infections in leukemia and hematopoietic stem cell transplantation

... Anti-thymocyte globulin (ATG) administered during conditioning before hematopoietic stem cell transplantation triggered a marked increase in both procalcitonin (PCT) and C-reactive protein (CRP) with a peak ... antibody administration [8] Pihusch and colleagues [9] prospectively studied PCT, CRP, and interleukin-6 (IL-6) in 350 stem cell recipients Conditioning with ATG increased all monitored markers In neutropenic ... diagnose infection in patients receiving ATG prior to hematopoietic stem cell transplantation We also assessed renal and liver functions and their relationship to PCT and CRP changes Materials and...

Ngày tải lên: 13/08/2014, 16:20

... Patterns of T -cell reconstitution by assessment of T -cell receptor excision circle and T -cell receptor clonal repertoire after allogeneic hematopoietic stem cell transplantation in leukemia patients–a ... evaluating Tcell reconstitution in acute leukemia patients after alloHSCT and may further support and explain reconstitution of RTEs measured by quantitative detection of total sjTRECs Materials and ... using the QIAprep Spin Miniprep Kit (Qiagen, Germany) To precisely determine the percentage of cells carrying sjTRECs, we used a duplex vector that included a fragment of the δRec-ψJa sjTREC and...

Ngày tải lên: 10/08/2014, 21:23

... used during the conditioning, prevented hyperbilirubinemia [8] It has been reported that UGT1A1 inducers, including phenobarbital, rifampin and phenytoin, were used in the diagnosis and treatment ... transaminase and bilirubin levels were almost normal during the conditioning and within 100 days after transplantation, although indirect hyperbilirubinemia repeatedly happened during chemotherapy ... daunorubicin, idarubicin, and cytarabine prior to HSCT This may suggest that fludarabine and busulfan had low liver toxicity in GS patients [7] It could also be possible that phenytoin, an inducer...

Ngày tải lên: 10/08/2014, 21:23

... mends a system for scoring chronic GVHD manifestations in organs and sites, including the skin, mouth, eyes, gastro­ intestinal tract, liver, lungs, joints and fascia, genital tract, and performance, ... (Th2) cells can initiate a response against autoantigens leading to B -cell hyperre­ activity and production of autoantibodies, causing targetorgan damage, including skin, mucosa, eyes, joints, and ... GVHD is initiated, T-cells produce additional proinflammatory cytokines, including tumor necrosis fac­ tor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-2, which in turn attract more T-cells...

Ngày tải lên: 12/02/2014, 19:20

... hematopoietic stem cells are infused in order to shorten the past transplant neutropenic interval by 4–6 days compared with the same dose of cyclophosphamide without hematopoietic stem cell support, and ... systemic lupus erythematosus Rheumatology 1999, 38:767-772 Burt RK, Slavin S, Burns WH, Marmont A: Induction of tolerance in autoimmune disease by hematopoietic stem cell transplantation: getting ... systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem- cell transplantation: a phase I study Lancet 2000, 356: 701-707 Traynor A, Burt RK: Haematopoietic stem cell transplantation...

Ngày tải lên: 09/08/2014, 01:23

... 32: Hematoxylin and eosin staining of the rat heart upon infarction 181 Figure 33: Masson Trichrome staining of the rat heart upon infarction 182 Figure 34: von-Willebrand factor staining for endogenous ... molecular and cellular changes leading to ventricular remodeling Important mediators that are involved in remodeling include wall stress, neurohormonal activation, renin-angiotensin system, inflammatory ... Angiotensin II also increases DNA and protein synthesis in both cardiomyocytes and fibroblast and hence is a major player in hypertrophy and fibrosis (Sadoshima et al, 1993) Norepinephrine and angiotensin...

Ngày tải lên: 14/09/2015, 09:26

... research, including Spanish speakers, and individuals undergoing reduced intensity transplantation or receiving treatment for disease relapse following transplantation The knowledge gained from ... current status of hematopoietic cell transplantation Annu Rev Med 2003, 54:491-512 Horowitz MM: Uses and growth of hematopoietic cell transplantation In Thomas’ hematopoietic cell transplantation ... analyses Covariates, including biologic, physiologic, and treatment-related factors, are anticipated to influence HRQL and will be incorporated into the cross-sectional and longitudinal analysis as...

Ngày tải lên: 20/06/2014, 15:20

... Vwa, D13S317, and TPOX) were informative and showed the coincidence of profile between AML blasts after transplantation and the donor’s cells, supporting full engraftment of the stem cell transplant ... of stem cell infusion Discussions and Conclusions Here we report a case of a secondary AML developing from donor-derived cells in a breast cancer patient who underwent allogeneic stem cell transplantation ... blast cells and donor DNA were coincident in XPD- and XRCC3-deficient homozygosity, supporting a donor origin for the leukemic blasts The XRCC3 protein plays a critical role in Homologous Recombination...

Ngày tải lên: 10/08/2014, 21:23

... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem ... after hematopoietic stem cell transplantation Clin Infect Dis 2005, 40:932-940 Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf R, Loeffler J, Aepinus C, Bock T, Jahn G, Hebart H: Infectious ... Bilateral interstitial infiltrates clinical studies have to be performed to examine the frequency of clinically relevant HHV-6 infections in these patient cohorts Consent statement Written informed...

Ngày tải lên: 12/08/2014, 04:21

... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem ... after hematopoietic stem cell transplantation Clin Infect Dis 2005, 40:932-940 Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf R, Loeffler J, Aepinus C, Bock T, Jahn G, Hebart H: Infectious ... Bilateral interstitial infiltrates clinical studies have to be performed to examine the frequency of clinically relevant HHV-6 infections in these patient cohorts Consent statement Written informed...

