... MapReduce is fundamentally a batch processing system, and is not suitable for interactive analysis You can’t run a query and get results back in a few seconds or less Queries typically take minutes or ... be analyzed For example, a SETI@home work unit is about 0.35 MB of radio telescope data, and takes hours or days to analyze on a typical home computer When the analysis is completed, the results ... attribution An attribution usually includes the title, author, publisher, and ISBN For example: “Hadoop: The Definitive Guide, Fourth Ed‐ ition, by Tom White (O’Reilly) Copyright 2015 Tom White,...
Ngày tải lên: 13/09/2016, 11:24
... Maryland Family Network is to ensure that young children and their families have the resources to learn and succeed Our Programs promote high quality child care, school readiness, and family support ... Family Network 1001 Eastern Ave., Second Floor Baltimore, MD 21202 Phone: 410-659-7701 Email: info@marylandfamilynetwork.org Website: www.marylandfamilynetwork.org Copyright 2010 Maryland Family ... success childhood experiences Success in school is built on the experiences a child has from birth to age – before he enters kindergarten Parents are the key to their child’s success...
Ngày tải lên: 24/02/2014, 18:20
DNA, RNA and proteins
... Mutations – Lets looks at different mutations THE DOG BIT THE CAT DNA and Mutations - Substitution THE DOG BIT THE CAT • Substitution - Replace just one letter: THE DOG BIT THE CAR DNA and Mutations ... protein production is complete, the ribosome releases the protein chain DNA and Protein Synthesis - Summary DNA and Protein Synthesis Practice making mRNA using the DNA template DNA and Protein Synthesis ... Synthesis DNA and Protein Synthesis • Codon: three bases code for a specific protein: ex: AAA = Lysine • The codons code for 20 amino acids • Just like the alphabet has 26 letters to make all...
Ngày tải lên: 13/03/2014, 16:38
Turning Many Projects into Few Priorities with TOC pot
... coordinated way.” In such a system, proficiency at managing single projects individually without proactively dealing with the interactions between them is not sufficient to assure the attainment ... capability of a resources and the pressure to multitask that is the commonly used and heavily loaded synchronizer usual result of these peak loads Once a synchronizer resource, is well within the ... conclusion buffer is sufficiently consumed to indicate heightened that it is enough to keep as little as one resource risk of the project promise, then it is clear that the effectively utilized to...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins docx
... positively (Arg, His, Lys) and negatively (Asp, Glu) charged residues, blue and red, respectively; hydrophilic residues (Asn, Gln, Ser, Thr), grey The figure was prepared using MOLMOL [31] probably ... respectively, than with 10 lm tyrosine, and there was still discernible production of PpiB when both amino acids were omitted This is presumably because of the presence of a trace of tyrosine as a contaminant ... staining by Coomassie Brilliant Blue, and only newly synthesized proteins were detected, including some minor species presumed to have been produced by proteolysis and ⁄ or premature termination of...
Ngày tải lên: 16/03/2014, 22:20
báo cáo khoa học: "Detection of DNA mismatch repair proteins in fresh human blood lymphocytes - towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening" doc
... level is substantially reduced ("plus” symbols) in some fresh lymphocyte samples and MSH2 is reduced ("diamond” symbols) in other samples In contrast, analysis of PHA stimulated fresh lymphocytes ... MMR proteins, lymphocytes were stimulated with a mitogen, PHA Cell lysates were then prepared For optimized expression of MLH1 and MSH2 proteins, fresh blood lymphocytes were routinely stimulated ... detectable in fresh lymphocytes (Figure 2A) MLH1 and MSH2 levels increased equally after stimulation by PHA (Figure 2B) MLH1 and MSH2 were readily detectable in immortalized lymphocytes and PHA treatment...
Ngày tải lên: 10/08/2014, 10:21
Báo cáo y học: "Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins" doc
... as likely kinetochore subunits (Figure 4) Regardless of which fungi contributed to the sequence blocks, the most highly conserved kinetochore subunits were invariably regulatory proteins such as ... closely related to a novel family of fungal proteins than the Nnf1 family The human kinetochore protein CENP-H is more closely related to a novel family of fungal proteins than the Nnf1 family ... strongly imply that all organisms with CDEI-II-III point CENs arose from a relatively recent common ancestor and CBF3 subunits are mapped on a phylogenetic tree (constructed using the highly conserved...
Ngày tải lên: 14/08/2014, 16:21
Turning Data into Information
... verify things such as allowing only numeric columns to be used with the Sum aggregate function The catch block will capture such problems at runtime Just after the “Display the results” comment, ... verify things such as allowing only numeric columns to be used with the Sum aggregate function The Catch block will capture such problems at runtime Just after the “Display the results” comment, ... method C# DataView managersOnly = new DataView(employees); managersOnly.RowFilter = "IsManager = true"; Visual Basic Dim managersOnly As New DataView(employees) managersOnly.RowFilter = "IsManager...
