incidence and demographics of renal cell cancer

... http://www.translational-medicine.com/content/9/1/133 Page of 10 Figure Effects of NVP-BEZ235 on renal cell carcinoma cells in vitro Targets of NVP-BEZ235, p-P70S6K, p-Akt and p-S6 were decreased in Caki-1, 769-P, A498 and 786-0 cells with ... Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells Lab Invest 2008, 88:962-972 Camp RL, Chung GG, Rimm DL: Automated subcellular ... complexes, mTORC1 and mTORC2 mTORC1 (rapamycin sensitive) consists of mTOR and Raptor, and its activation results in phosphorylation of p70S6 and 4E-BP1 mTORC2 consists of mTOR and the rapamycin-insensitive...

Ngày tải lên: 18/06/2014, 22:20

... http://www.translational-medicine.com/content/9/1/133 Page of 10 Figure Effects of NVP-BEZ235 on renal cell carcinoma cells in vitro Targets of NVP-BEZ235, p-P70S6K, p-Akt and p-S6 were decreased in Caki-1, 769-P, A498 and 786-0 cells with ... Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells Lab Invest 2008, 88:962-972 Camp RL, Chung GG, Rimm DL: Automated subcellular ... complexes, mTORC1 and mTORC2 mTORC1 (rapamycin sensitive) consists of mTOR and Raptor, and its activation results in phosphorylation of p70S6 and 4E-BP1 mTORC2 consists of mTOR and the rapamycin-insensitive...

Ngày tải lên: 20/06/2014, 04:20

... Oncol 2005, 23:8870-8876 Page of 12 Koutras AK, Krikelis D, Alexandrou N, Starakis I, Kalofonos HP: Brain metastasis in renal cell cancer responding to sunitinib Anticancer Res 2007, 27:4255-4257 ... metastasis from renal cell carcinoma: presentation, recurrence, and survival Cancer 2008, 113:1641-1648 14 Hofmann HS, Neef H, Krohe K, Andreev P, Silber RE: Prognostic factors and survival after ... CN, EH and AD collected patient data and follow-up information CN and AP drafted the manuscript All authors read and approved the final manuscript Author Details 1Department of Oncology and Palliative...

Ngày tải lên: 09/08/2014, 03:21

... Pathology revealed a 90% of clear cell RCC, 8% of papillary and 2% of chromophobe RCC (Group vs 2; p > 0.05) All margins of resection were negative At a mean follow-up of 15 months (6-37 months) ... crucial to get a better understanding of the genesis of those reactions Ahead of its time are, on one hand, the recently applications of HAs in the premature rupture of membranes where the adhesive ... for prevention of recurrence of prostate cancer following RP [41] To our knowledge this is the first study which compare the use of a HA and of the ISC in the enucleoresection of RCC The recent...

Ngày tải lên: 09/08/2014, 03:21

... laminin, and mediates cell- cell and cell- matrix adhesion [12,13] The present study aimed to determine the impact of a1, 2-FT gene transfection on the expression of CD44 on cells and the effects of ... groups (P > 0.05) The mRNA levels of CD44 and a1,2-FT in RMG-I and RMG-I-H cells The 2-ΔΔCT value of mRNA level of CD44 in RMG-I-H cells is 79% of that in RMG-I cells, which had no significant ... stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins J Cancer Res 1999, 59:4427-4434 36 Wielenga...

Ngày tải lên: 10/08/2014, 10:21

... on the growth rates of the low arginase producer cell lines CL-2 (P = 0.14) and Renca (P = 0.07) Cell viability of the cells was > 95% at the different points and conditions of the experiments ... produced by renal cell carcinoma cells can modulate L-arginine levels to regulate both cell growth and T cell function Blocking arginase may lead to a decrease in RCC cell growth and aid in restoring ... hours, the depletion of L-glutamine was significantly higher in CL-2 and Renca (P = 0.001 and P = 0.016) than in CL-19 (Figure 2C) Role of arginase II and effect of nor-NOHA on mRCC cell proliferation...

