local work function of catalysts and photoelectrodes

... family of cytoplasmic enzymes that are important for several aspects of leukocyte biology Both loss- and gain -of -function mutations in humans have been instrumental in our understanding of their ... the expression of ITK is extremely low and often undetectable in immunoblot analysis The activation of CD4+ cells, however, dramatically induces transcription of the ITK gene and is key for the ... differently from ITK–SYK in terms of transformation capacity, membrane localization and phosphorylation of key residues? Comparison between the activation of ITK–SYK and BTK–SYK To determine its activation...

Ngày tải lên: 14/02/2014, 18:20

... of antibodies against A band in host serum correlates with extended duration of disease and reduced lung function [20] An eight-gene cluster encodes functions for synthesis and export of A-band ... integration of the anomeric signals, the 4-keto and gem-diol forms of this compound coexist in equilibrium at an approximately : ratio Full assignment of the NMR spectra of compounds B and C and measurement ... assign C4 of compounds B and C It is of importance that a signal corresponding to C4 of compound B was observed at dC = 208.8 p.p.m and was indicative of a carbonyl group, whereas that of compound...

Ngày tải lên: 16/03/2014, 01:20

... function Φm,vac metal work function in vacuum Φs semiconductor work function ΦTaN/HfO2 effective work function of TaN in TaN/HfO2 stack ΦTaN/SiO2 effective work function of TaN in TaN/SiO2 stack ... electrode and gate oxide ΦCNL,d charge neutrality level of dielectric Φm metal work function ΦMS work function difference between gate electrode and substrate Φm,eff effective work function Φm,vac ... thickness) and (b) effective work function of TaN as a function of RTA temperature with and without HfN capping layer on top of the TaN/SiO2 stack 71 Fig 3.5 (a) Gate leakage measurement of HfN/TaN/SiO2...

Ngày tải lên: 14/09/2015, 17:53

... implications of the cycle of histone acetylation and deacetylation that accompanies cycles of transcription, and highlight the special significance of histone H4 lysine 16 acetylation Active chromatin and ... by Daneholt and co-workers [52,53] gave us one of our first glimpses of the true nature of transcribed chromatin In this model system, sequences immediately upstream and downstream of genes can ... with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130] However, in human cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4-K16 and defective...

Ngày tải lên: 14/02/2014, 18:20

... domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were generated by PCR and cloned ... series of GST-fused deletions of the CD2-1 region (Fig 3E) and examined the interactions between bacterially expressed proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the ... stability and rearrangement of microtubules in neuronal dendrites [13–15] and is associated with some neurological and psychiatric disorders [16,17] However, the structure– function relationship of...

Ngày tải lên: 14/02/2014, 19:20

... injury or neurodegenerative disease Synthesis and secretion of GIF in the brain Cellular and temporal localization of GIF synthesis Whilst the MT1 and MT2 isoforms are ubiquitously synthesized throughout ... Potential role of metal-binding/exchange properties of GIF in AD One of the primary pathological hallmarks of AD is the formation of b-amyloid (Ab) plaques, composed primarily of Ab(1–40) and Ab(1–42) ... investigate and understand the physiological roles of GIF within the brain Further studies are required to determine the function of GIF within the normal, injured and neurodegenerative brain, and to...

Ngày tải lên: 16/02/2014, 15:20

... patterns and processes at different levels of biological organization: from the life histories of individuals, to the structure and dynamics of populations and communities, to the fluxes and pools of ... variety of ecological phenomena, taxonomic and functional groups of organisms, and types of ecosystems Here we apply the metabolic theory of ecology to focus on some important correlates and consequences ... measuring and understanding the roles of different kinds of organisms in the flux and storage of elements in ecosystems The total biomass per unit area, W, is simply the sum of the body mass of all...

Ngày tải lên: 17/02/2014, 19:20

... colossal business of files and classifications and ledgers and statistics and registrations, an undertaking on a scale beside which Harrod's and Whiteley's and Selfridge's and Wanamaker's and the Magazin ... plates of cake, buns of a citron-yellow hue, pale pastries, ham sandwiches and packets of cigarettes The upper panels of one of its sides unfold to form a bar below and a penthouse roof above, ... metallic sides and roofs The shimmering foliage of tall trees, and a fine field of grass, which made a background to the huts, were fresh and green and restful to the eye Even the foreground of hard-trodden...

Ngày tải lên: 17/02/2014, 22:20

... essential to understand the molecular basis of Vrp1p function Like Vrp1p, Las17p and type I myosins localize to cortical patches with a polarized distribution and partially colocalize with cortical ... Vrp1p-dependent localization of Hof1p to the bud neck at elevated temperature and this in turn is important for cytokinesis and cell growth under these conditions Interestingly, mutation of K485 and R486 ... physiological role of this interaction is conserved [30,52] Interactions of Vrp1p and Las17p in yeast and WIP and WASP-family proteins in mammalian cells are direct and result in constitutive and apparently...

Ngày tải lên: 18/02/2014, 16:20

... of a hinge point at Arg53 that exhibits conspicuous minima of J(0) and J(xN) and a significant maximum of J(0.87xH), and that emerges not only within helix III, but also over a large portion of ... helix I, Ser27 and Leu34 in helix II, and Lys46 and Gln50 in the N-terminal portion of helix III For an isotropically tumbling globular molecule, in the absence of internal motions and with relaxation ... residues and hence does not conflict with the global interpretation of the data With the exclusion of the N-terminal octapeptidyl and C-terminal nonapeptidyl fragments of Glu17, Leu34 and Lys46,...