Ngày tải lên: 03/10/2013, 00:20
Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
... originally supposed that the p53 homologs have redundant functions in the regulation of gene expression, more recent data suggest that p73 and p63 proteins not act as ‘classic’ tumor suppressors, ... p53DBSs did not apparently influence p53 sequence-specific DNA binding Results To analyze the sequence-specific DNA binding of p53 and p73 proteins, we designed 50-mer oligonucleotide substrates bearing ... p53 family proteins does not appear to be straightforward The results of our in vitro binding experiments suggest that the expression of various p53 downstream genes might be differentially affected...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khoa học: Differentiation stage-dependent preferred uptake of basolateral (systemic) glutamine into Caco-2 cells results in its accumulation in proteins with a role in cell–cell interaction pptx
... side Higher glutamine concentrations in the medium resulted in higher glutamine uptake by the cells (Fig 1A) Uptake of apically and basolaterally administered glutamine was significantly different ... systemic routes can be used interchangeably to supply the enterocytes with glutamine Altogether, these data not allow a conclusion on the preferred side of glutamine supplementation Although the uptake ... glutamine is dependent on the dose and route of supplementation Data from a meta-analysis suggested that glutamine supplementation in critically ill patients may be associated with a decrease...
Ngày tải lên: 20/02/2014, 01:20
Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... similar to those of disordered poly(Lglutamic acid) at high pH and poly(L-lysine) at low pH [18,19] Accordingly, the ROA spectra of disordered poly(Llysine) and poly(L-glutamic acid) are reproduced ... usually contribute A similar positive band at » 1320 cm)1 dominates the ROA spectra of disordered poly(L-glutamic acid) at pH 12.6 and poly(L-lysine) at pH 3.0 (Fig 1) As these disordered polypeptides ... ROA spectra of disordered poly(L-glutamic acid) (top pair) and poly(L-lysine) (middle pair) in aqueous solution at pH 3.0 and 12.6, respectively, and of native human lysozyme at pH 5.4 (bottom...
Ngày tải lên: 21/02/2014, 15:20
Báo cáo khoa học: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria doc
... Cox10p suggests that it is an important step in the biogenesis of these subunits and subsequently the holoenzyme Assembly analysis of mitochondria 35 S-labeled Cox6a in patient The assembly of subunit ... important step in assembly of the holoenzyme Results In vitro import and assembly of nDNA-encoded complex IV subunits The assembly of a number of nDNA-encoded complex IV subunits was investigated ... the BN-PAGE analysis of nDNA-encoded complex IV subunits, it can be concluded that some newly imported subunits can assemble with pre-existing subunits into holo-complex IV Other subunits not integrate...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteins pptx
... Additionally, analysis of complex I from the gel shift in Fig 2A showed a comparable footprint pattern These results suggest a surprising possibility that complexes II and I may be closely related ... of the AATAAA sequence, respectively, competed slightly differently (Fig 2A, lanes 8–11) from Mut1 with both complexes These results show that the putative polyadenylation signal AATAAA, and also ... Methylation interference analysis The 3¢ end-labelled D-TERM DNA probe prepared as described above was partially methylated using dimethylsulphate essentially as described by Maxam and Gilbert [28]...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals pdf
... molecular cargo either directly or indirectly through adaptor proteins such as importin a Importin b is unable to bind directly to classical nuclear targeting motifs such as the NLS of SV40 T-ag ... Sf9 cells and subsequently analyzed by fluorescent microscopy The results show that lack of the fulllength flexible C-terminal region, containing both of the predicted signals, totally abolished ... the C-terminus, including only the second predicted NLS, were deleted, the pattern of subcellular distribution was also exclusively cytoplasmic (Fig 2C) These results suggest that the PEKRKQE(320–326)...
Ngày tải lên: 15/03/2014, 11:20
Báo cáo khoa học: 3¢- to 5¢ DNA unwinding by TIP49b proteins docx
... mostly hexamers (Fig 1B, left), whereas fraction mostly contained TIP49b monomers (Fig 1B, right) 2706 440 158 67 43 2000 A kDa 20 Hexamer 15 Monomer mAU 10 0 20 40 mL 60 80 100 B TIP49b: Hexamer ... elucidated, particularly in view of such diverse functions Although ATP hydrolysis is most likely essential for the functions of these proteins [7,8], most biochemical analyses of TIP49 proteins ... and open circles, respectively) D E mately 30 nucleotides Additionally, we note that both proteins were unable to unwind either blunt-ended short DNA substrates, such as three- and four-way junctions...
Ngày tải lên: 15/03/2014, 11:20
The future of internal audit is now Increasing relevance by turning risk into results pot
... and assurance reviews • Thematic audits • Issue-based audits 6% 5% Annually 40% Semiannually Quarterly No longer an annual process, the audit plan must be refreshed regularly (e.g., quarterly) ... CAEs in our survey And yet, only 18% of respondents use support of key business initiatives as a metric to measure internal audit’s effectiveness To help internal audit execute effectively and achieve ... presentations 57% 34% 63% Issue tracking 31% 6% Issue tracking 10% 59% 20% 37% Policies and procedures 59% 10% 5% Work planning 14% 0% 28% Issue reporting 53% 6% 4% 67% Issue reporting 29% 30% 40%...
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: DNA mediated disassembly of hRad51 and hRad52 proteins and recruitment of hRad51 to ssDNA by hRad52 pot
... soluble forms Consequently, the resultant ssDNA– protein complexes formed (see Fig 5) are soluble as they are recovered in the supernatant fraction of the assay Both of the assays suggested that addition ... (A) in the absence of any nucleotide cofactors and later subjected to centrifugation and the resulting pellet and supernatant were analysed by SDS PAGE followed by silver staining (C) Dynamic ... legends) at 37 °C for h Samples were subjected to native PAGE (6% acrylamide) in TBE buffer at 200 V for h at room temperature (25 °C) Subsequently the proteins were visualized by silver staining Experimental...
Ngày tải lên: 16/03/2014, 14:20
turning science into business patenting and licensing at public research ppt
Ngày tải lên: 18/03/2014, 15:22