Ngày tải lên: 10/08/2014, 22:20

... and sites that are considered outside of the “usual” metastatic pathway of RCC Rare metastatic sites of renal cell cancer A Medline/PubMed search for articles in English (mostly case series and ... base of her tongue (minor salivary gland) and no known history of renal cancer and a 61-year-old patient who presented seven years after primary treatment, with metastasis to both the submandibular ... Otorrinolaringol Esp 2006, 57(1):47-50 Andreadis D, Nomikos A, Barbatis C: Metastatic renal clear cell carcinoma in the parotid gland: a study of immunohistochemical profile and cell adhesion molecules (CAMs)...

Ngày tải lên: 10/08/2014, 23:20

... preparation and editing Author details Renal Molecular Oncology Group, Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of ... increase and with it the potential for developing novel biomarkers and potential therapeutic interventions Abbreviations ccRCC, clear cell renal cell carcinoma; pRCC, papillary RCC; RCC, renal cell ... adult cancers [31] and occur in 45 to 90% of sporadic RCCs [4,32,33] Inactivation of the 3p25 TSG VHL is of critical importance to the pathogenesis of ccRCC and occurs in up to 86% of tumors [34]...

Ngày tải lên: 11/08/2014, 12:20

... remain clinically occult for most of its course The classic presentation of pain, haematuria, and flank mass occurs in a minority of patients and is often indicative of advanced disease A tumour in ... Approximately 15% of renal cell carcinomas metastasize to the head and neck region – specifically, to the paranasal sinuses, larynx, jaws, temporal bones, thyroid gland, and parotid glands [3,4] Tongue ... assisted in the conception and design of the paper, and also helped in the acquisition, review and interpretation of the data MA contributed towards data collection and drafting of the manuscript SG...

Ngày tải lên: 11/08/2014, 21:22

... Richard S, Teh BT Genomic expression and single nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and renal oncocytoma BMC Cancer 2010 May 12:10:196 Koeman JM*, ... firm foundation from a clear understanding of the molecular epidemiology and pathology of RCC viii LIST OF FIGURES Figure : Histologic subtypes of epithelial renal tumours, 15 Figure 2: The ... Distinct clustering of gene expression profiles of chromophobe RCC and oncocytoma 134 Figure 19: Immunohistochemical profiling of renal oncocytoma and chromophobe RCC 138 Figure...

Ngày tải lên: 11/09/2015, 09:56

... data of childhood cancers from the Singapore Cancer Registry to describe the incidence, trends of incidence rates, and trends of survival rates for childhood cancers from 1968 to 1997 Data of 2129 ... (Parkin et al., 1988b) Trends of incidence for childhood cancers Time trends of incidence helped researchers to understand the mechanism of childhood cancers and the impact of the improvement in diagnostic ... calculate reliable incidence High quality data and standardized classification of childhood cancers made it possible for description and comparison of incidence between countries and over time The...

Ngày tải lên: 09/10/2015, 11:24

... loss in renal cancer A B Fig Role of TSP1 in angiogenesis, and localization in renal cells and tissue (A) Sections of RCC tumors and adjacent normal tissue (HNK) were stained for TSP1 and counterstained ... Thrombospondin-1 loss in renal cancer A D Veliceasa et al B C D E Fig Calcium uptake and mediators in HNK and RCC cells (A) Ca2+ uptake in response to VEGF by HNK and RCC cells HNK and RCC cells were preloaded ... in the cytoplasm and CM of P769 cells, and the lack of response to BAPTA-AM C, purified TSP1 or VEGF, respectively A B C D Fig Calcium channels and calbindin in HNK and P769 cells (A, B) mRNA...

Ngày tải lên: 07/03/2014, 05:20

... proteoglycans isolated from cell and medium fractions, both derived from SG+ ⁄ + cells, were mixed with internal standards of heparin (hep) and chondroitin sulfate (CS) and were subjected to anion ... expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut Immunology 105, 375–390 Caughey G (2001) New developments in the genetics and activation of mast cell ... processing of mast -cell carboxypeptidase A J Cell Sci 118, 2035–2042 14 Diamant B & Patkar SA (1975) Stimulation and inhibition of histamine release from isolated rat mast cells Dual effects of the...

Ngày tải lên: 07/03/2014, 11:20

... analyses of HHV-6A- and mock-infected JJHAN cells at dpi Note the CPE, i.e enlargement of cells, in HHV-6A infected cells D and E Detection of HHV-6 antigen gp60/110 in HHV-6A infected cells HHV-6A -and ... Infections of JJHAN cells with HHV-6A (U1102) Infections of JJHAN cells with HHV-6A (U1102) A Quantifications of cellular (diamonds) and extracellular (squares) HHV-6A DNA The log10 of the viral ... each other on basis of the number of living cells at the end of collection We used a set of antibodies directed towards cellular proteins, including cytoplasmic, cytoskeletal and surface proteins...

