mapping of cobit 5 with the most relevant related standards and frameworks
Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
Ngày tải lên :
17/02/2014, 11:20
... responsibilities have been reordered by the events of September 11, 2001; officials in the Department of Health and Human Services and in the Department of Homeland Security; and the interested public This ... management of the relationship with FDA must also be a high priority Interestingly, the nation recently faced the prospect of another war with Iraq, and the threat of CBW agents, with only one ... drug and biologics development because of the increased appreciation of the threat of biological weapons The CBW threat, both to national and homeland security, raises the question of whether...
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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
Ngày tải lên :
06/03/2014, 00:21
... respectively The ligand (5 lL) was injected 35 times into the 1.42 85- mL cell with stirring at 350 r.p.m The binding isotherms were calculated from received data, and fitted to a three-site binding model with ... ITC of ATP binding to GlnK The raw data were fitted with a three-site binding model for a PII trimer The upper panel shows the raw data in the form of the heat effect during the titration of 25 ... deprivation, in agreement with the lack of TnrA degradation in this strain GS was copurified with TnrA and the recovery of GS was independent of As a next step, the interaction of TnrA with GlnK was investigated...
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Báo cáo khoa học: Interactions of imidazoline ligands with the active site of purified monoamine oxidase A potx
Ngày tải lên :
07/03/2014, 10:20
... guanabenz and the values for 2-BFI and idazoxan are given in Table Evidence for the proximity of these ligands to the flavin in MAO-A comes from the influence of the ligand on the redox properties of the ... 149–222 of the MAO-B sequence [12] The crystal structure of MAO-B shows that some of the residues in this peptide lie between the entrance cavity and the active site [ 15] On the other hand, inhibition ... inhibition The use of purified enzyme simplifies the system for kinetics and also allows observation of the spectrum of the flavin cofactor in MAO-A The subtle changes in the flavin spectrum on ligand binding...
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Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt
Ngày tải lên :
08/03/2014, 08:20
... (3 .5 · 1 05 cells per 90-mm dish) and transfected the following day with the plasmid pTetoff together with the empty pTRE vector (lanes 1, 2) or together with pTRE-HuD (lanes 3, 4) or together with ... HuD (lane 4) and HuR (lane 6) (upper panel) Staining of the gel with ethidium bromide revealed equal loading of the gel and integrity of the RNA (lower panel) The positions of the 28S and 18S rRNAs ... binding of cellular HuR and of the unknown 55 -kDa protein to the MARCKS 52 nt RNA probe arguing that more than one protein recognize the same site (Fig 4E, lanes 5 7) Analysis of HuR and CstF64...
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Báo cáo khoa học: Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1) potx
Ngày tải lên :
17/03/2014, 09:20
... PDE5 identified by Turko and colleagues [13,14] H603, H607, H643, D644, E762, H6 75, T713, D 754 , Q7 65 and Q779 were used for the modeling Mutations of T713 and H6 75 that are cognate residues of ... PfuTurbo DNA polymerase The cycling conditions were 95 °C for 30 s then 12 cycles of 95 °C for 30 s, 55 °C for and 68 °C for 15 Ten units of DpnI restriction enzyme was added to the reaction following ... E672, H6 75, T713, D 754 ) overlaid the corresponding residues in the PDE4B2 reference structure (H234, H238, H274, D2 75, E304, H307, T3 45 and D392) with little deviation The coordinates of these residues...
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Báo cáo khoa học: Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton pot
Ngày tải lên :
30/03/2014, 10:20
... inhibits the store-operated TRP channels and cytoskeleton regulate each other 44 45 46 47 48 49 50 51 52 53 54 55 56 57 Ca2+ entry in neutrophils Toxicol Appl Pharmacol 209, 134–144 Karr TL, Kristofferson ... important for either development of the stereocilia of hair cells in the inner ear or proper localization of TRP channels at the tip of these stereocilia, which is crucial for the activity of these cells ... regions of the membrane is well established [ 158 ] However, the functional implications of this remain one of the current challenges We find the role of the cytoskeleton to be both direct and indirect...
