ischemia reperfusion induced oxidative stress

... MA, Mato JM & Lu SC (2002) Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A FASEB J 16, 1292–1294 Oxidative stress in VLCAD KO mice 26 Robertson G, ... oxidative stress byproducts in human hypertension Hypertension 41, 1096–1101 30 Sommerburg O, Grune T, Ehrich JH & Siems WG (2002) Adaptation of glutathione-peroxidase activity to oxidative stress ... present study provides strong evidence that fasting -induced hepatopathy and hepatomegaly are closely related to the development of oxidative stress in VLCAD KO mice An important observation is...

Ngày tải lên: 15/03/2014, 23:20

... depends on the kind of oxidative stress exerted The methodology described here offers the possibility to identify the proteins oxidized under various forms of oxidative stress, including PDT with ... study we focused on the detection of tyrosine oxidation of the intracellular proteins on oxidative stress induced by PDT of the cells A tyrosine analogue, tyramine, coupled covalently to fluorescein ... iodide (E,F) indicates dead cells with permeabilized plasma membrane Bar: 20 lm Discussion Oxidative stress induced by PDT can affect several types of biomacromolecules including proteins, lipids,...

Ngày tải lên: 23/03/2014, 15:21

... Cyclosporin A -induced oxidative stress M van der Toorn et al calcineurin therefore play a role in cyclosporin A -induced oxidative stress and disturbed Ca2+ homeostasis ... with antioxidative properties, including superoxide dismutase, catalase, and glutathione peroxidase, become upregulated upon exposure to CsA [7] It is evident that CsA induces oxidative stress, ... ª 2007 The Authors Journal compilation ª 2007 FEBS M van der Toorn et al Cyclosporin A -induced oxidative stress however, did not induce a significant increase in JC-1 fluorescence We subsequently...

Ngày tải lên: 30/03/2014, 08:20

... PM10 to oxidative stress repair enzyme, we used RT-PCR analysis Figure shows the expression level of catalase mRNA induced by Comparative study of PM2.5 - and PM10 - induced oxidative stress in ... that could be induced by PMs, rat lung epithelial cells were treated with different concentrations of PMs for day, and Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat ... PM2.5 induced more oxidative stress than PM10 In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form Comparative study of PM2.5 - and PM10 - induced...

Ngày tải lên: 07/08/2014, 17:22

... acute oxidative stress in various cells and tissues [18,59] Therefore, the purpose of this study was to determine the effect of DHT on mouse ES cells under conditions of H2O2 -induced oxidative stress ... cells exposed to H2O2 -induced oxidative stress 251 Fig Effect of hydrogen peroxide (H2O2) -induced p38 mitogen activated protein kinase (MAPK) and c-Jun N-terminal kinase /stress activated protein ... study, we showed that DHT prevented H2O2 -induced cell injury likely by the downregulation of p38 MAPK, SAPK/JNK and NF-κB in mouse ES cells Oxidative stress induced by ROS is a well known cause of...

Ngày tải lên: 07/08/2014, 20:23

... decreased compared with the peak in the ischemia/ reperfusion group (P < 0.05 versus ischemia/ reperfusion group) However, haloperidol did not alter ischemia/ reperfusion- induced change in the Ca2+ peak ... cerebral ischemia/ reperfusion injury [7] However, the role of dopamine D2 receptors on myocardial ischemia/ reperfusion injury has not been clear In this study, we applied myocardial ischemia/ reperfusion ... Science 2011, 18:18 http://www.jbiomedsci.com/content/18/1/18 Page of 11 A Before ischemia Ischemia Reperfusion IschemiaReperfusion Bromocriptine Haloperidol B Figure Changes of intracellular free...

Ngày tải lên: 10/08/2014, 05:21

... which arrhythmias are more easily induced by stress and injury from intraoperative hypothermic cardioplegia and ischemia- reperfusion [16] Various mechanisms of reperfusion arrhythmias in hypertrophied ... incidence of ischemia/ reperfusion- induced arrhythmias in hypertrophic rabbit hearts decreases after IP, which plays an important antiarrhythmic role in hypertrophied myocardium during ischemiareperfusion ... myocardium to ischemia- reperfusion injury during open heart surgeries [9,14,15] Pathological changes in cell structure and metabolism of hypertrophied myocardium decrease its tolerance to ischemia- reperfusion...

