implications for health and disease

... globalization, and adverse health outcomes and inequalities is not certain However, nutrition is a key determinant of health [3] and diet is a risk factor for obesity and chronic disease Therefore, it ... Globalization and health: a framework for analysis and action Bull World Health Organ 2001, 79:875-881 Labonte R, Schrecker T: Globalization and social determinants of health: Introduction and methodological ... Globalization and Food: Implications for the Promotion of "Healthy" Diets Globalization, Diets and Noncommunicable Diseases 2002 [http://www.who.int/hpr/NPH/docs/ globalization.diet .and. ncds.pdf] World Health...

Ngày tải lên: 11/08/2014, 14:21

... environmental health disparities and improving the health of all children The ultimate goal of the Children’s Environmental Health and Disease Prevention Research Centers is to create a healthy and sustainable ... goal of developing new clinical and public health applications to improve disease prevention, diagnosis and therapy NIEHS/EPA Children’s Environmental Health and Disease Prevention Research Centers ... reduce children’s health risks, protect children from environmental threats and promote their health and well-being in the communities where they live, learn and play Background For many reasons,...

Ngày tải lên: 12/02/2014, 19:20

... proteins, the Gs, Gi and Gq/11 to stimulate cardiac-specific ACII and ACV or PLC isoforms, utilizing cAMP-dependent PKA, PKC-a and PKC-f to activate a small subset of downstream effectors and ion channels ... to intercellular and intracellular signals to meet the individual environmental requirements Implications of receptor crosstalk for cardiac adaptation to diseases Cardiovascular diseases fall broadly ... in b1-AR and/ or uncoupling of b2-AR with an up-regulation in a1-AR in both experimental heart failure and in human disease strongly argues for the existence of a1-AR as a purposeful and productive...

Ngày tải lên: 21/02/2014, 15:20

... call for a framework for women’s health within health education, gender itself is “a key determinant of health (p 189); therefore, “a broader understanding of the meaning of women’s health and ... determinant of health (Paper prepared for the Canada-USA Forum on Women’s Health) Ottawa: Health Canada Kawachi, I., & Berkman, L F (2001) Social ties and mental health Journal of Urban Health, 78, ... important health determinant to include in studies of gender and health Attitudes and Values Next, there are a number of gendered attitudes and values that profoundly influence health For example,...

Ngày tải lên: 14/03/2014, 21:20

... signaling function, and elucidation of heparanase route and function in the cell nucleus, will advance the field of heparanase research and reveal its significance in health and disease Resolving ... Blood 95, 388–392 Theocharis AD, Skandalis SS, Tzanakakis GN & Karamanos NK (2010) Proteoglycans in health and adisease: novel roles for proteoglycan in malignancy and their pharmacological targeting ... proliferation and the formation of larger colonies in soft agar, in a Src- and EGFR-dependent manner [66] The clinical relevance of the heparanase–Src–EGFR pathway has been elucidated for head and neck...

Ngày tải lên: 15/03/2014, 23:20

... investigations in human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative intensity of expression ... alcohols and aldehydes, without generating toxic radicals, as is the case for the cytochrome P450 system [9] Even though the ADHs are known to be involved in both retinoid transformation and formaldehyde ... intensity of expression of the Adh1, Adh3, Adh4 and Aldh1 genes in the GI tract of rats and mice is summarized in Fig and Table Figures and document key findings and Fig documents probe controls Figure...

Ngày tải lên: 16/03/2014, 11:20

... the study have implications not only for health and health policy, but also for research They represent supporting evidence of the importance of health workers for health, and therefore they contribute ... DATASTATISTICS/Resources/table2_7.pdf] Health Statistics and Health Information Systems Death and DALY estimates for 2004 by cause for WHO Member States [http://www.who int/healthinfo/global_burden _disease/ estimates_country/en/index.html] ... does not affect population health As health workers generally account for the most important part of the health budget and variables accounting for health workers and the variable GDP are also...

