k b target genes as therapeutic targets in ibc
Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
Ngày tải lên :
06/03/2014, 09:22
... quadruplex-binding small molecule was first demonstrated using a disubstituted anthraquinone derivative [20] Many quadruplex-binding ligands have been reported G-quadruplexes as cancer drug targets subsequently ... J, Koebel P, Giraud-Panis MJ, Kaplan H, Kolkes A, Shin-Ya K < /b> et al (2006) The G-quadruplex 15 16 17 18 19 20 21 22 ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces ... protocol assay to quantitate telomerase inhibition by small molecules Anal Biochem 380, 99–105 25 Kim MY, Vankayalapati H, Shin-Ya K,< /b> Wierzba K < /b> & Hurley LH (2002) Telomestatin, a potent telomerase inhibitor...
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
Ngày tải lên :
11/09/2015, 16:04
... protein kinase C (Gukovskaya et al., 2004; Satoh et al., 2006) Ethanol feeding also induces a decrease in caspase expression and an increase in cathepsin B expression, indicating that ethanol abuse ... TAK1 is subsequently activated in the cytoplasm, leading to the activation of IkappaB kinase kinases (IKKs) (Shibuya et al., 1996) IKK activation leads to phosphorylation and degradation of IkappaB, ... administration of recombinant soluble fractalkine leads to an increase of neutrophil infiltration and an increase of several cytokines and chemokines in lung during acute pancreatitis In contrast, treatment...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
Ngày tải lên :
09/08/2014, 03:24
... KCNH1a, Eag1a, Eag 1b Kv 10.1 Kv 10.2 HERG, erg1, hergb Kv 11.1 KCNH erg2 Kv 11.2 KCNH erg3 Kv 11.3 KCNH elk3, elk1 Kv 12.1 KCNH elk2, BEC Kv 12.2 KCNH elk1, BEC Kv 12.3 KCNH in this channel lead ... variations in HERG currents in the mitotic cycle as shown in neuroblastoma cells [49] The Eag and HERG channels have been shown to be inhibited in tissues of varying histology by Eag and HERG blockers ... transformation by K+< /b> channels Increased expression of K+< /b> channels on cell membrane results in increased influx of Ca2+ ions resulting in increased transition of cells through G1/S phase of cell...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
Ngày tải lên :
30/03/2014, 09:20
... was no association observed in African American women (OR=0.81) This variant was found to be associated with increased breast cancer risk in all Chinese in Tianjin, Nanjing, Taiwan and Hong Kong ... 487 genes were resided in loci of high-amplitude CNA including known breast cancer genes such as EGFR, FGFR1, ERBB2, PPMID and ZNF217 In addition, several genes involved in oncogenesis such as ... 9;351(24):2519-29 [51] Nakayama N, Nakayama K,< /b> Yeasmin S, Ishibashi M, Katagiri A, Iida K,< /b> et al KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer Br J Cancer...
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Báo cáo y học: "Discovery of estrogen receptor α target genes and response elements in breast tumor cells" ppsx
Ngày tải lên :
14/08/2014, 14:21
... homolog, subfamily C, member 12 Protein folding [0006457] M62403 IGFBP4† Insulin-like growth factor binding protein 12 Signal transduction [0007165] NM_001089 ABCA3† ATP-binding cassette, sub-family ... matrices describing sites for (b) Sp1, (c) AP-1 and (d) GATA1 Both Sp1 and AP-1 are known to be involved in regulating ER binding in certain target genes GATA1 sites were included as negative controls ... Article R66 Lin et al R66.7 Table (Continued) List of putative ER target genes CTBS Chitobiase, di-N-acetyl- Carbohydrate metabolism [0005975] NM_006622 SNK serum-inducible kinase Protein phosphorylation...
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Báo cáo y học: "Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip" pptx
Ngày tải lên :
14/08/2014, 21:20
... Egr1 expression was blocked by inhibitors of EGFR, ERK1/2 and suramin This indicates that heparin-binding EGF-like ligands may be released from the irradiated cells and participate in the activation ... YI, Kim Y, Kim SY, Lee ES, Juhnn YS: G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes ... reported as bound by Egr1 indeed contain a significant increase in the frequency of EBSs Secondly, at least 43/ 283 (15%) genes are known to be UV responsive from other studies (Table S1 in Additional...
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Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
Ngày tải lên :
09/09/2015, 11:21
... xviii List of Abbreviations AIF ALP ALT AP-1 APAP APR AST ATP TTP BSA BTI CAT Apoptosis-inducing factor Alkaline phosphatase Alanine aminotransferase Activating protein-1 Acetaminophen (paracetamol) ... mixed injury by measuring the alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (TB) level in the liver function test (LFT) Among the three types of liver injury, ... Proteins Removal the source of injury Healing and repair injury Maintain homeostasis Figure Acute phase response and induction of acute-phase protein expression by TNF- cytokines and IL6 cytokines...
