... mechanisms [42,44] The study of the effect of pH on enzyme inactivation allows the calculation of the pKa of the His176 side chain involved in the inactivation reaction The rate of inactivation exhibited ... nitrogen atoms of the backbone of the residue preceding the catalytic Cys The conservation of this interaction is suggestive of its Fig The nal model of the clostripain catalytic domain The ribbon ... for details) in smaller face The model is of the cleaved clostripain lacking the internal nonapeptide The nal residue of the resultant a-chain, Arg181, and the rst residue of the b-chain, Ala191,...
Ngày tải lên: 23/03/2014, 12:20
... wild-type protein Our data is more consistent with an increased destabilization of the protein in the cytoplasm, a process that, in the case of the Gq family of proteins, is independent of receptor ... in favor of the need of other proteins to stabilize the proteins in the membrane The interaction of Ga subunits with Gbc could be a stabilizing factor Mutations on Gaq residues which locate in ... observed in the rate of degradation of the remaining mutant protein (20% left of the protein) vs the wild 5372 In this report we present evidence that endogenous Gaq, transfected Gaq and Ga16 proteins...
Ngày tải lên: 20/02/2014, 03:20
Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... factors including Ets, GATA, and MyoD/E-box binding factors The introduction of mutation into one of the putative Etsbinding sequences suppressed the promoter activity In addition, the specific binding ... assay (EMSA) using the Ets consensus site at )133 As the involvement of the Ets consensus binding site at )133 in the promoter activity of the mouse a3 integrin gene was suggested by the luciferase ... triplicate, and the error bars indicate the standard deviation attempted to introduce mutations into these sequences As shown in Fig 8, the introduction of mutation into one of the Ets-binding sequences...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx
... However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues in the same enzyme To obtain an insight into ... 1), thereby confirming the crucial role of Asp142 Catalysis in family 18 chitinases (Eur J Biochem 271) 259 In most ChiB structures, Asp142 is clearly defined, being either in the ÔdownÕ or in the ... positioned in the ÔupÕ position rows and shows that in the presence of the substrate, rotation of Asp142 towards Glu144 lowers the pKa of the latter by 0.8 pH units The calculated effects of the D140N...
Ngày tải lên: 07/03/2014, 14:20
Báo cáo khoa học: Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family ppt
... their equivalents in the other subunit of the second dimer (Fig 4A) In the case of P21212 (TcRpiB-R5P), the four molecules in the asymmetric unit represent the tetramer The two active sites of ... stages in the biological cycle of the parasite (i.e the epimastigote and the metacyclic trypomastigote in the insect vector, and the intracellular amastigote and the bloodstream trypomastigote in the ... Arg141¢ The other end of the substrate points into a deep pocket in the enzyme Moving along the ligand from the phosphate, O4 interacts with His102¢ and a water molecule that is in turn within hydrogen-bonding...
Ngày tải lên: 15/03/2014, 00:20
Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx
... and Yap1 in the C-terminal CRD (residues 570–650 in Yap1 and 330–409 in Yap2) was used to further provide an insight into the function Yap2 Domain swapping of the Yap1 c-CRD by that of Yap2 has ... twocysteine-based peroxidase functions in a similar way to Orp1 in the activation of Pap1, the Yap1 orthologue [22] In addition, a second Yap1 redox centre involved in the direct binding of N-ethylmaleimide ... growth in increasing concentrations of cadmium but not of H2O2 Because of the high degree of homology to Yap1, the role of the Yap2 cysteine residues may prove relevant for its activation Furthermore,...
Ngày tải lên: 30/03/2014, 16:20
báo cáo khoa học: " The Puf family of RNA-binding proteins in plants: phylogeny, structural modeling, activity and subcellular localization" potx
... 2000 nM samples, indicating that the low affinity binding of the AtPum-HD to the RNA resulted in a dissociation of the complex during electrophoresis Thus, the instability of the complex did not ... analysis of the amino acids located in the amino-terminal extensions that lie outside of the PUM-HD in AtPum proteins A comparison of the percentage of amino acid identity and similarity for the amino ... specificity of RNA targets by binding to Page 15 of 19 regions of the transcript that lie outside of the PUM-HD binding site The recruitment of other factors might also enhance the RNA binding specificity...
