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... proteinases. Proc Natl Acad Sci USA 80, 6066–6070. 13 Fan JQ, Ishii S, Asano N & Suzuki Y (1999) Acceler- ated transport and maturation of lysosomal alpha-galac- tosidase A in Fabry lymphoblasts ... h; Pro136Leu, 8 h). After the chase ASA was immunoprecipitated from the homogenates with the polyclonal ASA antiserum. Precipi- tated ASA was quantified after SDS ⁄ PAGE with a bio-imaging analyser (Fujifilm). ... Tyr201Cys substituted ASA with mAb C. Degradation of amino acid-substituted ASAs via the proteasome In order to investigate the degradation pathway of amino acid-substituted ASAs in the ER, we used

Ngày tải lên: 07/03/2014, 17:20

... signalregulated kinase ⁄ (ERK1 ⁄ 2) and protein kinase B (PKB) pathways that act downstream of oncogenic protein kinases [10,11] It is increasingly apparent that BIM as a mediator of tumour cell death ... pathway, the PKB pathway and the Janus kinase ⁄ signal transducer and activator of transcription (JAK-STAT) pathway, to promote proliferation, survival and transformation [56,57] The importance ... protein kinase ⁄ extracellular signal-regulated kinase kinase ⁄ kinases: mechanism of action in vivo, pharmacokinetic ⁄ pharmacodynamic relationship, and potential for combination in preclinical models

Ngày tải lên: 16/03/2014, 00:20

... Identification of calreticulin as a ligand of GABARAP by phage display screening of a peptide library Jeannine Mohrluder1,2, Thomas Stangler1,2, Yvonne Hoffmann1,2, Katja Wiesehan2, Anja Mataruga3 ă and ... folded GABARAP [22] The addition of CRT to GABARAP resulted in the disappearance of GABARAP resonances, a clear indication of binding (Fig 3B) Only weak amide signals for a Gln ⁄ Asn side chain and ... response Rmax was fitted as a separate parameter for each binding sensorgram The dissociation constant was obtained as Kd ¼ koff ⁄ kon NMR All NMR spectra were recorded at 25 °C on a Varian (Darmstadt,

Ngày tải lên: 16/03/2014, 05:20

... (adapted from International Reform Monitors, 2002) Canada: Canada’s national health care act stipulates the provision of health care to be an entitlement However, administration of health care ... inequality and poverty Ottawa: Status of Women Canada; 2001 [5] Day S, Brodsky G Women and the equality deficit: the impact of restructuring Canada’s social programs Ottawa: Status of Women Canada; 1998 ... increasing poverty and low income threatens Canadians’ health and health care system Canadian Review of Social Policy 2003;51:9–28 [19] Raphael D, Bryant T The limitations of population health as

Ngày tải lên: 22/03/2014, 11:20

... For each image, at least and as many as 12 height differences have been calculated and averaged together to give an overall feature height of each sample A summary of the averages is shown in ... nature, of the surface as the reaction time increased Also, an increase in the overall film thickness, as determined by ellipsometry, and an increase in the height, as demonstrated from AFM, measurements ... relationship of aT, explained as a ratio of relaxation times aT = τ ∗ (T ) / τ ∗ (TR ) (2) where TR is a reference temperature and T is the temperature of the measurement, was applied to Equation

Ngày tải lên: 23/03/2014, 01:20

... of nervous disease as exaggerated expressions of perverted character They can be traced directly and easily in many cases If a woman... The size of a triviality is often exaggerated ... brain-contraction, take a good inhalation of whatever pleasant feeling is nearest, and the expansion is a necessary consequence As we expand mentally, disagreeable... constantly analyzing ... as large as the houses, his blades of grass waving above the tops of the trees, and all things similarly disproportionate Or, worse, imagine a disease of the retina which caused a

