integration of cardiac structure and function

... genomics analysis of these functional RNAi datasets in breast and ovarian cancer, we have identified regulators of mitotic arrest and ceramide metabolism as mediators of taxane resistance and confirmed ... development of the next generation of predictive biomarkers across a wide range of solid tumor types Integration of personalized functional genomics into the clinical setting The generation of personalized ... distinguished: resistance of the tumor vasculature to the inhibition of VEGF and PDGF signaling (vascular resistance); and resistance of cancer cells to the hypoxic and nutrient-depleted microenvironment...

Ngày tải lên: 11/08/2014, 12:20

... and then give specific examples of the successful application of these methodologies to the evaluation of hepatobiliary structure, function, development, and xenobiotic response, in both 2D and ... validation and application of exogenous fluorescent probes, and endogenous fluores- cence, for the in vivo study of biological structure, function, and xenobiotic response, in STII medaka, in both 2D and ... applied to understanding the mechanisms and modes of actions involved in xenobiotic induced injury, a betterment of our comparative understanding, and ability to investigate and interpret hepatotoxicity...

Ngày tải lên: 13/08/2014, 13:20

... infrastructure (RNA and proteins) The structure and function of this information-processing complex are of great interest in the study of both normal cellular functions (such as differentiation and ... header portions of the genetic files offer a higher degree of freedom in terms of active control then the preset headers of the CHD The Page 18 of 29 D’Onofrio and An Theoretical Biology and Medical ... examination of the structure and function of computer hard drives and DNA Theoretical Biology and Medical Modelling 2010 7:3 Submit your next manuscript to BioMed Central and take full advantage of: ...

Ngày tải lên: 13/08/2014, 16:20

... REGULATOR OF GOLGI STRUCTURE AND FUNCTION LU LEI (B.SC.) UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY INSTITUTE OF MOLECULAR AND CELL ... regulator of Golgi structure and function, and one mechanism of Arl1’s functions is that it recruits its effectors — GRIP domain containing Golgins on to the Golgi membrane x List of Tables ... of guanine nucleotide binding mutants of Arl1 vi 4.5 Expression of the GDP restricted form of Arl1 (Arl1T31N) causes disassembly of the Golgi apparatus 4.6 Expression of GTP restricted form of...

Ngày tải lên: 17/09/2015, 17:20

... implications of the cycle of histone acetylation and deacetylation that accompanies cycles of transcription, and highlight the special significance of histone H4 lysine 16 acetylation Active chromatin and ... with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130] However, in human cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4-K16 and defective ... acetylation and deacetyla2192 tion, and transient recruitment of remodellers and transcription factors A cycle of transcription commences with the recruitment of transcription factors and co-factors...

Ngày tải lên: 14/02/2014, 18:20

... domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were generated by PCR and cloned ... series of GST-fused deletions of the CD2-1 region (Fig 3E) and examined the interactions between bacterially expressed proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the ... stability and rearrangement of microtubules in neuronal dendrites [13–15] and is associated with some neurological and psychiatric disorders [16,17] However, the structure function relationship of...

Ngày tải lên: 14/02/2014, 19:20

... patterns and processes at different levels of biological organization: from the life histories of individuals, to the structure and dynamics of populations and communities, to the fluxes and pools of ... University of Hertfordshire Body Size The Structure and Function of Aquatic Ecosystems Edited by ALAN G HILDREW School of Biological and Chemical Sciences, Queen Mary, University of London, ... detected and the processes that appeared to be important, and (ii) to compare freshwater and marine ecosystems In Body Size: The Structure and Function of Aquatic Ecosystems, both those questions of...

Ngày tải lên: 17/02/2014, 19:20

... representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain, blue; C-terminal domain, red) (C) Model structure of the PSI domain of cardosin A based on the crystal structure ... roles of plant APs References Davies, D.R (1990) The structure and function of the aspartic proteinases Annu Rev Biophys Biophys Chem 19, 189–215 Dunn, B.M (2002) Structure and mechanism of the ... isoforms by the excision of the prosegment and of most of the PSI [21] Conversely to what has been found in vivo [31], heavy and light chains of the processed forms of recombinant cyprosin are...

