like peptides and their clinical utility
Tài liệu Bank Credit - A Study of the Principles and Factors Underlying Advances Made by Banks to Borrowers docx
... source, by X, and the following equations stand forth: X= c ( 1R R ) andD~¿ ~ R Some cash might be lost as a result of rising prices and a consequent increased demand for hand to hand money 40 ... follows: Pages 13-29 and relative questions and problems 1-16 2, Pages 29-31 and relative questions and problems 17-26 xni XÎV FOREWORD TO TEACHERS Pages 32-51 and relative questions and problems 1-10 ... flexible and adaptable to the varying desires and views of share1 George Rae, The Country Banker, John Murray, London, 1885, p 253 Interviews on the Banking and Currency Systems of England, Scotland,...
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Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf
... thermotolerance, and is regulated by mouse HSF1 and chicken HSF3 through the activation of the heat shock genes [10,11] HSPs prevent the denaturation and aggregation of cellular proteins, and support their ... the SERINCI gene in human, mouse and chicken orthologous segments (Fig 1) [31] Likewise, the chicken HSF3 gene was located between Vsig4 and HEPH on chromosome 4, and orthologous segments containing ... likely to be an HSF3 pseudogene as no transcript was identified [31] Furthermore, HSF4 was located in a region between the TRADD–FBXL8 genes and the NoL3 gene in the human and mouse genomes, and...
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Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
... between the insulin receptor and Grb7 A role for two of its binding domains, PIR and SH2 Oncogene 19, 2052– 2059 Daly RJ, Sanderson GM, Janes PW & Sutherland RL (1996) Cloning and characterization of ... internalization and phosphorylation of the IR [17–19], IR content decreased in the plasma membrane fraction and reciprocally increased in the light mitochondrial–microsomal and Golgi ⁄ endosome fractions, and ... Time course and dose-dependence of in vivo insulin effects on Grb14, phosphorylated IRb (p-IRb) and IRb content in liver plasma membrane (PM) and Golgi ⁄ endosome (GE) fractions PM and GE fractions...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... the HTFN and APC and b-catenin-related factors Groups C and D involve smaller functional sets Group C contains the Rel family and CRE binding 6428 factors involved in the NFjB pathway and other ... as p300 and CBP Group D contain factors related to cell cycle and DNA repair-related factors (p53 and its direct interactors, and BCRA) It is noteworthy that it contains the structural and functional ... receptor and bHLH domains suggest that they were expanded by a diversification process derived from common ancestral genes via duplication and exon shuffling [28,55] They are believed to have expanded...
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the weakness of factors affecting sales activities at the website
... candidates to businesses, and www.khoadaotao.vn, which plays a bridge connecting trainers and learners, who have needs of study - One accountant does accounting to keep and develop capital and ... information and knowledge for their job This influences badly on their strategic planning to compete with other websites, presenting and demonstrating to the customers, etc On the other hand, the ... involved in the buying) and its buyers (their characteristics and buying styles) This step is known as the pre-approach The salesperson can consult standard sources, acquaintances, and others to learn...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
... the standard deviation of the two replicates (B and C) RAW cells were cotransfected with the pCI ⁄ ESE-1 expression vector, the NF-jB p50 and p65 expression vectors or a combination thereof and ... such as IL-1 [21], and TNF-a [21] can also induce ESE-1, and ESE-1 target genes with regard to inflammation so far identified by us include iNOS, COX-2 and potentially MMP-1 and MMP-13 (X Gu, F ... genes in normal and neoplastic cells Enzyme Protein 49, 20–37 Fournier T, Fadok V & Henson PM (1997) Tumor necrosis factor-alpha inversely regulates prostaglandin D2 and prostaglandin E2 production...