Ngày tải lên: 18/06/2014, 17:20

... of CTLA-4 function and dissociates from CTLA-4 upon ligand binding The ligands are the dimeric CD80 and the monomeric CD86 Binding of CD80 to the divalent CTLA-4 leads to the formation of a lattice-like ... rheumatoid arthritis (RA) and other autoimmune diseases 50 The human CD28 and CTLA-4 genes map to chromosome 2q33 and are separated by about 60 kilobases The homologies between CD28 and CTLA-4 strongly ... [81,82] For multiple sclerosis, most studies showed no indication for a contribution of CTLA-4 polymorphisms at positions –318 and +49 as a disease risk factor in Canadian, Polish, Finnish, and Dutch...

Ngày tải lên: 09/08/2014, 01:23

... its design and coordination, helped to perform the statistical analysis, and helped to draft the manuscript SS helped to perform the experimental work and the statistical analysis and helped ... of oxygen and in medium supplemented with 20% FCS and 320 mg/dL glucose Cell proliferation and cell viability Monolayers were harvested by trypsinisation and viable cell counts were performed using ... clinical and experimental indications that factors affecting vascular function or glucose supply are associated with an increased risk of disc disease For example, atherosclerosis [11] and smoking...

Ngày tải lên: 09/08/2014, 10:23

... Figure Conceptual framework for medical tourism and policy implications for health systems Pocock and Phua Globalization and Health 2011, 7:12 http://www.globalizationandhealth.com/content/7/1/12 ... impact on the health workforce and health systems in India Health Policy and Planning 2010, 25:248-251 UNESCAP: Medical travel in Asia and the Pacific: challenges and opportunities Thailand, United ... Bridges J: Health and medical tourism: what they mean and imply for health care systems In Health and Ageing Volume 15 The Geneva Association; 2006 Carrera P, Bridges J: Globalization and healthcare:...

Ngày tải lên: 11/08/2014, 14:21

... PPAR ligands seen in pre-clinical models of efficacy and safety in the context of human health and disease Peroxisome proliferator-activated receptors: structure, ligands, expression and target ... transcriptional activity [14,15] The ligand binding domain (LBD), or E/F domain of PPARs, is responsible for ligand-binding and converting PPARs to an active form that binds DNA and modulates gene expression ... Heber D and Koeffler HP Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in...

Ngày tải lên: 13/08/2014, 13:20

... Prophylaxis in the form of c-globulin replacement is standard for all patients [30,31] Over the last few years, several companies have developed small-molecule inhibitors for BTK [32] and ITK [33,34] ... consisting of the dimerizing TEL protein and SYK, was formed and has been shown to cause a rare form of myelodysplastic syndrome [68] Recently, ITK was the first and only known Tec family member reported ... kinases and disease A Hussain et al ITK–SYK, but not ITK or SYK themselves, is capable of transforming NIH-3T3 cells [70] In addition, we and others have demonstrated that the activation and plasma...

Ngày tải lên: 14/02/2014, 18:20

... normal situation, for a single gain, and n 2 for n copies TCGA provides an Array Design Format file with annotation data, including information on chromosomal location and gene symbol for each probe ... patients 16 Aneuploidy in Health and Disease with Alzheimer disease (AD) than in the healthy population This is likely not restricted to neuronal tissues as lymphocytes and splenocytes from the ... importance and physiological impact of genetic alteration ineluctable on the tumor Gene expression has been readily available for profiling many tumors, therefore, how 24 Aneuploidy in Health and Disease...

Ngày tải lên: 21/02/2014, 23:20

... increased risk, and in a nondisease specific way Thus, health promotive strategies are a viable and much needed direction for health education to take One general strategy aims to strengthen and enhance ... Journal of Health and Social Behavior 16: 1975 347-364, 73 Wildman RC, Johnson DR: Life change and Langner’s 22-item mental health index: A study and partial replication Journal of Health and Social ... predictors of health and mental health status These include: (a) stress, (b) social support and social networks, (c) competence, (d) socioeconomic status and (e) coping.’-&dquo; For example, loss...