Ngày tải lên: 12/08/2014, 03:21
Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects"
... recession, i.e the position of the gingival margin with respect to the cement enamel junction (CEJ); • CAL (clinical attachment level): i.e the position of the attachment in relationship to the CEJ; ... Considering that no previous report exist reporting on the use of EHA combined with autologous bone but without the application of a membrane in the treatment of infra bone defects, our clinical ... encouraging considering that in a similar study a mean value of the increase of the bone height of 0.5 mm was obtain with membrane application [31] CONCLUSIONS All these properties make HA useful in...
Ngày tải lên: 03/11/2012, 11:35
foreign languages in the labor market of vietnam demands, supplies and recommendation
... task, then it is not only confined to the Ministry of Labour or Ministry of Education and Training, it is also concerned with human resource planning in the Ministry of Planning or Ministry of Finance ... and teaching has helped Vietnam in the new era of integration On the other hand, the learning and teaching of English at the expense of other languages is posing serious issues We should first ... what are their education and training levels etc It is largely concerned in determining what training needs there are so that the labour supply can be shaped to meet the demands of the economy...
Ngày tải lên: 06/11/2012, 15:36
LINH DAM NEW TOWN - SOLUTION FOR THE HIGH-DENSITY DEVELOPMENT OF NEW SETTLEMENTS IN THE SOUTH-WEST OF HANOI
... the central area for the purpose of resettlement Generally, getting along with the rapid expansion, the east bank of the Red River exhibited the beginnings of urbanization The south-west of the ... components: Bac Linh Dam (North of Linh Dam), Linh Dam peninsula in the middle and Linh Dam expansion (South of Linh Dam) The success of the project has set the stage for a series of New Towns that ... tropical climate Among these, the outstanding point is the area of highstorey apartments and office buildings in the center of Linh Dam peninsula, surrounding by low-storey buildings, parks, open...
Ngày tải lên: 29/08/2013, 08:15
LINH DAM NEW TOWN - SOLUTION FOR THE HIGH-DENSITY DEVELOPMENT OF NEW SETTLEMENTS IN THE SOUTH-WEST OF HANOI
... nặng nhọc với mức thu nhập thấp, kéo theo điều kiện sống mức tối thiểu, tạm bợ khu nhà trọ rẻ tiền với điều kiện sinh hoạt an ninh không đảm bảo Đời sống tinh thần lao động hạn chế Họ thấy cô ... làm việc chợ lao động thuê trọ theo ngày (đêm), lại thuê nhà theo tháng Có khoảng 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt không đảm bảo, vệ sinh; 40,95% không sử dụng nước ... vật chất, tinh thần lao động nghèo nàn Họ thường tiêu tiết kiệm cho khoản chi phí sinh hoạt thiết yếu Có 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt thiếu thốn, vệ sinh Họ thường...
Ngày tải lên: 29/08/2013, 08:15
Assessment potential wind energy in the north area of Iraq
... that The prevailing direction of wind fall is from the north-west (NW) i.e (315°-00) which is more than 70 % of all the time The frequencies of wind coming from the remaining sectors are insignificant ... average value of wind speed in the North zone of Iraq during any calendar year A histogram of the wind direction measurements for the site of Tuz during this windy month is shown in Figure From ... preparation The northern area of Iraq (the area selected in this study) is considered transition zone because it located between mountain in the extreme north east and the opening plains in the south,...
