insights into nonprojectivity in hindi

... parsers for Hindi and other Indian languages. Hindi, being a morphologically rich, flex- ible word order language, brings chal- lenges such as handling non-projectivity in parsing. In this work, ... 2008b) can be extended to incorporate graph properties discussed in section 3 as constraints. Further, linguistic insights into non-projectivity can be used in parsing to identify when to generate the ... caused in Hindi, due to various linguistic phenomena mani- fested in the language, such as relative co-relative constructions, paired connectives, complex co- ordinating structures, interventions in...

Ngày tải lên: 20/02/2014, 09:20

... acetylcholinesterase FEBS Journal 275 (2008) 2659–2664 ª 2008 The Authors Journal compilation ª 2008 FEBS 2661 Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase ... fasciculin binding suggests that the back door route might become the most important route when the main entrance is blocked [8,9]. Recent kinetic crystallography studies provide some structural insights regarding ... Stojan J, Sussman JL, Zaccai G, Silman I & Weik M (2006) Structural insights into substrate traffic and inhibition in acetylcholinesterase. EMBO J 25, 2746–2756. 5 Gilson MK, Straatsma TP, McCammon...

Ngày tải lên: 07/03/2014, 05:20

Ngày tải lên: 08/03/2014, 16:20

Ngày tải lên: 23/03/2014, 07:20

Ngày tải lên: 21/06/2014, 19:20

... grouped into four classes according to their metal cofactors: copper and zinc-containing SOD (Cu,Zn-SOD), iron-containing SOD (Fe-SOD), manganese-containing SOD (Mn- SOD) and nickel-containing SOD ... metal-binding site at the interface of the two domains, which consists of four side chains: two (His31 and His79) from the N-terminal domain and two (Asp165 and His169) from the C-terminal domain ... ions incorporated into the enzyme as it accumulated in the E. coli cells. Indeed, the activity of the apo-enzyme was significantly lower than the metal-containing enzyme. Metal cofactors were incorporated...

Ngày tải lên: 14/02/2014, 22:20

... ATP-binding pocket. Pantoate binding to the ATP-binding site induced large changes in structure, mainly for backbone and side chain atoms of residues in the ATP binding HXGH(34–37) motif. Sequence-specific ... al. (2000) Proline inhibits aggregation during protein refolding. Protein Sci 9, 344–352. 17 Mitra A & Sarma SP (2008) Escherichia coli ilvN interacts with the FAD binding domain of ilvB and activates ... pan- toate–protein interactions in the canonical pantoate- binding site (site I). Fig. S4. Two-dimensional projection showing the pan- toate–protein interactions in the ATP-binding site (site II). Fig....

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 18/02/2014, 04:20

... N-terminal hairpin in HtA is intermediate between those in RNse T1 and a-sarcin, having 20 amino acids in HtA, 26 in a-sarcin and 12 in RNase T1. From a functional point of view, this reduction in ... N-terminal hairpin in sarcin were proposed to be the regions involved in lipid interactions [21]. In HtA, loop 2 (resi- dues 45–63) is much shorter than in a-sarcin (19 amino acids versus 41 amino ... structures. For instance, loop 2 is shorter in HtA than in a-sarcin, but the structure of the remain- ing part is the same in both proteins, including a short segment (N56, C57 and D58) forming a turn...

Ngày tải lên: 18/02/2014, 08:20

... ervatamin-C has a wider opening than that of ervatamin-A and lacks the proper environment in which to bind and fix the Leu side chain (P2) of E-64 tightly. In fact, S2–P2 binding is not compact in ervatamin-C, ... region on the surface of domain L con- taining the active site Cys. The S3–P3 interactions are mainly governed by side chain interactions, and accordingly the amino-4-guanidinobutane (P3) moiety of ... listed in supplementary Table S1. In contrast to the inhibitor interactions at the active site, the subsite interactions (S2–P2 and S3–P3) are differ- ent in ervatamin-A and ervatamin-C. S2–P2 interactions The...

Ngày tải lên: 18/02/2014, 16:20

... cysteinyl residue in the PIII disintegrin-like domain, residing in what is called the RGD loop in disintegrin domains (Fig. 6; residue 468, VAP1 num- bering). The potent integrin-binding inhibitor ... venom. Interesting structural features in disintegrin, disintegrin-like and cysteine-rich domains There are several interesting structural features associ- ated with SVMP disintegrin, disintegrin-like ... prodomain; M, metalloproteinase domain; S, spacer; D, disintegrin domain; DL, disintegrin-like domain; Cys, cysteine-rich domain; L, lectin-like. Snake venom metalloproteinases and venom complexity...