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báo cáo hóa học: "Validation of spinal motion with the spine reposition sense device" doc
Ngày tải lên :
19/06/2014, 08:20
... 70 .5% and 63%, respectively and the mean of these values is 66. 75% (Table 4) Relative spinal measurements in the thoracic versus lumbar spine Comparisons of the mean angular changes at the T4 and ... 3.76 0. 25 0.47 7.88 17.28 17.28 42.39 Full T L 50 . 65 36 .52 14.13 7.89 6. 15 0.98 0.76 27.30 23. 45 63 .54 48.39 Ref T L 39.37 31.70 7.67 7.00 4 .56 0.87 0 .57 23 .56 23.39 52 .4 42.34 2/3 T L 38. 75 31.34 ... for the movement of sit-to stand The propulsive impulse at the beginning of movement initiating forward momentum is thought to be generated by the angular velocity of the trunk and pelvis in the...
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báo cáo hóa học: "Reliability and validity of pendulum test measures of spasticity obtained with the Polhemus tracking system from patients with chronic stroke" pot
Ngày tải lên :
19/06/2014, 08:20
... While the objectivity, reliability, and validity of the pendulum test and the simplicity and portability of the Polhemus tracking system provide support for its use, the convergent validity of the ... contributed to the inertia of the leg against which the quadriceps and spasticity served as a brake Still, the addition of the weight did not improve the measurement properties of the pendulum test and ... associated with the various pendulum test measures obtained from the traces With the exception of the ICC associated with the velocity to first reversal during testing with no weight on the unaffected...
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báo cáo hóa học: " Shedding light on walking in the dark: the effects of reduced lighting on the gait of older adults with a higher-level gait disorder and controls" ppt
Ngày tải lên :
19/06/2014, 10:20
... (0.2 95) 35. 5 ± 3.2 (0.0 15) 5. 1 ± 2 .5 (0.3 65) 84.2 ± 33 .5 (0.013) *P-values shown in parentheses are based on within group comparisons between near dark and normal lighting All measures of gait ... helped with the interpretation of the results, reviewed the manuscript and participated in the editing of the final version of the manuscript 20 21 22 23 24 Acknowledgements We thank the participants ... adults with a HLGD To more fully characterize the gait of older adults with a HLGD and their reliance on visual input, we examined the effect of lighting changes on the gait of older adults with...
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Báo cáo tin học: "The maximum piercing number for some classes of convex sets with the (4, 3)-property" ppsx
Ngày tải lên :
07/08/2014, 15:23
... l2 the points of L with the largest and the least y-coordinate We define two discs, Da and Db , which cover all the points from C The discs Da and Db will be determined by their diameters aa and ... discs and satisfies the dual version of (4, 3)property See Figure Let a, b, c be the vertices of an equilateral triangle with side of length Let Aa be the arc of the circle with center a and radius ... two closed unit discs Then one of them, D1 , must cover two points from the set {a, b, c}, say a and b The distance between a and b is equal to the length of the diameter of the unit disc Hence,...
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Báo cáo y học: "The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28" docx
Ngày tải lên :
09/08/2014, 07:20
... summarized in Table The mean age of patients was 59 years with the majority less than 65 years Most of the patients were female (81%) with mean disease duration of 16 years The mean value of the DAS28 ... Comparisons of the RARBIS with the DAS28 Table shows the Spearman correlation with 95% confidence interval (CI) between the RARBIS and the DAS28 The total score was moderately correlated with the DAS28 ... significantly related to the DAS28 The laboratory subscale had a weak correlation with the DAS28 The other components were not correlated with the DAS28 When the subscale of medication use was added to the...
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Báo cáo y học: "The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28" pdf
Ngày tải lên :
09/08/2014, 07:20
... process, often taking years, and is never complete the subscales of the RARBIS with the aim to improve the correlation with the DAS28 will only lead to an overvaluation of the domains related ... component of the RARBIS It is therefore not surprising at all that the RARBIS correlates to some extent with the DAS28, and this correlation per se does not add to the validity of the RARBIS ... NA, Solomon DH: The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28 Arthritis Res Ther 2006, 8:R57 Landewe RB: The benefits of early treatment...
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Báo cáo y học: "Ablation of atrial fibrillation with the Epicor system: a prospective observational trial to evaluate safety and efficacy and predictors of success" pptx
Ngày tải lên :
10/08/2014, 09:22
... lesions without the need of large thermal gradients and without jeopardizing adjacent structures (Figure 1) [6] The purpose of this study was to evaluate the efficacy of left atrial HIFU ablation of ... with a left 90,00% AF 80,00% SR 70,00% 60,00% 50 ,00% 40,00% 30,00% 20,00% 10,00% 0,00% 40- 45 mm 45- 50 mm 50 -55 mm >55 mm Figure Percentage of patients with sinus rhythm or atrial fibrillation after ... rhythm was obtained in 100% of patients with paroxysmal AF, in 58 % of patients with persistent AF, and in 44% of patients with long standing persistent AF (Figure 3) The left atrial diameter measured...