Ngày tải lên: 05/09/2013, 16:10
A STUDY ON THE VIETNAMESE ENGLISH TRANSLATION OF EXHIBIT LABELS IN THE VIETNAM MUSEUM OF ETHNOGRAPHY
... five definitions, in spite of slight differences in the expressions, share common features that they all emphasize the importance of finding the closest equivalence in meaning by the choice of appropriate ... in the translation of exhibit labels in the Vietnam Museum of Ethnography (VME)? II SCOPE OF THE STUDY There are several types of exhibit labels in a museum: title or headline labels giving the ... not reflect the role of the speaker of the House of Commons as an independent person who maintains authority and order in Parliament (b) The SL concept is not lexicalised in the TL The SL word...
Ngày tải lên: 07/09/2013, 13:06
E-mail Security in the Wakmail Wake of Recent Malicious Code Incidents
... AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY ... practically speaking, this means in the context of the user launching the code Good practices include making certain that administrative accounts are kept to a minimum, that administrators use ... developed using script embedded in the body of the email message that executed as the message was rendered for viewing by the client Finally, the recent ILOVEYOU worm was similar in concept to the Melissa...
Ngày tải lên: 22/10/2013, 16:15
Tài liệu Designing for Profitability in the Physical Layer of Wireless Networks docx
... costs by reducing the volume of unneeded repairs Non-intrusive Testing and Monitoring for Proactive Maintenance Maintaining the health of the network is the prime responsibility of Operations ... causing an increased workload for reconfigurations and maintenance Meeting the challenge of increasing profits in the face of fewer capital and operating resources to manage this steadily growing and ... is evident in fiber connector cleaning Dirty connectors are the leading cause of poor fiber performance and the most likely failure points in the network, making periodic cleaning of connectors...
Ngày tải lên: 21/12/2013, 08:17
Tài liệu The Unix Family of Operating pdf
... the command line is actually much more flexible than a windowing interface Unix programs are designed to use together from the command line — as “building blocks” in an almost in nite number of ... combinations, to an in nite number of tasks No windowing system that we’ve seen (yet!) has this tremendous power • You can launch and close windowing programs from the command line, but windowing ... For example, a line in the section “Exercise: entering a few commands,” near the end of Chapter 1, shows the following: Get today’s date Enter date To follow the exercise, type in the word date...
Ngày tải lên: 21/12/2013, 11:15
Tài liệu 77 Introduction to the TMS320 Family of Digital Signal Processors docx
... typically, contains a branch instruction to the actual location of the interrupt service routine The return from the interrupt service routine, like in a subroutine, pops the top of the stack to the program ... by using both the data and the program buses to bring in the operands of the multiplication The data coming from the data bus can be traced in memory by an AR, using indirect addressing The data ... be the label of the first instruction of the subroutine The assembler and the linker resolve what the actual value is Calling a subroutine has the following effects: • Increments the program counter...
Ngày tải lên: 25/12/2013, 06:16
Tài liệu Conditions of the surface water and ground water resources in the rural area of the Mekong Delta, Vietnam pptx
... regime of the South Chinese Sea Here, the tidal amplitude is approx 1.5 m The study site Hoa An is located in an area where an interaction of the tidal regimes of the South Chinese Sea and of the ... Hau Giang province in terms of quality and quantity of the available water resources Thus, the improvement of the rural drinking water supply requires investigations regarding the specific local ... carried out The investigations were carried out by the end of the rainy season 2003 The parameters and analytical methods are listed in table The results of the analyses were tested on their plausibility...
Ngày tải lên: 16/01/2014, 17:20
A STUDY ON IMPROVING ENGLISH SPEAKING SKILLS TO 10TH FORM MINORITY STUDENTS AT GIA PHU HIGH SCHOOL IN THE NEW SET OF ENGLISH TEXTBOOK
... occurring in typical kinds of interactions These routines thus can be characterized in broad terms including the kinds of terms typically occurring in given situations, and the order in which the ... because of her insufficient investment in preparing the lessons In summary, we can see from the findings that the interview can really provide in depth the information about the reality of speaking ... of English speaking teaching and learning at Gia Phu High School summary of the findings According to the finding from the questionnaire, the realities of the students’ inhibition and unwillingness...
Ngày tải lên: 29/01/2014, 10:33