long circulating polymeric nanoparticles for drug and gene delivery to tumors
nanotechnology for cancer therapy, 2007, p.810
... intracellular delivery systems for drugs and genes using target-specific, long- circulating, biodegradable polymeric nanoparticles; and gold and iron-gold core-shell nanoparticles for biosensing, imaging, and ... target-specific drug and vaccine delivery systems for gastrointestinal tract infections; localized delivery of cytotoxic and anti-angiogenic drugs for solid tumors in novel biodegradable polymeric nanoparticles; ... 215 Tania Betancourt, Amber Doiron, and Lisa Brannon-Peppas Chapter 13 Long- Circulating Polymeric Nanoparticles for Drug and Gene Delivery to Tumors ...
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INHIBITION OF APE1’S DNA REPAIR ACTIVITY AS A TARGET IN CANCER: IDENTIFICATION OF NOVEL SMALL MOLECULES THAT HAVE TRANSLATIONAL POTENTIAL FOR MOLECULARLY TARGETED CANCER THERAPY
... patient and helping with my problems and for being such a wonderful friend Thank you to Dr Robertson for all your inputs for my project and for the well stocked candy jar To all my friends, for support, ... both here and in India, for being so encouraging and for always believing in me To my parents-in-law, Capt Prafull Bhate and Dr Jyotsna Bhate and my brother and sister-in-law, Anmol and Rama Bhate: ... am today is because of you guys! Finally, to my husband Dhruv Bhate, your love and support provided me with the strength to perservere through the tough times and the long distances Thanks for...
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Báo cáo sinh học: " Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy" pptx
... biodegradability, good biocompatibility, non-toxicity, higher stability, and controlled drug delivery Polymeric nanoparticles (nanospheres and NCs) not only maintain a prolonged circulation time in the body ... lipids are able to inhibit both presystemic drug metabolism and P-glycoprotein-mediated drug efflux [18] Several polymers have been proposed as nanocarriers for drug delivery systems For example, ... nanocapsules' cytotoxicity The NCs' cytotoxicity was evaluated using the SUM 225 cell line (Asterand, Inc., Detroit, MI, USA) The cytotoxicity after treatment of these cells with native Doc and Docloaded...
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báo cáo hóa học:" PTTG: an important target gene for ovarian cancer therapy" doc
... been commonly used as a vector for cancer gene therapy to transfer tumor-suppressor genes, anti-angiogenic factors, prodrug-activating genes, and immunostimulatory genes [102-104] Recently, Cho-Rok ... contributes to angiogenesis and metastasis D Apoptosis PTTG1 has been shown to regulate the expression of p53, a tumor suppressor gene that subjects to apoptosis by inducing apoptosis-inducing genes ... cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis Cytogenet Cell Genet 1999, 84:211-6 Heaney AP, Nelson V, Fernando M, Horwitz G: Transforming...
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báo cáo khoa học: " Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy" ppsx
... that only 40% of the total drug is releaed from the nanoparticles at 24 hours In vitro and in vivo toxicity studies of void polymeric nanoparticles An ideal drug delivery platform must be biodegradable, ... GS: Polymeric micelles for delivery of poorly water-soluble compounds Crit Rev Ther Drug Carrier Syst 2003, 20:357-403 Panyam J, Labhasetwar V: Biodegradable nanoparticles for drug and gene delivery ... void polymeric nanoparticles Toxicity6 Toxicity profile of void polymeric nanoparticles A) A series of eight pancreatic cancer cell lines were exposed to a 20fold range of void polymeric nanoparticles...
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báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx
... its association with magnetic nanoparticles Doses of 50 μM of Rh2(H2cit)4-loaded to maghemite nanoparticles and to magnetoliposomes were Page 12 of 17 more cytotoxic than the equimolar dose of ... LipMagh-Rh2(H2cit)4 have much potential for application in drug delivery systems, and they should be considered as a platform to enhance Rh2(H2cit)4 cytotoxicity, specifically in breast carcinoma ... suitable and effective platform for drug delivery systems that operate more specifically in tumor cells Methods Materials All solvents and reagents related to the synthesis of Rh2 (H cit)4 and Magh-Rh2...
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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy
... polymerdrug conjugates and immunoconjugates The potential of using drug delivery systems for cancer treatment have been demonstrated as early as 1974 for liposomes [6], and 1980 for polymeric nanoparticles ... cancer cells to TRAIL and synergistic cytotoxic effect achieved by simultaneous delivery of pac and TRAIL using P(MDS-co-CES) nanoparticles Cell cycle and caspase-dependent apoptosis studies ... suggestions on my TRAIL delivery work I would also like to express sincere appreciation to the members of my Ph.D committee who monitored my work and took effort to read and provide precious comments...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... control with lower toxicity An attractive approach to human cancer gene therapy is to exploit the genetic and epigenetic alterations in a cancer for targeting the expression of toxic genes Indeed, ... upstream and (5_-GCTGTGTGGGTCTGCTCTTTCAAGATG) downstream The polymerase chain reaction (PCR) was carried out for 30 cycles (98°C for 15 sec, 58°C for 30 sec, and 72°C for 40 sec and finally 72°C for ... group and others, transcriptional regulatory sequences of the H19 gene have emerged as candidates for cancer gene therapy H19 is a paternally-imprinted, maternally expressed, oncofetal gene that...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... heterotopic and orthotopic animal models for bladder cancer Expression of IGF2-P4 and H19 transcripts in heterotopic subcutaneous tumors In order to develop a model for heterotopic bladder tumors, ... relations phenomenon of IGF2 and H19 This vector was then used to transfect and to eradicate tumor cells in culture or to inhibit tumor growth (in vivo), in heterotopic and orthotopic bladder tumor models ... treatment, the tumors were excised and their ex-vivo weight and volume were measured Samples of the tumors were fixed in 4% buffered formaldehyde and processed for histological examination for evidence...