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Báo cáo y học: "Garden of therapeutic delights: new targets in rheumatic diseases" pptx
Ngày tải lên :
09/08/2014, 01:22
... respectively The cascade generally has three levels (shown on the left), including the MAP kinase kinase kinases (MAP3Ks), which activate the MAP kinase kinases (MAPKKs or MKKs), which, in turn, activate ... JNK activation after cytokine stimulation of FLS [44] Since cellular stress events can bypass MKK7 and use MKK4 to stimulate JNK, targeting MKK7 could be safer than broadacting JNK inhibitors Based ... ATF2, activating transcription factor-2; ERK, extracellular signal related kinases; JNK, c-Jun N-terminal kinase; MAPKAPK, mitogen-activated protein kinase-activated protein kinase; MEK1/2, mitogen-activated...
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Báo cáo y học: "4th meeting of the EU research network EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004" pot
Ngày tải lên :
09/08/2014, 01:23
... valuable data about new susceptibility genes By making use of adenovirus-based and cell-based transfers, the feasibility of novel therapeutic interventions will be capable of determination in future ... protein 1) to its surface Binding is mediated by two types of plasmidencoded protein, class I (20 kDa proteins) and class II (27.5–35 kDa proteins) Outer surface protein E was described as the ... antiapoptotic proteins Bcl-2 and members of the inhibitor of apoptosis family (cIAP-1, XIAP and survivin, which directly bind to and inhibit caspases), was strikingly reduced Dr Brigitte Mueller-Hilke (University...
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Báo cáo y học: " Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience" pdf
Ngày tải lên :
09/08/2014, 10:21
... in osteoarthritis with IL-1β blockers? It is indeed tempting to compare IVD degeneration to OA because the profile of cytokine production in human IVDs looks like the one observed in OA and because ... tolerability of a single intra-articular injection of anakinra (50 or 150 mg) in 170 patients with symptomatic OA of the knee [9] There was no improvement in knee pain, function, or measures ... Martel-Pelletier J, Lascau-Coman V, Dupuis M, Moldovan F, Sheppard M, Krishnan BR, Pelletier JP: In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention...
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Báo cáo y học: "Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as control" doc
Ngày tải lên :
09/08/2014, 14:20
... to genes: doubling the sample size Biometrics 1997, 53:1253-1261 Purcell S, Neale B, Todd-Brown K,< /b> Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a ... Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, Defelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker ... Borderline deviation from Hardy-Weinberg equilib- rium was found for HLA-DRB1*01 in controls and for *07 in cases (Table 6) Except for HLA-DRB1*01, all association results confirmed our assumption...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
Ngày tải lên :
09/08/2014, 14:22
... disease activity biomarkers has been remarkable and many potential new indicators of lupus activity have been recently uncovered Many of these novel biomarkers are only now beginning to be evaluated ... 18 Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW: Interferon-inducible gene expression signature in ... patients can be dissected based on their autoantibody profile and associated clinical organ manifestations, but they are also strikingly influenced by the genetic background [8] In a recent multivariate...
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Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes potx
Ngày tải lên :
10/08/2014, 05:21
... the binding site in T-ALL cells could be double E-boxes[17] Both LMO2-L and LMO2-S can interact with all these partners including LDB1, GATA1, TAL1 and E47 in a similar manner, but the binding ... amylose resin without recombinant protein and incubated with K5< /b> 62/Jurkat total protein; MAL-β-galactase, sample of purified MAL-β-galactase incubated with K5< /b> 62/Jurkat total protein used as a control; ... staining (Fig 3B) and both cleaved and fusion LMO2-L/-S protein could be detected by Western blot using anti-LMO2 antibody as arrows indicated (Fig 3C) In the MBP-pulldown assay, purified MBP-LMO2-L...
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báo cáo khoa học: " Identification of miRNAs and their target genes in developing soybean seeds by deep sequencing" doc
Ngày tải lên :
11/08/2014, 11:21
... identified target genes for 15 new miRNAs (Table 4); these targets belonged mainly to Class III and Class IV, like the targets of soybean or legume-specific miRNAs (Table 3) Unlike conserved miRNAs, ... MtN19-like protein induced by bruchin treatment [29] (Table 3; Figure 6b, c) Therefore, gma-miR398 may perform additional functions in soybean by targeting more genes Target genes of soybean- or ... than Arabidopsis and rice [7] In total, 207 soybean miRNAs were annotated in the miRBase database In this study, 26 new miRNAs were identified in soybean by deep sequencing and validated by experimental...
