justifications for freedom of expression
Tài liệu Freedom of Expression on the Internet - A study of legal provisions and practices related to freedom of expression, the free flow of information and media pluralism on the Internet in OSCE participating States ppt
Ngày tải lên :
18/02/2014, 00:20
... Committee of Experts for the Development of Human Rights (DH-DEV) “at the core of the examination of any interference in the exercise of freedom of opinion is therefore a balancing of interests ... reiterated the importance of freedom of expression as one of the preconditions for a functioning democracy In Budapest “[t]he participating States reaffirm[ed] that freedom of expression is a fundamental ... the exercise of the freedom of expression should be lawful Article 10 of the Convention stipulates that: Everyone has the right to freedom of expression This right shall include freedom to hold...
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Tài liệu GLOBAL SURVEY ON INTERNET PRIVACY AND FREEDOM OF EXPRESSION docx
Ngày tải lên :
18/02/2014, 00:20
... intersections between privacy and freedom of expression 95 4.1 The impact of poor protection for privacy on freedom of expression 4.2 Tensions between freedom of expression and privacy 4.2.1 The ... Internet space as part of promoting comprehensive freedom of expression online and offline As demonstrated by UNESCO’s 2011 publication Freedom of Expression: Freedom of Connection, the Changing ... Studies on Freedom of Expression and Access to Information (CELE) of the University of Palermo, Argentina Advisory Board • Eduardo Bertoni, Director, Center for Studies on Freedom of Expression and...
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FREEDOM OF EXPRESSION pptx
Ngày tải lên :
30/03/2014, 10:20
... the erosion of our freedoms happen without one smackdown of a fight The situation isn’t hopeless, though there are plenty of areas where the conflict is getting worse for freedom of expression ... activity of authors and inventors by the provi- 10 FREEDOM OF EXPRESSION ® sion of a special reward, and to allow the public access to the products of their genius after the limited period of exclusive ... first case, the makers of the anti–Fox News T-shirts didn’t back down and instead brought in the ACLU, which forced Fox News to call off its attack dogs Victory for freedom of expression In the...
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Report of the Special Rapporteur on the promotion and protection of the right to freedom of opinion and expression, Frank La Rue* ppt
Ngày tải lên :
06/03/2014, 21:20
... compatibility of blocking child pornography on the Internet with the right to freedom of expression in the context of discussions on the proposal for a directive of the European Parliament and of the ... organized by the Ministry of Foreign Affairs of Sweden These meetings brought together experts and human rights defenders working on a range of Internet and freedom of expression- related issues ... advantages and challenges of new information and communication technologies, including the Internet and mobile technologies, for the exercise of the right to freedom of opinion and expression, including...
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Báo cáo khoa học: Design of expression vectors for RNA interference based on miRNAs and RNA splicing potx
Ngày tải lên :
07/03/2014, 11:20
... vectors generate efficient knockdown of target proteins To examine the efficiency of generation of RNAi for pSM155 and pSM30, we examined the knockdown of expression of firefly Luciferase (Luc) HeLa cells ... efficiency for the downstream ORF in unprocessed pri-miRNAs However, expression of the marker (regardless of the placement location) could only occur at the expense of failure of cleavage of primiRNA ... sequences for the miRNA expression cassette is a successful general strategy for improving marker gene protein expression In this study, insertion of the miRNA-based artificial miRNA expression...
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Báo cáo khoa học: Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome docx
Ngày tải lên :
07/03/2014, 12:20
... sequestering of fatty acids to protect cells against the harmful detergent effects of excess free fatty acids [10], regulation of the expression of specific genes, and the control of cell growth ... amplify intron of the fabp1a gene from zebrafish genomic DNA using the following conditions: initial denaturation of genomic DNA at 94 °C for min, followed by 30 cycles of 94 °C for 30 s for DNA denaturation, ... combined represent the expression pattern of the mammalian FABP1 gene, presumably the expression pattern of the ancestral gene Again, this suggests subfunctionalization [44,45] of the ancestral gene...
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Báo cáo khoa học: Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2a receptor mediated activation of MEK⁄ ERK-CREB cascade doc
Ngày tải lên :
28/03/2014, 22:20
... Involvement of MEK signaling in the enhancement of COX-2 expression (A) Inhibition of Fluprostenol-activated COX-2 expression by kinase and COX inhibitors 3T3-L1 cells were cultured in the presence of ... denaturation at 94 °C for min, followed by 32 cycles of 98 °C for 10 s, 55 °C for 20 s and 60 °C for 20 s The amplified PCR products (expected size 168 bp) were analyzed by performing agarose gel ... and suppression of the early phase of adipogenesis in mouse adipocytic 3T3-L1 cells PGF2a promoted the production of anti-adipogenic PGF2a and PGE2 by enhancing the expression of COX-2 through...
