mechanical+adaptation+of+bone+bioreactors+for+orthopedic+tissue+engineering+applications

... RELEASE SYSTEM OF NITRIC OXIDE FOR CARDIOVASCULAR TISSUE ENGINEERING APPLICATION ZHANG QINYUAN B.Eng (Hons), National University of Singapore A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... function and patency of the vascular grafts, the concept of vascular tissue engineering (VTE) that involves the principles of engineering and life sciences in the development of vascular substitutes ... main isoform classes with different regulation and activities [133, 144] One main class is the constitutive class, which is made up of the neuronal isoform (nNOS) and the endothelial isoform (eNOS)...

Ngày tải lên: 10/09/2015, 09:08

... DEVELOPMENT OF A BIOREACTOR FOR LIGAMENT TISSUE ENGINEERING TEY CHENG HWEE (M.Sc.), NTU A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF ORTHOPAEDIC SURGERY NATIONAL UNIVERSITY OF ... understanding of tissue development and the mechanisms of disease, off-the-shelf provision of essential transplantable tissue and scale-up for commercial production of engineered tissues This ... on tissue engineering of the ACL xiv CHAPTER 1: INTRODUCTION 1.1 ANATOMY AND FUNCTION OF LIGAMENT Ligaments are bands of dense, highly ordered fibrous connective tissue connecting bone to bone...

Ngày tải lên: 04/10/2015, 10:25

... nucleotides In addition, the complexation of Li+ ion stabilizes the conformation of the cyclononane ring of 1, resulting in a rather simple situation of discrimination amongst the nucleotides ... K(UMP) = 710 M-1 ([Li+] = mM and π = mN · m-1) Therefore, conditions suitable for discrimination of the nucleotides and for most efficient binding of a single nucleotide component can be selected ... 4A, the binding constants of the nucleotides to the monolayer of gradually decreased as the surface pressure increased This is because expansion of the molecular area of by binding to the nucleotides...

Ngày tải lên: 21/06/2014, 04:20

... factors Table List of antibodies for FACS Table Sequence of primers used for conventional RT-PCR Table Sequence of primers used for real-time RT-PCR Table List of antibodies for IHC and IF Table ... Associate Professor Cao Tong, Vice-Dean (Research), Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, and Professor Lee Eng Hin, Director of Graduate ... the breakdown of the joint’s cartilage Cartilage is the part of the joint that cushions the ends of the bones and allows easy movement of joints The breakdown of cartilage causes the bones to rub...

Ngày tải lên: 11/09/2015, 09:57

... submitted for the degree of Doctor of Philosophy in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor Swee Hin TEOH and Associate Professor ... selection for liver tissue engineering 2-11 Scaffold fabrication for liver tissue engineering 2-16 Scaffold surface modification 2-20 Tissue culture for liver tissue engineering ... fabrication for tissue engineering, and the state of the art of BALs and cell-based tissue construct transplantation therapies for liver tissue engineering Chapter is on fabrication of bioactive...

Ngày tải lên: 12/09/2015, 10:22

... submitted for the degree of Doctor of Philosophy in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor Teoh Swee Hin and Associate Professor ... growth of the tissue over the scaffold Fig 2.5 Five core technologies (biomaterials, cells, scaffolds, bioreactors, and medical imaging) required for tissue engineering [15] 13 Tissue engineering of ... solvent-free method of hot roll-milling The purpose of biaxial drawing is to enhance the mechanical properties of the film PCL films were shown to be suitable for membrane tissue engineering applications...

Ngày tải lên: 14/09/2015, 08:36

... DEVELOPMENT OF CHITIN BASED MATERIALS FOR TISSUE ENGINEERING APPLICATIONS CHOW KOK SUM (B.Sc Hons, NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY NATIONAL ... in the treatment of malfunctioning or lost organs An important focus in this new approach is the search for suitable materials for development of a variety of tissue engineering applications Chitin ... new methodologies of developing chitin-based materials for tissue engineering applications In tissue engineering, a temporary matrix is required to serve as an adhesive substrate for the implanted...

Ngày tải lên: 17/09/2015, 17:20

... MICROCARRIERS FOR BONE TISSUE ENGINEERING APPLICATIONS FENG YONG YAO, JASON B.Eng.(Hons), National University of Singapore A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT OF MECHANICAL ... of two kinds of osseous tissue: cortical bone and trabecular bone Cortical bone covers the outer surface of the bone and is a dense and compact tissue, which sustains major loading forces It is ... Literature Review 2.1 Bone biology In order to develop engineering considerations for the bone tissue engineered construct, it is necessary to understand the biology of bone The bone is the major...

Ngày tải lên: 22/09/2015, 15:18

... Determination of suitable solid media and incubation conditions for the growth of yeast B1.1.2 Optimisation of cultivation conditions 40 for mass production of yeast in broth B1.1.3 Determination of log ... characterisation of blank microspheres and 47 micro -bioreactors B7 Determination of viable yeast contents of yeast-calcium 48 alginate micro -bioreactors B7.1 Study of effects of sodium chloride ... efficiency of free yeast and 102 micro -bioreactors A Assay of ethanol A1 Optimisation of gas chromatography-mass spectrometry 102 102 conditions for assay of ethanol A2 Optimisation of ethanol...

Ngày tải lên: 30/09/2015, 06:24

... cardiovascular tissue engineering In some studies, blending of material is carried out to achieve better properties The use of preformed scaffolds in tissue engineering offers the advantage of a greater ... Cardiovascular Tissue Engineering The limitation of existing therapies necessitates the need for alternative therapies A novel method of regenerative medicine is proposed in the form of cardiovascular tissue ... biomaterial for tissue engineering applications However, the hydrophobic surface of PCL scaffold, which is lack of functional groups, generates an unfavorable cell affinity This setback hinders PCL for...