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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
... exponential growth phase, and the cells were then washed and resuspended in SMM without nitrate, and finally incubated for a further 20 Samples were taken before and after the shift, and soluble cell-free ... glutamine and AMP [9] Mutations in TnrA that result in constitutive expression of the TnrA-activated amtB promoter all lie within the C-terminal region of TnrA, and impair the interaction between GS and ... monomers, and is a small regulatory protein that belongs to the PII protein family GlnK homologs bind to AmtB and regulate its activity, depending on the cellular nitrogen status [14] Like other...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... adaptor and signalling proteins, initiate multiple signalling events [16–20] The EGFR is implicated in the control of cell proliferation and differentiation, cell survival, apoptosis and cellular ... migration The EGFR and other ErbB receptors are prone to undergo multiple mutations, gene amplification and ⁄ or overexpression processes in a variety of human cancers, thus contributing to their pathogenesis ... kinase and the capacity to transform fibroblasts, as measured by foci formation by transfected cells, and these effects are further increased by introducing additional mutations at S1057 and S1142,...
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Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
... Insulin is a polypeptide hormone that regulates glucose, lipid and protein metabolism and promotes cell growth and differentiation On ligand binding, the insulin receptor tyrosine kinase initiates ... pathway and its downstream effectors [23] This pathway is a key signal transducer of many growth factors and cytokines and has been implicated in the regulation of cell growth, cell migration and ... injury [18], and subsequently in rodent cardiac [19,20] and renal transplantation models [21] Two important mechanisms of CO protection involving p38 mitogen-activated protein kinase (MAPK) and guanylyl...
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Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt
... HuR and the neuron-specific HuD [51] The cDNAs of human HuR and HuD were cloned into prokaryotic expression vectors and recombinant GST-HuD and HuR were expressed in E coli Purified GST-HuD and ... entire cis elements, and all trans factors, including their regulation and post-translational modifications like phosphorylation, of the MARCKS mRNA will be necessary to understand the linkage of ... the nucleus and binds the 52 nt CU-rich RNA (A) Quiescent Swiss 3T3 cells were harvested and extracts separated into nuclear and cytoplasmic fraction by centrifugation (see Materials and methods)...
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Feasibility Study – The critical success factor in project management pot
... products or Services : - Demand analysis of products - Which segment (quality) and which price could be accepted at such quality - Current and future competitors • Technology and services to launch ... good at both technical and economic background • Must be experienced in similar or nearby project before • Well knowledge and good senses in Human Resource Management And the soft skills should ... have different stages in development and implementation 10 Preparation for investment Implementation of investment Investment license Operation Payment Hand-over Supervision Bidding Contracts...
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Báo cáo khoa học: Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor pptx
... 163 and 166 in sTF are adjacent to the Gla domain of FVIIa, and positions 200 and 201 are situated near EGF1 and the so-called hydrophobic stack, which is a linker between the Gla domain and ... domain and the N-terminal portion of the TF2 domain (Fig 1) Mutation and labeling of positions 99 and 104 had little effect on the FX-activating ability of the AEDANSsTF–FVIIa complex Mutation and ... the impact of mutation and labeling of sTF on FVIIa binding and enhancement of FVIIa activity The ability of the IAEDANS-labeled sTF variants to stimulate FVIIa was assessed and the Kd values for...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... serum-starved for h and then stimulated (b and d) or not (a and c) for with EGF Hrs was then immunoprecipitated and analyzed by 2D gel electrophoresis and immunoblotting with anti-Hrs Ig (a and b) or antiphosphotyrosine ... were stripped and Fig Hrs phosphorylation is caused by both EGF and TGFa Hep-2 cells were serum-starved for h and stimulated with EGF or TGFa as indicated Hrs was immunoprecipitated and phosphorylation ... images are shown to illustrate colocalization between active Src and Hrs (yellow) (d), Hrs and EEA1 (turquoise) (e) and active Src and EEA1 (purple) (f) Examples of enlarged structures are pointed...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... its Ig -like domain [14,15] The cytokine oncostatin M (OSM) first binds to gp130 and then induces heterodimerization with LIFR [12] or OSMR [16] Besides the CBM and Ig -like domains both gp130 and ... gp130 are involved in ligand binding: the Ig -like domain and the CBM [9–11] In the case of LIF-induced heterodimerization of LIFR with gp130, the cytokine first binds to the Ig -like domain of the LIFR ... Jak binding sites (box1 and box2, gray boxes) were replaced by the strongly and specifically STAT1-activating motif YDKPH of the interferon-c receptor to cytokines like IL-6 and IL-11 that lead to...
