investigatory project on human health and disease

Ngày tải lên: 13/08/2014, 13:20

... fuel burning and industry. Both peak ozone concentrations and rising background concentrations have negative impacts on human health, crop production, tree and other vegetation growth. ã ... revision of the 1999 Protocol to Abate Acidification, Eutrophication and Ground-level Ozone. This Protocol is one of the eight multilateral environmental agreements under the UNECE Convention on Long-range ... reactions in sunlight from air pollutants emitted from fossil fuel burning and industry. Both peak ozone concentrations and rising background concentrations have negative impacts on human health, ...

Ngày tải lên: 17/02/2014, 22:20

Ngày tải lên: 18/02/2014, 04:20

Ngày tải lên: 22/03/2014, 11:20

Ngày tải lên: 29/06/2014, 16:20

Ngày tải lên: 06/07/2014, 15:19

Ngày tải lên: 20/11/2014, 23:58

... intervention and prevention methods and strategies. n Enhance communication, innovation and research. n Promote multidisciplinary interactions among basic scientists, clinicians and behavioral and ... community and are committed to eliminating environmental health disparities and improving the health of all children. The ultimate goal of the Children’s Environmental Health and Disease Prevention ... more contributions to the scientific understanding of complex interactions between the environment, genetics, and other factors and how those interactions affect children’s health from preconception...

Ngày tải lên: 12/02/2014, 19:20

... of transformation capacity, membrane localization and phosphorylation of key residues? Comparison between the activation of ITK–SYK and BTK–SYK To determine its activation capacity, we constructed the ... PH–TH domains of the two fusion proteins play key roles in the activation process and are responsible for varia- tions among different cell types. TEC kinases and disease A. Hussain et al. 2006 ... example, R520 and R525, located in the kinase domain, both non- sense and missense mutations cause XLA (P < 0.001). This provides immediate insight into potential con- formational restrictions, as...

Ngày tải lên: 14/02/2014, 18:20

Ngày tải lên: 21/02/2014, 23:20

... knowledge. London: H. M. Stationery Office, 1932;1–332. 9. McCollum EV. A history of nutrition. Boston: Houghton Mifflin, 1957. 10. Guggenheim KY. Nutrition and nutritional diseases. The evolution of ... plasma ammonia concentration, daily urinary excretion of orotic acid, and urinary N excretion. They found no alterations due to the arginine-free diet. These results would lead to the conclusion that ... the mechanisms of hormone action upon the regulation of amino acid oxidation and protein breakdown and synthesis in humans (184). There are areas in which administration of a specific amino...

Ngày tải lên: 06/03/2014, 05:21

... management and communication components, a number of international regulatory and standard-setting bodies have introduced uniform standards. These include standards for human- health and environmental-safety ... Monitoring of the environmental impacts of GM crops in various regions and from investigation over longer time periods may be necessary to conclude on effects and consequences. 3.5 Monitoring ... new, conventionally bred varieties of a crop plant may also have impacts — both positive and negative — on human health and the environment. 1.4 Recent international controversies and study...

Ngày tải lên: 13/03/2014, 21:48

... measures such as number of bed days and the maternal rating of child health while controlling for chronic health conditions. However, the level of chronic health conditions in children living in poverty ... parents and other adults, the microcontext of interactions between parents and children, the macrocontext of the neighborhood one lives in and the availability of basic educational and health ... explanation for health differences between blacks and whites (84). The Cumulative and Ecological Effects of Poverty on Children Once the methodological and conceptual issues surrounding the definition...

Ngày tải lên: 14/03/2014, 11:20

... evolution: selection, drift, mutation and migration. Evolution’s role is central in the sub-discipline of biology that addresses health and disease in humans and training in evolutionary thinking ... the opportunity for global monitoring of changes in genetic expression at transcriptional and translational levels in response to variations in environmental conditions. The availability of genomic ... combination of transcriptional and post- transcriptional regulation, gene expression can be rapidly and powerfully controlled to maximize the utility of genomic information throughout the long lives...

Ngày tải lên: 14/03/2014, 21:20

... is no contradiction in these results. We have shown that the balance between acti- vation and degradation is dependent on the activation- temperature as well as trypsin concentration and the two ... Journal compilation ª 2010 FEBS 29 formation of heterodimers and complexes, compart- mentalization, and the role of exosites in substrate deg- radation and enzyme inhibition. Activation mechanisms To ... progression and were highest during the M phase. These observations sug- gest that intracellular association of MMP-1 to mito- chondria and nuclei have implications for the control of cell growth, and...

Ngày tải lên: 15/03/2014, 00:20

... The Neuronal Environment Humana Press Brain Homeostasis in Health and Disease Edited by Wolfgang Walz The Neuronal Environment Neuronal Energy Requirements 33 those under resting conditions, both ... specialization in synap- tic integration and action potential conduction. Even small changes of certain extracellular ion concentrations, as well as in the dimensions of the extracellular space, alter ion ... ionic conditions, leads to hyperpolarization. Under extreme conditions, such as synchronous neuronal activity during epileptic seizure, and if glial K + uptake mecha- nisms are operational one...

Ngày tải lên: 15/03/2014, 19:20

... I, Sanderson RD, Ilan N & Vlodavsky I (2010) Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J 277, 3890– 3903. 36 Goldoni ... phosphorylation and acti- vation and subsequent degradation, but it also pro- motes adhesion and migration on fibrillar collagen [55,60]. In extravillus trophoblasts, instead, decorin inhibits migration ... influencing a host of cellular functions such as proliferation, differentiation, sur- vival, adhesion, migration and inflammatory responses. All of these functions are mediated by the intrinsic SLRP...

Ngày tải lên: 15/03/2014, 23:20

... on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spread- ing on extracellular matrix and respond ... Cohen-Kapaln V, Dowek J, Sanderson RD, Ilan N & Vlodavsky I (2010) Proteoglycans in health and disease: new concepts arising for heparanase func- tion in tumour progression and metastasis. FEBS ... tissues and some musculoskeletal tissue. Here, our under- standing of syndecan shedding and its function in wound healing and tumour progression is reviewed. Other reviews on syndecan structure and...

Ngày tải lên: 15/03/2014, 23:20

... heparan- ase: gene cloning, expression and function in tumor progression and metastasis. Nat Med 5, 793–802. 23 Ilan N, Elkin M & Vlodavsky I (2006) Regulation, function and clinical significance ... the pro- gression of primary tumors. Conclusions and perspective Although much has been learned in the last decade, the repertoire of heparanase functions in health and disease is only starting ... influ- ences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma. Blood 109, 4914–4923. 90 Sanderson RD, Yang Y,...

Ngày tải lên: 15/03/2014, 23:20