management of amyotrophic lateral sclerosis

... the films (data not shown) The time course of the inhibition of expression of SOD1 and enhanced green fluorescent protein (EGFP) after addition of lgÆmL)1 of dox to fully expressing tTA cell lines ... the effects of chronic exposure to a small amount of G93ASOD1, as seen in the motor neurons of FALS1 patients To explain the different amounts of GSH in cells with varying levels of G93ASOD1, ... and the lack of a decrease in GST However, the effect of longer exposure of cells to even a low level of mutant protein, studied in the conditional model, was to cancel induction of GCLC, eliminating...

Ngày tải lên: 29/03/2014, 23:20

... Incidence of amyotrophic lateral sclerosis in Europe J Neurol Neurosurg Psychiatry, 2010 81(4): p 385-90 Marin, B., et al., Incidence of amyotrophic lateral sclerosis in the Limousin region of France, ... profiling of CSF in early amyotrophic lateral sclerosis PLoS One, 2010 5(10): p e13223 44 Kumar, A., et al., Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis ... gabapentin in a transgenic model of familial amyotrophic lateral sclerosis Ann Neurol, 1996 39(2): p 147-57 25 McGoldrick, P., et al., Rodent models of amyotrophic lateral sclerosis Biochim Biophys...

Ngày tải lên: 30/09/2015, 10:12

... S10RR023684 (to H Zhu) is acknowledged for purchase of the 4800 Plus MALDITOF-TOF mass spectrometer References Hughes JT (1982) Pathology of amyotrophic lateral sclerosis Adv Neurol 36, 61–74 Deng HX, Hentati ... dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362, 59–62 Pasinelli P & Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics Nat ... analysis to profile alterations of lipid raft-associated proteins in the spinal cord of the G93A SOD1 transgenic mouse model of ALS Alterations of a consortium of 67 lipid raft-associated proteins...

Ngày tải lên: 23/03/2014, 04:21

... absorption of toxic metals This leads to the presence of excess levels of divalent or trivalent cations, which in turn leads to the mobilization of calcium and metals from the bone and deposition of ... malacissans Beitr Pathol 1889, 6:513-524 Page of 17 Patten BM, Engel WK: Phosphate and parathyroid disorders associated with the syndrome of amyotrophic lateral sclerosis In Human Motor Neuron Disorders ... Brust JC: Neurologic aspects of cobalamin deficiency Medicine (Baltimore) 1991, 70:229-245 30 Kroliunitskaia T: On the treatment of patients with lateral amyotrophic sclerosis with vitamin B12...

Ngày tải lên: 11/08/2014, 02:21

... ALS 30 NEUROFILAMENTS……………… .33 1.3.1 Molecular Biology of Neurofilaments… 33 1.3.1.1 Structure and assembly of neurofilaments… .33 1.3.1.2 Transport of Neurofilaments………………… ... …A1 viii ABSTRACT One of the pathological hallmarks of motor neuron death in Amyotrophic Lateral Sclerosis (ALS) is the abnormal accumulations of phosphorylated neurofilaments in the neuronal ... 34 1.3.2 Neurofilament function…………… .36 1.3.2.1 Biological function of neurofilaments 36 1.3.2.2 Function of neurofilaments is regulated by phosphorylation… 36 1.3.3 Neurofilaments...

Ngày tải lên: 10/09/2015, 09:29

... contribute to the understanding of the molecular mechanism underlying the mutation-causing disease 1.2 What is Amyotrophic lateral sclerosis? Amyotrophic lateral sclerosis (ALS) also known as Lou ... STUDIES OF VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS Lua Shixiong B.Sc (Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE ... features of ALS pathology resulting in specific death of motor 24 neurons 1.4.2 Structural consequences of mutations The first examination of the effect of the P56S mutation on the structure of VAPB...

