integrating and validating inter and intra patient variation on multiple scales

... alteration in EAAT2 expression, such as amyotrophic lateral sclerosis [11], Alzheimer’s disease [12], and Huntington disease [13] Interventions targeting on the glutamate transporter have been conducted ... stepped down and up on the safe board, and the latency of stepping down till the rats stayed on the board for were recorded Session two (P24) was conducted one day later Rats were placed on the safe ... injury in neonatal rats A-D, Nissl stains of coronal brain sections from rat sacrificed on P14 after left carotid artery ligation and subsequent two-hour hypoxia on P7 Panel A, B, C and D represents...

Ngày tải lên: 10/08/2014, 10:20

... manifestations of severe hyponatraemia with cessation of seizure activity Too rapid a correction of serum sodium can trigger demyelination of pontine and extrapontine neurons to occur after one or ... Severe hyponatremia: complications and treatment QJM 1995, 88(12):905-909 Roberts TJ, Nijland MJ, Williams L, Ross MG: Fetal diuretic responses to maternal hyponatremia: contribution of placental ... that they have no competing interests Authors' contributions TC had direct participation in management of the case, collected and analysed data, and drafted, revised and referenced the manuscript...

Ngày tải lên: 11/08/2014, 19:21

... international community The present study focused on understanding the alterations in GABA content, total GABA and GABAB receptors and GAD expression in the cerebellum and brain stem of hypoxic neonatal ... back to near control by the timely resuscitation with glucose, alone and in combination with oxygen The deleterious effect of oxygen alone and epinephrine resuscitation in neuronal response through ... rats and the effects of various resuscitations on these alterations The effectiveness of various resuscitation methods like administration of 100% oxygen and intravenous fluids like 10% glucose and...

Ngày tải lên: 10/08/2014, 05:21

... therapy and a combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with APS According to the guidelines of the American Heart Association (APASS) ... disease in multiple organs, miscarriages, and livedo reticularis Materials and Methods We focused on the secondary prevention of stroke with APS, and compared single antiplatelet therapy and a combination ... patients http://www medsci org Int J Med Sci 2010, 17 Figure Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention...

Ngày tải lên: 26/10/2012, 09:48

... Parental concerns for the child with febrile convulsion: long-term effects of educational interventions Acta Neurol.Scand 2001; 103: 288-93 11 Huang MC, Liu CC, Huang CC, Thomas K Parental responses ... into objects Biting oneself Pneumonia secondary to fluid aspiration Injury from prolonged or complicated seizures Medication side effects related to the treatment and prevention of seizures (if ... Reaction and Response to Febrile Seizures in Children Parental reaction and response to febrile seizure occurrence in children can comprise physical, psychological, and behavioral manifestations...

Ngày tải lên: 26/10/2012, 10:03

... attention The International Conference on Population and Development (ICPD) in Cairo, 1994 [1] and the 4th World Conference on Women in Beijing [2] drew attention to women’s health and the need to have ... practices, and the preferred means of decision-making on maternal, neonatal and child health issues between intervention and control districts Methods Study setting This cross-sectional comparative ... before every interview Confidentiality was maintained by removing all identifiers of the respondents during data entry Results This section includes the comparison between intervention and control...

Ngày tải lên: 12/02/2014, 19:20

... treatment and care interventions for women and their children A comprehensive approach to care based on simplification, standardization, and integration is needed to scale-up interventions and strengthen ... sanitation and hand-washing with soap ● Malaria IPT and access to malaria control programs and ITNs ● Nutrition assessment, counseling and support, including micronutrient supplementation and deworming ... support, and growth and development monitoring including Vitamin A and other micronutrient supplementation and deworming ● Interventions to promote safe water, preventive hygiene practices, sanitation...

Ngày tải lên: 12/02/2014, 19:20

... preconditioning and postconditioning Basic Res Cardiol 104, 189–202 Sugrue MM, Wang Y, Rideout HJ, Chalmers-Redman RM & Tatton WG (1999) Reduced mitochondrial membrane potential and altered responsiveness ... as an internal control (B) TRAP1 levels were normalized with b-actin under normoxic or hypoxic conditions (C–G) TRAP1 expression detected by immunofluorescence under normoxic conditions (C) and ... expression causes cell damage under normoxic and hypoxic conditions Our data also indicate that 1932 Fig TRAP1 overexpression prevented the hypoxia-induced reductions in cell viability and Dw...

Ngày tải lên: 16/02/2014, 14:20

... inhibition and TRAIL in osteoarthritic disease and chondrocyte apoptosis, and the hypoxic inhibition of cartilage and chondrocyte degeneration Results Macroscopic and radiographic examination of ... ALLN and TRAIL increased caspase-8 activation and JNK phosphorylation However, both caspase-8 activation and JNK 7380 phosphorylation were inhibited under hypoxic conditions (Fig 6B) MTP and ROS ... the activation of caspase-8 under normoxic conditions, but that caspase-8 activation was inhibited under hypoxic conditions In addition, the enhancing effect of proteasome inhibition on TRAIL-induced...

Ngày tải lên: 18/02/2014, 14:20

... frozen and sectioned with a cryostat at 30 lm, and consecutive sections were collected in 6-well plates containing NaCl ⁄ Pi These free-floating sections were then mounted on glass slides and air-dried, ... Expression and purification of PEP-1–HSP27 fusion protein Following induction of expression, PEP-1–HSP27 fusion proteins were purified using an Ni2+-nitrilotriacetic acid Sepharose affinity column and ... affected detection of PEP-1–HSP27 fusion protein transduction by direct fluorescence, we used FITC-conjugated PEP-1–HSP27 fusion proteins for transduction into non-fixed or fixed astrocytes The intracellular...

