... equal to theline drawn from the vertex of the segment to the circumference ofthe circle which is the base of the segment.5Next to these, that, in every sphere, the cylinder having a1 The later ... taken, the straight <lines> between the <two> points either all fall on the same side ofthe line, or some fall on the same side, and some on the line itself, but none on the other ... 246have the same limits): that such <lines> are unequal, when they areboth concave in the same direction and either one of them is whollycontained by the other and by the straight < ;line& gt;...
... [16,17]. The BH3domain-only proteins are a subfamily ofthe Bcl-2family involved in the initiation of apoptosis through the mitochondrial pathway. The key event in the mito-chondrial pathway is the ... The Authors Journal compilation ª 2010 FEBS 1325 The ubiquitin ligase Itch mediates the antiapoptoticactivity of epidermal growth factor by promoting the ubiquitylation and degradation ofthe ... keyregulator of cell survival [12]. Maintaining the balancebetween cell survival and apoptosis is critical in the maintenance of a healthy organism, and tipping the equilibrium in one or another direction...
... Electron density of RTA R213D in the vicinity of residue 213. The backbone and sidechains ofthe R213D substitution are shown as stereoimages in thick ball and stick andthe position ofthe Arg213 ... Electron density of RTA N122A in the vicinity of residue 122. The backbone and sidechains ofthe N122A substitution are shown as stereoimages in thick ball and stick andthe position ofthe Asn122 ... levels and, as such, these mutantscould not be purified. To assess the effect of substitutionsmade at each ofthe arginyl residues on catalytic activity of RTA, the ability of each ofthe purified...
... interms ofthe number ofthe enzymes involved, the kineticmechanisms ofthe competing enzymes andthe number aswell as the nature ofthe allosteric controls. Whether suchdiversity in the organization ... a realistic, detailed descrip-tion ofthe branch-point between the methionine and threonine biosynthesis pathways. In the following the modelis used to investigate the sensitivity ofthe two-enzymesystem ... consequence ofthe time delay in the enzymatic chain.Subtraction ofthe rate ofthe cystathionine b-lyase sidereaction from the total rate of NADH oxidation yielded the actual rate of cystathionine...
... freedom of opinion and expression, but also a range of other human rights, and to promote the progress of society as a whole. Chapter III of the report underlines the applicability of international ... technologies, for the exercise ofthe right to freedom of opinion and expression, including the right to seek, receive and impart information andthe relevance of a wide diversity of sources, as ... so, usually the judiciary, for the purpose of protecting the rights of others, for example to secure evidence to prevent the commission of a crime, and must respect the principle of proportionality.40...
... in the world and 43% ofthe global burden of disease. Based on current trends, by the year 2020 these diseases are expected to account for 73% of deaths and 60% ofthe disease burden.Low - and ... of established noncommunicable diseases.WHO has the unique authority andthe clear mandate to lead the development and implementation ofthe global strategy for the prevention and control of ... dealt with in the context of overall health system strengthening and that the infrastructure ofthe system, in both the public and private sectors, has the elements necessary for the effective...
... Montan˜oLF&Lo´pez-Marure R(2005) Dehydroepiandrosterone inhibits the prolifera-tion of HUVEC by enhancing the expression of p53 and p21, restricting the phosphorylation of RB, and isandrogen- and estrogen-receptor ... and 55 years old, and itis the second most common cause of death from can-cer among Mexican women [21]. Therefore, the aim of this work was to evaluate the effect of pharmacologicaldoses of ... not significantly, and there was nodifference between the response of each cell line. When the inhibitors were used in combination with DHEA,none of them was able to abrogate the inhibitioninduced...
... Rotterdam, the Netherlands The N-terminal domain (NTD) andthe ligand-bindingdomain (LBD) ofthe androgen receptor (AR) exhibit aligand–dependent interaction (N/C interaction). Aminoacids 3–36 in the ... carried out. The resultsare presented in Fig. 3. In the absence of ligand, none of the AR NTD proteins showed LBD interaction. However, in the presence of ligand, both AR.NTDwt and AR.NTDD3–13 ... 5787 Amino acids 3–13 and amino acids in and flanking the 23FxxLF27motif modulate the interaction between the N-terminal and ligand-binding domain ofthe androgen receptorKarine Steketee1,*,...
... the presence of sodium sulfite, a strong stimulator of ATPhydrolysis [16]. The relative rates of ATP hydrolysis of these reconstituted assemblies in the presence of either Ca2+or Mg2+as the ... sequences of truncated mutants. Listed below are the amino-acid sequences and PCR primers of truncationmutants (D)ofthec subunit of spinach chloroplast ATP synthase. The numbers in the plasmids ... deletions of c subunit up to 20 residues compared with the activ-ity ofthe abWT assembly. The inhibitory effect ofthe e subunit on ATPhydrolysis of these abc assemblies varied to a large extent. These...
... he pins the credibilitydue to the history of Richard. The questions are these, 1. Had not the queen-mother andthe other heads ofthe York party been fully assured of the death of both the young ... house of Yorkwas vested in the duchess of Suffolk and her descendants. The massacre ofthe children of Clarence and the duchess of Suffolk show what Henry the Eighth thought ofthe titles both of ... jealous ofthe earl of Suffolk, whom one bequeathed to slaughter, andthe other executed; for if the children of Edward the Fourth were spurious, and those of Clarence attainted, the right of the...
... contributionsAll ofthe authors were involved in designing the research. BE and JLLconducted the research and DD oversaw management ofthe restaurant. BEhad primary responsibility for analyzing the data and ... writing the paper, withall ofthe authors contributing by reviewing and editing drafts of the manuscript. All authors read and approved the final manuscript.Author details1University of Illinois ... USAFull listof author information is available at the end ofthe articleâ 2013 Ellison et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms ofthe CreativeCommons...
... is often decided by the couple, individuals were usually consulted on the choice of their mate. Their parents do not prevent of against their choice, they even get marriage and tell to their ... home when they are 18 years old or when they can live themselves. In the family, the role of a husband and a wife are equal. Women do not kept their family name but used their husband's ... spouses that establishes rights and obligations between them, between them and their children, and between them and their in-laws. The definition of marriage varies according to different cultures,...
... sacrosanct. In the case of FGC in Africa, understanding the function and importance of the practice in the ways of life of people in Senegal and elsewhere, and the processes by which the practice ... Canada, the Netherlands, and Britain, impose strict and, in the Introduction 7 entirely new. Rather, what is new is the number of claims, the opportunities tomake such claims, andthe publicity they ... exclusion on the basis of their identity. They may not even viewthemselves as having a distinctive identity17 and therefore are unaware thatidentity is the basis upon which they enjoy some ofthe privileges...