... MA, Mato JM & Lu SC (2002) Spontaneous oxidativestress and liver tumors in mice lacking methionine adenosyltransferase 1A FASEB J 16, 1292–1294 Oxidativestress in VLCAD KO mice 26 Robertson G, ... oxidativestress byproducts in human hypertension Hypertension 41, 1096–1101 30 Sommerburg O, Grune T, Ehrich JH & Siems WG (2002) Adaptation of glutathione-peroxidase activity to oxidativestress ... present study provides strong evidence that fasting -induced hepatopathy and hepatomegaly are closely related to the development of oxidativestress in VLCAD KO mice An important observation is...
... depends on the kind of oxidativestress exerted The methodology described here offers the possibility to identify the proteins oxidized under various forms of oxidative stress, including PDT with ... study we focused on the detection of tyrosine oxidation of the intracellular proteins on oxidativestressinduced by PDT of the cells A tyrosine analogue, tyramine, coupled covalently to fluorescein ... iodide (E,F) indicates dead cells with permeabilized plasma membrane Bar: 20 lm Discussion Oxidativestressinduced by PDT can affect several types of biomacromolecules including proteins, lipids,...
... Cyclosporin A -induced oxidativestress M van der Toorn et al calcineurin therefore play a role in cyclosporin A -induced oxidativestress and disturbed Ca2+ homeostasis ... with antioxidative properties, including superoxide dismutase, catalase, and glutathione peroxidase, become upregulated upon exposure to CsA [7] It is evident that CsA induces oxidative stress, ... ª 2007 The Authors Journal compilation ª 2007 FEBS M van der Toorn et al Cyclosporin A -induced oxidativestress however, did not induce a significant increase in JC-1 fluorescence We subsequently...
... PM10 to oxidativestress repair enzyme, we used RT-PCR analysis Figure shows the expression level of catalase mRNA induced by Comparative study of PM2.5 - and PM10 - inducedoxidativestress in ... that could be induced by PMs, rat lung epithelial cells were treated with different concentrations of PMs for day, and Comparative study of PM2.5 - and PM10 - inducedoxidativestress in rat ... PM2.5 induced more oxidativestress than PM10 In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form Comparative study of PM2.5 - and PM10 - induced...
... acute oxidativestress in various cells and tissues [18,59] Therefore, the purpose of this study was to determine the effect of DHT on mouse ES cells under conditions of H2O2 -induced oxidativestress ... cells exposed to H2O2 -induced oxidativestress 251 Fig Effect of hydrogen peroxide (H2O2) -induced p38 mitogen activated protein kinase (MAPK) and c-Jun N-terminal kinase /stress activated protein ... study, we showed that DHT prevented H2O2 -induced cell injury likely by the downregulation of p38 MAPK, SAPK/JNK and NF-κB in mouse ES cells Oxidativestressinduced by ROS is a well known cause of...
... decreased compared with the peak in the ischemia/ reperfusion group (P < 0.05 versus ischemia/ reperfusion group) However, haloperidol did not alter ischemia/ reperfusion- induced change in the Ca2+ peak ... cerebral ischemia/ reperfusion injury [7] However, the role of dopamine D2 receptors on myocardial ischemia/ reperfusion injury has not been clear In this study, we applied myocardial ischemia/ reperfusion ... Science 2011, 18:18 http://www.jbiomedsci.com/content/18/1/18 Page of 11 A Before ischemiaIschemiaReperfusion IschemiaReperfusion Bromocriptine Haloperidol B Figure Changes of intracellular free...
... which arrhythmias are more easily induced by stress and injury from intraoperative hypothermic cardioplegia and ischemia- reperfusion [16] Various mechanisms of reperfusion arrhythmias in hypertrophied ... incidence of ischemia/ reperfusion- induced arrhythmias in hypertrophic rabbit hearts decreases after IP, which plays an important antiarrhythmic role in hypertrophied myocardium during ischemiareperfusion ... myocardium to ischemia- reperfusion injury during open heart surgeries [9,14,15] Pathological changes in cell structure and metabolism of hypertrophied myocardium decrease its tolerance to ischemia- reperfusion...
... Chikahisa L, Ueha T, Kanemaru K, Noda K: Ginkgo biloba extract protects brain neurons against oxidativestressinduced by hydrogen peroxide Brain Res 1996, 712(2):349-352 38 Fu D, Ng YK, Gan P, Ling ... 10.1186/1749-7221-5-12 Cite this article as: Cheng et al., EGb761 protects motoneurons against avulsion -induced oxidativestress in rats Journal of Brachial Plexus and Peripheral Nerve Injury 2010, 5:12 ... expression in injured motoneurons EGb761 treatment diminished avulsioninduced motoneuron death by attenuating the avulsioninduced NO production and cNOS, iNOS activities in the injured spinal...
... and reactive nitrogen species (ROS/RNS) in severe oxidativestress conditions such as sepsis, trauma, surgery, ischemia, hypoxia and ischemia- reperfusion lead to the loss of membrane integrity ... attenuation of I/R induced axonal degeneration and histopathological alterations (Fig 7) Discussion In the present study, tacrolimus showed significant amelioration of ischemiareperfusioninduced behavioral, ... such I/R induced vasculatic neuropathy clinically resemble to diabetic, rheumatoid vasculatitis, vascular inflammatory and demyelinating related neuropathy [40] Ischemiareperfusioninduced vasculitic...
