liposomes as carriers for controlled drug delivery

... nmol of liposomes At the indicated time points, cell-associated fluorescence was assessed For assessment of in vitro drug delivery by anti-CD134 liposomes, activated A2b cells were incubated at 37°C ... Netherlands) Liposomes used for investigating in vitro binding and internalization contained 0.1 mol% Texas red-phosphatidylethanolamine (Molecular Probes Europe) Liposomes used for studying drug delivery ... whether CD134 can be used as a target for specific drug delivery to activated auto-aggressive CD4+ T cells in arthritis For this purpose, the rat adjuvant arthritis (AA) model was studied In this model,...

Ngày tải lên: 09/08/2014, 06:22

... ordered mesoporous silicas and their potential application in controlled drug delivery The recent application of mesoporous silicas extended to controlled drug delivery has raised much interest ... contrast to small molecular drug IBU, the fabrication of controlled drug delivery system for large protein model drug BSA is more complicated, as it involves not only the properties of drug matrix ... the drug release rate can be mathematically expressed as J =− dM t = f (kt ) dt A 15 / Literature Review Drug Drug is dispersed uniformly in non-degradable matix Matrix Increasing time Drug Drug...

Ngày tải lên: 13/09/2015, 19:46

... interest of controlled release systems, the biodegradability of drug delivery systems is also taken into account with the use of poly(esters) as drug delivery materials as early as the 1970s ... on drug delivery systems Drug delivery is defined as the system to dispense a pharmaceutically active compound in the body to attain a therapeutic effect In an extension of free drugs, drug delivery ... for drug delivery purposes in the last decade [11] Multivarious drug delivery systems have seemingly evolved from the concept of nanotechnology and continue to so today The research on drug delivery...

Ngày tải lên: 30/09/2015, 06:07

... attractive vectors for gene delivery For example, the transfection efficiency of pHCMV-β-galactosidase plasmids was at least 4-fold higher when delivered by the Herpes simplex virus than by liposomes ... studied as vectors for gene delivery as their inherent cytoinvasive property offers a distinct advantage over non-viral nanoscale gene delivery platforms [Zhang and Godbey, 2006] Gene delivery ... and fPC-Dox was readily released upon dilution, with both samples exhibiting a sustained drug release profile at simulated physiological condition About 40% of the drug load was released within...

Ngày tải lên: 11/09/2015, 14:22

... minimized This assures cost reduction as a result of minimized drug consumption and shortened postoperative recovery ix Specifically, MPC was designed for regulation of hypnosis using BIS as the controlled ... are measurable On the other hand, the concentration of intravenous drug in the brain is not easily measurable As a result, anesthesiologists face more challenges in titration of these drugs as they ... therefore the response can be viewed as an approximation of an impulse response For inhalational drug, lungs compartment and for intravenous drug, the “blood” (or more appropriately, “plasma”)...

Ngày tải lên: 14/09/2015, 08:25

... properties and performance characteristics of EC gel was potentially useful for its application as a topical drug delivery system for moisture-sensitive drugs The EC gel to be selected for topical ... maintain the therapeutic drug concentration, only highly potent drugs can serve as appropriate candidate for transdermal drug delivery The most common form of transdermal drug delivery system comes ... pathway from oral drug administration The potential systemic and gastrointestinal side effects as well as variable drug bioavailability associated with first-pass metabolism for drugs administered...

Ngày tải lên: 15/09/2015, 17:10

... withdrawn from PG phase The centrifuge time for β-carotene was 15 to achieve better phase separation The solution was diluted appropriately with mobile phase solution before HPLC assay 2.5 Solubility ... Zieria and some Chinese medicinal plants like Asari Herba and Asiasari Radix [65,69,70] Asari Herba was reported to be used as a skin penetration enhancer for administration of buprenorphine [71] ... intervals for HPLC assay 2.8 In Vitro Skin Permeation Setup for Reversibility Study Epidermis was cut into smaller pieces before treatment An enhancer solution, 50 µl of 5%(w/v), or PG (as control) was...

Ngày tải lên: 16/09/2015, 08:31

... BACKGROUND AND RESEARCH REVIEW 2.1 Drug Delivery 2.2 Controlled Drug Delivery 2.3 Advantages of Controlled Drug Release 2.4 Drug Release Mechanisms Involved in Controlled Delivery Systems 2.5 11 Factors ... cases where controlled delivery is actually an enabling technology for a drug For example, the drug is unstable or highly toxic without the controlled delivery devices The most active areas for ... and controlled drug delivery systems [4] Of these methods, controlled drug delivery has attracted considerable attention Various kinds of polymeric systems have been developed for controlled drug...

Ngày tải lên: 17/09/2015, 17:20

... pH-dependent Cu release was clearly demonstrated and release was accelerated as the pH was reduced In vitro toxicity of CuCNPs in HeLa cells The toxicity of CuCNPs to cancer cells was investigated ... Cu release was observed at pH 7; however, release was much slower at this pH (particles at pH had released approximately 55% of their Cu at 12 h) compared to pH At pH 5, CuCNPs had released over ... release, which led us to further investigate Cu release as a function of competing ligand Cu release experiments conducted in 100 mM citrate buffer at pH 4, 5, and revealed faster metal release...

Ngày tải lên: 21/06/2014, 02:20

... both passive diffusion and slow matrix degradation [12,13] Page of 18 The nano -drug delivery system used here provides controlled and sustained PS-341 delivery for selective inhibition of proteasome ... Proteasome-Glo Chymotrypsin Cell Based Assay (Promega) We observed a significantly better decrease (~1.2 fold, p < 0.05) in proteasome activity when using the PLGA-PEG mediated PS341 delivery as ... the proteasome as a therapeutic target is that proteasome inhibitors may affect normal protein-processing machinery (proteostasis) The nano -drug delivery system used here provides a feasible alternative...

