kinematics of a particle dynamics

... structures and interactions of feedback loops, and consists of variables for cause and effect, and causal links. A causal link con- nects a cause variable with an effect variable by a link with a positive ... num- ber of simulation steps along the time axis. System Dynamics makes extensive use of diagrams, especially of two types: causal loop, and stock and flow. Causal loop A causal-loop diagram identifies ... Burns , Musa : Structural Validation of Causal Loop Diagrams. Proceedings of the Atlanta SD Conference: July 2001; Atlanta . 49. Richardson G: Problems with causal-loop diagrams. System Dynamics Review...

Ngày tải lên: 18/06/2014, 17:20

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Ngày tải lên: 05/09/2013, 15:28

... Republic, Trinidad and Tobago, Uruguay, and Venezuela); CABEI in Belize, Costa Rica, the Dominican Republic, El Salvador, Guatemala, Honduras, Nicaragua, Panama; and Argentina and Colombia outside ... this, we use a great amount of quantitative data from the annual reports and financial databases of MDBs that the FORO Nacional Internacional research program has been tracking periodically. The ... subregion, and; CDB in Anguilla, Antigua and Barbuda, the Bahamas, Barbados, Belize, British Virgin Islands, Dominica, Grenada, Guyana, Haiti, Jamaica, Montserrat, St. Kitts and Nevis, St. Lucia, St....

Ngày tải lên: 16/02/2014, 06:20

... Ma J & Jiang H (2005) Conformational transition of the amyloid b-peptide. Proc Natl Acad Sci USA 102, 5403–5407. 25 Lemkul JA & Bevan DR (2008) A comparative molecu- lar dynamics analysis ... phenomenon. A greater knowledge of the most basic interactions between Ab and a model mem- brane can lead to a more complete understanding of the membrane-aided assembly of Ab and the resulting damage ... Area per lipid headgroup as a function of time for control DPPC simulations. Fig. 5. Area per lipid headgroup as a function of distance from the protein; simulations A1 and A2 are shown at each...

Ngày tải lên: 18/02/2014, 08:20

... mechanochemical nature of a- CT catalysis A more detailed analysis of the influence of chemical glycosylation on the dynamics of a- CT from the theor- etical simulations was additionally performed to gain a deeper ... modeled. Table S4. Average rmsd (A ˚ ) for the conserved catalytic residues calculated from MD simulations of a- CT and the various Lac -a- CT conjugates modeled. This material is available as part of ... quantitative analysis of the HX decay data was done by a two-exponential model: X ẳ A 1 exp k HX;1 ịt ỵ A 2 exp k HX;2 ịt ỵ A 3 where A 1 , A 2 , and A 3 are the fractions of the fast, slow and stable...

Ngày tải lên: 19/02/2014, 05:20

... immunoprecipi- tated with antisera directed against P48 and TF, analyzed on SDS/ PAGE and visualized with a PhosphorImager. (B) Quantification of data presented in panel (A) , after correction for translation ... directed against SecA, indicating that it is a complex of the radiolabeled (G-10L)94PhoE and SecA (Fig. 4B, lane 1). In addition, cross-linking adducts of  220 kDa and  40 kDa were also immunoprecipitated from ... a- helical core region as indicated. The leader peptidase cleavage site is depicted with an arrow. Table 1. Bacterial strains and plasmids used in this study. Ts, temperature sensitive. Cam r and Amp r ,...

Ngày tải lên: 08/03/2014, 09:20

... increase active-site local stability and reduce catalytic activity of a cold- adapted alkaline phosphatase. Biochim Biophys Acta 1774, 679–687. 32 Janeway CML, Xu X, Murphy JE, Chaidaroglou A & Kantrowitz ... Riccardi L, Villa C, Fantucci P & De Gioia L (2006) Flexibility and enzymatic cold-adaptation: a comparative molecular dynamics investigation of the elastase family. Biochim Biophys Acta, Proteins Proteomics ... mutated W274 to either a lysine (analogous to E. coli AP) or a histidine (analogous to mammalian APs). The spin-label was placed at residue 67 in both cases. Studies on E. coli AP have shown that K328...

Ngày tải lên: 16/03/2014, 01:20

... human alpha-lactalbumin by molecular dynamics simulation. J Mol Biol 306, 329–347. 31 Marchi M & Ballone P (1999) Adiabatic bias molecular dynamics: a method to navigate the conformational space of complex ... exploration of the conformational space outside the native state at room temperature was car- ried out by a biased molecular dynamics (BMD) scheme, similar to that used by Paci et al. [30]. All ... Gillespie JR, Talapatra A, Minert LJ, Ionescu-Zanetti C, Millett I & Fink AL (2001) Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates. Biochemistry 40,...

Ngày tải lên: 16/03/2014, 23:20

... structure of a- syn showed that a- syn homodimers can adopt nonpropagating (head-to-tail) and propagating (head-to-head) conformations. Propagating a- syn dimers on the membrane incorporate additional a- syn ... Abnormal accumulation of NACP ⁄ a- synuclein in neurodegenerative disorders. Am J Pathol 152, 367–372. 5 Wakabayashi K, Matsumoto K, Takayama K, Yoshi- moto M & Takahashi H (1997) NACP, a presynaptic protein, ... molecular mode- ling and molecular dynamics simulations, in combina- tion with biochemical and ultrastructural analysis, that a- syn can arrange into homodimers that can adopt nonpropagating and...

Ngày tải lên: 23/03/2014, 09:21

... sensitivity of the stochastic model as a function of frequency. This was done using Equation 7 and a Gaussian external force that was band-limited to 200 Hz and had a standard deviation of 1 pN. For each choice ... the basis of Equation 7 for a random Gaussian force that was band-limited to 200 Hz and had a standard deviation of σ s = 1pN.(b) Sensitivity as a function of the amplitude of the sinusoidal external ... contributions AS, LH and AN carried out simulation and bifurcation analysis of the deterministic model. AN carried out calculation of the Lyapunov exponent. KD and BL carried out numerical calculations of...

Ngày tải lên: 20/06/2014, 23:20

... E 2 are locally asymptotically stable and E 3 is a saddle. There exists the global stable manifold W s (E 3 ) that separates the positive quadrant so that all orbits below this manifold are attracted ... 〚u 1 ,u 2 〛 other than u 1 and u 2 , then the interior of 〚u 1 ,u 2 〛 is either a subset of the basin of attraction of u 1 or a subset of the basin of attraction of u 2 . Kalabušić et al. Advances in Difference ... There exists a continuous increasing curve W E which is a subset of basin of attraction of E. All orbits that start below this curve are attracted to (+∞, 0). All orbits that start above this curve are attracted...

Ngày tải lên: 21/06/2014, 00:20

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Ngày tải lên: 07/08/2014, 10:21

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Ngày tải lên: 26/10/2014, 14:31