Ngày tải lên: 18/02/2014, 16:20

... extent of membrane localization of Noxo1b and Noxo1c The intensities of immunoreactive bands for HA-Noxo1b and HA-Noxo1c in (B) were quantified using a LAS-1000plus (Fuji film) image analyzer and ... Intracellular localization of Noxo1b and Noxo1c in CHO cells (A) Intracellular localization of Noxo1b (upper panels) and Noxo1c (lower panels) in quiescent CHO cells In merged images (right panels), localization ... 2006 FEBS 3665 Expression and function of Noxo1c R Takeya et al Expression of Noxo1b and Noxo1c in various human tissues To compare the distribution pattern of Noxo1b and Noxo1c, we designed variant-specific...

Ngày tải lên: 19/02/2014, 06:20

... isoforms by the excision of the prosegment and of most of the PSI [21] Conversely to what has been found in vivo [31], heavy and light chains of the processed forms of recombinant cyprosin are ... by the prosegment, but also by the 13 residues of the N-terminal of the mature enzyme and by the ÔflapÕ The anchorage of the prosegment and of part of the N-terminus in the active site cleft is ... atypical and their localizations are unexpected New questions concerning functional significance and specialization of this multigene family of proteases are now starting to be addressed and will...

Ngày tải lên: 19/02/2014, 12:20

... population of a-BTX binding a7* nAChRs which is mainly localized perisynaptically, and a less abundant population of a3* nAChRs which contain a5 and b4 subunits and in some cases b2 subunits, and is localized ... pharmacological and physiological properties of the channel In situ hybridization and immunohistochemistry data show overlapping distributions for a variety of subunits, and electrophysiological and other functional ... development of selective drugs is the identification and pharmacological characterization of the various receptor subtypes, and the determination of their precise subunit composition and physiological function( s)...

Ngày tải lên: 19/02/2014, 12:20

... Letters denote the five residues of one of the three sides of sbwAFP or six residues of one of two sides of TmAFP The strands that make up the three, parallel b-sheets of the protein are designated ... structure and PDB code shown below each panel (A) Overlap of isoform 337 with the structure of the longer isoform CfAFP-501 using the main chain of residues Thr23fiAsn90 in isoform 337 and residues ... addition of an additional one, two or three b-helical coils compared to the shorter isoforms In the case of one sbwAFP isoform, named CfAFP-501, a detailed examination of the structure and function...

Ngày tải lên: 19/02/2014, 16:20

... divergent E3 region of the receptor [15] We studied the function and trafficking of such truncated receptors, mimicking cleaved and shed receptors Moreover, we re-evaluated the function of a mutant receptor ... Leu378 and Glu409 are schematized Note that the N-terminus of the b1 and b2 mutant receptors originate in the divergent E3 region, whereas the TM409 mutant receptor is deleted of both E3 and most of ... Generation of truncated mutants corresponding either to b-subunits of the TSHR, or to a receptor deleted of almost the entire extracellular domain To understand the role of receptor cleavage and shedding,...

Ngày tải lên: 21/02/2014, 00:20

... perform immune functions This mechanism leads to activation of phenoloxidase, which oxidizes catechols, leading to the formation of toxic quinones and melanin [1,2], and to the activation of cytokines ... SPE and Easter [31] Injection of either of these M sexta proteinases into larvae stimulated the expression of antimicrobial peptide genes, suggesting that they might function in activation of ... was demon¨ strated by RNA interference experiments to function in antifungal immunity [20], and injection of the active forms of B mori and T castaneum Spatzle-1 into ¨ insects has been shown...

Ngày tải lên: 06/03/2014, 09:22

... of eRF1 Fig S11 The Ramachandran map plot (/ and w torsion angles for the protein backbone) of all 24 conformers of the NMR families of solution structures of the closed and open conformers of ... minidomain and the zinc-binding domain of the zinc finger protein Ynr046w [25] (Fig 8) The fit of the heavy atoms (Ca, C, and N) from three b-strands and the a-helices of both the closed and the open ... calculation for the open and closed conformers of the C-terminal domain of human eRF1 Fig S3 NOE map of the minidomain (residues 329– 372) of human eRF1 NMR structure and function of the eRF1 C-domain...

Ngày tải lên: 06/03/2014, 11:20

... identification and distribution of TLP genes in nature, the structural and functional characterization of the TLP from various organisms, and the evolution of TLP and transthyretin The identification of TLPs ... S dublin TLP and zebrafish TLP are found in the flexible portions of strands B and C that protrude towards the solvent and in the conformation of the long loop connecting strands D and E [17] Greater ... conformation observed in b-strands A, G and H [17] Structural nature of the TLP and transthyretin active sites One of the striking features of transthyretin is the central channel of the protein into which...

Ngày tải lên: 07/03/2014, 00:20

... steps of ribosome biogenesis and ⁄ or ribosome function Indeed, a systematic study of the incorporation of RPs into preribosomes led to the identification of the in vivo assembly pathway of the ... activity of RP mRNA for adjustment of the biosynthesis of ribosomes to the requirements of cell growth and differentiation In addition, a relevant contribution of protein turnover to the regulation of ... sclerosis complex (TSC)1– TSC2, and the mammalian target of rapamycin (mTOR) C1 complex (composed of raptor, mLst8, and mTOR) The role of TSC1–TSC2 in the translation of TOP mRNAs has been recently...

Ngày tải lên: 07/03/2014, 01:20