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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc
Ngày tải lên :
20/06/2014, 07:20
... H89, SB203580 or U0126 on expression of Effect of3 Tnfaip6(B) or Ptgs2(C) mRNA Effect of H89, SB203580 or U0126 on expression of Has2(A), Tnfaip6(B) or Ptgs2(C) mRNA For reference, the h COC value ... EGF for 40 h; +U0126: COCs were cultured with FSH, LH and U0126 for 40 h; +U0126+EGF: COCs were cultured with FSH, LH, U0126 and EGF for 40 h lular mechanism of induction of the expression of ... and Ptgs2 expressions (Figure 3A, B, C) Although the lower level of these gene expressions resulting from the addition of U0126 was not overcome by the addition of EGF, the addition of EGF to...
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Báo cáo hóa học: "Multicriteria Gene Screening for Analysis of Differential Expression with DNA Microarrays" potx
Ngày tải lên :
23/06/2014, 01:20
... impeded their use for practical experiments First, is the need for improved relevance of the fitness criterion to the scientific objectives of the experiment It is often difficult for an experimenter ... techniques for experimental data DIFFERENTIAL EXPRESSION PROFILE EXPERIMENTS This type of experiment is very common in genetics research [19, 20] and involves comparing gene expression profiles of a ... paired-t test of hypotheses (1) with fcmin = at a FDR level of 20% The second stage of the “Two-stage FDR-CI” algorithm selects Ᏻ2 as a subset of Ᏻ1 at the prescribed FDR-CI level of 20% Stage of the...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
Ngày tải lên :
09/08/2014, 07:20
... transducer and activator of transcription Discussion The findings of the present study suggest involvement of AP1 and NF-κB, but not of p38 or ERK1/2, in the TNF-αenhanced formation of the immunostimulating ... photographic reproductions C Meeuwisse is acknowledged for performing computer analysis of the Cyp7b promoter Dr R Hampl is acknowledged for the performance of the radioimmunoassay analysis References Zvaifler ... chromatography The amount of 7α-OH-DHEA is expressed as the percentage [3H]-7α-OH-DHEA of the total amount of [3H]-label measured Results are expressed as the mean ± standard error of the mean of triplicate...
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Báo cáo khoa học: "Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome" pps
Ngày tải lên :
09/08/2014, 07:21
... conditions: 94°C for 12 minutes; 50 cycles of 94°C for 15 s, 55°C for 40 seconds and 72°C for 20 seconds The purified plasmids served as internal standards and helped in calculating the level of each ... system, Page of (page number not for citation purposes) World Journal of Surgical Oncology 2008, 6:56 Table 2: Primer pairs used for real time quantitative-PCR analyses Primers for human α-catenin ... to one of the primer in the primer pair Each reaction included Hot-start Q-master mix (Abgene), 10 pmol of specific forward primer, pmol of reverse primer (with the Z sequence), 10 pmol of FAMtagged...
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Báo cáo y học: "ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data" doc
Ngày tải lên :
09/08/2014, 23:20
... to the different isoforms The relative strength of the segments corresponds to the abundances of the two isoforms (Figure S9 in Additional file 1) Examining levels or changes of particular genes ... of a particular gene/splicing event or set of genes/splicing events ExpressionPlot provides simple mechanisms to perform all of these steps Back end pre-processing tasks (RNA-Seq) Alignment ExpressionPlot ... the ExpressionPlot back end generates Pvalues that are not adjusted for multiple testing This should be kept in mind when setting cutoffs on the website We usually use a P-value cutoff of 10 For...
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Báo cáo y học: " Prevention for those who have freedom of choice – or among the choice-disabled: confronting equity in" pps
Ngày tải lên :
10/08/2014, 05:20
... Review of HIV Behavioral Interventions for Reducing Sexual Risk Behavior of Men Who Have Sex with Men Journal of Acquired Immune Deficiency Syndrome 2005, 39:228-241 Agha S, Van Rossem R: Impact of ... condoms every year For victims of sexual violence, however, condoms are not usually and option The main impact of an apparently protective intervention, like male circumcision, will be for HIV-negative ... incidence of HIV STI and Pregnancy: A decade in Review Journal of Adolescent Health 2004, 34(1):3-26 Mullen PD, Ramirez G, Strouse D, Hedges LV, Sogolow E: Metaanalysis of the effects of behavioral...