Ngày tải lên: 18/02/2014, 17:20

... the maternal genotype and environment (Gluckman, 1994 and Walton, 1954) Among the socio-economic factors of interest are income (wealth), education, occupation or employment and marital status Related ... al (2010) rather found a positive and significant relationship between primary and secondary education on one hand and LBW on the other hand The results also indicate that the gender of the child ... Statistical Service and Macro International Inc (MI) (2004) Ghana Demographic and Health Survey 2003 Calverton, Maryland: GSS and MI Ghana Statistical Service (GSS) and Macro International Inc (MI)...

Ngày tải lên: 19/02/2014, 22:20

... cardiopulmonary resuscitation, cardioversion, defibrillation, cardiac and non-cardiac surgical procedures, blunt chest trauma with possible cardiac contusion and cocaine abuse CK and coronary reperfusion ... grafting Cardiac Troponins Cardiac Troponins (cTn) control the calcium-mediated interaction of actin and myosin It exists in three isoforms: troponin C, troponin I and troponin T Troponin C exists in ... recurrent elevation in CK-MB concentration alone should not be relied upon to diagnose reinfarction, but should be accompanied by recurrent ST segment elevation on ECG and at least one other supporting...

Ngày tải lên: 20/02/2014, 08:20

... synchronous round of replication upon reoxygenation However the extent of replicon synchrony attained by the hypoxic incubation alone, i.e absence of active replicons in the state of elongation, ... hypoxic and normoxic conditions The signal intensities are slightly stronger under hypoxic than under normoxic conditions This seems reasonable, as hypoxic suppression of replicon initiation accumulates ... hypotonic preparation of nuclei, fraction contains ‘soluble nuclear proteins’ which are extractable from nuclei by Triton X-100 containing buffer, and in fraction 3, the chromatin fraction, all...

Ngày tải lên: 21/02/2014, 00:20

... IEEE International Conference on Intelligent Processing Systems (ICIPS-1998) Ewing Gary, Ferguson Lindsey, Freer Yvonne, Hunter Jim and McIntosh Neil 2002 Observational Data Acquired on a Neonatal ... make diagnosis, or confidence in decision Conclusion We have described our work on summarizing physiological data from a neonatal intensive care Content selection used segmentation (an existing data ... responsible for lexical selection and aggregation Finally the fourth module, realization is responsible for generating the grammatical output We have used the small corpus we collected from NEONATE,...

Ngày tải lên: 22/02/2014, 02:20

... singlestranded M13mp18 DNA containing segments of the SV40 genome cloned in either direction into the plasmid SmaI site by standard procedures [26] For fixation of the single-stranded SV40 probes onto ... chromosome by protein–protein interactions or by any other means than interaction with single-stranded DNA under hypoxic culture conditions Following re-oxygenation, part or all of the prebound ... be the reason that T antigen remains bound to the SV40 origin after initiation of replication? Several explanations are possible First, initiation of replication upon re-oxygenation is not exactly...

Ngày tải lên: 22/02/2014, 04:20

... expression CB-R activation Protection Protection Protection Protection Toxicity Protection [28] [30] [31] [37] [48] [38] Protection NT Protection Protection Protection NT Protection Toxicity Toxicity ... communication and strengthening [4] and, hence, long-term blockade by competitive or noncompetitive NMDA antagonists, as is necessary for stroke treatment, may be irrational [5] The same reasoning ... neurons through a mechanism similar to depolarization-induced suppression of excitation (see below) A similar noxious effect was demonstrated with another CB1 antagonist, rimonabant (1 mgÆkg)1 intravenously),...

Ngày tải lên: 07/03/2014, 03:20

... protein-beta, interferon regulatory factor-1, signal transduction and activator of transcription-3, and early growth response-1 have been demonstrated to mediate post-ischemic neuronal damage [49,58–63] ... of cytokines and chemokines enhance the expression of adhesion molecules, such as intercellular adhesion molecule (ICAM-1), on cerebral endothelial cells, facilitating the adhesion and transendothelial ... the adhesion molecules ICAM-1 [27–30], P-selectin and E-selectin [31,32] and integrins [33,34] on endothelial cells and leukocytes, which promote the adhesion and transendothelial migration of leukocytes...

Ngày tải lên: 07/03/2014, 03:20

... memory [40] and in spatial long-term memory [41] A forebrain neuronal conditional NF-jB-deficient mouse model confirmed the prominent role of neuronal NF-jB in memory and cognition by demonstrating ... response to diverse extracellular signals (including glutamate and TWEAK) and to intracellular events [such as the generation of reactive oxygen species (ROS) and the elevation of Ca2+ content] ... transmission and maintenance of LTD in the hippocampus, whereas other members of the NF-jB family might be responsible for the induction of LTD and the late phase of long-term potentiation [42]...

Ngày tải lên: 07/03/2014, 03:20

... stroke patients, and neuroprotection should be evaluated on a long-lasting and functional basis, rather than on an acute and histological basis Also, careful and rigorous selection of patients ... compilation ª 2008 FEBS 39 PARP-1 and the ischemic neurovascular unit F Moroni and A Chiarugi of endothelial tight junctions and decreases the expression of the adhesion molecule intercellular adhesion ... cell proliferation include the generation and release of ROS from NADPH oxidase and mitochondria, sustained increase of the cytosolic Ca2+ concentration and finally nuclear translocation of mitogen-activated...

Ngày tải lên: 07/03/2014, 03:20