Ngày tải lên: 05/03/2014, 18:20

... isotope and one or two isotopes of higher mass of minor abundance The major and minor isotopes are 1H and 2H for hydrogen, 14N and 15N for nitrogen, 12C and 13C for carbon, and 16O, 17O, and 18O for ... Professor of Medicine and Public Health Schools of Medicine and Public Health University of California at Los Angeles Los Angeles, California Chief, Division of Nephrology and Hypertension Harbor-UCLA ... L.D Nutrition Analyst National Center for Health Statistics Centers for Disease Control and Prevention United States Public Health Service Hyattsvile, Maryland HELEN W LANE, R.D., Ph.D Chief Biomedical...

Ngày tải lên: 06/03/2014, 05:21

... Rứisland, Anders Vredin, seminar participants at the Norges Bank Macro-Finance Forum, the 2012 Meeting of the International Finance and Banking Society, and the 2012 Meeting of the Society for ... Shiller (1981) and LeRoy and Porter (1981) have shown that stock prices See, for example, Roxburgh, et al (2012) Examples include Iacoviello (2005), Iacoviello and Neri (2010), and Walentin and Sellin ... knowledge is imperfect 12 See, for example, Kannan, Rabanal and Scott (2009), Angelini, Neri, and Panetta (2010), Christensen and Meh (2011), and Lambertini, Mendicino and Punzi (2011) then, the...

Ngày tải lên: 06/03/2014, 08:20

... properly for cleavage and, for some substrates, exosite-binding is an absolute requirement for degradation A recent review [8] focused on current knowledge with respect to structural and functional ... tissue diseases Knowledge about the regulation of MMP activity is therefore important for understanding various physiological processes, as well as the pathogenesis of a large number of diseases ... in two enzyme forms with Arg17 and Thr64 as N-terminal residues b-hematin induced truncation results in two enzyme forms with Arg42 and Leu54 as new N-terminal residues, with the former identical...

Ngày tải lên: 15/03/2014, 00:20

... only second hand Therefore, understanding the elements of the neuronal environment and the interactions with neurons, and with each other, is crucial in understanding the development and impact ... Freeman and Håkan Widner,1998 Gene Therapy for Neurological Disorders and Brain Tumors, edited by E Antonio Chiocca and Xandra O Breakefield, 1998 Highly Selective Neurotoxins: Basic and Clinical ... regions, and even a whole, perfused brain for hours and days, intact and functional These in vitro preparations deserve attention, and should be given the chance to prove themselves before anyone...

Ngày tải lên: 15/03/2014, 19:20

... manacapi@ rand.org RAND Project AIR FORCE RAND Project AIR FORCE (PAF), a division of the RAND Corporation, is the U.S Air Force’s federally funded research and development center for studies and analyses ... Level Users and Training Infrastructure Information Needs and Flows by Type and Level AETC Management Information Needs and Flows Cost Information Data Needs and Flows Capacity Information ... information useful for decisionmakers The research reported here was sponsored by the Air Education and Training Command (AETC/CV) and HQ Air Force Deputy Chief of Staff, Personnel (AF/DP) and...

Ngày tải lên: 15/03/2014, 20:20

... fibrillogenesis and skin homeostasis Glycoconj J 19, 249–255 Brandan E, Cabello-Verrugio C & Vial C (2008) Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and ... antagonistic ligand of the Met receptor J Cell Biol 185, 743–754 54 Theocharis AD, Skandalis SS, Tzanakakis GN & Karamanos NK (2010) Proteoglycans in health and disease: novel roles for proteoglycan ... Institutes of Health grants RO1 CA39481, RO1 CA47282, and RO1 CA120975 (RVI) and by the Deutsche Forschungsgemeinschaft (SFB 815, project A5, SCHA 1082 ⁄ 2-1, Excellence Cluster ECCPS), and Else Kro¨...

Ngày tải lên: 15/03/2014, 23:20