lab automation and drug discovery research

... (Bone), Majja (marrow and myeloid tissue) and Shukra (Sperm/Ovum)} and waste products or malas { mutra (urine), purisha (faeces) and sveda (sweat)} (Vasant, 2005) 2 Drug Discovery Research in Pharmacognosy ... adulterated and not comply with the standards prescribed for authentic drug Drug adulteration The adulteration and substitution of herbal drugs is the burning problem in herbal industry and it has ... molecules Preliminary tests and screenings on plant extracts are faster and easily done following standard procedures and methods in manuals and literature They detect the presence and amount of basic...

Ngày tải lên: 27/06/2014, 10:20

... metabolism-relevant ligands Click here data file bio-ligands Ligands and theand2 of bio-ligands and binding ATP, ligands Additionalfor file 1ownerships of metabolism-relevantADP and block numbers ... ACD-SC-derived ordinary molecules; Ligands, sc-PDB-derived ligands; Ligands (≤ 3), ligands covering ≤ folds; Ligands (4-9), ligands covering 4-9 folds; Ligands (≥ 10), ligands covering ≥ 10 folds Implications ... 0.43 80 Ligands (≥ 10) Acceptor 3.87 Ligands (4-9) 8.21 0.90 24 Molecules 3.35 0.05 2,184 Ligands 5.87 0.09 2,176 2,072 Ligands (≤ 3) 0.09 7.69 0.53 80 Ligands (≥ 10) AlogP98 5.74 Ligands (4-9)...

Ngày tải lên: 14/08/2014, 08:20

... Bioinformatics and cheminformatics in drug discovery The combination of random screening and rational drug design have played an important role in drug discovery [44] The traditional drug discovery ... targets and drug of the approved, clinical trial, and experimental drugs These database lead to a better understanding of the disease and benefit for drug discovery Src promotes tumour invasion and ... been made for drug discovery, the successful drugs did not increase significantly over the past few decades Bioinformatics and cheminformatics tools are explored to make drug research and development...

Ngày tải lên: 10/09/2015, 09:04

... to generate patient and disease specific pluripotent stem cells in two folds One, making such cells helps us in research to understand disease mechanisms, drug screening and toxicity studies ... assays as a standard of hESCs as a model for drug discovery 29 One of the major areas of stem cell differentiation research is the derivation of osteolineage for bone tissue engineering and bone reconstruction ... the implant, but also helps us to understand development of osteoblast cells that constitute the bone and their function In sum, either as a model for drug discovery or implant testing, hESCs are...

Ngày tải lên: 16/10/2015, 15:38

... Facilitating Drug Discovery 1.4.1 Overview of emerging technologies of drug discovery 1.4.2 The need of drug target databases for drug discovery 1.4.3 Adverse drug reaction (ADR) target database for drug ... QSAR in drug discovery have become supported by QSAR databases [Hansch, 1995; http://mmlin1.pha.unc.edu/~jin/QSAR/] 1.4.2 The need of drug target databases for drug discovery Drug discovery and development ... the small and medium size databases These are functional databases and often able to aid in biological/medical research, drug discovery, and human healthcare CHAPTER Figure 1.1 The collaboration...

Ngày tải lên: 17/09/2015, 17:19

... (2009) Ligand efficiency and fragment-based drug discovery Drug Discov Today 14:278–283 83 Orita M, Ohno K, Niimi T (2009) Two ‘golden ratio’ indices in fragment-based drug discovery Drug Discov ... Fragment and Virtual Screening 61 Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey, and Roderick E Hubbard Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery ... approaches in drug discovery, 2006; Zartler and Shapiro, Fragmentbased drug discovery: a practical approach, 2008; Kuo, Fragment based drug design: tools, practical approaches, and examples, 2011)...

Ngày tải lên: 29/05/2014, 23:54

... drug discovery and development Drug Discovery Today 11: 806-811 [14] Lowe JA, Jones P, Wilson DM (2010) Network biology as a new approach to drug discovery Current Opinion in Drug Discovery and ... These and many other such studies describe the way of incorporation of safety aspect in drug discovery process for Ayurvedic drugs Concept of Drug rediscovery” Contemporary Drug discovery and ... extension of Drug rediscovery from ayurvedic drugs can be done for benefit of contemporary science of medicine and that would be “stage drug discovery based on 16 Drug Discovery and Development...

Ngày tải lên: 27/06/2014, 17:20

... has evolved in training and practice, is collaborative between the mother and the consultant, and does not involve an expert driven demonstration of the infant's behavior and functioning The authors ... exposed, preterm infants) used in research and clinical settings (Boukydis & Lester, 1999 [20]; Boukydis, Bigsby and Lester, 2004 [21]; Bigsby, Boukydis, Andreozzi and Lester, 2004[24]) as well as ... G: Women living with drug abuse and HIV disease: Drug abuse treatment access and secondary prevention issues J Psychoactive Drugs 1995, 27(4):401-411 Jones HE: Drug addiction during pregnancy...

Ngày tải lên: 11/08/2014, 18:20

... hypoglycaemic drugs The symptoms of both forms of diabetes are similar (and include tiredness, extreme thirst and related copious urine production) The onset of type is more insidious, and patients ... antipsychotic drugs, which can increase both glucose and lipid levels and often increase weight It may also have a role in treating polycystic ovarian syndrome which can cause obesity and infertility ... used drug to treat type diabetes, and is one of only two oral antidiabetic drugs on the World Health Organization (WHO) list of essential medicines However, we still not completely understand...

