in bypass of lesions induced by platinum based chemotherapeutic drugs

... homotypic interaction and IL-17 Deficiency of Act1 in fibroblasts blocks IL-17 -induced cytokine and chemokine expression The absence of Act1 results in a selective deficiency of IL-17 -induced activation ... strong inducer of RAGE in RA-FLS IL-17 exerts an important role in inflammatory diseases both directly and indirectly The up-regulation of RAGE is one of the functions of IL-17 for modulating the inflammatory ... results in subsequent activation of proinflammatory responses Furthermore, the activation of NF-B results in increased RAGE expression and increases the number of ligand binding sites, which in turn...

Ngày tải lên: 12/08/2014, 17:22

... constraints [192,193,175] In addition to the main phosphorylation sites at serines 106 and 293, Tax is structurally characterized by the presence of an aminoterminal zinc finger and by a leucine-rich ... pathways involved in viral expression include protein kinase C, calmodulin and intracellular calcium mobilisation More physiological stimuli of viral expression include cross-linking of membrane ... Expression of viral proteins Uneven distribution in one daugther cell Cell death induced by immune response, intrinsinc or extrinsic apoptotic pathways Accounts for activation of immune reponse Silencing...

Ngày tải lên: 13/08/2014, 09:20

... scavenging abilities of the drugs of interest are investigated using the 2, 2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic) acid (ABTS) assay ABTS is oxidized in the presence of an oxidizing agent to ... manner Increasing the temperature of incubation induced Aβ aggregation more significantly in a temperature-dependent manner with about 20% increase in the aggregation status following a 96hour incubation ... bound by intramolecular hydrogen bonding that would not be able to be separated in the tricine gel and remains in the stacking gel as presented here The time-dependence of Aβ aggregation, in part,...

Ngày tải lên: 09/09/2015, 18:54

... implying a large increase in the proportion of apoptotic cells (Figure 36b) However, pre-treatment with SPRC significantly reversed the Aβ -induced increase in apoptosis by decreasing the number of ... expression of the 87 kDa cleaved product in the Aβonly group, an indication of increased apoptosis following the application of Aβ Although there was a corresponding increase in the expression of the ... the mechanisms of cell death in drug-treated cells, the involvement of autophagy was investigated The proportion of orange/green fluorescence indicates the extent of staining of acidic autophagic...

Ngày tải lên: 09/09/2015, 18:54

... quickly in solution and remains as the HS- anion, masking the actual production of H2S by the cells By considering this, it can be concluded that the intracellular production of H2S induced by SPRC ... STUDY II in Aβ -induced injury (275) and catalase is the main antioxidant defense in eliminating H2O2 Hence by increasing catalase, the cells can effectively clear the H2O2 produced by Aβ 6.2.5 ... simultaneously increased in both studies by SPRC that points to a plausible role of SPRC in maintaining the SOD/GPx balance Besides, post-translational modifications of the structure of GPx enhance...

Ngày tải lên: 09/09/2015, 18:55

... concentrations of drugs on Aβ -induced cytotoxicity Figure 23: Effects of pre-treatment of drugs on H2S concentrations in cell medium Figure 24: Effects of pre-treatment of drugs on cystathionine-β synthase ... fragmentation using TUNEL staining Figure 37: Effects of pre-treatment of drugs on PARP and pro-caspase expressions in cell lysates Figure 38: Effects of pre-treatment of drugs on autophagy using acridine ... expressions in cell lysates Figure 61: Effects of pre-treatment of drugs on autophagy using acridine orange staining Figure 62: Effects of pre-treatment of drugs on LC3 expression in cell lysates...

Ngày tải lên: 09/09/2015, 18:55

... linked to the induction of lymphangiogenesis in the LNs However, the molecular mechanism underlying the remodeling of lymphatic vessels in the LNs during inflammation is still in its infancy Of ... sources of VEGF ligands including VEGF-A, VEGF-C and VEGF-D in the draining LNs as well as at the site of inflammation through a study using a bacterial pathogen -induced acute inflammation model in ... al., 2006) This finding demonstrated that signals initiated within activated draining LNs could increase the migration of DCs, despite the latter being in an “upstream” location against the unidirectional...

Ngày tải lên: 10/09/2015, 09:29

... shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ⁄ reperfusion injury [14] In our studies, ... [22] ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23] Activated KCs cause oxidative stress on the surrounding tissue, releasing large ... in ammation induced by Citrobacter rodentium infection was mainly TLR4-independent because hepatic CYPs mRNA expression was similarly downregulated and cytokine mRNAs were similarly induced in...

Ngày tải lên: 14/02/2014, 18:20

... image of Si nanowire using Au (d) HRTEM image of Si nanowire using Pt Both were single crystal (e) EDS line mapping of Si nanowires using Au catalyst (f) EDS line mapping of Si nanowires using ... formation of platinum silicide upon cooling We characterized the catalyst globule/nanowires interfaces by HRTEM and observed platinum silicide layers showing different lattice fringes from Si in the ... (g) HRTEM image of interfaces between the globule and nanowire grown with Pt Arrows indicates the platinum silicides showing different lattice fringe to Si (h) HRTEM image of interfaces between...

Ngày tải lên: 16/03/2014, 15:05

... Pt4+ or Pt2+ into Pt0 Based on an understanding of the intermediate Pt-Hads, we added nPt to the single-mediator strategy of M + NAD+ nPt was introduced to play two functional roles in our tandem ... feature The possibility that the increase in the amount of generated NADH is mainly a result of the increase in surface area through adsorption of nPt on the working electrodes should be rejected, ... electrodes On the other hand, the addition of nPt to the solution including M and NAD+ resulted in an increase of the amount of NADH generated on the platinum disk electrode (Figure b) Therefore,...