Ngày tải lên: 19/02/2014, 12:20

... domain of each subunit contributes to the formation of the hydrophilic pore ACh binding protein has structural and functional homology to the extracellular ligand binding domain of the nAChR, and ... pharmacological and physiological properties of the channel In situ hybridization and immunohistochemistry data show overlapping distributions for a variety of subunits, and electrophysiological and other functional ... development of selective drugs is the identification and pharmacological characterization of the various receptor subtypes, and the determination of their precise subunit composition and physiological function( s)...

Ngày tải lên: 19/02/2014, 12:20

... the structure and PDB code shown below each panel (A) Overlap of isoform 337 with the structure of the longer isoform CfAFP-501 using the main chain of residues Thr23fiAsn90 in isoform 337 and ... other and with proteins that have a similar fold Structure of sbwAFP and TmAFP The structure of sbwAFP has been determined by X-ray ˚ crystallography to 2.5 A and by NMR at both 30 °C and °C ... method and PDB code shown below each panel (A) Overlap of X-ray structure with °C NMR structure using the main chain of residues Ser12fiThr70 in the structure alignment (B) Overlap of the X-ray structure...

Ngày tải lên: 19/02/2014, 16:20

... solution structure of the C-domain (A) Stereo view of the ensemble of the final 48 calculated structures Twenty-four structures of the closed protein conformer are shown in red, and 24 structures of ... structure calculation for the open and closed conformers of the C-terminal domain of human eRF1 Fig S3 NOE map of the minidomain (residues 329– 372) of human eRF1 NMR structure and function of ... of eRF1 Fig S11 The Ramachandran map plot (/ and w torsion angles for the protein backbone) of all 24 conformers of the NMR families of solution structures of the closed and open conformers of...

Ngày tải lên: 06/03/2014, 11:20

... identification and distribution of TLP genes in nature, the structural and functional characterization of the TLP from various organisms, and the evolution of TLP and transthyretin The identification of TLPs ... structures of these proteins, all tetrameric, showed significant similarity to the published structures of transthyretin By way of example, a comparison of the structure of S dublin TLP with the structures ... in TLP structures as a result of alterations to the formation of hydrogen bonds between strands The carbonyls of residues V104 and P105 (zebrafish TLP numbering), in the middle of b-strand G,...

Ngày tải lên: 07/03/2014, 00:20

... Valverde et al Structure and function of KH domains A B C Fig 10 Crystal structure of tandem type II KH domains of NusA in complex with RNA The tandem KH1–KH2 domains of NusA recognize RNA ligand 5¢-GAACUCAAUAG ... in which the b1-strand and b2-strand are adjacent and parallel to each other, and the b¢-strand is adjacent and antiparallel to the b1-strand (Fig 1) The length and sequence of the variable loop ... 2719 Structure and function of KH domains R Valverde et al Fig Solution structure of the FBP KH3–KH4 domain bound to ssDNA The third and fourth KH domains of FBP recognize ssDNA 5¢-dTTTT (A) and...

Ngày tải lên: 07/03/2014, 05:20

... III, a-helix (B) Top view of the threedimensional structure of GlcNAc kinase The relative positions of cysteines are labeled with a star Ó FEBS 2002 Structure and function of GlcNAc kinase (Eur ... positions of the cysteines of GlcNAc kinase are displayed in Fig 5B Cysteines C211 and C45, whose Fig Predicted three-dimensional structure of GlcNAc kinase (A) Front view of the threedimensional structure ... catalytic mechanism of GlcNAc kinase Kinetic characterization of GlcNAc kinase and cysteine mutants In order to get a more detailed insight into the functions of specific cysteine residues of GlcNAc kinase,...