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Báo cáo y học: " Therapeutic targets for HIV-1 infection in the host proteome" pot
Ngày tải lên :
13/08/2014, 09:21
... mostly includes ribosomal subunit genes as well as genes encoding betaactin, beta-5-tubulin, & myosin light polypeptide Figure K-< /b> Means clustering analysis of Tat-induced genes K-< /b> Means clustering ... 300 200 B) cyclin A siRNA cdk9 siRNA cdk2 siRNA OBF-1 siRNA Rev-BP2 siRNA HEXA EXT2 PPGB HIV-1 Rev-BP2 OBF-1 cdk9 cdk2 No siRNA cyclin A1 100 PPGB siRNA cyclin A cdk2 cdk9 OBF-1 Rev-BP2 PPGB PARP ... action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins Oncogene 1995, 11:1581-1588 Clarke B, Chetty R: Cell cycle aberrations in the pathogenesis of...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
Ngày tải lên :
14/09/2015, 14:04
... myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and nuclear lamins (Luthi ... plethora of caspases found in mammalian systems –activator caspases caspase 2, 4, 8, 9, 10, 12, executioner caspases caspase 3, 6, and inflammatory caspases caspase 1, 5, 11 have distinct roles ... activation of caspase making caspase capable of cleaving and activating downstream caspases including caspase 3, and which now carry out the execution phase of apoptosis (Degterev et al., 2003) In addition...
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Computational study of therapeutic targets and ADME associated proteins and application in drug design
Ngày tải lên :
15/09/2015, 22:19
... therapeutic target information As indicated in previous section, three important information communities should be included in TTD: therapeutic target information, information about targets binding ligands ... bioinformatics databases, the application of biological databases is broad, both in the academia and industries In our research, three pharmainformatics* databases: Therapeutic Target Database (TTD), Therapeutically ... United Kingdom (European) EMBL SRS Databases: EMBL… Analysis Tools Getentry Databases: DDBJ… Analysis Tools Figure 1-2: Primary public domain bioinformatics servers 1.2.2 Brief introduction to bioinformatics...
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IDENTIFICATION OF IRF6 DOWNSTREAM TARGET GENES IN ZEBRAFISH
Ngày tải lên :
01/10/2015, 17:26
... Epiboly of zebrafish Epiboly was first described in the teleost fish Cyprinus by von Baer in 1835 as the overgrowth of the yolk by the blastoderm (Betchaku and Trinkaus, 1978) The term epiboly ... PVDF membranes were blocked overnight in blocking buffer at °C (5% skim milk, 10 mM Phosphate buffer, 137 mM NaCl, 2.7 mM KCl, 0.1% Tween20, pH7.4) After blocking, the membranes were placed in primary ... were labeled with biotin using Biotin 3’-DNA Labeling Kit (Pierce, 89818) The labeling reaction was carried out by mixing 10 μl of 5X terminal deoxynucleotidyl transferase (TdT) reaction buffer,...
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Signaling pathway inhibitor library screening reveals b catenin TCF4 as a novel telomerase regulator in cancer cell lines
Ngày tải lên :
02/10/2015, 17:14
... specifically blocked by Mitogen-activated protein kinase kinase (MEK) inhibitor (Maida et al 2002) The effect of EGF on hTERT has also being shown to be dependent on the two juxtaposed Ets binding site ... telomerase inhibitors They vary in form of screening targets as well as the screening approaches A summary of telomerase targeted cancer therapy and screening that has being published is available in ... N-terminal (TEN) domain, (ii) telomerase RNA binding domain (TRBD domain), (iii) reverse transcriptase domain (RT domain) and (iv) the lowly conserved C-terminal domain (CTE domain) (Jacobs et...
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IDENTIFICATION OF IRF6 DOWNSTREAM TARGET GENES IN ZEBRAFISH
Ngày tải lên :
09/10/2015, 10:49
... Epiboly of zebrafish Epiboly was first described in the teleost fish Cyprinus by von Baer in 1835 as the overgrowth of the yolk by the blastoderm (Betchaku and Trinkaus, 1978) The term epiboly ... PVDF membranes were blocked overnight in blocking buffer at °C (5% skim milk, 10 mM Phosphate buffer, 137 mM NaCl, 2.7 mM KCl, 0.1% Tween20, pH7.4) After blocking, the membranes were placed in primary ... were labeled with biotin using Biotin 3’-DNA Labeling Kit (Pierce, 89818) The labeling reaction was carried out by mixing 10 μl of 5X terminal deoxynucleotidyl transferase (TdT) reaction buffer,...
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