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báo cáo khoa học: "Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells" doc
Ngày tải lên :
10/08/2014, 22:20
... was performed on an ABI Prism 7000 Real Time Thermalcycler with the following cycling condition: cycle at 48°C for 45 minutes, cycle at 94°C for minute, cycles of 94°C for 15 seconds, 63°C for 30 ... abundance of HER2 expression in all new donors (data not shown) Isolation of natural killer cells using anti-CK56 antibody showed that these cells were also a source of HER2; however, expression of ... therefore, differences in expression between normal and tumor cells may be better appreciated[29] In addition, the quantitation of expression may allow assessment of expression levels of the target and...
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Báo cáo y học: " Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in viv" pdf
Ngày tải lên :
11/08/2014, 08:21
... with 40 µl of Opti-mem Separately, µl of oligofectamine was mixed with 24 µl of Opti-mem and incubated at room temperature for 15 These solutions were mixed at room temperature for 40 For co-injection ... (Gibco-Invitrogen) was mixed with 12 µl of Opti-mem and incubated at room temperature for 15 Solutions were combined for 40 and brought to a final volume of 100 µl The expression of IL-12p40 mRNA and IL-12p70 ... 12–16 h before transfection For siRNA transfections µl of a 20 µM siRNA duplex (target or control) solution was mixed with 47 µl of Opti-mem (Gibco-Invitrogen) In a second tube µl of oligofectamine...
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Báo cáo khoa học: " In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence" docx
Ngày tải lên :
12/08/2014, 18:22
... efficiency of translation and hence overall expression of the gene product It functions by slowing down the rate of scanning by the ribosome and improving the chance of it recognising the start of translation ... and an intron A Insertion of the Kozak sequence increased the expression in all the cells whereas addition of the intron A decreased the expression In vectors used for DNA vaccines strong promoters ... codon For optimal expression it is recommended to use the full consensus (GCC)GCC A/G CC ATG G [21,22] Our efforts to Th1 focus the immune response of horses by vaccinating them with vectors of...
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Báo cáo y học: " Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs" pptx
Ngày tải lên :
13/08/2014, 09:20
... Establishment of a model system for investigation of cyclin T1 function in macrophage differentiation The functional significance of the induction of cyclin T1 expression upon differentiation of primary ... performed to determine the expression of cyclin T2a and β-actin Page of 16 (page number not for citation purposes) Retrovirology 2006, 3:32 Transcriptional profiling: validation and analysis of ... 20% of genes induced by PMA require cyclin T1 for their normal level of induction, while greater than 15% of genes repressed by PMA require cyclin T1 for their normal level of repression Therefore,...
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Báo cáo y học: "Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells" pptx
Ngày tải lên :
13/08/2014, 13:20
... (Figure 5A) Activation of caspases 3, 8, and requires the processing of pro-protein precursors to smaller active forms To monitor the effects of Zn and Cd, we examined the integrity of pro-caspase 3, ... Tax Actin 10 11 Figure Western blot analysis of Tax expression in the JPX-9 cells Western blot analysis of Tax expression in the JPX-9 cells Tax expression was equally induced by either Zn or ... or CdCl2 for 24 hours Note that XIAP expression in ZnCl2 treated JPX-9 cells was reduced while its expression in CdCl2-treated JPX-9 cells was maintained Page of 12 (page number not for citation...
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Báo cáo y học: "Gene expression-based screening for inhibitors of PDGFR signaling" potx
Ngày tải lên :
14/08/2014, 08:20
... establishes proof of concept, however, for the notion that mRNA expression signatures can be effectively used as a read-out for the identification of inhibitors of signal transduction, often thought ... inhibited expression of the pathway signature, the following procedure was performed For each compound on each plate four ratios were determined: expression of EGR1 versus expression of ATP5B(VEGR1/ATP5B), ... extracellular receptor inhibition mechanism of ATA Discussion In this report, we describe the proof -of- concept efforts to approach the discovery of inhibitors of signal transduction using a novel chemical...
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Báo cáo y học: "Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression" pptx
Ngày tải lên :
14/08/2014, 14:21
... of probe sets; 2% of these yielded QTLs composing 99% of all QTLs The center circled point shows that a threshold of 0.525 selected 17% of probe sets, of which 8% yielded QTLs composing 90% of ... the tissue of origin Raw probe 100 200 300 100 200 300 Figure Distribution of P-values from QTL mapping of brain RNA expression Distribution of P-values from QTL mapping of brain RNA expression ... by analysis of variance of the log-transformed, normalized expression In the interests of speed, age and sex of animals were not included as cofactors in the analysis of variance Raw heritability...
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