Ngày tải lên: 12/07/2015, 15:49

... applied for the selection and prioritization of compounds in drug discovery The research work has been allocated into four parts, each catering to a different stage of the drug discovery process In ... In the next step, the candidate drug enters the development process (clinical trials) in which it will be tested in humans for its efficacy and safety Novel drug discovery and development is known ... SRC validation and test sets selected by the scoring scheme Dashed lines and circles denote aromatic bonds and atoms respectively Continuous lines and circles denote aliphatic bonds and atoms respectively...

Ngày tải lên: 08/09/2015, 22:12

... Lin, Mr Patel Dhavalkumar Narendrabhai and Dr Sogand Zareisedehizadeh Also I must thank research assistants and lab technologists in Departments of Pharmacy and Pharmacology, namely, Ms Yang Jun, ... Linearity, LOD and LOQ data of α-amyrin and β-amyrin standard calibration curves 162 Table 5.3 163 Table 5.4 Absolute and analytical recovery of α-amyrin and βamyrin Stability of α-amyrin and β-amyrin ... amyrin standard and (C) β- amyrin standard 65 Figure 3.2 Gas chromatograms of (A) 70% methanol extract of A elliptica, (B) hexane fraction, (C) α-amyrin standard and (D) β-amyrin standard 67...

Ngày tải lên: 10/09/2015, 08:25

... wet -lab experiments will enter the next phase of drug discovery From hit to lead to clinical trial drugs and to approved drugs, the drug discovery process is still time and money consuming (48) and ... Therapeutics and Applications in Drug Discovery x Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery List of Tables Chapter Table Statistics of the drug targets, drugs and their ... multi-target drugs and drug combinations, which are more efficacious and vii Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery less prone to resistance than single-target drugs...

Ngày tải lên: 12/09/2015, 09:10

... 1.2.2 Ideal drug candidates An ideal drug combination should consist of at least three drugs that are active against drug susceptible and drug resistant (MDR and XDR) tuberculosis and produce ... SB Pharmacokinetics and pharmacodynamics of anti-infective drugs: approaches and challenges in drug discovery and development International conference on Pharmacology and Drug Development, 9th ... of multi -drug- resistant and extensively -drug- resistant (MDR-TB and XDR-TB) TB strains Today, treatment for drug- resistant TB relies on the second-line drugs [aminoglycosides (kanamycin and amikacin),...

Ngày tải lên: 22/09/2015, 15:17

... understanding of computational models for drug discovery, and introduces chemically intuitive interpretations Thereby, we hope to contribute to further enhanced communication in interdisciplinary drug ... Clinical Development Drug Discovery Figure 1: The major steps of the drug development process determine whether it is safe to test the drug in clinical trials, where the drug is tested in a group ... potency values, and the profiling of ligands against a panel of related targets Aside from the development of LBVS methods, understanding the resulting models is a key aspect in drug discovery Beneath...

Ngày tải lên: 26/11/2015, 09:59

... OPEN DISTRIBUTED AUTOMATION AND CONTROL WITH IEC 61499 Open Distributed Automation and Control Open Distributed Automation and Control with IEC 61499 with IEC 61499 • ... DISTRIBUTED AUTOMATION AND CONTROL WITH IEC 61499 IEC 61131-3: Modern (1993) Software IEC 61131-3: Modern (1993) Software Engineering for Automation and Control Engineering for Automation and Control ... interaction JHC/2001-04-03 p 17 OPEN DISTRIBUTED AUTOMATION AND CONTROL WITH IEC 61499 Open Distributed Automation and Control Open Distributed Automation and Control with IEC 61499 with IEC 61499 •...

Ngày tải lên: 20/08/2012, 11:15

... Web mining is a very hot research topic which combines two of the activated research areas: Data Mining and World Wide Web The Web mining research relates to several research communities such ... objects (products, service, pages etc) and subjects (users), categorization of objects and subjects, mapping between and across objects and/ or subjects, and determination of the set of actions ... navigation pattern discovery and web site personalization has special meaning for the e-commerce society and the Web marketplace allocation, and will be very helpful for both Web user and administrator...

Ngày tải lên: 31/08/2012, 16:46

... resistance) [24] Monitoring HBV Drug Resistance Several options are currently available to monitor HBV drug resistance, and can generally be divided into genotypic assays and phenotypic methods The ... United States, and Central Africa; B and C predominate in Asia; D is associated with southern Europe, the Middle East, and India; E is uniquely African; and F is found in Central and South America ... Not well standardized Can indicate and confirm emergence of antiviral resistance Wide variation in test sensitivities Direct marker and gold standard for HBV viral replication No gold standard among...

Ngày tải lên: 03/11/2012, 09:41

... when and what the crontab command Used to manipulate the crontab files Useful commands for examining the current status of your system’s file system include df and du Commands for examining and ... sections are: · · disk and file system observation The commands du and df process observation and manipulation The commands ps, kill, nice and top df df (disk free) summarises that amount of free ... pages for the sa command for more information Page 372 So what? This section has given a very brief overview of process and login accounting and the associated commands and files What use these...

Ngày tải lên: 19/10/2013, 02:20

... gloves, and outer garments, and from raw product to processed product; (4) Maintenance of handwashing, hand sanitizing, and toilet facilities; (5) Protection of food, food packaging material, and ... September and 15, 1999, November 16 and 1, 1999, and February 2, 2000 FDA, DHHS, Hazard Analysis and Critical Control Point (HACCP); Procedures for the Safe and Sanitary Processing and Importing ... allergens; and (9) Physical hazards (d) Processors should evaluate product ingredients, processing procedures, packaging, storage, and intended use; facility and equipment function and design; and plant...

Ngày tải lên: 25/10/2013, 21:20