involvement of oxidative stress in alzheimer disease
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
Ngày tải lên :
19/06/2014, 22:20
... use of vitamin E and vitamin C in combi-
nation reduced the prevalence and incidence of AD in an
elderly population; however, the use of either of these
vitamins alone had no effect [110]. Finally, ... Peroxynitrite-induced alterations in synapto-
somal membrane proteins: insight into oxidative stress in
Alzheimer& apos;s disease. J Neurochem 1999, 72:310-317.
87. Bonfoco E, Krainc D, Ankarcrona ... complex leads to the
initiation of complex signaling events leading to protein
tyrosine phosphorylation and activation of the src-family
kinases Lyn and Fyn as well as the tyrosine kinase Syk
[30,32,52]....
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
Ngày tải lên :
09/08/2014, 06:22
... ageing.
Conclusion
This study provides insight into the involvement of oxidative
stress in the pathogenesis of OA from the viewpoint of oxi-
dative stress induced genomic instability, especially tel-
omere ... article
Potential involvement of oxidative stress in cartilage senescence
and development of osteoarthritis: oxidative stress induces
chondrocyte telomere instability and downregulation of
chondrocyte ... Our findings
clearly show the presence of oxidative stress in degenerat-
ing cartilage, and the resultant telomere erosion and dys-
function of chondrocytes in vitro and in vivo, suggesting a
role...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
Ngày tải lên :
23/03/2014, 07:20
... oxidative stress- induced changes in
D. discoideum development. Interestingly, oxidative stress resulted in PARP
activation within 5 min that was inhibited by benzamide. Oxidative stress-
induced ... confirming PARP activation in
D. discoideum under oxidative stress.
PARP inhibition during oxidative stress- induced
growth changes in D. discoideum
PARP inhibition conferred protection against ... observed during oxidative
stress (Fig. 4A,B). Under oxidative stress, partial inhi-
bition of PARP activity led to altered growth, suggest-
ing that oxidative stress could be leading to cell...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... that a full dose of
indomethacin alone despite a significant reduction in
brain inflammation had only a marginal effect on brain
oxidative stress in the Tg2576 mice [16]. This finding sug-
gests ... implicating both oxidative
stress and inflammatory mechanisms in AD pathogenesis.
Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3
Effect of indomethacin plus ... brain sections from mice on placebo or receiving indomethacin plus vitamin EFigure 6
Representative pictures of brain sections from mice on placebo or receiving indomethacin plus vitamin E.
Indomethacin
Vitamin...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
Ngày tải lên :
21/02/2014, 03:20
... activation of p38 induced by
oxidative stress, we further examined whether its activation
is responsible for the induction of apoptosis in F9 cells using
SB202190, a potent inhibitor of p38. As shown in ... important role in protection of neuronal cells
against stress- induced apoptosis [26]. In accordance with
these findings, ischemia/reperfusion in the rat forebrain
induces the expression of HSP105/110 ... mitogen-activated protein kinase
(p38). Furthermore, oxidative stress- induced apoptosis was
suppressed by SB202190, a potent inhibitor of p38, in F9
cells. These findings indicated that the activation of p38...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
Ngày tải lên :
07/03/2014, 12:20
... [Ca
2+
]
c
increases to excessively
high levels in neurons following periods of intense neur-
onal activation. Reaching further from the possibility of
the involvement of TRP channels in the delayed ... depolarization of in situ mitochondria by
oxidative stress parallels a decrease in NAD(P)H level
in nerve terminals. Neurochem Int 36, 483–488.
61 Chinopoulos C & Adam-Vizi V (1999) Depolarization
of in ... imposing a continuous load of
calcium to the neuron. The turning point upon which
the cell looses the ability to buffer the incoming calcium
resulting in an abrupt, sustained and irreversible
increase...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
Ngày tải lên :
18/06/2014, 16:20
... cell
activity of several LOX inhibitors, including aesculetin (a
nonselective LOX inhibitor), MK886 (an inhibitor of the
5-LOX-activating protein), zileuton (a 5-LOX inhibitor),
baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress
and cell death play important roles in the efficacy of many
antineoplastic agents [13,14].
