in vitro release of dox from pegl dox
Sulfatides containing liposomes as novel nano carriers targeting gliomas
Ngày tải lên :
11/09/2015, 16:06
... Fig.4.5 in vitro release of DOX from SCL -DOX 92 Fig.4.6 in vitro release of DOX from PEGL -DOX 93 Fig.4.7 DNase I digestion and nuclei DOX quantifications 94 Fig.4.8 Accumulation and intracellular ... distribution of DOX in cells of U87-MG and CCF-STTG1 96 Fig.4.9 The in vitro cytotoxicity of DOX in different formulations 97 Fig.5.1 SCL -DOX plasma concentration-time profiles in Balb/C mice following ... as binding clathrin heavy chains on the cytosolic side to allow for polymerization of clathrin subunits forming a polyhedral lattice scaffold Proteins including amphiphysin and endophilin bring...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
Ngày tải lên :
14/02/2014, 18:20
... [238–240] Even in the absence of protein–protein interactions, factors can assist each other’s binding to DNA within nucleosomes This principle is illustrated in the model shown in Fig 7A In this scenario, ... bind in the absence of Fos ⁄ Jun [239] In contrast, Sp1 can only bind very weakly to in vitro reconstituted nucleosomes [249] Relative to its binding to free DNA, Sp1 binding to nucleosomes in ... This involved progressively fractionating chromatin into (i) highly soluble small chromatin fragments readily released from nuclei during digestion (fraction S1), (ii) the bulk of the remaining...
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
Ngày tải lên :
19/02/2014, 16:20
... maintenance of the active chromatin state in the Ig-b locus In transient transfection assays, the DNA fragment containing a DHS at )2.1 kb shows no enhancing activity of the Ig-b promoter in ... deletion (containing two Pit-1 binding sites) of the DHS I region which is located within the locus control region (LCR) in the human GH locus, show loss of H3 and H4 acetylation ranging from 32 kb ... Definition of 5¢ and 3¢ structural boundaries of the chromatin domain containing the ovalbumin multigene family J Biol Chem 257, 1501–1507 Weintraub H & Groudine M (1976) Chromosomal subunits in active...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
Ngày tải lên :
09/08/2014, 07:20
... number of factors, including the longevity of the injected protein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity Our data obtained by ... model of autoimmunity Transient autoimmunity can be induced in mice by the administration of a single high dose of LPS This induces a pulse of nucleosomes and chromatin in the plasma within the ... purchased from Pharmingen-Becton Dickinson (San Diego, CA, USA) Biotinylated antibodies were detected using an allophycocyanin-conjugated streptavidin antibody (Pharmingen-Becton Dickinson) Staining...
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Digital Communications I: Modulation and Coding Course
Ngày tải lên :
18/10/2013, 06:15
... ) = Hc ( f ) Lecture Taking care of ISI caused by tr filter Taking care of ISI caused by channel 12 Example of pulse shaping Square-root Raised-Cosine (SRRC) pulse shaping Amp [V] Baseband tr ... represented by a sinc(t/T) function multiply by another time function Example of Nyquist filters: Raised-Cosine filter Lecture Pulse shaping to reduce ISI Goals and trade-off in pulse-shaping Reduce ... Today we are going to talk about: Another source of error: Inter-symbol interference (ISI) Nyquist theorem The techniques to reduce ISI Pulse shaping Equalization Lecture Inter-Symbol Interference...
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Quantitative aspects of ruminant digestion and metabolism - Phần 1
Ngày tải lên :
24/10/2013, 17:15
... activity of the small intestine is directly mediated by MMC The J Dijkstra et al increases in digesta flow that occur with increasing intake are the result of increases in the amount of digesta ... obtain kinetic data, and methods of fitting data to models for estimating kinetic parameters will be reviewed Terminology Before proceeding, some terminology that will be used in the remainder of ... varied from as little as h to more than 40 days Data collection method Both in vitro and in situ techniques use time-series sampling to obtain kinetic data In vitro methods involve the incubation of...
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Quantitative aspects of ruminant digestion and metabolism - Phần 2
Ngày tải lên :
24/10/2013, 17:15
... Proceedings of the Nutrition Society of Australia 14, 153 Faichney, G.J (1990) Effect of level of intake and grinding of lucerne hay on the efficiency of rumination in sheep Proceedings of the ... of daily infusion rate per kg DM Samples taken from the duodenal bulb during intraruminal infusion of 169 Yb chloride (Faichney et al., 1989) and from the pyloric antrum during intraruminal infusion ... following termination of a continuous infusion (see preamble to Eq (3.7)) and ti is the time (h) elapsed since the termination of the infusion After substituting Zi in Eqs (3.1)–(3.3) and confirming...
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If I do … and If I did… & If I knew… I wish I new
Ngày tải lên :
27/10/2013, 22:15
... stopped raining, we could go out (=we would be able to go out) Nếu trời tạnh mưa, chơi (= chơi) D Không dùng when câu tương tự câu này: They would be offended if we didn’t accept their invitation ... được) It rains a lot here I wish it didn’t rain so often Ở trời mưa nhiều ớc trời đừng có mưa thường xuyên It’s very crowded here I wish there weren’t so many people (but there are a lot of people) ... wouldn’t buy that coat If I was you… Nếu anh không mua áo khoác I’d go out if it weren’t raining if it wasn’t raining… Tôi trời không mưa I wish it were possible I wish it was possible Ước điều xảy...
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I will and I am going to do & Will be doing and will have done
Ngày tải lên :
27/10/2013, 22:15
... dụ vào lúc 30, Kevin xem trận đấu (Kevin will be watching the match) Một ví dụ khác: I’m going on holiday on Saturday This time next week I’ll be lying on a beach or swimming in the sea Tôi nghỉ ... what about 9.30? Vậy hả, 30 có không? Kevin: Fine The match will be finished by then Được Trận đấu lúc kết thúc B “I will be doing something” (future continuous)=Tôi làm việc dở dang vào thời điểm ... nhiều will going to Chẳng hạn bạn nói: I think the weather will be nice later Hay I think the weather is going to be nice later Tôi nghĩ thời tiết tới tốt Khi nói việc xảy (something is going to happen),...
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Quantitative aspects of ruminant digestion and metabolism - Phần 3
Ngày tải lên :
29/10/2013, 00:15
... Models to interpret degradation profiles obtained from in vitro and in situ incubation of ruminant feeds In: McNamara, J.P., France, J and Beever, D.E (eds) Modelling Nutrient Utilisation in Farm ... after incubation in cell-free enzymes (amylases, cellulases, etc.) Protein degradability Kinetics of ammonia production after incubation in rumen fluid: the inhibitor in vitro method Kinetics of ... differences in the estimates of extent of degradation of feeds if samples are incubated in the rumen of different In Vitro and In Situ Techniques for Estimating Digestibility 103 ´n ´ ruminant species...
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Quantitative aspects of ruminant digestion and metabolism - Phần 4
Ngày tải lên :
29/10/2013, 00:15
... weakening of particles during ruminal fermentation occurs, as illustrated by reduction in grinding energy of chopped dietary material with time of exposure to in situ ruminal incubation (Fig 5.5) In ... fermented and comminuted) is less during rumination than during eating (Girard, 1990; Das and Singh, 1999) Reasons for this may include: (i) increased salivary input during eating; combined with (ii) ... differential sorting within the RR of particles having undergone differing degrees of digestion and having differing chemical and physical properties The kinetic validity of calculating FPR from the...
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Woe Is I - Pronouns and Case
Ngày tải lên :
01/11/2013, 16:20
... saying Here, ask yourself what does the boss disapprove of? Certainly not me! Rather, he disapproves of my leaving the office early You Could Look It Up Linking verbs indicate a state of being ... day-long meeting." 81 Danger, Will Robinson Direct objects appear in more guises than a quick-change artist A pronoun can be the direct object of a verb, the object of an infinitive, the object of a ... disapproves of (me, my) leaving the office early Answer: The meaning of the sentence requires the possessive case: my Therefore, the sentence should read: "The boss disapproves of my leaving the office...
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Quantitative aspects of ruminant digestion and metabolism - Phần 5
Ngày tải lên :
07/11/2013, 23:15
... maintain redox balance in the rumen However, a number of other factors, including the uptake of hydrogen for biohydrogenation of unsaturated long-chain fatty acids and the uptake or release of ... estimated from the enrichment of rumen NH3 and its rate of decline after a single intraruminal injection of 15 N-ammonium salts (Nolan and Leng, 1974), indicate that there is considerable intraruminal ... Transactions in Ruminants 183 Degradability of protein supplements To assist in feeding management of livestock, tabulations of degradability coefficients for proteins in specific feed ingredients...
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Quantitative aspects of ruminant digestion and metabolism - Phần 6
Ngày tải lên :
07/11/2013, 23:15
... vitamin or cofactor In another example, the combination of a pectin-utilizing bacterium (B ruminicola) increased the degradation and utilization of lucerne pectin (Gradel and Dehority, 1972) In ... component of many ruminant diets, especially those including grain Some cellulolytic bacteria, such as certain strains of B succinogenes, are also amylolytic In general, however, the principal ... level and reading off the intercept on the time axis Values of m determined in this way by Russell and Baldwin (1978) for rumen bacteria grown on a single energy substrate in a defined medium are...
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Quantitative aspects of ruminant digestion and metabolism - Phần 7
Ngày tải lên :
07/11/2013, 23:15
... average of the mixed population? Dinius et al (1976) noted that monensin decreased ruminal ammonia concentrations In vitro studies indicated that ionophores inhibited amino acid deamination (Van ... animals had been consuming monensin In vitro studies indicated that monensin caused a significant decrease in microbial growth yields, but these mixed ruminal bacteria were obtained from unadapted animals ... already resident in the rumen In the late 1980s, Flint et al (1989) reported that a strain of S ruminantium persisted in the rumen for more than 30 days, but in most other cases ruminal inoculation...
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Tài liệu Quantitative aspects of ruminant digestion and metabolism - Phần 8 docx
Ngày tải lên :
15/12/2013, 08:15
... rate of rumen fluid of 15% per hour, about 5% of the WSC ingested would escape from the rumen In such a situation and assuming a daily intake of 20 kg DM containing 15% WSC, only 150 g/day of WSC ... protein flows to the duodenum, but quantities remain relatively small There are a number of reasons why intrinsic degradation characteristics obtained from in situ or in vitro incubations are inadequate ... concept of energy costs of nutrients and ion transport, and of protein synthesis and degradation in tissues of the total gastrointestinal tract of growing lambs No efforts are known, however, of integrating...
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Tài liệu Quantitative aspects of ruminant digestion and metabolism - Phần 9 pptx
Ngày tải lên :
15/12/2013, 08:15
... and in acting as a protein reserve by increasing readily in size in response to increase in protein availability, decreasing as it becomes inadequate Lobley et al (2000) found in a survey of eight ... and histidine) amino acids (EAA) and the non-essential (arginine, ornithine, citrulline, alanine, glycine, serine, aspartate, asparagine, glutamate, glutamine, proline and tyrosine) amino acids ... free amino acids infused into the abomasum will be absorbed in the upper small intestine, whilst casein amino acids will be absorbed from the lower half of the small intestine SCFA Absorption In...
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Tài liệu Quantitative aspects of ruminant digestion and metabolism - Phần 10 pptx
Ngày tải lên :
15/12/2013, 09:15
... origin due to minimal rates of lipolysis Thus infusion of insulin, while maintaining euglycaemia, caused only a small decrease in the already low plasma NEFA concentration in the growing steer (from ... was infused while maintaining euglycaemia Maximally inhibited NEFA concentrations are assumed to be the result of insulin-independent, LPL-catalysed hydrolysis of circulating TAGs In the study of ... 0.01 0.1 10 100 1000 Dose of ß-adrenergic agent (µg/kg (in vivo) or x107 mol/l (in vitro) ) Cow in vivo Pig in vivo Cow in vitro Pig in vitro Fig 13.7 Effect of dose of in vivo b-adrenergic challenge...
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Tài liệu Quantitative aspects of ruminant digestion and metabolism - Phần 11 ppt
Ngày tải lên :
15/12/2013, 09:15
... tracer following the administration of a constant infusion (a) or of a flooding-dose (b) of a labelled amino acid In (a) the ratio of the isotopic activity of the label at the end of the infusion ... effect of infusion of insulin like growth factor (IGF)-I, IGF-II, and insulin on glucose and protein metabolism in fasted lambs Journal of Clinical Investigation 88, 614–622 Eisemann, J.H., Huntington, ... Stimulation of circulating insulin-like growth factor I (IGF-I) and insulin-like growth factor binding proteins (IGFBP) due to administration of a combined trenbolone acetate and estradiol implant in...
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Tài liệu Quantitative aspects of ruminant digestion and metabolism - Phần 12 docx
Ngày tải lên :
15/12/2013, 09:15
... of the insulin-like growth factor (IGF) system, including its binding proteins, in bovine mammary glands Interconnections between the GH axis and other hormonal control mechanisms are beginning ... weaning The reduction in efficiency of protein utilization in neonatal pigs from birth to 26 days of age is mirrored by changes in sensitivity and responsiveness of protein deposition to insulin ... possibility that glutamine could regulate the inflammatory response in the intestinal mucosa of humans These possibilities are worthy of investigation in ruminant animals in which glutamine supplementation...
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