... GPx, three anti -oxidative indicators, were remarkably lower in group than in groups and 3, and notably lower in Figure Histopathological scoring of ischemia- reperfusion (IR) -induced renal injury ... mean ± SD NQO = NAD(P)H quinone oxidoreductase Group = Normal control; Group = Ischemia reperfusion; Group = Ischemiareperfusion + adipose-derived mesenchymal stem cells Symbols (*, †, ‡) indicate ... http://www.translational-medicine.com/content/9/1/51 Page 10 of 17 Figure Changes in protein expressions of inflammatory and oxidative markers in kidney after ischemia- reperfusion (IR) A) Remarkably higher expression of intercellular adhesion...
... production of NO and increased NO may decrease the activity of GS and increase the oxidativestress in anoxia /reperfusion 148 induced excitotoxicity Global hypobaric hypoxia (Anoxia) is associated with ... increased oxidativestress in anoxia and reperfusion http://www.medsci.org Int J Med Sci 2010, 151 Figure 3: Activity of glutamine synthetase in different regions of rat brain in anoxia and reperfusion ... glutathione synthesis was increased by oxidativestress (55) From our study, the increased concentration of TBARS and decreased concentration of TAS supports the oxidativestress in anoxia In this study...
... Anabaena to oxidativestress [29,30] Because alr2505 is the only cysteine desulfurase-encoding gene induced in response to oxidative stress, we named the corresponding protein oxidativestress -induced ... to oxidativestress The pkn transcriptional unit is composed of four ORFs: Alr2502, Alr2503, Asr2504 and Alr2505, the expression of which is specifically induced when Anabaena is exposed to oxidative ... OsiS: oxidativestress -induced cysteine desulfurase the sulfur atom is released from the persulfide and the active...
... isonicotinoyl hydra- Oxidativestress and intralysosomal iron zone, systematic name: NÂ-[(1Z)-(2-hydroxyphenyl) methylene]isonicotinohydrazide) fully protects against oxidativestress -induced mitochondrial ... cells to oxidative stress, either in the presence of sih or following pretreatment with dfo, we nd strong evidence for a primary role of lysosomal redox-active iron in oxidativestress -induced ... Authors Journal compilation ê 2006 FEBS 3107 Oxidativestress and intralysosomal iron T Kurz et al Fig Lysosomal rupture is an early event after oxidativestress Acridine orange (AO)relocation assay...
... accordance with the Ó FEBS 2002 Hsp105 enhances oxidativestress -induced apoptosis (Eur J Biochem 269) 4147 Fig Enhancement of oxidativestress -induced apoptosis by over-expression of Hsp105a ... Hsp105a seemed to enhance the oxidativestress -induced activation of p38 but not JNK in F9 cells As Hsp105a enhances the activation of p38 induced by oxidative stress, we further examined whether ... p38, respectively Ó FEBS 2002 Hsp105 enhances oxidativestress -induced apoptosis (Eur J Biochem 269) 4149 Fig Suppression of oxidativestress -induced apoptosis in F9 cells by a potent p38 inhibitor...
... apoptosis In fact, ROS -induced oxidativestress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidativestress is involved in ... NSC-741909 may induce oxidativestress through a specific pathway that is affected by NDGA or that NDGA is potent antioxidant that can effectively block NSC-741909 inducedoxidativestress NDGA inhibits ... oxidative stress- mediated activation of MAP kinases, particularly the JNK and p38 kinases, which sensitizes those cells to chemotherapeutic drug- and radiation -induced cell death [42] Thus, oxidative...
... http://www.jbiomedsci.com/content/18/1/35 RESEARCH Open Access MiR-204 regulates cardiomyocyte autophagy induced by ischemia- reperfusion through LC3-II Jian Xiao1†, Xiaoyan Zhu2†, Bin He3†, Yufeng Zhang1, Bo Kang1, ... Zhinong Wang1* and Xin Ni2* Abstract Background: Autophagy plays a significant role in myocardial ischemia- reperfusion (IR) injury So it is important to inhibit autophagy to protect cardiomyocytes besides ... randomized to Control and IR groups IR group was treated with 30 ischemia by ligating the left anterior descending coronary artery, followed by h reperfusion by loosing the ligation The expression of miR-204...
... of Ca2+ under KA stress *P < 0.01 as compared to the KA control K A (12 mg/kg) Figure In vitro and in vivo effect of PETL extract and GABA on the KA -induced oxidativestress KA -induced lipid peroxidation ... the oxidativestress or convulsions Resveratrol protects against KA -induced neuronal damage and subsequent epilepsy [54] Stopping seizure activity promptly is the best way to prevent SE -induced ... protection Pu-Erh leaf extract and GABA ameliorates oxidativestress in KA -induced status epilepticus The molecular mechanisms of PETL extract and GABA on SE -induced excitotoxicity warrants further study...
... cells, upon oxidative stress, GSSG may either recycle to GSH or exit from cells, leading to overall glutathione depletion [33] Cells deprived of GSH are much more prone to undergo oxidativestress ... an oxidative mechanism may be a point of convergence of many different apoptogenic stimuli (i.e., H2O2, tumour necrosis factor, cycloheximide and natural killer cells, all eliciting oxidative stress) ... cells) inducing the death programme in hepatocytes, probably throughout oxidativestress GdCl3 can block the Pb(NO3)2 -induced cascade by destroying Kupffer cells, and in turn, can modify extracellular...