Ngày tải lên: 11/08/2014, 00:22

... characterization of drug- loaded polymeric micelles 81 4.3.3 In vitro drug release and drug loading of singe drug- loaded micelles 82 4.3.4 In vitro drug release and drug loading of dual drug- loaded ... carrier system for hydrophobic drug delivery for enhanced delivery of anticancer drugs to cancer cells, prolonged the circulation and sustained release Self-assembled polymeric micelles based on biodegradable ... effective system for anticancer drug delivery The system has been developed for physically encapsulating of hydrophobic drugs because most of anticancer drugs are hydrophobic in nature Self-assembled...

Ngày tải lên: 10/09/2015, 09:06

... time -controlled and/or target -controlled 22 INTRODUCTION delivery of drug In time -controlled delivery, the drug is released in a pre-determined rate while in target -controlled delivery, the drug ... 1995) C3 Drug release mechanisms of controlled release delivery system Drug release mechanisms depend on the properties of the polymeric carrier, drug and additives present The release of drug from ... obtained by decreasing stirring rate Hence, the first strategy was to employ particle size to control drug release However, this was met with limited success as drug release was retarded to a...

Ngày tải lên: 13/09/2015, 20:39

... suggested a form of delayed release where little or no drug was released for 30 days before a gradual controlled release was observable thereafter The objective of this experiment was to evaluate ... viability on days 2, and x 106 cells were collected for caspase activity level measurement using a Caspase-3/CPP32 Fluorometric Assay Kit from Biovision Caspase activities levels were determined by re-suspending ... date specifically of controlled release implants for Paclitaxel 2.1 DEVELOPMENT OF CONTROLLED RELEASE IMPLANTS FOR CHEMOTHERAPY TO THE BRAIN Over the last three decades there has been a rise in...

Ngày tải lên: 05/10/2015, 21:33

... OSM-PCLA-PEG-PCLA-OSM 1.2.2 Controlled drug/ protein delivery 1.2.2.1 Controlled drug/ protein delivery In past few years, controlled drug/ protein release to treatment for dangerous diseases such as epidemic, ... controlled release and are therefore categorized as follows [48]: Diffusion -controlled Swelling -controlled Chemically -controlled The popular drug/ protein release model from hydrogels is diffusion -controlled ... after injected to human body, and drug loading into this gel and releasing are controlled easily Then the application for drug and protein delivery systems was also investigated 1.2 Background...

Ngày tải lên: 13/05/2016, 10:14

... of as little as $233,600 and a yearly increase in revenue of $655,014 (46,720,000 x 1.402 cents) from increased meat yield The added revenue from increased meat yield alone would pay for the controlled- atmosphere ... cost of controlled- atmosphere killing as “reasonable and affordable to improving welfare of billions of poultry slaughtered for human consumption.” Payback Period Considering the increased revenue ... yield per bird can lead to a significant increase in revenue For example, with as little as a percent increase in yield, Raj (1998) estimates that, for a plant that processes 1.3 million broilers...

Ngày tải lên: 31/03/2014, 08:20

... requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, Chapter 11 for ocular delivery, ... Particle Formation 59 RESS with Solid Cosolvent for Nanoparticle Formation 63 Supercritical Antisolvent Process for Particle Formation 66 SAS with Enhanced Mass (EM) Transfer (SAS-EM) ... process, one can add compounds (e.g., polymers for controlled release) that will coprecipitate with the drug for smart drug delivery applications The key aspect of getting nanoparticles of the desired...

Ngày tải lên: 04/06/2014, 15:15

... SWCNT used as drug carriers Although there are exciting prospects for the application of CNTs as drug carriers in medicine, one of the key obstacles in the way for the use of SWCNT as drug carriers ... application of CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems ... diseases [10] This delivery system provided the first instance for nanocarriers to deliver drugs into neurons in the central nervous system, opening the door for the drug delivery system for...

Ngày tải lên: 20/06/2014, 22:20

... route was explored Similar to oral delivery, IV delivery of DCU was limited by the poor aqueous solubility of DCU The poor aqueous solubility of DCU is such that it cannot be formulated for IV delivery ... Wilmington, DE, USA) The mobile phase used was 0.1% formic acid (A) and acetonitrile with 0.1% formic acid (B) A gradient was used and is described as follows: 10% B at and hold for 0.2 min, linear gradient ... 2.0 The total run time was 2.0 min, and the flow rate was 0.75 mL/min An AB Sciex QTRAP 5500 mass spectrometer was used for detection The MRM transition monitored for DCU was m/z 225.4 to m/z 100.2...

Ngày tải lên: 21/06/2014, 03:20

... the drug from inner phase and then slower release Nevertheless, the release rate of mixed micelles was faster than that of CLE before the first 12 h, the release rate of the two formulations was ... release medium was taken and replaced by fresh medium The content of propofol in the medium was measured by HPLC method as described above The cumulative release percentage of propofol was calculated ... in the aqueous phase of the micelles and CLE, separation of the two phases was performed using ultracentrifugation Ultracentrifugation was performed at 10,000 rpm (14000 g) for 20 Amicon ultra...

Ngày tải lên: 21/06/2014, 04:20

... interface Finally, CNT-based interfaces, as demonstrated, could be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The ... reconstituted in a 0.1% BSA solution in PBS) was casted on the CNT array and then crosslinked with a 30% CaCl2 solution as previously reported for drug release assessment PC12 cells were seeded on an ... of a polymeric thin film acting as drug delivery device For drug release kinetics investigation, bovine serum albumin (BSA, A3156 from Sigma, MW = 66,430 g/mol) was added to an alginate solution...

Ngày tải lên: 22/06/2014, 00:20