Ngày tải lên: 18/06/2014, 18:20

... analyses of HHV-6A- and mock-infected JJHAN cells at dpi Note the CPE, i.e enlargement of cells, in HHV-6A infected cells D and E Detection of HHV-6 antigen gp60/110 in HHV-6A infected cells HHV-6A -and ... Infections of JJHAN cells with HHV-6A (U1102) Infections of JJHAN cells with HHV-6A (U1102) A Quantifications of cellular (diamonds) and extracellular (squares) HHV-6A DNA The log10 of the viral ... each other on basis of the number of living cells at the end of collection We used a set of antibodies directed towards cellular proteins, including cytoplasmic, cytoskeletal and surface proteins...

Ngày tải lên: 20/06/2014, 01:20

... against ovarian cancer Incubation of immune cells with ovarian cancer cells lead to generation of antigen specific T cells against THP-1 and other peptide epitopes of ovarian cancer [126] Other ... prostate and ovarian cancer patients contained high levels of soluble MICs and correlated increased soluble MIC expression with decreased expression of NKG2D on T cells and a subset of NKT cells ... cells, most NKT cells, and a subset of CD4 + T cells [105] When NKG2D binds to its ligands, it induces the cytotoxic activation and proliferation of the immune cell However, MICA and MICB can be...

Ngày tải lên: 20/06/2014, 07:20

... μCi) of 86Y-CHX-A"-panitumumab F(ab’)2 and imaged and days post-injection of the RIC (c) Specificity was demonstrated by co-injecting 100 μg of panitumumab with the RIC and blocking uptake of the ... in renal cell cancer (RCC) Eur J Cancer 2002, 38:178 24 Liu Z, Liu Y, Jia B, Zhao H, Jin X, Li F, et al: Epidermal growth factor receptor-targeted radioimmunotherapy of human head and neck cancer ... 59.5% of the radioactivity was bound The addition of 10 μg of unlabeled fragment, which reduced the percentage of bound radioactivity to an average of 3.5%, demonstrated the specificity of the...

Ngày tải lên: 21/06/2014, 02:20

... as between 0.60 and 0.80 on the anxiety subscale [14] It has been reported that using cut-off score of ≥ on HADS-A, GAD was detected with a sensitivity of 0.89 and a specificity of 0.75 [19] Statistical ... and marital status (p = 0.342) Similarly, no association between anxiety and family income, and anxiety and occupational status existed Results Of 406 study participants 279 (69%) were male and ... factor profile present for anxiety and depression in our setting Some of these factors are linked to a very early marriage, hostile in-laws, financial dependency on males, and lack of intimate and...

Ngày tải lên: 08/08/2014, 23:20

... injury and in loss of self-tolerance as the biological system ages Senescent T cells: facilitators of inflammation Expansion of CD4+ and CD8+ T cells that have lost the expression of CD28, and are ... Therapy Vol No Goronzy and Weyand Figure Replicative senescence and shifts in gene expression Cumulative replication of T cells is associated with telomeric erosion and loss of CD28 and CD40L expression, ... (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells Clin Exp Immunol 1998, 114:113-118 Markovic-Plese S, Cortese I, Wandinger KP,...

Ngày tải lên: 09/08/2014, 01:23

... Contemporary epidemiology of renal cell cancer Cancer J 2008, 14(5):288-301 Pascual D, Borque A: Epidemiology of kidney cancer Adv Urol 2008, 782381 Motzer RJ, Bander NH, Nanus DM: Renal- cell carcinoma ... with clear cell features are composed of pleomorphic cells with abundant clear cytoplasm and well-defined cell borders Nuclei are moderately pleomorphic with irregular borders and often eccentrically ... Baltaci S, Göğüş O: Diagnostic utility of cytokeratins 7, 10 and 20 in renal cell carcinoma and oncocytoma Turkish Journal of Pathology 2008, 24(3):140-146 Page of 16 Mazal PR, Stichenwirth M, Koller...

Ngày tải lên: 09/08/2014, 03:21