Ngày tải lên: 10/08/2014, 09:21

... Chikahisa L, Ueha T, Kanemaru K, Noda K: Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide Brain Res 1996, 712(2):349-352 38 Fu D, Ng YK, Gan P, Ling ... 10.1186/1749-7221-5-12 Cite this article as: Cheng et al., EGb761 protects motoneurons against avulsion -induced oxidative stress in rats Journal of Brachial Plexus and Peripheral Nerve Injury 2010, 5:12 ... expression in injured motoneurons EGb761 treatment diminished avulsioninduced motoneuron death by attenuating the avulsioninduced NO production and cNOS, iNOS activities in the injured spinal...

Ngày tải lên: 10/08/2014, 10:20

... and reactive nitrogen species (ROS/RNS) in severe oxidative stress conditions such as sepsis, trauma, surgery, ischemia, hypoxia and ischemia- reperfusion lead to the loss of membrane integrity ... attenuation of I/R induced axonal degeneration and histopathological alterations (Fig 7) Discussion In the present study, tacrolimus showed significant amelioration of ischemia reperfusion induced behavioral, ... such I/R induced vasculatic neuropathy clinically resemble to diabetic, rheumatoid vasculatitis, vascular inflammatory and demyelinating related neuropathy [40] Ischemia reperfusion induced vasculitic...

Ngày tải lên: 10/08/2014, 10:20

... GPx, three anti -oxidative indicators, were remarkably lower in group than in groups and 3, and notably lower in Figure Histopathological scoring of ischemia- reperfusion (IR) -induced renal injury ... mean ± SD NQO = NAD(P)H quinone oxidoreductase Group = Normal control; Group = Ischemia reperfusion; Group = Ischemia reperfusion + adipose-derived mesenchymal stem cells Symbols (*, †, ‡) indicate ... http://www.translational-medicine.com/content/9/1/51 Page 10 of 17 Figure Changes in protein expressions of inflammatory and oxidative markers in kidney after ischemia- reperfusion (IR) A) Remarkably higher expression of intercellular adhesion...

Ngày tải lên: 18/06/2014, 19:20

... lipopolysaccharide -induced inflammation in rats Anesthesiology 2003; 98: 89-95 Liu R, Ishibe Y, Ueda M Isoflurane-sevoflurane administration before ischemia attenuates ischemia- reperfusion- induced injury ... after ischemia reperfusion injury in rabbits Anesth Analg 2008; 106: 1353-1359 Centurion SAR, Centurion LM, Souza MEJ et al Effects of ischemic liver preconditioning on hepatic ischemia/ reperfusion ... to ischemia- reperfusion injury J Neurol Sci 2006; 247: 47-52 35 Yoshidome H, Kato A, Edwards MJ et al Interleukin-10 inhibits pulmonary NF-kappaB activation and lung injury induced by hepatic ischemia- reperfusion...

Ngày tải lên: 25/10/2012, 11:00

... production of NO and increased NO may decrease the activity of GS and increase the oxidative stress in anoxia /reperfusion 148 induced excitotoxicity Global hypobaric hypoxia (Anoxia) is associated with ... increased oxidative stress in anoxia and reperfusion http://www.medsci.org Int J Med Sci 2010, 151 Figure 3: Activity of glutamine synthetase in different regions of rat brain in anoxia and reperfusion ... glutathione synthesis was increased by oxidative stress (55) From our study, the increased concentration of TBARS and decreased concentration of TAS supports the oxidative stress in anoxia In this study...

Ngày tải lên: 26/10/2012, 09:07

... Anabaena to oxidative stress [29,30] Because alr2505 is the only cysteine desulfurase-encoding gene induced in response to oxidative stress, we named the corresponding protein oxidative stress -induced ... to oxidative stress The pkn transcriptional unit is composed of four ORFs: Alr2502, Alr2503, Asr2504 and Alr2505, the expression of which is specifically induced when Anabaena is exposed to oxidative ... OsiS: oxidative stress -induced cysteine desulfurase the sulfur atom is released from the persulfide and the active...

