consequently, knowledge of the origin and molecular control of adipocyte progenitor...
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue pdf
Ngày tải lên :
29/03/2014, 22:21
... and leptin, the inflammatory chemokines tumor necrosis factor-a (TNFa) and an array of interleukins, and angiogenic and vasoactive molecules such as vascular endothelial growth factor (VEGF) and ... adipocytes and the adipose microvascualture, and the marked similarities in tumor growth and hypoxia compared with those of adipose tissue expansion remain of great interest Adipose tissue and lymphatic ... Peripheral lymphatic management, uptake and transport of adipocyte secretions and reverse transport of lipids and lipophyllic molecules from the interstitium is therefore of great importance not only to...
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Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps docx
Ngày tải lên :
29/03/2014, 23:20
... chemical shifts of the three species on the left hand side of Schemes and 2, the two neutral and one positively charged forms of the Table Assignment of the state of tautomerization of ThDP during ... basis of the accumulated understanding of enzyme mechanisms, such proton transfers are likely to be mediated by general acid ⁄ base catalysts, such as His, Asp and Glu, and perhaps Cys, Lys and ... bands corresponding to the AP and IP forms have different phases enables the simultaneous observation of the two tautomeric forms, notwithstanding the proximity of the bands to each other, and...
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reaction mechanisms of inorganic and organometallic systems (topics in inorganic chemistry)
Ngày tải lên :
01/04/2014, 10:37
... units of A will be those of k and 18 Reaction Mechanisms of Inorganic and Organometallic Systems £a will have the energy units of R The k is determined by experiments at several temperatures, and ... units of k depend on the rate law and must give the right-hand side of Eq (1.3) the same units as the left-hand side A simple example of the need to define the rate in order to give the meaning of ... [A] = [A]0 to [A] and t = to /, gives and predicts that a plot of In [A] versus t should be linear with a slope of -k\ The linearity of such plots often is taken as evidence of a first-order rate...
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maskill - investigation of organic reactions and their mechanisms (blackwell, 2006)
Ngày tải lên :
04/06/2014, 15:26
... monographs on techniques of physical organic chemistry and texts which describe mechanisms of organic reactions The excellent 1986 text, Investigation of Rates and Mechanisms of Reactions, edited ... Reactions and Their Mechanisms The abbreviated representations of mechanisms introduced by Ingold and Hughes and their colleagues are still widely used [3]; they are concise, easy to understand and ... Potential and current 6.5.2 The electrochemical double layer and the charging current 6.5.3 Mass transport and current 6.6 The kinetics and mechanisms of follow-up reactions 6.6.1 Nomenclature 6.6.2 Mechanisms...
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