Ngày tải lên: 03/05/2014, 17:44

... network since it has been shown that MT disruption is involved in apoptosis [50,51] Depolymerization of tubulin may be caused by an increase in PDT induced intracellular calcium (Ca2+) [52] Role of ... investigated by collecting these signals in the list mode using cell-quest software (Beckton and Dickenson, USA) Analysis of light scatter was performed by off-line gating using appropriate windows created ... M: Photodamage induced by Zinc(II)-phthalocyanine to microtubules, actin, alpha-actinin and keratin of HeLa cells Photochem Photobiol 2001, 73:283-289 Gantchev TG, Gowans BJ, Hunting DJ, Wagner...

Ngày tải lên: 18/06/2014, 16:20

... not block the increase in the level of F11R mRNA induced by IFNg, we examined whether the IFNg -induced increase in the level of F11R mRNA could be blocked by AG490, a known inhibitor of the Jak/Stat ... differences in F11R mRNA observed at the indicated concentrations of cytokines in comparison to levels of F11R mRNA measured in the absence of cytokines Since the inhibition of the activity of NFB by ... role of F11R in the initiation of atherogenesis This study demonstrates that inhibition by specific siRNA of the de-novo biosynthesis of F11R, induced in endothelial cells by inflammatory cytokines,...

Ngày tải lên: 18/06/2014, 19:20

... saline controls found localized to the RGCL and INL in retinas of DR rats (Figure 1D), whereas no staining was detected in retinas of saline controls (Figure 1C) Increased SR expression in retinas ... results indicate that SR is elevated in retina and Dserine is increased in aqueous humor in the STZinduced model of DR The increased SR expression in retina may result from activation of the JNK ... as: Jiang et al.: Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin -induced diabetic retinopathy Journal of Neuroinflammation 2011 8:119 ...

Ngày tải lên: 19/06/2014, 22:20

... to line up and form short chains Overall, these short chains appear to orientate along the y axis, though the orientation of a single chain is less definite During this stage, the dominating ... are captured by the change of h in the z direction We consider concurrent surface kinetics including diffusion, redeposition, and sputtering The time evolution of the surface is given by: ∂h = −∇ ... process that happens by the removal of atoms similar as etching In this case, the induced nanostructures such as ripples or islands are composed of the same material as that of the substrate However,...

Ngày tải lên: 21/06/2014, 03:20

... detected in 55% of Rubinstein–Taybi syndrome patients, leaving the diagnosis in 45% of patients to rest on clinical features only Interestingly, this microdeletion of 16p13.3 was found in a young ... abnormality in the cyclic adenosine monophosphate-response element-binding protein has previously been determined as a cause of Rubinstein–Taybi syndrome However, microdeletion of 16p13.3 comprising ... comprising cyclic adenosine monophosphate- response element-binding protein and tumor necrosis factor receptorassociated protein genes is a rare scenario in the pathogenesis of Rubinstein–Taybi syndrome...

Ngày tải lên: 21/06/2014, 19:20

... drawings on transparent sheets were scanned and analysed using WinRhizo [8] Competition aboveground by pine was assessed using the relative irradiance and a competition index As Pinus-dominated ... each seedling experienced a specific degree of competition from the pine overstory, depending on pine number, size and distance Aboveground competition by pines was assessed by measuring the distance, ... development of naturally-regenerated beech saplings [15, 16] This index is computed as the sum of vertical angles from the top of each target tree (= beech seedling) to the top of each surrounding pine...

Ngày tải lên: 08/08/2014, 00:21

... follicle-stimulating hormone, luteinizing hormone, prolactin and dehydroepiandrosterone sulfate were in the normal range Since the patient experienced increasing episodes of vomiting, a repeat gastroscopy ... followed by amenorrhea However, only abdominal swelling and abdominal pain are reported as symptoms of Krukenberg tumors, whereas abnormal vaginal bleeding and amenorrhea occur in only 20% of patients ... of gastric adenocarcinoma The neuroendocrine markers CD56, chromogranin and synaptophysin were negative ruling out a neuroendocrine subpopulation of the tumor In addition, Krukenberg tumors of...

Ngày tải lên: 09/08/2014, 07:21

... writings of Augustine of Hippo, the great 4th century theoretician of early Christianity, and of Plato, the great philosopher of ancient Greece By examining both Augustine and Plato, Alexander in effect ... is a kind of super hothouse for the creation of every sort of dislocation, and therefore inevitably of all kinds of addiction He stresses the disruptive, dislocating and even disintegrating powers ... and intriguing turns is its examination of addiction (in this broad sense) in writings from other times and cultures, including from ancient civilizations For example, Alexander focuses on writings...

Ngày tải lên: 11/08/2014, 18:20

... recorded in the following consecutive steps: Twice over two minutes at one-minute intervals, in the supine position (Base 1) Four times over four minutes at one-minute intervals, during PLR (lower ... Post-resuscitation syndrome Acute poisoning Vasopressive agents Norepinephrine 10 Epinephrine 11 Norepinephrine (µg/kg per minute) Epinephrine (µg/kg per minute) 0.6 (0.3–0.7) 0.4 (0.3–1) between ... pressure in the left ventricular filling velocity profile Am Heart J 1989, 118:954-962 Boulain T, Achard JM, Teboul JL, Richard C, Perrotin D, Ginies G: Changes in BP induced by passive leg raising...

Ngày tải lên: 13/08/2014, 03:20