Ngày tải lên: 23/03/2014, 02:20

... Idem MAP2-for MAP2-rev GCTTGAAGGCGCTGGATCTGCGACAATAG GACTGGGCTTTCATCAGCGACAGGTGGC 91489–91517 92431–92404 NC_000067 Idem Tau-for Tau-rev GTGAACCACCAAAATCGGAGAACGAAGC CAGGTTCTCAGTAGAGCCAATCTTCGACCTGAC 78772–78800 79013–78981 NC_000077 Idem STOP-for STOP-rev AGAGTCGGATGCAGTTGCCCGGGCAACA GGCTCCTCCAGCACCCTCCGGGTCCCG 210–237 657–631 NC_000073 ... Biolo ´ gica, Facultad de Ciencias Quı ´ micas, Universidad Nacional de Co ´ rdoba, Argentina 2 Departamento de Biologı ´ a Molecular, Facultad de Ciencias Exactas, Fı ´ sico-Quı ´ micas y Naturales, ... Idem Doublecortin-for Doublecortin-rev CCCCAAACTTGTGACCATCATTC GGAGAAATCATCTTGAGCATAGCG 705–728 967–943 NM_010025 Idem LIS1-for LIS1-rev CGAACTCTCAAGGGC ATGCATCAGAACCATGCACG 1288–1303 1427–1407 NM_95116 Idem Tubulin a6-for Tubulin a6-rev AGCCCTACAATTCCATCCTCACC GCTGAAGGAGACGATGAGGGTGA 6854–6876 7646–7624 NC_000081

Ngày tải lên: 23/03/2014, 05:22

... standard of a food is based on the processing and handling of the food, as well as on the conditions of the raw materials A food item prepared with water contaminated with pathogenic microorganisms ... and health effects Peter Sahlin Manuscript Fermentation as a method of food preservation - a literature review Part II - Food safety Peter Sahlin Manuscript Production of organic acids, titratable ... dehydration The dehydration is mainly caused by too many of severe incidences of diarrhoea The main cause for getting diarrhoea is the ingestion of food not having the appropriate standard regarding

Ngày tải lên: 24/03/2014, 04:20

... the apostrophized ‘s’ can also stand for ‘is’ or ‘has’ in contracted forms, where it has a linguistically sounder claim to be treated as a separate word But if you want a tag set capable of processing ... bring an extraordinary amount of largely tacit knowledge to the task of making sense of the characters on the page The computer, however, lacks this knowledge If you want to take full advantage of ... text corpora what it “learned” from the training set The “knowledge” of the automatic tagger may consist of a set of rules or of a statistical analysis of the results Either way, a good tagger will

Ngày tải lên: 24/03/2014, 19:20

... by a grant from the Marian Chace Foundation to Madeleine Hackney and a grant from the American Parkinson Disease Association to Gammon Earhart References Argue, J (2000) Parkinson ... 10.1007/s10465-007-9039-2 Ó 2007 American Dance Therapy Association promising non-traditional approach to ameliorating balance and gait problems among elderly individuals. The goal of this study was to determine ... length and stability decrease when individuals with PD are placed in dual task conditions. Changes with dual task walking are greater in those with PD than those without and dual tasking may trigger

Ngày tải lên: 28/03/2014, 20:20

... based on the interest of local pharmacy student asso- ciations to participate and willingness to gather data, and included Australia, Bangladesh, Croatia, Egypt, Nepal, Sin- gapore, Slovenia, ... States of America: measures of the African brain drain. Human Resources for Health 2004, 2:17. 3. Hagopian A, Ofosu A, Fatusi A, Biritwum R, Essel A, Gary Hart L, et al.: The flight of physicians ... final-year pharmacy students from nine countries: Australia, Bangladesh, Croatia, Egypt, Portugal, Nepal, Singapore, Slovenia and Zimbabwe. Data were analysed by means of Principal Components Analysis