To investigate whether oxidative stress is involved in
the ... treatment of H460 cells with 1 μM of NSC-
741909 induced cluster formation of MKP1 and MKP7 at
all time points examined (2 - 8 h after the treatment) (Fig.
1A, B), suggesting that oxidative stress...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
Ngày tải lên :
19/06/2014, 22:20
... proteins including CD59, clus-
terin, vitronectin, C1-inhibitor, C4-binding protein,
decay-activating factor, and Factor H, which inhibit differ-
ent steps in the complement cascade. All of these ... present in the brains of Alzheimer
patients, but not in the brains of patients with other demen-
Journal of Neuroinflammation 2004, 1:18 http://www.jneuroinflammation.com/content/1/1/18
Page 4 of ... entorhinal cortex and the molec-
ular layer of the dentate gyrus [106,107], systemic admin-
istration of the excitotoxin kainic acid [108,109], or
injection of the neurotoxin colchicine into the...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
Ngày tải lên :
20/06/2014, 00:20
... response of the organism to particle-induced oxida-
tive stress. The observed increase of reducing species in
urine would mirror an increased level in blood originat-
ing from a response to oxidative ... only 10% of urate is excreted in the urine (the
remaining 90% being recirculated by the renal system
[3]), an increase of this antioxidant in blood will also
lead to an increase in urine. The ... been
reported to increase the serum levels of uric acid in
North Carolina police officers [4]. A similar increase of
plasma antioxidants in response to an increased oxid a-
tive stress was observed in newborns...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
Ngày tải lên :
07/08/2014, 17:22
... PM10
suggesting that PM2.5 induced more oxidative stress than
PM10. In the single strand breakage assay using pBR322
DNA, the ratio of changed form II/total plasmid DNA (form
F
ig. 10. RT-PCR analysis of ... analysis of Nrf-2
No remarkable change of expression level in Nrf-2,
proteins related with many transcriptional and anti -oxidative
stress enzyme, was observed in the groups of three
concentration of ... Expression of Nrf2 protein in the PM2.5
-
and PM10
-
t
reated rat lung epithelial cell was determined by Weste
rn
B
lotting. The lower shows the ratio of Nrf2/actin usi
ng
c
alculatging by densitometor....
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
Ngày tải lên :
07/08/2014, 23:22
...
significantly reduced (p ＜ 0.05) in all groups compared to
the control group. Similar finding have been reported in
other study during oxidative stress [24]. No significant
changes in GST activity was ... resistant
strain of insect [38]. GST levels were also increased
significantly after 30 days of exposure to protect RBCs
from oxidative damage. Further significant decreases in
GSH levels in our study ... alterations
in antioxidant status in rat erythrocytes: a possible involvement
of reactive oxygen species. Toxicol Lett 1999, 105, 197-205.
19. Klimek J. Cytochrome P-450 involvement in the NADPH-...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
Ngày tải lên :
08/08/2014, 00:22
... 5D).
Anaplerotic fixation of CO
2
by PEPC increased in re-
sponse to O
3
in both groups of seedlings (Figs. 5E–5H) dur-
ing the growing season. The level of activity decreased in
the neoformed flush of the episodic ... by immersing
the tubes for 5 min in boiling water. The colorimetric determination
of NO
2
−
was done by mixing 0.25 mL of incubation medium with
0.25 mL 0.02% N-(1-Naphtyl) ethylenediamine and ... preformed flush, consisting of preformed leaves and
the second flush as neoformed flush consisting of neoformed leaves
as described by Gregory [18].
2.1.2. Harvesting of seedlings
Seedlings were randomly...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
Ngày tải lên :
09/08/2014, 01:23
... sVEGFR-1.
Endothelium injury is critical in SSc and is suspected to
occur early in the disease process. Circulating sVCAM-1 is
a recognised marker of disease activity and a possible
marker of disease severity ... production, including
hypoxic conditions and stimulation by transforming growth
factor, CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-
dative stress also promotes angiogenesis [13]. The link
between ... treated 0.5 ml of serum with 0.5 ml of 10 mM din-
itrophenylhydrazine in 2 M HCl, or with 0.5 ml of 2 M HCl
alone for the blank. Samples were incubated for 1 hour at
room temperature in the dark,...
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