Ngày tải lên: 12/08/2014, 04:22

... developments and innovations in cell- based therapies containing basic and clinical chapters from the respected authors involved in stem cell studies and research around the world It thereby complements and ... Bhatnagar and Ashraf Z Badros Chapter Proteasome Inhibition and Hematopoietic Stem Cell Transplantation in Multiple Myeloma 221 Helgi van de Velde and Andrew Cakana Chapter 10 Autologous Stem Cell Transplantation ... and B.C Li Chapter Recent Advances in Hematopoietic Stem Cell Gene Therapy 107 Toshihisa Tsuruta Section Clinical Aspects of Stem Cell Transplantation Chapter Progress in Hematopoietic Stem Cell...

Ngày tải lên: 18/02/2014, 04:20

... factors including the key pluripotency regulator Oct4 Conserved RNA binding protein and stem cell marker Inhibitor of microRNA processing in embryonic stem (ES) and carcinoma (EC) cells Table Combinations ... factors into somatic cells By using these viral delivery systems, 12 New Advances in Stem Cell Transplantation Fig Methods for producing induced pluripotent stem cells (iPSCs) by non-integrating ... stem cells in the host In conclusion, Cell Transplantation is bridging cell transplantation research in a multitude of disease models as methods and technology continue to be refined The use of stem...

Ngày tải lên: 20/02/2014, 08:20

... marrow injury conditions [43], subsequent studies have expanded this finding to situations of inflammation [44], and peripheral tissue injury [45-47] Hematopoietic stem cells are being increasingly ... peak increase of approximately 53% in the number of CD34 expressing cells and and a 90% increase in CD133 cells in circulation Furthermore, a significant augmentation of cells possessing hematopoietic ... chemotactic interaction during hematopoietic stem cell mobilization induced by G-CSF or cyclophosphamide J Clin Inves 2003, 111:187-196 69 Cavaillon JMH-CN: Signals involved in interleukin synthesis and...

Ngày tải lên: 18/06/2014, 16:20

... grouped into four sections: 1) Hematopoietic stem cell properties, 2) Regulation of hematopoietic stem cells, 3) Hematopoietic stem cells in aging and disease, and 4) Hematopoietic stem cell therapy ... Part Searching for the Key to Expand Hematopoietic Stem Cells 205 Jeanne Grosselin, Karine Sii-Felice, Philippe Leboulch and Diana Tronik-Le Roux Hematopoietic Stem Cells in Aging and Disease ... signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo Cell Stem Cell Mar 6;2(3):274-83 Fuchs, E.(2008) Skin stem cells: rising to...

Ngày tải lên: 27/06/2014, 13:20

... haploidentical T -cell- replete hematopoietic stem cell transplantation Hematologica 2007, 92:414-417 Bignon JD, Gagne K: KIR matching in Hematopoietic stem cell transplantation Curr Opin Immunol 2005, ... Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/ CD19depletion and reduced intensity conditioning; an update Blood Cell Mol Dis 2008, 40:13-19 Handgretinger R, Chen X, ... stem cell transplantation using unrelated donors Blood 2004, 103:2860-2862 Lowe EJ, Turner V, Handgretinger R, et al.: T -cell alloreactivity dominates natural killer cell alloreactivity in minimally...

Ngày tải lên: 10/08/2014, 22:20

... autologous stem cell transplantation The presence of circulating plasma cells and hyperammonemia are both known to be indicators of advanced disease Plasma cell neoplasm should be kept in the differential ... http://www.jhoonline.org/content/2/1/48 A C B D E Figure nodules; of Wright Giemsa stain, aspirate of skin nodules; (C) Chest CT showing diffuse infiltrates; (D) H&E of BAL; (E) Skin (A) Kappa staining(B) ... Kappa staining(B) BAL (A) Skin nodules; (B) Wright Giemsa stain, aspirate of skin nodules; (C) Chest CT showing diffuse infiltrates; (D) H&E of BAL; (E) Kappa staining of BAL ment as a complication...

Ngày tải lên: 10/08/2014, 22:20

... adhesion molecule IFN-γ interferon gamma IL-1β interleukin-1 beta IL-4 interleukin-4 IL-6 interleukin-6 IL-8 interleukin-8 IL-10 interleukin-10 xvi IL-13 interleukin-13 iNOS inducible nitric oxide ... pyrocarbonate DISC death inducing signalling complex xv DIABLO direct inhibitor of apoptosis protein-binding protein of low isoelectric point Diva death inducer binding to vBcl-2 and Apaf-1 DMEM Dulbecco’s ... positive staining can also be seen in various adult mouse tissues including the brain stem and spinal cord…………116 4.2 Double fluorescent immunostaining indicated that Diva is expressed in neurons...

Ngày tải lên: 12/09/2015, 08:19

... formation, to a decrease in plasmin binding or to a combination of the two We demonstrate that both mAb 34D3 and mAb A10.2 inhibit plasmin binding to cells (Fig 5A) and fibrin (Fig 5B) in a concentration-dependent ... thus indicating accessibility and participation of both K1 and K4 in firmly anchoring plasmin to fibrin and cell surfaces Because the expanded Lys-form of plasminogen may be an intermediary in plasmin ... plasmin proteolytic activity on fibrinolysis and extracellular proteolysis, are lacking Furthermore, the relative importance of K1 and K4 in mediating interactions of plasminogen with fibrin and cells...

Ngày tải lên: 20/02/2014, 01:20