Ngày tải lên: 18/02/2014, 04:20

... isonicotinoyl hydra- Oxidative stress and intralysosomal iron zone, systematic name: NÂ-[(1Z)-(2-hydroxyphenyl) methylene]isonicotinohydrazide) fully protects against oxidative stress -induced mitochondrial ... cells to oxidative stress, either in the presence of sih or following pretreatment with dfo, we nd strong evidence for a primary role of lysosomal redox-active iron in oxidative stress -induced ... Authors Journal compilation ê 2006 FEBS 3107 Oxidative stress and intralysosomal iron T Kurz et al Fig Lysosomal rupture is an early event after oxidative stress Acridine orange (AO)relocation assay...

Ngày tải lên: 19/02/2014, 06:20

... accordance with the Ó FEBS 2002 Hsp105 enhances oxidative stress -induced apoptosis (Eur J Biochem 269) 4147 Fig Enhancement of oxidative stress -induced apoptosis by over-expression of Hsp105a ... Hsp105a seemed to enhance the oxidative stress -induced activation of p38 but not JNK in F9 cells As Hsp105a enhances the activation of p38 induced by oxidative stress, we further examined whether ... p38, respectively Ó FEBS 2002 Hsp105 enhances oxidative stress -induced apoptosis (Eur J Biochem 269) 4149 Fig Suppression of oxidative stress -induced apoptosis in F9 cells by a potent p38 inhibitor...

Ngày tải lên: 21/02/2014, 03:20

... apoptosis In fact, ROS -induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidative stress is involved in ... NSC-741909 may induce oxidative stress through a specific pathway that is affected by NDGA or that NDGA is potent antioxidant that can effectively block NSC-741909 induced oxidative stress NDGA inhibits ... oxidative stress- mediated activation of MAP kinases, particularly the JNK and p38 kinases, which sensitizes those cells to chemotherapeutic drug- and radiation -induced cell death [42] Thus, oxidative...

Ngày tải lên: 18/06/2014, 16:20

... http://www.jbiomedsci.com/content/18/1/35 RESEARCH Open Access MiR-204 regulates cardiomyocyte autophagy induced by ischemia- reperfusion through LC3-II Jian Xiao1†, Xiaoyan Zhu2†, Bin He3†, Yufeng Zhang1, Bo Kang1, ... Zhinong Wang1* and Xin Ni2* Abstract Background: Autophagy plays a significant role in myocardial ischemia- reperfusion (IR) injury So it is important to inhibit autophagy to protect cardiomyocytes besides ... randomized to Control and IR groups IR group was treated with 30 ischemia by ligating the left anterior descending coronary artery, followed by h reperfusion by loosing the ligation The expression of miR-204...

Ngày tải lên: 10/08/2014, 05:21

... of Ca2+ under KA stress *P < 0.01 as compared to the KA control K A (12 mg/kg) Figure In vitro and in vivo effect of PETL extract and GABA on the KA -induced oxidative stress KA -induced lipid peroxidation ... the oxidative stress or convulsions Resveratrol protects against KA -induced neuronal damage and subsequent epilepsy [54] Stopping seizure activity promptly is the best way to prevent SE -induced ... protection Pu-Erh leaf extract and GABA ameliorates oxidative stress in KA -induced status epilepticus The molecular mechanisms of PETL extract and GABA on SE -induced excitotoxicity warrants further study...

Ngày tải lên: 10/08/2014, 10:20

... cells, upon oxidative stress, GSSG may either recycle to GSH or exit from cells, leading to overall glutathione depletion [33] Cells deprived of GSH are much more prone to undergo oxidative stress ... an oxidative mechanism may be a point of convergence of many different apoptogenic stimuli (i.e., H2O2, tumour necrosis factor, cycloheximide and natural killer cells, all eliciting oxidative stress) ... cells) inducing the death programme in hepatocytes, probably throughout oxidative stress GdCl3 can block the Pb(NO3)2 -induced cascade by destroying Kupffer cells, and in turn, can modify extracellular...

Ngày tải lên: 13/08/2014, 13:20