Ngày tải lên: 08/03/2014, 10:20

... system, and by HPLC on a C18 reverse-phase column It was found to be at least 98.4% pure Fig Structure of SDTG (A) and time course of inactivation of recombinant GST I by SDTG at pH 6.5 and 25 ... 2,4,6-trinitrobenzenesulfonic acid, and the amount of covalently bound SDTG was determined by subtraction of the total number of carboxy and amino groups in the modified and unmodified enzyme The results of this experiment ... course of inactivation of wild-type GST I and mutant Phe51Ala by SDTG Wild-type (r) and mutant Phe51Ala (j) were incubated in the presence of 72.7 and 92 lM SDTG, respectively, at pH 6.5 and 25...

Ngày tải lên: 16/03/2014, 16:20

... Ministry of Education, Science, and Culture of Japan, and a fellowship from Katayama Chemical Industries, Co., Ltd (Osaka) to T.Y Ó FEBS 2004 Effects of DiS-C on mitochondrial structure and function ... induction of mitochondrial PT To validate this interpretation, we further characterized the actions of DiS-C3(5) on the mitochondrial structure and function and compared them with those of Ca2+, ... the absence/ presence of Pi in the incubation medium Thus, it was of interest to us to examine the effects of DiS-C3(5) on mitochondrial structure and function in the absence of Pi Where Ca2+ had...

Ngày tải lên: 16/03/2014, 18:20

... hemocyanin structure and function equilibrium constant, lo, describes the ratio of conformations r and t in the absence of ligand: lo ¼ ½t0 Š ½r0 Š Three-state MWC model An extension of the simple ... the absence of divalent ions [3] This characteristic is shared also by other Hcs of the genus 2061 P monodon hemocyanin structure and function Fig Analysis of the aggregation state of Penaeus ... properties of the protein and to trace the evolutionary pathway of the allosteric behaviour Results Characterization of the oligomeric state of P monodon Hc In gel-filtration experiments of native...

Ngày tải lên: 23/03/2014, 13:20

... digestion and primer extension ´ analysis at C1400 and C1411 of the 3-minor domain of 16S rRNA, at positions located in the central loop of domain V, and in helices H42-H44 and H95 of 23S rRNA ... subunit of type IC restriction modification enzyme EcoR124I E Sisakova and M Weiserova Laboratory of Molecular Genetics of Bacteria, Division of Cell and Molecular Microbiology, Institute of Microbiology, ... Laboratory of Biophysical Chemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran E-mail: divsalar@ibb.ut.ac.ir One of the most widely studied and fascinating proteins of...

Ngày tải lên: 23/03/2014, 15:20

... form and function of novel complexes such as HAMLET and ELOA, we have provided new evidence that a loss of native structure can endow proteins and their complexes with distinct and beneficial functions ... successfully target and kill tumor cells in humans and animals In view of this extensive documentation, we propose that it would be useful if HAMLET were used Structure and function of HAMLET-type ... effectively reduced the viability of mouse embryonic fibroblast and liver cell cultures, neuroblastoma cell line SH-SY5Y and a rat pheochromo- Structure and function of HAMLET-type complexes cytoma...

Ngày tải lên: 29/03/2014, 21:20

... values of r2 and sum of squares ( · 10)3) were as follows: citrate, competitive 0.92 and 518 versus noncompetitive 0.95 and 351; isocitrate, competitive 0.98 and 121 versus noncompetitive 0.99 and ... from those of other bacteria in gene organization and regulation [13,16,17], making ArCMLE1 an interesting target for structural and functional studies Results Cloning and sequencing of the pcaB1S2 ... sequences of the CMLE1s from members of the Rhizobiales, such as ArCMLE1 and AtCMLE1, are significantly shorter than the isofunctional enzymes from other bacteria (Fig 2) Expression of ArCMLE1...

Ngày tải lên: 30/03/2014, 10:20