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Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... Alpha helices show negative peaks at 208 and 222 nm and a positive peak at 190 nm, while beta sheets show a negative band near 220 nm and a positive band at 190 nm Accordingly, Fig 1C shows the ... interaction with physiological ligands were synthesized The peptides (GPO)10 [20], GFOGER [21] and RGQOGVMGF [22] were cross-linked and used for SPR experiments and functional assays in vitro, ... (e) and 0.25 lM (f), and those for (B) were lM (a), lM (b), lM (c), 0.5 lM (d), 0.3 lM (e) and 0.15 lM (f) Dissociation of the aegyptin-ligand complex was monitored for 1800 s (30 min), and a...
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Báo cáo khoa học: Control of transferrin expression by b-amyloid through the CP2 transcription factor pdf
... and lipids, and are believed to be responsible for much of the cellular and tissue injury associated with reperfusion disorders [22] In cases of AD, redox-active iron is associated with NPs and ... transferrin, CP2 and b-tubulin (as a loading control) (bottom panels) The band intensity was measured, and transferrin protein levels were normalized relative to b-tubulin (C,D) After transfection and Ab ... used, and are indicated as a mutant 1, mutant and mutant The method used for mutation of transferrin promoters is described in Experimental procedures (B) Each of the constructs shown in (A) and...
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The Ubiquitous Triclosan A common antibacterial agent exposed ppt
... anti-bacterial agents and on industry to stop marketing and advertising the antibacterial qualities of their products, calling their use in households, “superfluous and risky.” He also demanded that industry ... not necessary in everyday use, and washing hands with lation between too much hygiene and increased allergies ordinary soap and warm water is an effective way to ward and asthma.28 This hypothesis ... tension of water, and thus wash away unwanted bacteria Lather hands for at least 10 to 15 seconds and then rinse of in warm water It is important to wash hands o�en, especially when handling food,...
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Báo cáo khoa học: The potyviral virus genome-linked protein VPg forms a ternary complex with the eukaryotic initiation factors eIF4E and eIF4G and reduces eIF4E affinity for a mRNA cap analogue ppt
... possible mixed-type noncompetitive ligand binding of eIF4E and the cap to the VPg was reported previously [11] However, as the amount of free and bound ligand was not determined, a nonlinear double-reciprocal ... contained three groups of polypeptide chains according to their relative molecular masses: a group with bands in the range of 180 kDa, a 54-kDa band, and a single chain of 26 kDa (Fig 4B, lane 4) The ... band (>205 kDa) corresponds to the heterotrimer eIF4G–eIF4E–VPgÆGST (% 260 kDa; Fig 4A, compare lanes 3, and 5) The intermediate band (% 80 kDa) observed in native conditions contained VPg and...
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Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx
... to R Vignali and P.D Vize for the Xenopus HNF1b and lim1, Pax2/8 cDNAs, respectively, and Elizabeth A Jones for antibodies 3G8 and 4A6 We thank Kathy Astrahantseff, Christoph Waldner and Karin Dudziak ... Identical amino acids between b and a or human b and Xenopus b sequences are shown and conserved amino acid changes are indicated by + well as the developing kidney, liver, gut and pancreas express HNF1b ... cyst -like structures or thickening of the tubules (Fig 6E,F), similar to the fraction showing this phenotype in Pax8 and lim1 coinjected embryos (Table 1) Therefore, cyst -like structures and thicker...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose