in vivo evaluation of oral dosage form performance

... were fixed in 10% phosphate buffered formalin, embedded in paraffin, sectioned, and stained with hematoxylin and eosin (H&E) In vivo pharmacokinetics and bioavailability In vivo pharmacokinetic study ... i.v at a dose of 200 mg/kg In vivo pharmacokinetics The plasma levels of EPI were determined following a single i.v injection of EPI or PA/EPI (10 mg/kg EPI equiv.) in female Wistar rats The plasma ... novel hydrophobized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcomas Cancer Res 58:3385–90 Gustafson,...

Ngày tải lên: 23/04/2013, 21:38

... quantify the fixation of oral implants [15] A limited number of studies prove the feasibility of detecting several forms of femoral implant loosening, in vitro and in vivo using techniques based ... Jaecques S, Perre G Van der: Followup of implant performance using RSA In Proceedings of the International seminar Prediction and evaluation of total hip replacement performance: can we plan success? ... der: The influence of contact conditions on resonance frequencies of a hip stemfemur system: a finite element analysis In Proceedings of the International seminar Prediction and evaluation of total...

Ngày tải lên: 20/06/2014, 01:20

... gas to produce coating with thickness ranging from 40-70 microns (nominal 50 microns) The coating had a minimum total crystallinity of 65% The minimum HA fraction in the crystalline phase was 90% ... finite dissolution rate of crystalline hydroxyapatite provides a continuous source of calcium and inorganic phosphate [18] In our present study, as well as in those reported by others, bone often ... minimum of ten years in patients less than thirty years old J Bone Joint Surg Am 1997, 79:44-52 Garino JP, Steinberg ME: Total hip arthroplasty in patients with avascular necrosis of the femoral...

Ngày tải lên: 20/06/2014, 04:20

... length of cm, for the in vivo administration of incompatible solutions, phenytoin and TPN, using a swine model, did not lead to precipitates large enough to cause adverse clinical effects in our ... did not show any alteration of the histogram suggesting particle size > µm in diameter At no point did any of the Research paper Evaluation of incompatible drugs in a venous catheter Reyes et ... using the control catheter Blood sampling was performed mid-way through the phenytoin bolus administration, and at 1, 5, 10, and 15 intervals for all ports of both catheters Sampling was performed...

Ngày tải lên: 12/08/2014, 18:20

... Medicine Heidelberg: Springer-Verlag; 2002 23 Martin C, Papazian L, Perrin G: Performance evaluation of three vaporizing humidifiers and two heat and moisture exchangers in patient with minute ... is increased [16,30], causing an increase in carbon dioxide levels, especially during low tidal volume ventilation [31] HMEs also cause an increase the inspiratory work of breathing, with an increase ... the offset was maintained, with no significant variations We used this offset (in the order of 0.1–0.2°C) to correct the measurements obtained during the study In each condition, the average of...

Ngày tải lên: 12/08/2014, 20:20

... degree of Master of Engineering in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor Teoh Swee Hin and Dr Alvin Yeo No part of this ... tissue engineering 2.2.1 Degradation of PCL polymer Degradation behaviours of scaffolds play an essential role in the engineering of new tissue, as the rate of degradation is intrinsically linked ... engineering in dentoalveolar application can be extremely challenging 1.1.3 PCL-TCP scaffolds: Current drawback The use of synthetic polymers in the field of tissue engineering has been widely investigated...

Ngày tải lên: 09/10/2015, 11:18

... discussed in Chapter In Chapter 5, in vitro cellular study of transferrin conjugated LPNPs is performed using MCF7 human breast adenocarcinoma cells In Chapter 6, in vivo pharmacokinetics, complete ... THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2011 Acknowledgements First of all, I would like to express my profound gratitude ... protein binding after IV administration (Extra et al., 1993) Docetaxel is mainly bound to alpha acid glycoprotein, lipoproteins, and albumin Among them, alpha acid glycoprotein is the main determinant...

Ngày tải lên: 09/10/2015, 11:18

... management of ART was defined as initiation or continuation of the first-line regimen (stavudine [d4T], lamivudine [3TC], and nevirapine [NVP]) in a patient with confirmed HIV infection, WHO clinical ... reports of deficiencies in quality of care, and decided to conduct a nationwide evaluation of quality of HIV/AIDS-related care as provided by TMs Page of description of the selection and training of ... hundred and sixty-nine técnicos were initially reported to have received ART training After inspection of training lists and consultation with provincial HIV/ AIDS coordinators, 53% of these names...

Ngày tải lên: 18/06/2014, 17:20

... were suspended in 100 μL of culture medium and subcutaneously inoculated into the right flank of mice using a 1.0 mL syringe Intravenous injection of reagents and tumor growth inhibition study ... reported in clinical trials against a wide variety of tumors One of the biggest shortcomings of this drug, however, is its low anti-tumor activity against drug-resistant cells, for example adriamycin-resistant ... and development of multidrug resistance Human hepatoma HepG2 cells were purchased from the Institute of Hematology of Tianjin, Chinese Academy of Medical Sciences (Tianjin, China) To develop...

Ngày tải lên: 21/06/2014, 03:20

... becoming a subject of increasing interest because of their potential in tissue engineering applications [20] They can be obtained from adult bone marrow and are capable to differentiate into ... ratios, strain of Acetobacter and extended times of fermentation interfere in the final product obtained [2,19] In addition, the choice of a particular cellulose structure will depend on the clinical ... Committee at the School of Veterinary Medicine and Animal Science, São Paulo State University Before surgery, anesthesia was induced by intramuscular injection of a combination of xylazine 2%, 10 mg/kg...