Ngày tải lên: 12/10/2015, 17:34

... criteria for the diagnosis of amyotrophic lateral sclerosis Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1(5): 293-299 Salton SR, Volonte C, D'Arcangelo G Stimulation of vgf gene expression ... with amyotrophic lateral sclerosis Am J Clin Nutr 2001; Int J Med Sci 2008, 74(3): 328-334 26 Kong J, Xu Z Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral ... dysfunction of oxidative phosphorylation in mitochondria of transgenic mice J Biol Chem 2002; 277(33): 29626-29633 28 Menzies FM, Ince PG, Shaw PJ Mitochondrial involvement in amyotrophic lateral sclerosis...

Ngày tải lên: 03/11/2012, 10:52

Ngày tải lên: 19/06/2014, 22:20

... and demographic details of subjects ALS, amyotrophic lateral sclerosis; n, Number; M, male; F, female; y, years; mo, months; B, bulbar; L, limb; Age, age of onset, duration of disease are indicated ... patients with amyotrophic lateral sclerosis Neuroreport 2002, 13:2199-2201 Iłzecka J: Cerebrospinal fluid vascular endothelial growth factor in patients with amyotrophic lateral sclerosis Clin ... difference among the groups (p < 0.05) Expression of VEGF-A and CCL2 were normalized to expression of endogenous control b-actin ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth...

Ngày tải lên: 19/06/2014, 22:20

... amyotrophic lateral sclerosis Neuroreport, Vol 4, No 6, pp 819-822 40 Amyotrophic Lateral Sclerosis Weydt, P & Moller, T (2005) Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis ... trial of talampanel in subjects with amyotrophic lateral sclerosis Amyotroph Lateral Scler, Vol 11, No 3, pp 266-271 Pasinelli, P & Brown, R.H (2006) Molecular biology of amyotrophic lateral sclerosis: ... Neuron Diseases /Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop...

Ngày tải lên: 22/06/2014, 03:20

... presymptomatic amyotrophic lateral 220 Amyotrophic Lateral Sclerosis sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL Proceedings of the National Academy of Sciences of the United ... & Beal, M F (1997b) Evidence of increased 214 Amyotrophic Lateral Sclerosis oxidative damage in both sporadic and familial amyotrophic lateral sclerosis Journal of neurochemistry, Vol.69, No.5, ... Model of Amyotrophic Lateral Sclerosis 189 Lauriat TL, Richler E, McInnes LA (2007) A quantitative regional expression profile of EAAT2 known and novel splice variants reopens the question of aberrant...

Ngày tải lên: 22/06/2014, 03:20

... familial amyotrophic lateral sclerosis patient survival." PLoS Biol 6(7): e170 Wijesekera, L C and Leigh, P N (2009) "Amyotrophic lateral sclerosis. " Orphanet J Rare Dis 4: 300 Amyotrophic Lateral Sclerosis ... superoxide dismutase and amyotrophic lateral sclerosis. " Annu Rev Biochem 74: 563-93 Van Den Bosch, L (2011) "Genetic rodent models of amyotrophic lateral sclerosis. " Journal of biomedicine & biotechnology ... interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis. " J Biol Chem 276(16): 12791-6 298 Amyotrophic Lateral Sclerosis Shipp, E L., Cantini, F., Bertini, I., Valentine,...

Ngày tải lên: 22/06/2014, 03:20

... familial amyotrophic lateral sclerosis Journal of Biological Chemistry, Vol.283, No.20, pp 13528–13537 Khare, S.D & Dokholyan, N.V (2006) Common dynamical signatures of familial amyotrophic lateral sclerosis- associated ... their redox potentials Proceedings of the National Academy of Sciences of the United States of America, Vol.103, No.37, pp 13860–13865 308 Amyotrophic Lateral Sclerosis Ferri, A.; Fiorenzo, P.; ... signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis Proceedings of the National Academy of Sciences of the United States of America, Vol.104, No.30, pp 12524-12529 Gurney,...

Ngày tải lên: 22/06/2014, 03:20

... activity in subsets of mutant Protein Aggregates in Pathological Inclusions of Amyotrophic Lateral Sclerosis 351 superoxide dismutases associated with familial amyotrophic lateral sclerosis J Biol ... sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations Ann Neurol, Vol.61, No.5, pp 427-434, ISSN 0364-5134 Protein Aggregates in Pathological Inclusions of Amyotrophic ... in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with Protein Aggregates in Pathological Inclusions of Amyotrophic Lateral Sclerosis 355 posterior column involvement...