Ngày tải lên: 18/06/2014, 17:20

... likelihood estimation (FIML) (available in the Mplus 4.2 [30] software package) by using all available data to assess whether the estimates may have been biased by non-random missing data patterns (n ... that physical activity partially mediates the impact of chronic conditions on several health outcomes that are important to quality of life Physical activity of at least 1,000 Kcal per week was ... Columbia, V6T 2B5, Canada, 5Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, British Columbia, V6T 1Z3, Canada and 6Centre for Health Evaluation and

Ngày tải lên: 18/06/2014, 22:20

... tion of MUAPs and their classification to the correspond- ing MUs, that was shown to be able to classify a small but representative sample of MUs. The detection part of this algorithm (based ... with an inter-electrode distance of 10 mm. The detection area was assumed to be circular. The radius of the detection area (10 mm) was estimated based on [16] and [17]. The simulated location of ... estimation of aMR (see Figure 1): aMR ≈ FR * nrMUs * RatioAreas (2) Where RatioAreas = ratio between part of the muscle within the electrode detection area and total muscle cross-section area The

Ngày tải lên: 19/06/2014, 10:20

... This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com ... This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com This is trial version www.adultpdf.com ... trial version www.adultpdf.com This is trial version www.adultpdf.com [...]...This is trial version www.adultpdf.com

Ngày tải lên: 19/06/2014, 15:20

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Ngày tải lên: 19/06/2014, 15:20

... Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S: Activation of NADPH oxidase in Alzheimer's disease brains Biochem ... complex and the initiation of intracellular signaling events regulating oxidase assembly and activation has been described [31,32] The NADPH oxidase The phagocytic NADPH oxidase plays an essential ... microglial NADPH oxidase maybe largely responsible for the oxidative damage observed in the AD brain Astrocytes and the NADPH oxidase Astrocytes are the most abundant glial cell type in the brain and

Ngày tải lên: 19/06/2014, 22:20

... (accepting) accepting and negative and neutral expresssions: activation accompanied by in amygdala, evaluation of: hippocampus, Task performance: parahippocampal recognition of gyrus, medial type of emotion ... circuit (amygdala, hippocampus, insula, temporal lobe as well as anterior cingulate, medial, orbito, and dorsolateral prefrontal cortices) of social phobic patients are greater than those of controls ... physical signs with imbalances in autonomic neurotransmission In this formulation, the physical complaints typical of social phobia, are associated with rapid release of catecholamines (noradrenaline,...

Ngày tải lên: 01/11/2013, 08:20

... way as if through the eyes of an observer Again, it is difficult to grasp the meaningfulness of this finding, let alone as evidence of a bias However that may be, this putative ‘‘bias’’ is assigned ... treated as if originating in a scale of equal intervals This violates the basic postulates of the analysis of variance The relevant data should have been properly treated through some form of ... instance of a ‘‘category mistake.’’ According to Ryle (1949) this logical fallacy consists of treating the label for a class of events as if it were a member of that class From this vantage point...

Ngày tải lên: 01/11/2013, 08:20

... definitions aside, I shall now consider how the construct of social skills has been assessed in research Assessment of Social Skills of Social Phobic Individuals As the assessment of social skills had ... value of matching treatment with patients’ patterns of fear Based on extreme responses to a role-play and a ‘‘rationality’’ test, 39 patients were classified as either predominantly behavioral ... consider social phobia not as a breakdown in social ability but as emerging out of a pattern of meaningful actions that constitute a means to an end Although not necessarily abnormal in themselves,...

Ngày tải lên: 01/11/2013, 08:20

... (shy, anxious) behavior by the teacher as well as peer assessment of social behavior (popularity, aggression, and isolation) at school At the age of no association was found between shy and anxious ... appeasement and avoidance of conflict typical of social phobic individuals Parental Alcoholism David et al (1995) found an association between parental alcoholism and phobia (both social and agoraphobia); ... variables such as maternal anxiety and an array of variables indexing temperament Nonetheless, it must be borne in mind that an even greater proportion of infants classified as anxiously attached...

Ngày tải lên: 01/11/2013, 08:20