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Improvement of different vaccine delivery systems for cancer therapy pptx
... encapsulate and deliver foreign genetic materials into specific cell types including cancerous cells Both viral and non-viral vectors were developed and evaluated for delivering therapeutic genes into ... effectively and directly transferred into the cytosol This system has been applied to deliver proteins into cells [24], but not yet to deliver antigens into DCs for cancer immunotherapy In vitro and ... such as vaccinia virus and other poxviruses, adenovirus and BCG have been evolved specifically to deliver DNA into cells and are the most common gene delivery tools used in gene therapy [37,38]...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... presents HGF to its receptor, triggering receptor kinase activity and signaling pathways involving the binding of ezrin to ezrin–radixin–moesin proteins, and thus actin cytoskeleton binding and Ras ... vasoactive mediators for vascular permeability, serum fibrinogen for fibrin clot formation and growth factors ⁄ cytokines ⁄ matricellular proteins to initiate granulation tissue formation, activate ... decorated PLGA nanoparticles for delivery of 5-fluorouracil Drug Deliv 17, 561–572 Yadav AK, Mishra P & Agrawal GP (2008) An insight on hyaluronic acid in drug targeting and drug delivery J Drug Target...
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recombinant antibodies for cancer therapy, methods and protocols
... range of humoral and cellular effector mechanisms Each immunoglobulin subclass differs in its ability to interact with Fc receptors and complement and thus to trigger cytolysis and other immune ... FDA-approved as an orphan drug for the treatment of acute myeloid leukemia of patients 60 yr or older and who are not considered candidates for cytotoxic chemotherapy (44) To retarget effector cells of the ... rodent framework residues to be retained is generally unique for each reshaped antibody and can therefore be difficult to foresee Such approach was successfully used for humanizing a MAb 4D5 against...
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nanocarriers as an emerging platform for cancer therapy
... through ligand–receptor interactions, and bound carriers are internalized before the drug is released inside the cell (Fig 1) In general, when using a targeting agent to deliver nanocarriers to cancer ... 75 Nanoshells (Gold-silica) (~130) Gold nanoparticles (10–40) Nanocages (30–40) No drug (for photothermal therapy) No drug (for photothermal ablation) No drug 37, 103 104 90, 105 Dendrimers (~ ... carbohydrates, and small molecule drugs Several aptamers have also been developed to bind specifically to receptors on cancer cells, and thus may be suitable for nanoparticle-aptamer conjugate therapy41 For...
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Báo cáo sinh học: "Targeting TNF-α for cancer therapy" potx
... used to deliver gene therapy vectors into tumors For example, RGD Burton and Libutti: Journal of Biology 2009, 8:85 85.3 Table Angiogenesis factors Factors affecting endothelial proliferation and ... protein to the tumor and delivery by gene therapy We recently reported the evaluation of a potential novel gene therapy for melanoma using a targeted adeno-associated virus-phage (AAVP) vector to ... angiogenesis, tumor growth, and invasion PDGF (platelet-derived growth factor) Induces angiogenesis, cellular proliferation and migration in synergy with transforming growth factor beta (TGFB) and...
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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc
... months but started to grow towards the end of the study (8 months) on long- term exposure to tamoxifen and placebo Tumors from both groups were retransplanted into athymic mice Tumors which grew ... that long- term estrogen deprivation by an AI reduces the sensitivity of the tumour cells to therapy and interruptions to therapy allows resurgence of estrogenic stimulation leading to restoration ... of JFR and KLC AA collected data, performed analysis, drafted, revised and finalised the manuscript KLC and JFR revised and approved of the contents of the manuscript All authors read and approved...
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Báo cáo khoa học: "The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy" pdf
... infrastructure for the clinical research and trials with pragmatic goals that would be ideally suited to LMCs, few suggestions for this are: For older drugs a) To tailor treatment to patients, community and ... compared to the parent drug The key enzyme in this bio-transformation is the CYP2D6 Recent pharmacological and clinical pharmacogenetics evidence suggests that genetic variants and drug interaction ... by CYP 450 enzymes for the formation of clinically relevant metabolites 4-OH-tamoxifen and endoxifen which both have a greater affinity to the estrogen receptors and ability to inhibit cell proliferation...
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Báo cáo khoa học: "Proposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence" ppsx
... including those posterior and lateral to the aorta and the vena cava and those anterior to the vena cava had
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Báo cáo khoa học: "Target splitting in radiation therapy for lung cancer: further developments and exemplary treatment plans" pps
... withdrawn and the primary tumor alone is treated to 79,2 Gy V20 right and left lung and V25 both lungs is 49%, 22% and 26%, respectively V50 for the heart is 2% Peripheral tumor located lateral and ... right and left lung and V25 both lungs is 37%, 19% and 25%, respectively D(max) for the heart is Gy The mean dose to the primary tumor of these six patients amounts to 81,9 Gy (79,2 – 90,0 Gy), to ... proposed this method for head and neck, breast and craniospinal treatments With the availability of independently moving jaws asymmetric collimators were used to split the beam for head and neck patients...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25