... alone did
not increase the extent of staining. However, in cells that
had been cocultured with CDO and a cytotoxic drug,
staining was significantly increased, indicating the presence
of senescence. ... therefore interferes with
cAMP-induced gene transcription. We have examined the
effect of this CDO alone and in combination with a range of
common chemotherapeutic agents in colorectal cancer cell
lines. ... an increase in p21
waf1
expression,
loss of CDK function, and the generation of cells with
senescence characteristics.
In the first part of the investigation, we determined the
effect of continuous...