Ngày tải lên: 18/02/2014, 18:20

... Pleckstrin (PH) homology domain in the N-terminal region, all the other PLD isoenzymes possess a calcium- and phos- pholipid-binding domain (C2 domain) at the N-ter- minus [5]. From white cabbage, ... present in all members of the PLD superfamily. However, there is low similar- ity in the remaining parts of the molecules. Most mam- malian PLDs contain a PX and a PH domain instead of the C2 domain ... interactions. We assume that calcium ions are involved in enzyme activation by guiding the protein to the membrane, mediating sub- strate binding, or adjusting the charge distribution at the active...

Ngày tải lên: 19/02/2014, 02:20

... the CKL57 strain. We do not know whether the lack of immunoreactivity in the latter strain was due to the inability of the truncated protein to insert into and be stable in the inner mitochondrial ... c 1 were observed in the single deletion mutants tested, except for the increase of the intermediate form of c 1 in the strain lacking subunit 6. Subunit 6 is an acidic protein that interacts with ... to detect proteins in transit and not yet inserted into the inner mitochondrial membrane. The fact that both core proteins decreased by the same extent in the various deletion strains suggests...

Ngày tải lên: 19/02/2014, 12:20

... between arginine and agmatine. Agmatine, which results from decarboxylation of arginine by arginine decarboxylase, is a metabolic intermediate in the biosynthesis of putrescine and higher polyamines ... agmatine in E. coli agmatinase and l-arginine in B. caldovelox arginase [37], indicating that the substrate specificity of these enzymes rely mainly in substituents at C-a. This has been, in fact, ... arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and cata- lysis in the arginase superfamily. Structure Fold Des 7, 435–448. V. Lo ´ pez et al. Interaction...

Ngày tải lên: 20/02/2014, 02:21

... under investigation in our laboratory. In any case, despite the structural differences between agmatinase and arginase, agmatine and arginine were fixed in essentially the same position in the ... urea [1]. Agmatine, which results from decarboxylation of arginine by arginine decarboxylase [2], is a metabolic intermediate in the biosynthesis of putrescine and higher polyamines [1] and may ... arginases (Fig. 4). Since the arginase loop contains residues that interacts with the a-carboxylate group of the substrate arginine [13], and this is the part of the molecule that makes arginine...

Ngày tải lên: 21/02/2014, 01:21

... Yellow arrows indi- cate b sheets, and cylinders indicate helices (green, PYR domain; blue, R domain; pink, PP domain). To illustrate the binding sites for the substrate (PADP in this model), activator ... tetramer, but, in contrast to ThDP, the binding domains are recruited from one subunit only. The main chain nitrogens of residues I322 and I303 interact with nitrogen atoms of the adenine ring and the ... crystal structures, indicating that binding of acetyl CoA may induce changes in the protein conformation in solution. Berthold et al. [4] published crystal structures of OfODC in complex with the...

Ngày tải lên: 06/03/2014, 11:20

... some or significant cuts in spending. Only 4% are increasing their investment in print. Insight #10. Direct Mail, Telemarketing and Event Marketing Increase As mentioned in Insight #3, marketers ... are increasing online investment while 36% are decreasing investment in traditional tactics. Only 17% of respondents are decreasing spend for online tactics while 25% are increasing investment ... be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, faxing, emailing, posting online or by any information storage and retrieval...

Ngày tải lên: 06/03/2014, 21:20

... differences in exposure times during western blot- ting. We also observed a slight increase in SREBF1 protein level triggered in the presence of the NT siRNA, in agreement with the slight increase in SREBF1 ... membrane protein 2; NT, nontargeting; RISC, RNA-induced silencing complex; RNAi, RNA interference; siRNA, small interfering RNA; SREBF1, sterol-responsive element-binding protein 1; TLR3, Toll-like ... processes in a cell type-dependent man- ner. For instance, an increase in the cell cycle timing could be expected following the downregulation of PCNA, coding for a protein involved in the control...

Ngày tải lên: 07/03/2014, 05:20

Ngày tải lên: 07/03/2014, 06:20