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Báo cáo y học: "Variations in brachial plexus and the relationship of median nerve with the axillary artery: a case report." pps
Ngày tải lên :
10/08/2014, 10:20
... from roots C5, C6, C7, C8 and T1 (Figure and 2) The upper trunk was formed by the union of C5 and C6 Before joining the C6, the C5 gave a direct branch to the Subclavius Muscle and the Dorsal ... division of the upper trunk One of the posterior divisions fused with Figure Plexus of the right side of 57 year old male cadaver (In Situ) Brachial Brachial Plexus of the right side of 57 year ... Diagram of the Brachial Plexus of the right side of 57 year old male cadaver Shaded portions represent the posterior cord and its branches the posterior divisions of the upper trunk and the lower...
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báo cáo khoa học: "mRNA detection of individual cells with the single cell nanoprobe method compared with in situ hybridization" doc
Ngày tải lên :
11/08/2014, 00:22
... mainly in the vicinity of the nucleus Usually β-actin mRNA is known to exist mainly in the vicinity of the nucleus, and these results agreed with the results of our previous work and other studies ... divided into classes within the range of -0.1 and 0.7 The center of each image is the position of the center of the AFM probe inserted β-actin mRNA was not detected in the region of Fig 3(a) whose ... 0. 25, the probability of β-actin mRNA detection was 100% However, the average quantities of β-actin mRNA detected by the SCN method were 50 and 120 molecules within the range of 0. 25 to 0.4 and...
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báo cáo khoa học: " Control of mandibular incisors with the combined Herbst and completely customized lingual appliance - a pilot study" ppsx
Ngày tải lên :
11/08/2014, 20:20
... overcorrection of 4 .5 There is no relation between the amount of incisor rotation and the amount of under- or overcorrection (Adjusted R-squared: 0.29) Age has no effect either on the amount of movement ... the study, interpreted the data and reviewed all iterations of the paper DW and AH designed the study AH and RS analyzed the data DW and RS supervised the clinical sample and data collection DW ... retrospective nature of the study and the small number of patients included, the following conclusions could be drawn The Incognito system allows precise torque control with a mean error of 2.2° ± 1.0°...
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Báo cáo y học: "Comparison of bedside measurement of cardiac output with the thermodilution method and the Fick method in mechanically ventilated patients" pot
Ngày tải lên :
12/08/2014, 19:21
... (Fig 1a) The results of the Passing and Bablok regression of QTFICK against QTTHERM are shown in Figure 1b The 95% confidence interval of the intercept did not include (–0.70 to –0.06) and the upper ... QTFICK and QTTHERM was –0.8 l/min, with a lower limit of agreement (magnitude of underestimation of QTFICK by QTTHERM) at –2.3 l/min and an upper limit (magnitude of overestimation of QTFICK by QTTHERM) ... each patient The statistical association between QTFICK and QTTHERM was expressed in terms of the Z coefficient of correlation with the 95% confidence interval The agreement between the two techniques...
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Báo cáo y học: "Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome" pptx
Ngày tải lên :
13/08/2014, 16:20
... The main clinical endpoint was the appropriateness of the antibiotic therapy given within the first 24 hours following the onset of sepsis (that is, first-line empirical antibiotic therapy) The ... validated The SOFA score was therefore calculated daily during the course of sepsis, and was preferred to the SAPS II as a predictive model of organ dysfunction and outcome The survival of patients ... analysis The main baseline characteristics of the included patients are presented in Table The main source of infection was found to be the lung (51 .7%) In more than one-half of the cases of Page of...
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effectiveness of teaching grammar with the use of dictogloss for students of k37a maths class, at hanoi college of education = hiệu quả dạy ngữ pháp bằng phương pháp dictogloss cho sinh viên lớp sư phạm
Ngày tải lên :
02/03/2015, 14:30
... bearing the rules of structure which they have to generalize from these examples themselves or with their teacher‟s suggestions, and from these examples, they derive an understanding of the rules, and ... consider the following main factors regarding the learners: The age and level The size of the group of learners The constitution of the group (monolingual or multilingual?) Their needs and ... degree and have much experience in teaching English in the faculty One is the head of Division of Non-major English and the other is a lecturer with 7-year experience of working with the textbook and...
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