Ngày tải lên: 22/06/2014, 03:20

... D., et al (2007) Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Vol 8, No 3, (June ... (2010) Analysis of OPTN as a causative gene for amyotrophic lateral sclerosis Neurobiology of Aging, Vol 32, No 3, (March 2011), pp 555.e13-4, ISSN 1558-1497 500 Amyotrophic Lateral Sclerosis Benajiba ... elevation of tumor necrosis factor alpha 472 Amyotrophic Lateral Sclerosis (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93ASOD1 mouse model for amyotrophic lateral sclerosis...

Ngày tải lên: 22/06/2014, 03:20

... screening of TARDBP mutation in amyotrophic lateral sclerosis Neurobiology of Aging, 2010, Ahead of print Iida A., et al (2011) Optineurin mutations in Japanese amyotrophic lateral sclerosis Journal of ... impairment of amyotrophic lateral sclerosis- linked mutations in FUS/TLS Annals of Neurology, 2010, Ahead of print Jackson M., et al (1996) Analysis of chromosome 5q13 genes in amyotrophic lateral sclerosis: ... patient with sporadic amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Vol 10, No 2, (April 2009), pp 118-122, ISSN 1748-2968 22 Genetics of Familial Amyotrophic Lateral Sclerosis Emily...

Ngày tải lên: 22/06/2014, 03:20

... progression of dysphagia in amyotrophic lateral sclerosis Auris Nasus Larynx, Vol 31, No 3, pp 247-54, 03858146 (Print) 0385-8146 (Linking) Multidisciplinary Rehabilitation in Amyotrophic Lateral Sclerosis ... Rehabilitation in Amyotrophic Lateral Sclerosis 575 Miller, R.G.;Jackson C.E.;Kasarskis E.J., et al (2009a) Practice parameter update: The care of the patient with amyotrophic lateral sclerosis: drug, ... TDP-43 mutation in familial amyotrophic lateral sclerosis Ann Neurol, 63, 4, 538-542 Part Clinical Research in ALS 24 Multidisciplinary Rehabilitation in Amyotrophic Lateral Sclerosis Louisa Ng and...

Ngày tải lên: 22/06/2014, 03:20

... Neuron Diseases /Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop ... Rehabilitation in Amyotrophic Lateral Sclerosis 557 Louisa Ng and Fary Khan Chapter 25 Assessment and Management of Respiratory Dysfunction in Patients with Amyotrophic Lateral Sclerosis 579 Daniele ... Genetics of Amyotrophic Lateral Sclerosis 479 Max Koppers, Michael van Es, Leonard H van den Berg, Jan H Veldink and R Jeroen Pasterkamp Chapter 22 Genetics of Familial Amyotrophic Lateral Sclerosis...

Ngày tải lên: 28/06/2014, 11:20

... Neuron Diseases /Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial “Clinical Limits of Amyotrophic Lateral Sclerosis workshop ... Absence of response to therapy and the development of upper motor neuron signs should reinforce the possibility that amyotrophic lateral sclerosis may be present Since amyotrophic lateral sclerosis ... patient prognosis and management It is therefore important to appreciate the range of possible presentations of amyotrophic lateral sclerosis Case Presentation: We present the case of a 57-year-old...

Ngày tải lên: 10/08/2014, 22:20

... without evidence of implant failure Discussion Lateral instability is one of the causes of failure after TKA There is very little information in the literature documenting the incidence of this fortunately ... shown that the higher BMI of our patient at the time of ligament reconstruction is predictive of poor outcome [7] Therefore, because of her obesity, the probability of failure with any reconstructive ... and lateral view (C) of the left knee of our patient, showing significantly increased gap on the lateral side There was no radiographic evidence of implant loosening This lateral instability was...

Ngày tải lên: 11/08/2014, 12:20