Ngày tải lên: 26/11/2015, 22:40

... Principles of Tissue Engineering constraint imposes unusual demands on tissue engineering strategies for skeletal tissues II PRINCIPLES OF TISSUE ENGINEERING The basic component of any tissue engineering ... different tissues and the clinical applications that tissue engineering can target These chapters therefore cover the breadth of tissue engineering in orthopedics, and can educate all of us Tissue engineering ... Consideration of this relatively pragmatic approach may be the way to maintain forward progress of this field, while continuing to work toward the ultimate applications Orthopedic applications of tissue engineering...

Ngày tải lên: 27/06/2014, 10:20

... by the density of the condensation [19] Technical aspects of the micromass technology In the context of tissue engineering, ex vivo tissue generation may be optimised by the use of cell re-aggregation ... also able to build up a micro -tissue similar to that of bone repair tissue without collagenassociated mineral formation The fabrication of a selfassembled skeletal tissue seems not to be limited ... extracorporal bone tissue engineering Part I Int J Oral Maxillofac Surg 2004, 33(4):325-332 Meyer U, Joos U, Wiesmann HP: Biological and biophysical principles in extracorporal bone tissue engineering...

Ngày tải lên: 11/08/2014, 23:22

... approach for the delivery of PHIs is necessary We therefore propose the use of PHI-delivering scaffolds as a strategy for improving vascularization in tissue engineering applications As a proof -of- concept, ... Roles of PHIs in Bone Tissue Engineering and Regeneration 64 4.1 Introduction 65 4.2 Bone development and regeneration 65 4.2.1 Mechanisms of bone formation 65 4.2.2 Bone ... healing 28 2.4 Potential applications of PHIs in tissue engineering 31 Chapter Incorporation of a PHI into Scaffolds: A Vascularization Strategy for Tissue Engineering Applications 33 3.1 Introduction...

Ngày tải lên: 09/09/2015, 11:11

... 4.2 Overview of aspect ranking framework 71 4.3 Performance of aspect ranking in terms of NDCG@5 T-Test, p-values

Ngày tải lên: 09/09/2015, 17:53

... key motivation for the use of bioinformatics (Luscombe et al 2001) The initial successes of bioinformatics were favoured by the information-oriented nature of molecular biology For many purposes, ... software tools The applications presented are relevant to the biomedical fields of immunology and virology These applications were chosen as proofs of concept, and the applications of the approach ... derived from information theory, capable of scaling the study of sequence variability to populations of tens of thousands of related sequences We define peptide entropy, a measure of antigenic...

Ngày tải lên: 12/09/2015, 08:18

... development as a biocatalyst for industrial applications Hence, elucidation of the molecular determinants of the substrate specificity of AtdA is first required before engineering of the enzyme to expand ... ENGINEERING OF ANILINE DIOXYGENASE FOR BIOREMEDIATION AND INDUSTRIAL APPLICATIONS ANG EE LUI B Eng (Hons.), National University of Singapore A THESIS SUBMITTED FOR THE DEGREE OF PHILOSOPHY ... reported which of the five subunits controls the substrate specificity of aniline dioxygenase The lack of characterization of the structural determinant of the substrate specificity of AtdA limits...

Ngày tải lên: 12/09/2015, 10:22

... DEVELOPMENT OF A BIOREACTOR FOR IN-VITRO ENGINEERING OF SOFT TISSUES KYAW MOE (B.Eng (Hons.), YTU, Yangon) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT OF MECHANICAL ENGINEERING ... in tissue engineering now allow for new approaches to treat these ligament and tendon injuries Tissue engineering offers the possibility of replacing damaged human tissue with functional neotissue ... disease, off-the-shelf provision of essential transplantable tissue, and possible scale-up for commercial production of engineered tissues Mechanical stress plays a significant role in tissue formation...

Ngày tải lên: 04/10/2015, 15:46

... stationary) 16 2.5.2 Advantages of electrospun nanofibers for tissue engineering:  The fibers in the nano scale offer much larger scope for engineering and biological applications than the conventional ... [41]  Recently, there has been a center of attention given to the applications of nanofibers in tissue engineering TE refers to the efforts of to perform specific biochemical functions using ... to thank all Prof Seeram’s lab members for their assistance in the completion of this project I would like to thank the Department of Mechanical Engineering and Faculty of Science for their constant...

Ngày tải lên: 05/10/2015, 19:04

... Soil……………….122 5.3 FEM Form of the Balance of Linear Momentum in the Solid Phase…125 5.4 FEM Form of the Balance of Linear Momentum in the Fluid Phase…129 5.5 FEM Form of Conservation of Mass for the Mixture…………………132 ... Bao, Yu (Ph.D., Civil Engineering) A Biot Formulation for Geotechnical Earthquake Engineering Applications Thesis directed by Professor Stein Sture The mechanical behavior of saturated soil is ... entitled: A Biot Formulation for Geotechnical Earthquake Engineering Applications written by Yu Bao has been approved for the Department of Civil, Environmental, and Architectural Engineering ...

Ngày tải lên: 13/11/2014, 09:24

... IMPROVING THE MECHANICAL AND FUNCTIONAL PERFORMANCE OF EXTRUSION-BASED ADDITIVE MANUFACTURED SCAFFOLDS FOR BONE TISSUE ENGINEERING MUHAMMAD TARIK ARAFAT (B.Sc in Mechanical Engineering, BUET) ... THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MECHANICAL ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2011 Acknowledgements Acknowledgements First and foremost, I would ... objective of this study was therefore to develop additive manufactured scaffolds with improved mechanical and functional performance for bone TE applications In this context, a number of objectives...

Ngày tải lên: 10/09/2015, 15:51