Ngày tải lên: 12/08/2014, 18:22

... through the form factors of 5.25-inch, 3.5-inch, 2.5-inch, 1.8-inch and 1.3-inch The smallest disk drives are of size inch and 0.85 inch which were designed for personal mobile information devices ... information processing, information transferring and information storage In fact, information storage technology plays a crucial role in modern devices and systems, such as computer, entertainment systems ... of In- Situ Diagnosis Methods for the Evaluation of Mechanical and Magnetic Performance of Hard Disk Drives ZHU JIN （B.Eng (hons) HUST, P.R.China） A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF...

Ngày tải lên: 05/10/2015, 22:15

... rutin treated rats in single dose study using WinNonlin 49 3.3 R- warfarin (mean) curve fitting for (a) control and (b) rutin treated rats in single dose study using WinNonlin 50 3.4 Changes in ... protein binding affinity differs between the two enantiomers of warfarin The S- isomer has a greater affinity to protein binding in man compared to the R- isomer Some of the drug interactions of ... warfarin curve fitting for (a) control and (b) rutin treated rats using WinNonlin 71 4.3 Mean R- warfarin curve fitting for (a) control and (b) rutin treated rats using WinNonlin 72 4.4 Changes in...

Ngày tải lên: 09/10/2015, 11:24

... provide important information in terms of optimizing processes of environmental sampling To overcome some of the above-mentioned limitations, an evaluation procedure was designed in a previous study ... subjects interviewed Exploring the generality of such a categorization in other geographical scenes, incorporating the analysis of places considered ‘‘unattractive,’’ is one of the aims of the ... familiarity or recognition of visualized scenes may play in processes of aesthetic evaluation The development of evaluation procedures aimed at identifying categories of known and/or familiar places...

Ngày tải lên: 19/02/2014, 17:20

... are in agreement with those of a recent work in which GatY has been identified by other means as an in vivo substrate of GroEL [27] Interestingly, GatY is also included in a list of proteins that ... Services Department of the Weizmann Institute by a single injection of 150 lg of the purified protein, followed by two booster shots of the same amount of protein at 2-week intervals Serum was ... protein family [15] E coli contains five small members of this family including UspA itself (Fig 2), and one larger protein consisting of two UspA domains in tandem [17] The small members of this...

Ngày tải lên: 22/02/2014, 07:20

... Small Clinical Interpretation of Brain PET Scans: Performing Visual Assessments, Providing Quantifying Data, and Generating Integrated Reports Daniel H.S Silverman 33 FDG PET in the Evaluation ... the forms During the intake evaluation, the physician conducts the initial history to obtain information about the chief complaint; background information on the onset, course, and progression of ... consists of administering a battery of standardized tests to assess cognition Test result interpretation is based on comparing the Clinical Evaluation of Dementia and When to Perform PET 19 performance...

Ngày tải lên: 05/03/2014, 23:20

... spectrum of the porphyrin contained in Zn-PP-KatA, in a pyridine ⁄ water ⁄ NaOH ⁄ Tween-80 mixture, was not similar to that of the reference solution of Zn-PP in the same solvent, indicating that ... protein, in binding porphyrins It is not known how haem is transported intracellularly in bacteria, and the mechanisms by which haem is incorporated into soluble and membrane-bound proteins inside ... compounds being taken up into the cell and incorporated into vital haem proteins instead of haem [5] We show here that haem analogues are indeed taken up and can be incorporated into haem proteins,...

Ngày tải lên: 06/03/2014, 11:20

... provide insights into the importance of their roles in the overall performance of the network A similar experimental evaluation of the roles of individual elementary mechanisms in vivo is very difficult ... sequences of the GAL genes through its N-terminal DNA binding site Gal80p inhibits the transcriptional activity of Gal4p by binding to its 28 amino acid region at the carboxyl terminal [25–27] In vitro ... reflected by the sequence of interactions; (c) parameters quantifying strength of interactions; and (d) spatial localization of protein in a compartment or shuttling of proteins between compartments...

Ngày tải lên: 07/03/2014, 16:20

... selenocysteine residue in a C-terminal Sel-tag [18] Der p carrying the Sel-tag had an intact core sequence and maintained allergen-specific IgE-binding epitopes and the use of a Sel-tag enabled labelling ... difficult to follow the in vivo clearance and turnover of an allergen after inhalation In this study we used a novel approach for specific labelling of proteins in order to investigate how an airborne ... deposited in the airways of mice and metabolized The labelling method involves the incorporation of a selenocysteine residue and the gamma-emitter selenium-75 (75Se) within an engineered C-terminal...

Ngày tải lên: 07/03/2014, 21:20

... shown in Fig 4C Interestingly, both tags are recognized more efficiently in the context of the PSI-G loop region than at the C-terminus Topology of PSI-G in vivo In order to examine the topology of ... or light harvesting complex (LHCI), consisting of four members (Lhca1–4) of the chlorophyll a ⁄ b binding protein family LHCI is bound along one side of PSI only, in the vicinity of the PSI-F and ... indicating that the loop region becomes more accessible, presumably by disrupting protein–protein interactions within PSI, or by altering the conformation of the loop His-tags were employed in...

Ngày tải lên: 07/03/2014, 21:20

... protein extracts were obtained as described in experimental procedures A single band of about 53 kDa was detected in liver and lung indicating that the amount of p53 protein was significantly increased ... reproduced in lung, which can explain in part the conflicting results found in adults and children given b-carotene or vitamin A [29] Moreover, in lung of rats injected with high-dose of vitamin A over ... cyclin dependent kinase inhibitor that is a critical target of p53 in facilitating G1 arrest, we also studied the expression of p21WAF1/CIP1, and found that it is increased in chronic-vitamin...

Ngày tải lên: 08/03/2014, 08:20